Articles tagged with Animal Diseases
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A team of researchers at the University of Toronto has developed a rapid screening system to identify compounds that can stop the growth of amyloid proteins. The study found 40 compounds that demonstrate the ability to inhibit amyloid formation, providing a promising lead for future disease treatments.
A new study found that older macaques with smaller social networks suffer less from infectious disease. The research suggests a powerful reason for reduced social connections in aging animals, including humans.
The Center for Genomic Diagnostics at the University of Illinois will develop sensitive and rapid biosensors to detect African swine fever virus. The grant aims to improve on-farm detection and surveillance, providing timely control measures.
A recent study employs zebrafish to model Nager syndrome, revealing the role of sf3b4 mutations in facial development and apoptosis. The research suggests that FGF8 plays a critical role in disease pathogenesis and provides a potential therapeutic strategy.
Chung-Ang University researchers have identified a potential anti-aging drug called IU1 that enhances proteasomal activity and autophagy, leading to improved muscle strength and extended lifespan in fruit flies. The study suggests that preventing disruption of protein homeostasis mechanisms could be key to increasing longevity and impr...
Researchers at Ohio State University discovered that a strain of rat hepatitis E can infect and spread among pigs, raising concerns about the potential transmission of the virus to humans. The study found that infected pigs shed the virus in their feces, highlighting the need for improved food safety procedures.
Researchers comprehensively reviewed cerebellar involvement in Parkinson's disease, highlighting the pathophysiological role of the cerebellum in motor and non-motor symptoms. Studies showed abnormal α-synuclein aggregation, neurodegeneration, and altered functional connectivity between the cerebellum and other brain regions.
Researchers at WVU are working on a project to inhibit the myeloperoxidase enzyme, which feeds pancreatic cancer growth. By targeting this enzyme, they hope to boost the body's immune system to fight cancer, showing promise in mouse models and potential for future clinical trials.
Researchers at Osaka Metropolitan University have successfully generated high-quality feline induced pluripotent stem cells (iPSCs) without a genetic footprint. These cells exhibit properties similar to human iPSCs and can differentiate into various cell types, making them a promising tool for veterinary regenerative medicine research.
A new vaccine created by Mizzou researchers protects cattle from bovine anaplasmosis, a devastating tick-borne disease causing hundreds of millions of dollars in economic losses. The vaccine has been proven to give immunized cattle protection for at least a month and is being discussed with industry partners for future distribution.
A preclinical study found that enhancing PGK1 activity can restore neuronal energy supply in low-fuel conditions, preventing axon dysfunction and degeneration. The researchers also discovered the unexpected role of DJ-1 as an energy-supplying partner of PGK1.
A WVU biologist is studying how genes establish animal body plans and contribute to regenerative abilities. He has identified Hox genes as key players in planarian regeneration, suggesting their functions may differ in highly regenerative versus poorly regenerative organisms.
Parents who struggle with alcohol use disorders can pass along symptoms of early aging to their children, affecting them well into adulthood. These accelerated aging effects include high cholesterol, heart problems, arthritis, and early onset dementia.
A new study from the University of Surrey found that higher faecal bacterial diversity at one month old is positively associated with the athletic performance of Thoroughbred foals. Lower bacterial diversity in early life also increases the risk of respiratory disease and soft-tissue issues.
A preclinical study led by Weill Cornell Medicine researchers found that the iron-chelating drug deferiprone can selectively target and kill ovarian cancer cells. By starving cancer cells of iron, deferiprone triggers a cellular stress response, prompting the immune system to attack them.
Researchers study T cells and monocytes interaction in the meninges before they attack the brain and spinal cord, potentially leading to new disease progression targets. The findings could provide a pathway to treating other neurological diseases like Alzheimer's and Parkinson's.
Researchers at Okinawa Institute of Science and Technology have successfully treated a newly discovered parasitic copepod species that was killing squid eggs. The eco-friendly treatment uses peracetic acid to kill the parasites in under two minutes, with zero effect on squids or their generations.
A new genetic test has identified a mutation causing progressive retinal atrophy (PRA) in English Shepherd Dogs, allowing breeders to eliminate the disease from their population. The test is available for purchase and will help prevent the disease from being passed on to puppies.
A team of Texas A&M researchers will conduct a five-year study on brucellosis in Armenia to improve detection capabilities and provide education. The project aims to better understand the disease's presence and prevalence, allowing the Armenian government to develop a control plan to stop its spread.
Co-circulation of Mayaro and chikungunya viruses has been observed in Roraima, Brazil's northernmost state, according to a recent study. The finding highlights the need for more effective epidemiological surveillance in the region. Deforestation and human activities may facilitate transmission in urban areas.
Researchers found increased liver oxidative stress and impaired antioxidant defenses in a DS murine model. The study suggests potential therapeutic strategies targeting oxidative stress and lipid metabolism to prevent or mitigate liver-related complications.
Researchers found that disease transmission between farms persists despite movement restrictions, with cattle movement activities being the strongest predictor of farm infections. The study calls for a multifaceted approach to managing Salmonella Dublin, including closer monitoring and targeted interventions.
Researchers at UAB have developed a method to assess cardiac dynamics in fruit flies using deep learning and high-speed video microscopy. The study uses this approach to analyze the effects of aging and dilated cardiomyopathy on heart function, with potential applications for human cardiovascular research.
Researchers have identified Stomoxys flies as carriers of pathogenic bacteria that cause bovine mastitis. The study found that these bacteria are more abundant in the fly gut than in manure samples, suggesting a link between insect bites and disease transmission.
A study found that heath goannas are more effective in removing blowflies from the landscape than introduced European mammals. This reduces the emergence of 'fly strike', a disease affecting sheep, and has significant implications for the Australian sheep farming industry.
Researchers discovered Songling virus in Haemaphysalis concinna ticks collected near the China-North Korea border. The study used RT-qPCR and next-generation sequencing to characterize the virus, revealing similarities with other strains.
Researchers at the University of Michigan Health Rogel Cancer Center discovered that pediatric DIPG tumors have a distinct metabolic pathway that allows them to evade treatment. By inhibiting this pathway, radiation therapy became effective in killing cancer cells.
A study by Virginia Tech researchers found that shelter dogs paired with suitable companions exhibited reduced stress levels and were adopted more quickly. The findings suggest that matching dogs with compatible roommates could alleviate stress and improve their adoptability, leading to better outcomes for animal shelters.
Researchers developed DiFC, a two-color diffuse flow cytometry system that detects rare cancer cells in the bloodstream without invasive methods. The technology provides insights into cancer progression and response to treatments by studying different subpopulations of cancer cells simultaneously.
Researchers at Texas A&M University developed vessel-chip technology to create a platform for preclinical drug discovery, reducing the need for animal testing. The system mimics human circulatory systems using tissue-engineered microfluidic devices.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
Researchers at the University of Toronto discovered a new RNA virus, Apocryptovirus odysseus, associated with severe inflammation in humans infected with Toxoplasma gondii. The virus is found in two hypervirulent strains of the parasite, exacerbating toxoplasmosis disease and triggering an immune response.
Researchers identified a novel virus in pet trade zebrafish that causes hemorrhaging in laboratory fish, revealing a risk of viral transmission. The study found that viruses circulating in healthy pet trade zebrafish can transmit to laboratory animals and cause severe disease.
A deadly epidemic discovered last year in the Red Sea has spread to the Indian Ocean, annihilating most sea urchin populations and threatening coral reef stability. The researchers identified a scuticociliate parasite as the cause of the mass mortality.
Researchers have found that a parasitic worm, Eleaophora schneideri, is likely contributing to the decline of moose populations in some regions. The study found microfilariae scattered throughout the brains of infected animals, leading to potential increased morbidity and mortality.
UD researchers discovered white blood cells filled with fat surrounding veins are key contributing factors to wooden breast syndrome. The disease affects up to 5% of broiler chickens, rendering meat tough and chewy. Spatial transcriptomics helped advance studies of obesity in humans.
The North American Bsal Task Force has helped keep the novel pathogen at bay by developing diagnostic techniques, a rapid response template, and a surveillance program. Thirty-five of 80 North American amphibians can be infected with Bsal, causing lethal skin disease in susceptible species.
A deep learning tool has been developed to reliably diagnose moon blindness in horses based on photos, with a high accuracy rate of 93%. The tool supports veterinary doctors in making diagnoses, particularly valuable for less experienced professionals or horse owners in regions with limited vets.
Researchers identified alterations in the monkeypox virus genome that correlate with increased transmissibility, shedding light on the 2022 outbreak. The study's findings may help develop more effective prevention and treatment strategies.
Researchers found that ketogenic diets reduced plasma levels of total Tau in females, mitigated elevations in plasma lipids, and improved circulating lipids. However, neither continuous nor intermittent ketogenic diets improved measures of cognitive or motor behavior in the TgF344-AD rat model.
A new study reveals that disease-resistant fish exhibit lower viral loads and higher survival rates compared to susceptible counterparts. The results demonstrate the benefits of breeding resistant animals for sustainable food production and animal welfare.
Researchers investigate how early-stage Alzheimer's disease affects memory formation by examining synaptic connections and amyloid beta. The study aims to understand the role of NMDA receptors in synaptic plasticity and how they might be hijacked by amyloid beta, leading to memory dysfunction.
Researchers from USF have made significant findings on the genetic basis of disease, using a joint genome-wide association study to track co-evolution between Tasmanian devils and an infectious cancer. The study provides valuable insights that can inform epidemiological models and devil management strategies.
The study emphasizes the need for international cooperation to implement ecological interventions, such as protecting food sources and natural habitats, to prevent pathogen spillover. By conserving biodiversity, bats can be less stressed, reducing their shedding of viruses that can infect humans.
Researchers found that humans transfer viruses to domestic and wild animals at a rate twice that of animal-to-human transmission, highlighting the importance of monitoring viral exchange between species. This study's findings have significant implications for understanding zoonotic diseases and conservation efforts.
The study highlights the emergence and spread of harmful pathogens due to climate change. The medical community must update their education and training to combat global warming and its impact on disease behavior.
A new study has identified a crucial role for plant MLKL proteins in regulating cytoplasmic calcium ion concentration, which is responsible for innate immune responses. The research found that activated plant MLKLs maintain higher calcium levels, activating downstream immune machinery and conferring disease resistance.
Researchers have identified a gene responsible for the development of starvation-induced fatty liver in cavefish, which are able to protect their liver due to reduced fat accumulation. This genetic basis has implications for understanding and addressing liver conditions in humans, including Type 2 diabetes and obesity.
A potentially fatal parasite has been discovered in the Colorado River in California, affecting dogs and causing liver and intestinal illness. Researchers confirm the presence of Heterobilharzia americana, a flatworm that can be transmitted through snails and water, highlighting the need for awareness and precautions among dog owners.
Researchers used single-cell RNA sequencing to analyze the effects of APC treatment on AD transgenic mice, revealing alterations in glial cells and upregulated genes associated with AD progression. APC treatment downregulates inflammatory processes and recovers nervous system functions.
The lack of standardized controls in lifespan studies leads to misleading outcomes and makes it difficult to compare results. Researchers propose solutions for quality control by checking inter- and intra-study consistency of lifespan data.
Researchers at San Diego Zoo Wildlife Alliance have made a groundbreaking discovery that establishes individual baseline values for African elephant blood cell counts, enabling earlier detection and intervention of clinical EEHV infection. This study provides a tool for elephant care facilities to improve preventive medicine and lifesa...
A new study published in GeoHealth suggests that forests can provide natural protection against disease transmission, including malaria. The research found that deforestation increases the risk of malaria, especially among children from poorer households and communities with certain dominant mosquito species.
Sea cucumbers, known as the 'janitors' of the ocean, have been found to be a missing component in maintaining healthy coral reefs. Their removal due to overfishing has led to an increase in coral disease and a decline in biodiversity.
The Almodóvar lab is studying the link between HIV and pulmonary hypertension, a condition that increases pressure in lung arteries. By examining the interactions between different cell types and using a humanized mouse model, researchers hope to propose novel therapies to prevent lung diseases in people with HIV.
Researchers developed a new recombinant flu vaccine called Hexaplex, which provided superior protection against H1N1 and H3N2 viruses in animal models. The vaccine's combination of six proteins from different groups resulted in strong antibody production and T-cell activation, offering broader immunity.
A new study aims to enhance and prolong vaccine effectiveness by delivering adjuvants to white blood cells using lipid nanoparticles. The research, led by WVU professor Sharan Bobbala, has the potential to provide broader protection against evolving viruses and multiple diseases.
Researchers at Texas A&M discovered that immune genes are frequently exchanged between Myotis bat species during seasonal mating swarms, potentially helping humans fight emerging diseases. The study's findings have opened new questions about the importance of hybridization in evolution and its impact on genomicists' knowledge.
A new study from the University of Pennsylvania School of Veterinary Medicine sheds light on how Chronic Wasting Disease (CWD) impacts the gut microbiome, providing a potential tool for disease surveillance. Researchers found that certain types of gut bacteria can differentiate between CWD-positive and -negative deer.
A team of scientists has decoded the evolution of Marek's Disease Virus, a fatal disease in chickens, using ancient DNA from up to 1,000-year-old chicken bones. The study found that the virus was already widely distributed over 1,000 years ago and became increasingly aggressive due to global chicken farming and vaccine use.