Articles tagged with Bone Tissue
Recent discoveries on proteoglycan roles in bone and tooth development have been made, challenging previously held views of their structural function. The symposium aims to provide an update on these findings, which have significant implications for mineralized tissue biology and craniofacial development.
Scientists from Tomsk Polytechnic University have developed a technology to create individual, 3D-printed dosimetry phantoms tailored to each patient's anatomy, enabling more accurate radiotherapy treatment plans. The new phantoms can replicate complex internal structures and take into account implants and pacemakers.
Scientists at ICN2 have found that bone's mineral component exhibits flexoelectricity, which triggers the bone repair process. This effect is localized to the tip of microfractures and signals to osteoblasts where damage needs repair.
A team of researchers from the University of Bonn has discovered a unique type of bony tissue called pneumosteum, which is found in birds and some dinosaurs. This discovery provides new insights into the evolution of their respiratory systems and opens up possibilities for studying extinct species.
Western University researchers have found a high prevalence of bone lesions in the feet of 19th-Century Dutch farmers who wore wooden shoes, also known as klompen. The study suggests that these shoes were partly to blame for the injuries and trauma suffered by the farmers.
Red-toothed shrews experience a dramatic decrease in braincase size from summer to winter, with some organs even shrinking by 30%. This seasonal change may help them conserve energy during food scarcity.
A study by Cornell University researchers found that prolonged bisphosphonate use can alter the composition of bone, making it more brittle and susceptible to fractures. The study suggests that long-term treatment beyond FDA recommendations may increase the risk of atypical femoral fractures.
A new bioactive foam can be molded to fit irregular skull defects, attracting bone cells to naturally regenerate bone. The foam hardens in place, providing a low-cost alternative to current bone grafts.
Researchers at Tufts University found that exercise-induced irisin increases bone formation and thickness in mice, mimicking the effects of exercise on the skeletal system. The study suggests a potential new mechanism for regulating bone metabolism.
A long-term study found that extra physical education classes improved girls' bone mass, structure, and strength. Girls who received 200 minutes of physical education per week showed significant gains in cortical thickness and volumetric bone mineral density compared to controls.
Human pluripotent stem cells can be directed into functional osteoblasts by adding the molecule adenosine, enabling efficient regeneration of bone tissue. The breakthrough could lead to regenerative treatments for patients with critical bone defects and soldiers with traumatic bone injuries.
Researchers investigate the link between diet, obesity-linked Type 2 diabetes, and intervertebral disc degeneration. They suspect that a diet high in processed fats and sugars causes inflammation and modification of disc tissue, leading to degeneration.
Researchers developed a novel super-resolution imaging method to monitor dynamic protein binding, such as talin and vinculin, in living cells. The study revealed clustered binding of vinculins to talin, with five or more molecules binding in one second.
Researchers developed a supervised autonomous robot that excelled in open bowel surgery on pigs, potentially reducing complications and improving surgical outcomes. With further development, autonomous robotic surgery may take human error out of the operating room, benefiting patients undergoing soft tissue surgeries.
Using 3D bioprinting, Griffith University researchers are developing a new method to replace missing teeth and bone using totally bespoke tissue engineered components. The approach aims to reduce the risks of complications and provide a more invasive-free alternative.
Researchers confirm medullary bone, a gender-specific reproductive tissue found in birds, in a 68 million-year-old T. rex fossil. This discovery sheds light on the evolution of egg-laying in modern birds and provides a new tool for identifying dinosaur sex.
A new antibody treatment has shown promise in blocking the process of bone degradation caused by osteosarcoma, a rare type of bone cancer. The treatment reduced bone degradation by up to 80% in a cancer mouse model, offering hope for reducing amputations among young patients.
A NASA study found that exposure to microgravity inhibits the ability of mouse embryonic stem cells (mESCs) to differentiate and generate most cell lineages. This inhibition has significant implications for human tissue engineering and the use of stem cells to regenerate adult tissues.
Scientists developed a silk-based ink that can be used to print complex tissues with versatile functions, including loading with pharmaceuticals. The novel material is biocompatible, flexible, and stable in water, avoiding harsh processing conditions that damage cells.
A special issue of Calcified Tissue International & Musculoskeletal Research explores the relationship between bone material properties and skeletal fragility. The collection of reviews provides a comprehensive overview of the latest findings on mineral, collagen, and water compartments in bone.
A team of researchers has developed a novel method to regenerate bone tissue using the protein signals produced by stem cells. The approach is more sustainable and less risky than current standard therapies, which rely on ground-up bones from cadavers.
A UNSW Australia collaboration uses previously top-secret technology to image whole body organs at a cellular level, reducing analysis time from 25 years to weeks. The technology, developed with Google algorithms, explores osteoporosis and osteoarthritis, revealing connections between blood, bone, lymphatics, and muscle.
A team of researchers from Northwestern University has developed a tri-component synthetic graft to replace torn ACLs, utilizing nanotechnology and biomaterials. The artificial ligament's bone-like ends have healed into native bone, anchoring it in place.
Researchers at Yale School of Medicine have joined forces with a leading 3D biology company to develop 3D printed tissues for transplant research. The technology could shorten wait times for vital organs and eliminate the need for immunosuppressive drugs.
Researchers use NMR spectroscopy to enrich a mouse's carbon isotopes, enabling the growth of biological tissue in the lab. The technique has huge potential for scientific and medical breakthroughs, including replacing heart valves.
A new study led by Penn Dental Medicine researchers has reversed bone loss and inflammation in patients with leukocyte adhesion deficiency, a rare immune disorder. The breakthrough discovery identifies IL-17 as the key driver of periodontitis and bone loss in these patients.
Researchers developed a novel biomimetic tissue engineered bone graft that successfully repaired bone defects in rabbits. The graft, consisting of rabbit adipose derived stem cells and a porous beta-tricalcium phosphate scaffold, promoted osteogenesis and was biocompatible.
A new study reveals that iron may play a role in preserving ancient tissues within dinosaur fossils, but also concealing them. Hemoglobin is identified as a key player in this process, which could lead to the recovery of more preserved tissues from well-preserved fossils.
Research with baboons found that genetic differences may regulate bone remodeling, a natural process where mature bone tissue is removed and replaced. This could explain why older women taking bisphosphonates are at risk of atypical fractures in their femurs, due to slower bone growth and accumulation of bone tissue.
Researchers at the University of Pittsburgh developed a system to attract regulatory T-cells to inflamed gums, reducing inflammation and improving periodontal disease symptoms. The treatment showed promise in animal studies, offering a new therapeutic paradigm for treating gum disease.
Researchers at UTSA and SwRI are developing a synthetic drug-loaded scaffold for bone grafting, which could improve treatment outcomes for patients with large bone defects. The scaffold would be scalable and include drug-microparticles that release active growth factors to promote bone cell formation.
Researchers at Cornell University have developed a new X-ray imaging technique that visualizes damage in bone at the cellular level. The technique uses high-energy hard X-rays to produce images of microdamage in sheep bone with unprecedented resolution.
Polymer implants coated with a bioactive film can bond better with surrounding bone and tissues, reducing complications. The new technique uses microwaves to apply a hydroxyapatite layer that dissolves slowly, promoting stable bonding.
Researchers describe a new treatment approach for periodontal disease, targeting inflammation and promoting gum tissue regrowth. The controlled-release capsules release a protein that guides immune cells to the diseased area, reducing inflammation and creating an environment conducive to healing.
Researchers at University of Nottingham are developing new injectable materials that stimulate stem cells to form new blood vessels, heart and bone tissue. The goal is to create radical new treatments for diseases with no cure, reducing the need for invasive surgery.
Researchers at Brown University have discovered that the stiffness, viscosity, and other mechanical properties of adult stem cells can foretell what they will become, enabling a filter to extract needed cells from larger tissue samples. This breakthrough could lead to better healing outcomes in tissue engineering.
Researchers at NYSCF have successfully grown compact bone tissue using human embryonic stem cells, which can be used to repair and replace damaged bone in patients. The breakthrough could lead to personalized bone grafts that avoid immune rejection.
Researchers created fully biodegradable silk scaffolds with high-compressive strength, mimicking native bone features. The composite materials enhanced human mesenchymal stem cell differentiation and improved bone remodeling.
A recent study found that the ultrasonic bone aspirator can be a useful tool for cosmetic rhinoplasty, allowing precise removal of bone without damaging surrounding soft tissue. The device showed a positive safety profile and early results warranting further investigation and use.
Researchers at Arizona State University have developed a material that can detect and heal cracks in structural materials, increasing toughness by 11 times. The innovative 'autonomous adaptive structure' uses shape-memory polymers to mimic biological systems' healing traits.
Scientists discovered that blocking a molecule's function decreased bone hardness, causing hearing loss, while reactivating it restored the bone's hardness and hearing. The study reveals a molecular pathway regulating bone matrix properties, which may explain rare hearing disorders and connect to conditions like osteoporosis.
Researchers at Stevens Institute of Technology have developed a novel biomimetic approach using nanofibers to reconstruct intricate bone tissue, focusing on engineering cortical bone. The team aims to create robust platforms for complex tissue structures, with potential applications in reconstructive and transplant surgery.
Researchers discovered that human bone samples can act as a biological marker for dozens of metals and toxic elements. The study analyzed rib bones from 84 citizens in a non-industrial region in Russia, finding the presence of 44 additional elements beyond those naturally present in the body.
A research team from NIST and NIH developed a technique to rapidly optimize 3D cell growth media to meet the developmental needs of specific cell types. They found that cells prefer softer environments for development, but those in stiffer gels are more active in building bone tissue.
Researchers have developed a new technique to restore lost bone and gum tissue following periodontal disease, using layers of cells such as stem cells and gingival fibroblasts. The method has been shown to be successful in laboratory studies and has potential applications in other fields like skin grafts.
Researchers at Tel Aviv University have developed a biologically active scaffold made from soluble fibers that can help replace lost or missing bone. The technology, which has shown promise in animal models, could also be used to regenerate other types of human tissues, including muscle, arteries, and skin.
A new study reveals that people with coeliac disease are at risk of developing osteoporosis due to an immune system attack on their bone tissue. Researchers have identified a protein called osteoprotegerin as the target of this attack, leading to rapid bone destruction and severe osteoporosis.
A recent US Army study found that up to 70% of severely wounded soldiers develop excessive bone growth, causing severe pain and mobility issues. Researchers at Thomas Jefferson University discovered a way to prevent this condition by disrupting cellular changes needed to produce bone tissue.
Researchers are developing models to test strategies for treating complex combat injuries, including segmental bone defects and massive soft tissue defects. The center is also investigating ways to protect stem cells during insertion and enhance their healing properties.
The University of Western Ontario has received $45.5 million in funding from the Canada Foundation for Innovation to develop new methods for growing stronger lab-grown bones and tissue. This will help address conditions such as arthritis, osteoporosis, and traumatic injuries, where current lab-grown materials lack sufficient strength.
Researchers at Children's Hospital of Pittsburgh have identified pericytes as a promising source of multipotent adult stem cells. These cells can be extracted easily from blood vessels and grown in culture to produce various types of tissues, including bone, cartilage, and muscle.
Researchers at Georgia Institute of Technology successfully created artificial bones with a graded interface, allowing them to blend seamlessly into surrounding tissues like tendons. This breakthrough technology has the potential to improve outcomes in ACL surgery and other applications where tissue integration is critical.
A new study has shown that adding nanoparticles to porous materials can lead to denser bone tissue. Researchers found that the nanoparticles increased bone ingrowth by threefold after 12 weeks compared to a biodegradable plastic scaffold alone. The study paves the way for further research into tissue engineering and bone regeneration.
Researchers at the University of Michigan have discovered a method for controlling the growth rate of replacement tissue and forming new blood vessels. This breakthrough could be used in various medical procedures, such as bone grafts and dental treatments, to help patients with wound healing problems.
Researchers have found that adult stem cell changes underlie Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disease causing premature aging. The study reveals progerin's effect on adult mesenchymal stem cells, leading to accelerated maturation into bone and loss of fatty tissues.
Researchers at Columbia University have developed a novel porous structure that facilitates the delivery of bioactive cues, accelerating host tissue integration and new bone growth. This controlled-release approach reduces the need for high drug doses, offering a promising solution for orthopedic and dental implants.
Researchers at Max Planck Institute and ESRF study bone deformation using X-rays, revealing a hierarchical structure that allows bones to sustain large strains without breaking. The findings provide new insight into the design principles behind healthy bone fracture resistance.
Rutgers scientists have developed a polymer-based drug delivery system to kill bacteria that attack gum tissue during periodontal disease, promoting healing and regeneration of tissue and bone around teeth. The system treats bacterial infection, inflammation, and pain with pharmaceuticals incorporated into the material itself.
Researchers found that high salivary melatonin levels may be associated with lower periodontal disease severity, as measured by the community periodontal index score. This suggests that melatonin's antioxidant properties may help protect against inflammation and oxidative damage in the oral cavity.
Researchers have found that protein-coated dental implants can induce bone formation and promote tissue regeneration. In laboratory tests, the protein-induced bone growth nearly completely regenerates lost tissue around teeth.