Articles tagged with Bone Tissue
Researchers found evidence of fibrolamellar bone in early tetrapod Whatcheeria, suggesting rapid juvenile growth. This contradicts the long-held assumption that slow growth was ancestral for tetrapods, and instead reveals a more complex life history.
UCF researchers have designed a cerium oxide nanoparticle to protect bones against radiation damage from cancer therapy. The treatment also improves bone regeneration and kills cancer cells, reducing the risk of bone fractures and tissue damage.
Researchers have created a biomimetic mineralized layer that replicates the structure of natural tooth enamel, exhibiting increased nanohardness and surpassing the natural tissue in terms of strength. The new material can be used to restore or repair damaged enamel due to abrasion, erosion, or improper diet.
Researchers at Lehigh University developed a new method to accurately gauge healing progress of bone fractures using 3D models. The model identifies the cutoff point between soft tissue and bone, allowing for more precise predictions of bone behavior during the healing process.
A new series of expert reviews explores less common causes of bone loss, including pregnancy-associated osteoporosis and anorexia nervosa-related osteoporosis. The reviews provide comprehensive information on these unusual conditions and their impact on bone health.
Scientists at Texas A¼M University have created water-stable, 2D covalent organic framework nanoparticles that can guide human mesenchymal stem cells to form bone tissue. The new technology has the potential to impact the treatment of bone regeneration and improve drug delivery.
Researchers at RMIT University used high-frequency sound waves to turn stem cells into bone cells, overcoming challenges in mass production and pain associated with extraction. The innovative treatment is faster, simpler, and more efficient than existing methods.
Researchers used energy dispersive diffraction to create high-resolution 3D maps of bioapatite arrangements within shark centra, revealing key structures and their functions. The study provides insights into the structure-function relationship of the shark skeleton and could be applied to other organisms.
Researchers have developed a combination of materials that can morph into various shapes before hardening, similar to the natural process of bone development in the human skeleton. The soft material can be used to create microrobots that can inject themselves into complicated bone fractures and expand to form new bone.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
Regrowing healthy cartilage in damaged joints is a promising approach to treating arthritis. UConn bioengineers successfully regrowed cartilage in a rabbit's knee using piezoelectricity, a phenomenon that also exists in the human body.
The integration of optical sensing into orthopedic surgical devices has the potential to increase accuracy and improve outcomes in musculoskeletal repair. Researchers explore various types of optical sensing, including spectroscopy and imaging, to address unmet clinical needs in orthopedic surgery.
Researchers at INRS have developed a bioactive coating that mimics bone tissue using chitosan, collagen, and copper-doped phosphate glass. The coating promotes healing and reduces the risk of rejection, paving the way for improved orthopaedic implant success.
Researchers from Doshisha University developed a new imaging technique to measure oxygen concentration in osteoclasts, revealing key molecular mechanisms involved in bone resorption. The study found that hypoxia interferes with TET enzyme activity, limiting osteoclastogenesis.
Research reveals that captive animals on soft food diets may experience weaker skulls and reduced bite effectiveness when released back into the wild. The study found that rats fed softer diets had weaker skulls, but those switched from hard to soft food as juveniles also showed signs of weakened bone growth.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
Researchers developed a tool to investigate cause of death when skeletonised remains are recovered, providing a breakthrough in forensic lightning pathology. The study identified unique markers of lightning damage deep within the human skeleton, allowing for recognition of lightning strikes even when only dry bone survives.
Detailed analyses of cremated bone fragments from Tomb of Nestor's Cup uncovered at least three humans with varying life stages, alongside animal remains like goats and dogs. The study sheds new light on funeral practices and ancient Greek culture.
Researchers at Tel Aviv University successfully printed the first entirely active and viable glioblastoma tumor using a 3D printer. The 3D-bioprinted model includes functional blood vessels that simulate a real tumor, making it a promising tool for predicting treatment efficacy and drug development.
The journal honors the authors of its 10 most oft-cited 2019 papers with certificates of publishing excellence. The papers cover various topics in bone and musculoskeletal research, including muscle function, osteoporosis, and Paget's disease.
The researchers developed a biomaterial made from discarded bullfrog skin and fish scales that acts as a scaffold for bone-forming cells to multiply, leading to the formation of new bone. The biomaterial has shown low risk of triggering an inflammatory response and could be used to assist with bone growth around surgical implants.
Researchers developed natural polymer coatings that significantly improved metal electrochemical corrosion properties and allowed for cell attachment while disallowing bacterial attachment. These coatings can be modified to possess multifunctionality, opening a new era of applications in bone tissue engineering.
A new special issue of Calcified Tissue International brings together state-of-the-art reviews on key issues in CKD-MBD. The reviews cover topics such as pathogenesis, epidemiology, challenges in management, including after kidney transplantation, and the role of bone biopsy in management.
A novel technique using an ancient inorganic salt-based material has been developed to pinpoint and illuminate bone damage, potentially leading to more efficient X-ray diagnostics and treatment. The new method could also be used for advanced applications such as bioimaging and optogenetics.
A team at Tokyo Medical and Dental University developed a material that aids in bone healing, allows for clear assessment of bone damage and clarifies probable patient outcomes. The material incorporates a fluorescent molecule, enabling real-time visual analysis and predictions of therapeutic outcomes.
Researchers develop bioinks that can mimic the dynamic properties of native tissue, enabling the creation of functional tissues and organs. The goal is to produce personalized materials that would not be rejected by the body.
Researchers at NYU Tandon and NYSF have developed a system to sculpt bone tissue with features smaller than a single protein, opening doors for disease modeling, cell research, and targeted therapies. The technology could revolutionize drug discovery and develop better orthopedic implants.
Researchers found that pentosidine and carboxymethyl-lysine, two types of advanced glycation end products, are significantly associated with prevalent vertebral fracture in postmenopausal women. The study suggests that these AGEs may impact bone status via different mechanisms, contributing to impaired bone quality.
The UMass team developed a novel biomaterial, demineralized bone paper, that mimics the dense structural matrix of bone. This material supports cellular processes and can be used to model bone remodeling and disease progression.
Researchers at the University of New South Wales have created a novel ceramic-based ink that enables 3D printing of bone-like structures complete with living cells. This breakthrough technology allows for in-situ fabrication of bone tissue, which may revolutionize bone repair and regeneration techniques.
Researchers developed biocompatible tissue grafts that repaired both bone and cartilage in the temporomandibular joint (TMJ) of pigs. The study showed promising results with intact grafts after 6 months, outperforming existing designs.
Researchers analyzed fossil bones of Panthasaurus maleriensis, an ancestor of modern amphibians, and found phases of rapid and slow growth depending on the climate. The study provides valuable insight into the prehistoric past, with the Indian site showing evidence of both young and adult animals.
Researchers found that donors without fractures had more flexible collagen and mineral nanostructure than those with fractures. The study suggests that flexibility at the nanoscale could be an important predictor of future bone fractures, highlighting the need for new treatments targeting nanoscale bone health.
The study developed a composite material that can be used for regenerating bone tissue, comprising a scaffold made of fibroin and loaded with magnetic nanoparticles. The material stimulates cell growth and differentiation when exposed to a magnetic field, mimicking the cellular microenvironment.
Researchers have uncovered a previously unknown substructure in healthy bone tissue using new X-ray techniques, revealing deviations in the orientation of nanocrystals. This discovery has significant implications for understanding bone diseases and developing new biomaterials.
Researchers at Texas A&M University have developed new biomaterials to advance the field of 3D bioprinting functional tissues. They created a highly printable bioink that can be used to engineer 3D-functional bone tissues, which could potentially create new treatments for patients suffering from arthritis and bone fractures.
The journal has announced its most frequently cited papers from 2018-19, which will be freely accessible. These papers focus on various aspects of musculoskeletal research, including bone metabolism, osteoimmunology, and gut-muscle axis.
Researchers at Penn State developed a novel bioprinting technique that uses aspiration-assisted printing to place tiny tissue spheroids in precise locations, enabling the creation of homogeneous and heterocellular tissues. This method has potential applications in regenerative medicine, drug screening, and microphysiological systems.
A team of scientists has created a new class of 3D-printed biomaterials that can direct the regeneration of functional tissue in damaged cartilage. The materials are designed to provide cells with the exact cues they need to form tissue organized in the same way as natural cartilage.
Researchers at Penn State are using a $2.8 million NIH grant to explore 3D bioprinting for craniomaxillofacial reconstruction. They will investigate bioprinting bone, skin, and other tissues directly during surgery to correct defects in the face, mouth, and skull.
Researchers at Rice University have created a grooved method to seed 3D-printed scaffolds with living cells, enabling the growth of different tissue types in a single platform. This innovative approach protects cells from heat and shear stresses, allowing for the creation of hard implants that can heal bone, cartilage, or muscle.
Researchers have found that Saussurea extract has antimicrobial properties and can speed up bone tissue regeneration. The study suggests using Saussurea to treat bacterial bone infections, which are resistant to antibiotics.
Recent expert reviews provide valuable updates on vitamin D's role in maternal health, rheumatoid arthritis, respiratory disease, and muscle. Key findings include the importance of routine vitamin D supplementation in childhood and pregnancy to support calcium metabolism.
The introduction of small doses of aluminum into the HA lattice enhances biocompatibility, improves matrix properties, and enables application as a coating for implants and high-temperature bioceramics
Researchers studied a small, toothless beak-like structure in prehistoric birds from the Cretaceous period. The predentary, found only in ancient ornithuromorphs, may have aided prey capture with proprioceptive capability and kinetic movement.
Researchers at Lehigh University have created a new biofabrication method that allows for the regeneration of multiple tissues, such as cartilage and bone, within a single scaffold. This breakthrough could potentially treat debilitating conditions like osteoarthritis, which affects approximately 27 million Americans.
Ibrahim Tarik Ozbolat has received $1.5 million in grants to explore ways to bioprint biological tissues like bone, lungs and other organs for use as models in various studies. The projects will investigate current questions about bioprinting of cell spheroids and develop 3D printed models of the lung and upper respiratory environment.
Recent advances in focal and sclerotic bone diseases have led to a clearer characterization of conditions like Paget's disease, fibrous dysplasia, and Camurati-Engelmann disease. This improved understanding has enabled the development of new therapeutic approaches for these disorders.
During their 6,000-km journey to spawn, European eels undergo dramatic silvering and skeleton breakdown, redistributing minerals for energy reserves. The study found significant bone loss in females, with toxic metals transferred to ovaries, raising concerns about conservation impacts.
A case study reveals that taking high doses of vitamin D can lead to kidney damage and malfunction. Patients should be better informed about the risks of using excessive amounts of vitamin D, particularly in low-risk individuals.
Researchers have developed a new group of medicinal products called IASPs that increase muscle and bone mass in mice. The treatment has shown promise in counteracting osteoporosis and improving muscle mass, but its effects on blood cells are still being studied.
Biofabricated tissues with micropores allow for efficient nutrient and oxygen diffusion, enabling the growth of larger tissue samples. The novel approach uses stem cells derived from human fat and sodium alginate porogens to create porous tissue strands that can be implanted in bone or cartilage defects.
Chondral defects are common, with slow self-healing properties of articular cartilage limiting treatment effectiveness. Cartilage tissue engineering offers new hope for patients, using various scaffold materials and preparation techniques to treat chondral defects.
A team of scientists has found medullary bone in a Cretaceous bird fossil, providing the first occurrence of this tissue outside of modern birds. The discovery links birds and dinosaurs, challenging previous assumptions about their relationship.
Researchers developed a targeted therapy that enhances fracture repair in vivo, reducing healing time by 60% without impacting surrounding healthy tissue. The therapy, DAC, was found to double bone density and improve treatment intervals, offering potential benefits for the orthopedic community.
Researchers developed an arthroscopic near infrared spectroscopic probe to evaluate articular cartilage and subchondral bone structure and composition. This technique provides comprehensive information on joint tissue health, enhancing the treatment outcome of arthroscopic intervention.
A study published in PLOS ONE reveals that modern humans colonized Madagascar thousands of years later than previously thought. The research, led by Atholl Anderson, analyzed animal bone material and found evidence of megafaunal extinction starting around 1200 years BP.
Researchers have solved a 160-year-old mystery about the origin of vertebrates' skeletons by studying ancient fossils. They found that heterostracan skeletons were made from a unique tissue called aspidin, which is later revealed to be bone-like in structure.
Researchers identified urinary markers that differentiate between hip replacement patients who develop bone tissue destruction and those who do not. The combination of α-CTX and IL-6 biomarkers predicted osteolysis with high accuracy.