Articles tagged with Animal Diseases
The Almodóvar lab is studying the link between HIV and pulmonary hypertension, a condition that increases pressure in lung arteries. By examining the interactions between different cell types and using a humanized mouse model, researchers hope to propose novel therapies to prevent lung diseases in people with HIV.
Researchers developed a new recombinant flu vaccine called Hexaplex, which provided superior protection against H1N1 and H3N2 viruses in animal models. The vaccine's combination of six proteins from different groups resulted in strong antibody production and T-cell activation, offering broader immunity.
A new study aims to enhance and prolong vaccine effectiveness by delivering adjuvants to white blood cells using lipid nanoparticles. The research, led by WVU professor Sharan Bobbala, has the potential to provide broader protection against evolving viruses and multiple diseases.
Researchers at Texas A&M discovered that immune genes are frequently exchanged between Myotis bat species during seasonal mating swarms, potentially helping humans fight emerging diseases. The study's findings have opened new questions about the importance of hybridization in evolution and its impact on genomicists' knowledge.
A new study from the University of Pennsylvania School of Veterinary Medicine sheds light on how Chronic Wasting Disease (CWD) impacts the gut microbiome, providing a potential tool for disease surveillance. Researchers found that certain types of gut bacteria can differentiate between CWD-positive and -negative deer.
A team of scientists has decoded the evolution of Marek's Disease Virus, a fatal disease in chickens, using ancient DNA from up to 1,000-year-old chicken bones. The study found that the virus was already widely distributed over 1,000 years ago and became increasingly aggressive due to global chicken farming and vaccine use.
A team of scientists used ancient DNA to trace the evolution of Marek's Disease Virus, revealing genetic alterations that increased its virulence over time. The study highlights the importance of preserving archaeological remains in understanding the emergence of deadly diseases.
A comprehensive review of targeted therapies for lupus nephritis discusses the challenges of current treatments and proposes strategies to overcome obstacles. Recent advancements in B-cell targeting and alternative approaches such as CAR-T cells are highlighted.
Researchers discovered that Nectandrin B, a bioactive lignan compound from nutmeg, extends the lifespan of Drosophila melanogaster by as much as 42.6%. The study found that Nectandrin B reduces intracellular ROS levels and improves age-related symptoms such as locomotive deterioration and neurodegeneration.
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.
The Georgetown Global Health Center has launched PHAROS, a first-of-its-kind wildlife disease database that collects records of viruses and bacteria in wild animals. The platform aims to predict pandemics like the weather by allowing scientists to share and manage their data, with the goal of making 'one health' a data-driven field.
A study of house finches found that sick birds are more social than healthy ones, preferring to eat with their flock. This behavior may be driven by the benefits of group living for sick birds, but also poses a risk to healthy birds due to increased disease transmission.
Researchers have summarized recent advances in enzyme-activated near-infrared fluorescent probes for non-invasive visualization of enzyme dynamics and disease status. These probes offer high specificity, sensitivity, and biocompatibility, making them valuable assets in biomedical research and healthcare.
Researchers observed Canada goose flocks before and after a population-management cull, finding that the birds strengthened existing relationships rather than forming new connections. This social conservatism helps reduce the potential for increased disease transmission.
A systematic review published in the journal Virulence reveals that introducing more diverse gut bacteria can improve outcomes for people and animals infected with cryptosporidium. This may be achieved through diet, probiotics, or faecal transplant therapy.
A recent study found that insufficient antibody transfer to newborn beef calves leads to negative health effects, including increased medical treatment needs and mortality rates. Researchers recommend beef calf-specific colostrum intervention strategies and better vaccine management for pregnant cows and heifers.
Researchers at Texas A&M University have found a correlation between flavonoid compounds and reduced endometriosis symptoms. Flavonoids like Quercetin and Kaempferol show promise in easing inflammation, with studies suggesting they may help suppress the symptoms of inflammatory diseases like endometriosis.
Asian longhorned ticks, originating from East Asia, have been detected in Ohio, with over 1 million estimated in a single pasture. Researchers stress the need for early detection and targeted control measures to manage these persistent pests.
A recent analysis of the Golden Retriever Lifetime Study data notes a potential correlation between canine sterilization and hemangiosarcoma development. Intact females consistently have lower diagnosis rates, while spayed females show an increasing risk beyond 8 years old.
Researchers developed a PCR test that accurately identifies the causative agent of visceral leishmaniasis, a neglected disease affecting Brazil and Latin America. The test can detect co-infection by both Leishmania infantum and Crithidia, with infection by Crithidia more frequent than previously thought.
A new project will monitor how changing environmental conditions shape viral outbreaks in wild rodent populations to identify hotspots with high potential for spillover into people. The team will use metaviromics and AI to analyze data from wild rodents in the UK and Eastern Uganda.
Researchers analyzed gut and skin microbiota in Shiba Inu dogs with atopic dermatitis, finding that treatment with Oclacitinib restored balance to the microbiome. The study suggests that microbes may serve as potential therapeutic targets for canine atopic dermatitis, offering new disease management strategies.
A new study reveals a distinct genetic fingerprint of Leishmania mexicana in non-traveler patients with cutaneous leishmaniasis, suggesting locally acquired cases are on the rise. The CDC warns that domestic sand flies may acquire a deadly form of visceral leishmaniasis via imported dogs.
Researchers mapped mosquito's tree of life, revealing how the insects chose their hosts and evolved disease transmission. The findings suggest mosquitoes started out feeding on amphibians and later moved to other groups as they flourished.
A team of researchers aims to develop drug therapies by targeting genes that affect metabolism in people with Down syndrome, potentially improving their quality of life. The project will focus on the protein SIM2, which has been linked to breast cancer and metabolic changes in individuals with the condition.
Pioneering work on bacteriophages to combat disease has received an £800,000 boost from the Biotechnology and Biological Sciences Research Council. The grant will advance production of phages to combat disease in the veterinary field and bring them to market.
Brazilian researchers screened 160 existing drugs and identified six compounds effective against Toxoplasma gondii. Almitrine, a COPD treatment, showed significant reduction in brain parasite load. Further studies are needed to repurpose these drugs for toxoplasmosis treatment.
Researchers discovered a synthetic plant biology approach to prevent protein aggregation in human cells and nematodes, using the plant enzyme stromal processing peptidase (SPP) derived from chloroplasts. This finding opens the door to testing SPP as a potential therapy for Huntington's disease.
A study found that a water additive containing pomegranate extract can limit the formation of plaque and tartar in dogs after professional dental cleaning. The additive was shown to reduce plaque buildup by 47% and tartar by 24%, promoting healthy gums.
A UNIGE team investigated the destruction of neurons at different times of the day using fruit fly models and found that cellular stress was more deleterious to neurons at night. This suggests that the circadian clock exerts a protective effect on dopaminergic neurons against oxidative stress.
A study by Washington State University researchers found epigenetic alterations associated with elk treponeme-associated hoof disease, suggesting a systemic impact. The findings also suggest that the disease may be heritable, raising concerns about its transmission and susceptibility.
Researchers at Tokyo University of Science have uncovered a novel mechanism for sorting endocytic cargo, revealing a specific compartment within the trans-Golgi network that determines the fate of cargo. This discovery has implications for understanding basic life processes and diseases caused by disruptions in endocytosis.
A study analyzing data from KoalaBASE found that car strikes, dog attacks, and chlamydia-related illnesses are responsible for a significant number of koala deaths in South East Queensland. The research suggests that interventions such as road signs, overpasses, and information campaigns can help reduce these fatalities.
A new study found that a deadly frog disease, Perkinsea, is more widespread in Central Florida than expected, infecting over a third of sampled frogs. The disease is linked to cooler temperatures and higher precipitation, posing a concern for threatened species like the gopher frog.
Accelerometer sensors can detect sickness behavior in wild boar, allowing for early detection of African Swine Fever. The study found that infected boars were 10-20% less active daily than healthy ones, making this technology a potential tool for disease control and prevention.
A new study by Lund University reveals that disease affects blackbirds for three weeks, rather than just a day or two. The simulated bacterial infection stimulates the birds' immune system, causing them to stop their activities earlier in the evenings and have reduced daily activity periods.
A new study published in BioScience documents the progress of the InvaCost endeavour, which has compiled data on the economic cost of biological invasions. The database now includes over 13,553 entries and provides a clear picture of the major threats posed by invasive species to ecosystems, biodiversity, and human well-being.
Researchers discovered a subtype of avian flu virus is undergoing mutational changes that could increase its risk of being passed on to humans. The study found the virus can cause severe animal infections and be transmitted through airborne droplets.
A new MU study highlights the protective role of innate lymphoid cells and interferons in reducing neurological effects of Brucellosis. The findings could lead to improved diagnostics and therapies for neurobrucellosis, a condition that can cause long-term neurological complications.
A study found more than one in five infected shelter dogs with heartworm or Lyme disease, highlighting the importance of preventive medications. The research also showed that climate change is expanding the geographic range of disease-carrying ticks and mosquitoes.
Research found that increased biodiversity can either help or hinder disease outbreaks in wildlife, depending on environmental conditions. Environmental pollutants like road salt changed the susceptibility of amphibian species to parasites, with higher biodiversity communities experiencing a dilution effect when exposed to pollutants.
Researchers analyzed aerial images of seal colonies to study distribution patterns and found harbour seals stay at larger distances from conspecifics than grey seals, suggesting an evolutionary response to respiratory virus susceptibility. This finding provides opportunities to gather more information about pinnipeds in remote regions.
QUT researchers have created a booster vaccine using implant technology to protect wild koalas from Chlamydia disease. The new device allows for in-the-field vaccination without recapturing the animals, reducing human interference and increasing vaccination efficiency.
A vaccination campaign in Cambodia has successfully protected endangered wild cattle from lumpy skin disease (LSD), a highly contagious viral disease. The campaign, launched in collaboration with the Wildlife Conservation Society, has vaccinated over 20,000 domestic cattle and water buffalo to prevent the spread of LSD to wild ruminants.
The study established a broad range of reptile cell lines, including those from crocodilians, snakes, turtles, tortoises, and lizards. This breakthrough will help advance reptile conservation and replace the need for live animals in scientific research, leading to improved animal welfare.
Researchers propose disease-oriented dosing of rapamycin to delay age-related diseases and increase lifespan. By decelerating early development of these diseases, rapamycin may help individuals live longer.
Researchers from IU School of Medicine have diagnosed a Sumatran Orangutan named Mila at the Indianapolis Zoo with Alkaptonuria, a rare autosomal recessive disorder. The diagnosis was confirmed through molecular analysis of DNA, providing veterinarians with crucial information on Mila's health and treatment options.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
Scientists at the University of Pittsburgh Center for Vaccine Research have identified a protein responsible for lethal liver disease in mice infected with Rift Valley fever virus. Removing this protein, Lrp1, from the liver prevented viral replication and extended mouse lifespan.
Researchers discovered that adult and aged mice demonstrated improved performance in behavioral tasks after environmental enrichment, with MSK1 playing a vital role. The study highlights the importance of MSK1 in converting positive experiences into cognitive benefits across the lifespan.
Researchers have developed a computational tool to compare large datasets and predict immune responses to disease, potentially leading to better vaccines. The new algorithm, designed by La Jolla Institute for Immunology scientists, uses machine learning to identify underlying patterns in immune system data.
A UK survey of rabbit owners found that 1 in 5 pets suffer from painful or debilitating ear disease. Lop-eared and older rabbits were most at risk, highlighting the need for better diagnosis and treatment.
Researchers found osteochondrosis dissecans in fossil bones of Ice Age predators, with an incidence as high as 7% in shoulder and knee joints. The study suggests dwindling populations may have contributed to the disease's prevalence in these ancient species.
A team of researchers from the University of South Australia used a contact-free technique to extract cardiac signals from chimpanzees by filming subtle movements in their face or thorax. The study found that chimpanzees show similar responses to human babies when experiencing fear, excitement, or joy, and that nature scenes can calm t...
Researchers found that biting midges responsible for transmitting the virus are active on warmest days throughout the winter, contrary to previous theories. The discovery suggests that bluetongue virus transmission is likely ongoing year-round, with potential economic impacts for cattle farming.
Researchers warn that exploding wild pig and macaque populations in Southeast Asia pose significant zoonotic disease risks to humans. The study, led by the University of Queensland, found that these animals can carry diseases that can be transmitted to people, highlighting the need for urgent management solutions.
Researchers found that an iron-rich diet can prevent deadly symptoms in mice during active infection, while a functional adaptive immune system is required for immunity against future infections. The study paves the way for the development of new vaccines that could promote immunity for those with diarrheal diseases.
The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
A new study found that wild and feral cats in high-human population density areas release more Toxoplasma gondii parasites. Temperature fluctuations also played a role in parasite shedding from domestic and wild cats. The findings suggest managing feral cat populations could reduce toxoplasmosis transmission risk.
Scientists have developed an innovative platform using engineered human tissue to study how pathogens carried by mosquitoes impact and infect human cells. This breakthrough holds promise for studying other disease vectors like ticks, which spread Lyme disease.