Researchers solve 'bloodcurdling' mystery
Researchers at Harvard University have uncovered a fundamental feedback mechanism that regulates blood clotting, leading to new insights into bleeding disorders and potential treatments.
Blood
Articles tagged with Blood
Life Sciences
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
447,757
articles
2542
topics
Health and Medicine
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
431,843
articles
751
topics
Social Sciences
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
260,756
articles
745
topics
Physical Sciences
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
257,913
articles
1552
topics
Applied Sciences and Engineering
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
225,386
articles
998
topics
Scientific Community
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
193,043
articles
157
topics
Space Sciences
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
29,662
articles
175
topics
Research Methods
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
21,889
articles
139
topics
Mathematics
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
3,023
articles
113
topics
Bleeding disorders going undiagnosed; new guidelines to help
Women with heavy menstrual cycles may be at risk for undiagnosed bleeding disorders. The new guidelines emphasize recognizing symptoms beyond just heavy bleeding, such as family history and laboratory tests. Early diagnosis can prevent complications like bleeding to death during menstruation, childbirth, or surgical procedures.
Mosquito evolution spells trouble for Galapagos wildlife
Researchers discovered that the Galapagos giant tortoise and marine iguana are targeted by mosquitoes feeding on reptile blood, raising fears of devastating native wildlife diseases. The mosquito's adaptation to life in Galapagos could enable rapid spread of new diseases due to the islands' lack of immunity.
Contrary to guidelines, compression stockings do not reduce the risk of blood clots after stroke
A randomised controlled trial of 2518 patients found no significant reduction in deep vein thrombosis with compression stockings. In fact, skin complications were more common in those who received the stockings. The study's findings challenge national stroke guidelines and recommend revising treatment protocols.
Monash researchers lead the way in blood clotting discovery
A Monash-led research team has discovered a new link between disturbed blood flow and blood clotting, which is identified as the precise mechanism by which these changes activate the clotting process. This discovery may explain the lack of effectiveness of commonly used anti-clotting therapies.
Regulating the sugar factory in diabetes
Researchers have identified a gene that controls abnormal sugar production in the liver, a major problem for people with diabetes. The study found that ARNT is decreased in both insulin-producing cells and liver cells of people with Type 2 diabetes.
Women with gestational diabetes during pregnancy have a substantial and persistently elevated risk of type 2 diabetes post birth
A recent study found that women who develop gestational diabetes during pregnancy are seven-and-a-half times more likely to develop type 2 diabetes post-birth. This increased risk remains for several years, emphasizing the need for continued monitoring and intervention. Early identification and treatment of related factors, such as lip...
Diabetics' heart attack risk can be reduced, research finds
Research published in The Lancet found that diabetics who maintain intensive, low blood sugar levels are significantly less likely to suffer heart attacks and coronary heart disease. This is due to a 17% reduction in heart attacks and a 15% reduction in coronary heart disease.
Research points to a new way to protect kidneys threatened by insufficient blood or toxins
Researchers at MCG report breakthrough in treating acute renal failure by blocking mitochondrial fragmentation caused by vascular obstruction, trauma, chemotherapy, and toxins. This can prevent kidney cells from committing suicide and lead to acute renal failure.
American College of Medical Genetics affirms importance of newborn screening dried blood spots
The American College of Medical Genetics emphasizes the value of residual newborn screening dried blood spots in improving child health. The statement supports the storage and use of these spots to enhance newborn screening programs nationwide, while maintaining privacy and confidentiality.
Intriguing early results for device that reshapes enlarged, leaky heart valve
The CARILLON Mitral Contour System safely treats leaky mitral valves even in patients with moderate-to-severe heart failure. After treatment, patients experienced less shortness of breath and reported a better quality of life.
Elevated level of certain protein in urine linked to increased risk for blood clots
Researchers found a strong association between microalbuminuria and venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Microalbuminuria was associated with a higher risk of VTE, even in the absence of traditional risk factors.
Oral rivaroxaban better than subcutaneous enoxaparin for preventing blood clots after knee replacement (Record4 study)
A phase III study found that oral rivaroxaban is more effective than subcutaneous enoxaparin in preventing blood clots (venous thromboembolism/VTE) after knee replacement surgery. The study, published in The Lancet, showed a 31% reduction in relative risk for patients given oral rivaroxaban.
Simple blood test proves powerful ally in the fight against malaria
Scientists at Karolinska Institutet have developed a simple blood test that provides accurate results, helping to ensure patients receive the right treatment. The rapid diagnostic tests (RDT) are being used in low-income countries to improve healthcare outcomes and combat malaria.
Test for hormones in blood not reflective of hormones in breast tissue; breast cancer risk
Researchers at Georgetown University Medical Center found that hormone levels in blood do not accurately reflect breast cancer risk. The study suggests that measuring hormones in blood may give a false impression of breast cancer risk and an imprecise picture of how these hormones affect breast cancer development.
Male sex dysfunction drugs show promise in the lab for treating female sexual disorders
Researchers found that phosphodiesterase type 5 inhibitors, commonly used to treat male erectile dysfunction, can also relax female rat internal pudendal arteries and improve blood flow. The study suggests that these drugs may be effective in treating female sexual dysfunction caused by inadequate blood supply.
Blood tests reveal tobacco smoke residues in non-smoking New Yorkers
A Health Department study found that 57% of adult New Yorkers have elevated cotinine levels, indicating recent exposure to toxic secondhand smoke. This highlights the need for households with smokers to set a 'no smoking' policy at home.
Lead in the blood increases women's mortality
A study of 533 American women found that those with blood lead concentrations above 8μg/dL were three times more likely to die of coronary heart disease. The research adds to the existing evidence on the adverse effects of lead on health, particularly among older cohorts exposed to higher levels of environmental lead.
How a woman nearly lost her leg because of grapefruit
A woman developed a large blood clot in her left leg after eating grapefruit for breakfast every morning on an aggressive weight-loss diet. Treatment with clot-busting medication and a stent resolved the issue, but underlying factors included oral contraceptive use and an inherited mutation.
Accurate assessment of heart disease leads to earlier, more aggressive therapy
A study published in the Journal of Nuclear Medicine found that myocardial perfusion testing with gated single photon emission computed tomography (gated SPECT) is a more accurate predictor of prognosis in chronic ischemic heart disease. Gated SPECT identified individuals at risk for future cardiac events, enabling early initiation of ...
Blood test for brain injuries gains momentum
A blood test can predict the seriousness of a head injury and detect the status of the blood-brain barrier, offering a simpler and faster alternative to CT scans. The test, known as S-100B, has shown accuracy in predicting traumatic abnormalities and could lead to a 30% reduction in unnecessary CT scans.
Chemists: Light-activated 'lock' can control blood clotting, drug delivery
Researchers design a lock-like molecule that controls blood clotting based on exposure to light. The biological hardware could be used to prevent the formation of tiny blood vessels that feed tumors, and also release drugs only on diseased cells or organs. This technology has potential applications in cancer treatment and drug delivery.
Individualized stroke treatment available for patients, though underutilized
Researchers found that 89% of patients treated with catheter-based therapy (CBT) showed significant improvement in neurologic disability and NIHSS score. CBT may be an effective alternative for ischemic stroke patients ineligible for intravenous thrombolysis, with potential benefits including earlier treatment windows.
Large users of zopiclone assessed as impaired
A new study found a positive link between high levels of zopiclone in the blood and impaired driving assessments. Researchers also noted that drivers with zolpidem had no such association, suggesting that these substances have varying abuse potentials.
A fast magnetic fix for sepsis?
A team of researchers has created a microdevice that uses magnetism to remove pathogens from the bloodstream, showing promise as a potential treatment for sepsis. The device, developed by Chong Wing Yung and Don Ingber, achieved over 80% clearance of fungi in contaminated human blood.
Increasing number of Americans have insufficient levels of vitamin D
A significant decline in US vitamin D levels has been reported, with serious consequences including increased cancer and heart disease risks. The study suggests that higher doses of vitamin D supplementation may be necessary to address this growing epidemic.
Genome-wide association scan reveals landscape of inherited variability in response to warfarin dose
Researchers have identified three genes - VKORC1, CYP2C9, and CYP4F2 - responsible for over 40% of warfarin dose variability. The study provides a comprehensive overview of the genetic landscape influencing dose variability, paving the way for more accurate warfarin dosing and reduced patient risk.
Less of a stink in diabetes patients?
Studies have shown that patients with type II diabetes have lower blood levels of hydrogen sulfide, a compound that helps regulate blood pressure. Lower H2S levels may contribute to microvascular dysfunction and increased risk of vascular complications in these patients.
NRL researchers report a forceful new method to sensitively detect proteins
NRL researchers have developed a forceful new method to detect proteins with unparalleled sensitivity and simplicity. The approach can identify as few as 35 attomolar concentrations in under 10 minutes, making it ideal for medical diagnostics, food testing, and national security.
Framingham Heart Study launches new project to develop blood tests for heart disease
Researchers will analyze frozen blood samples from over 7,000 FHS participants to identify biomarkers associated with heart disease and metabolic syndrome. The goal is to develop simple blood tests to predict high-risk patients.
Study suggests blood test for Alzheimer's possible
A study by researchers at the University of Georgia found a direct relationship between two specific antibodies and the severity of Alzheimer's disease symptoms. The team detected higher levels of these antibodies in patients' blood samples, which could lead to an early diagnosis and potentially improve patient quality of life.
Also in the March 10 JNCI
Daily folic acid supplements may increase prostate cancer risk by more than twice that of placebo. Baseline dietary folate intake and plasma levels showed a trend towards reduced risk but did not reach statistical significance. Researchers suggest large epidemiological studies using improved methods to study diet and cancer prevention.
For old or young dialysis patients, AV fistulas remain pure gold
Researchers found that arteriovenous (AV) fistulas are the preferred access method for dialysis treatment at any age, with no significant difference in patency or openness between elderly and younger patients. AV fistulas allow continuous high volumes of blood flow, enabling efficient dialysis treatments.
Blood test predicts chance of dementia
Researchers developed a blood test to measure progranulin levels, predicting the risk of frontotemporal dementia (FTD) in patients. A shortage of progranulin leads to brain cell death, causing FTD, and this test can detect it before symptoms appear.
After a few drinks, older adults more impaired than they think
A recent study found that older adults who consume moderate amounts of alcohol perform worse on cognitive tests than their younger counterparts, despite similar blood alcohol levels. The researchers suggest that this is due to factors other than age-related declines in cognitive skills, such as changes in how alcohol affects individuals.
Updated formula measures kidney function more accurately
A new calculation eliminates obstacles in measuring kidney function in children, relying on various blood tests that can be performed in a clinical setting. The study's findings suggest an accurate estimate is crucial to properly treat children with acute and chronic kidney problems.
Women less likely to have a stroke after mini-stroke
Research reveals women are 30 percent less likely to experience a stroke within 30 days of a mini-stroke, with significant reductions in cardiac events and mortality rates over the course of one year.
Vitamin D deficiency may increase risk of colds, flu
A large-scale study suggests that vitamin D deficiency may increase the risk of respiratory infections, such as colds and flu. Individuals with chronic respiratory disorders, like asthma and emphysema, are particularly susceptible to these infections.
Women less likely to receive critical care after a stroke, MSU researchers find
A recent Michigan State University study found that women are 30 percent less likely to receive a critical clot-busting drug after a stroke. Women also experience longer emergency room delays and poorer quality of care compared to men, despite being more than 60% of all stroke deaths.
Clot-buster boosts survival, decreases disability for deadly subset of stroke
A multicenter study led by Johns Hopkins shows that an experimental clot-busting treatment can increase survival rates and improve function in patients with intracranial hemorrhage, a lethal form of stroke. After six months, about 10% had no lingering disability and 40% were independently caring for themselves.
Genetic profiles can help avoid incorrect dosing of a common drug, say Stanford scientists
Scientists developed a gene-based strategy for warfarin dosing using data from over 5,000 patients worldwide. The algorithm predicts ideal doses with high accuracy, reducing the need for trial-and-error approaches.
Genetic information can improve administration of anticoagulant
A study confirms that using genetic information can more accurately estimate warfarin doses, reducing the risk of overdose or underdose. The gene-based dosing algorithm was found to be more effective than traditional clinical formulas in identifying patients at high risk of bleeding or clotting.
JAMA article contends earlier study overstated validity of findings on bisphenol A
A new letter in JAMA contests an earlier study's associations between bisphenol A and various health issues, citing statistical limitations. The authors conclude that the findings could be due to chance rather than real health concerns.
Unrelated and mismatched cord blood transplantation can still help children with deadly conditions
Researchers found that unrelated cord blood transplantation from a mismatched donor is effective in treating children with life-threatening diseases. The study showed low incidence of complications and improved access to transplant for patients with ethnic and racial minorities.
Program for kidney disease patients effective for reducing serum phosphorus levels
Patients with end-stage renal disease who participated in an education program to limit their intake of phosphorus-containing food additives showed a significant decline in serum phosphorus levels. After 3 months, intervention participants had a 0.6-mg/dL larger decline in average phosphorus level compared to control participants.
Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
Scientists at the German Cancer Research Center have discovered that reduced production of LSR in the liver leads to elevated blood fat levels in obese mice. Restoring LSR production with leptin therapy reverses this effect, reducing blood fat levels and promoting fat breakdown.
Novel economical blood test for hepatitis C
A novel blood test for hepatitis C virus has been developed by researchers at Bonn University and the Bernhard-Nocht Institute for Tropical Medicine. The test is significantly cheaper than existing commercial tests, while maintaining equal sensitivity, and can be used to monitor blood banks in poorer countries.
Green tea may negate the effects of a common cancer therapy
A new study suggests that green tea components may negate the effects of bortezomib (Velcade) in patients taking this medicine. The EGCG polyphenol in green tea bound to boronic acid-containing compounds like bortezomib cancels out their antitumor effects.
Women with high blood pressure during pregnancy face future of complications
Researchers found that women who experienced complications due to hypertension in their first pregnancies are at a higher risk of hypertension after pregnancy. The study, conducted on over 11 million women, also showed that each subsequent affected pregnancy compounds the risks.
Developing countries need support to ethically conduct unlinked anonymous HIV testing
A team of researchers highlights challenges and concerns with unlinked anonymous HIV testing in developing countries. They outline strategies to harmonize high-quality surveillance with international ethical standards, including reviewing justifications, providing confidential voluntary testing, and strengthening local capacity.
Researchers: Molecular forklifts overcome obstacle to 'smart dust'
University of Florida researchers develop a new approach to lab-on-a-chip technology by harnessing biologically powered molecular forklifts. This innovation allows for the creation of 'smart dust' that can detect biological threats and other contaminants without the need for electricity or rinsing.
Workers exposed to lead show more cognitive problems later in life
A follow-up study found that workers exposed to lead at work showed greater cognitive problems after age 55, even when current blood levels of lead were controlled. The researchers linked cumulative exposure to mild deficits in spatial ability, learning and memory, and overall cognitive score.
Why bladder cancer is deadlier for some
Research reveals bladder cancer is more lethal in women and African-Americans, with mortality rates up to 114% higher than their white male counterparts. The study found that traditional factors accounting for only part of the difference, suggesting other important factors are at play.
Mountaineers measure lowest human blood oxygen levels on record
Climbers on an expedition led by UCL doctors reached record-low oxygen levels in their blood, averaging 3.28 kPa, which is significantly lower than the normal human range of 12-14 kPA. The study aims to inform critical care treatment strategies for patients with low oxygen levels.
Biomarkers improve ischemic stroke prediction
Researchers found that testing two inflammation biomarkers, Lp-PLA2 and hs-CRP, improved the prediction of ischemic stroke in patients. Adding both biomarkers to traditional risk factors provided the most accurate picture of stroke risk.
DIAS-2 trial fails to replicate findings of previous trials showing benefit desmoteplase for stroke
The DIAS-2 trial found desmoteplase ineffective in treating acute ischemic stroke due to low clinical response rates and higher mortality rates. The authors attribute the failure to replicate previous findings to mild strokes and imaging limitations.
Nature, nanotechnology fuse in electric yarn that detects blood
Engineers at the University of Michigan have developed a carbon nanotube-coated smart yarn that can detect blood and monitor health. The yarn, made from a combination of natural cotton and nanotechnology, is flexible and durable, making it suitable for wearable applications.
University of Maryland researchers discover gene mutation that appears to help prevent heart disease
Researchers discovered a gene mutation that significantly reduces triglyceride levels and produces a favorable cholesterol profile in the Old Order Amish population. Carriers of this mutation have higher levels of HDL-cholesterol and lower levels of LDL-cholesterol, reducing the risk of cardiovascular disease.
Risk of death may be higher with drug commonly used during cardiac surgery
A systematic review of 49 randomized trials found aprotinin to be slightly more effective at controlling blood loss but with a higher risk of death. Health Canada is set to decide on its use, with alternative treatments like tranexamic acid and aminocaproic being suggested as alternatives.
Thrombosis patients face greater risks than previously believed
A study of 387 patients found that 43% developed postthrombotic syndrome, a long-term complication not addressed by traditional treatment approaches. The risk factors identified include age, previous DVT, and larger blood clots at diagnosis.