Articles tagged with Bone Tissue
Researchers at Johns Hopkins Kimmel Cancer Center have achieved a 95% cure rate for sickle cell disease using a reduced-intensity bone marrow transplant regimen, preserving fertility in most patients. The study reports low rejection rates and durable engraftment with minimal immunosuppression.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Researchers demonstrate that intraoral administration of abaloparatide combined with orthodontic force supports alveolar bone thickening. ABL-induced alveolar bone formation is linked to the focal adhesion pathway, where FAK activation plays a crucial role.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Osteosarcoma cells often have extra copies of the SETDB1 gene, making the cancer more aggressive and harder to treat. Blocking SETDB1 may help the immune system recognize and attack osteosarcoma cells, offering a promising new way to treat this type of bone cancer.
Researchers developed surface-modified apatite coatings using pH control to enhance cell adhesion and improve the biocompatibility of implants. The study found that controlling the nanoscale surface layer of apatite nanoparticles leads to better binding affinity with biological tissues.
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
A new study reveals that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, suggesting a potential therapeutic approach to restore bone healing in aged animals. The treatment also showed promise in improving the repair and function of other aging tissues.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
A team of biomedical engineers from the University of Melbourne has developed a groundbreaking 3D printing system that can fabricate complex human tissues in just seconds. This technology significantly improves the potential to predict and develop new pharmaceutical therapies, reducing the need for animal testing.
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
Researchers at Osaka Metropolitan University have found that plasma irradiation can enhance tendon-to-bone junction repair, leading to faster healing rates and stronger repairs. The study used rabbit models to test the effects of plasma on rotator cuff injuries, showing promising results.
The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.
A new proteomics study explores the relationship between protein and transcript levels in young-adult and old mice bones. The research identifies key targets associated with bone mineral density and aging, shedding light on protein-specific changes that occur with age.
A team of researchers discovered a protein that blocks bone-forming cells by preventing them from maturing. The study found that the protein CLEC14A reduces bone formation, while its absence leads to increased mineralized bone tissue.
A recent study published in Knee Surgery, Sports Traumatology, Arthroscopy found that children who undergo surgery for discoid lateral meniscus are at higher risk of developing further knee injuries with age. Younger patients were particularly prone to relapse after surgery.
A University of Virginia engineer developed a workflow to combine advanced imaging technologies for improved understanding of porous bone, which could inform disease detection. The method allows for three-dimensional rendering of bone structure across various length scales.
Researchers at Aston University have created a potential treatment for bone cancer using gallium-doped bioactive glasses, which has shown a 99% success rate in killing osteosarcoma cells. The therapy also promotes early stages of bone formation and regenerates diseased bones.
Researchers are studying the role of stress hormones and mineralocorticoid receptors in bone health as we age. The goal is to understand how balance between these factors affects our skeletons. By investigating this complex relationship, scientists hope to develop new insights into osteoporosis and other age-related bone disorders.
A new study uses nanoscopic 3-D imaging to analyze ancient bone samples, revealing insights into protein and tissue preservation during fossilization. The technique shows that Ice Age bones still retain original collagen protein frameworks, offering a potential proxy for screening specimen suitability for molecular sequencing.
Researchers develop mechanobiomaterials inspired by biomechanics to modulate biological responses with material-tissue mechanical interactions. This approach aims to create biomaterials that can adapt to changing mechanical environments in vivo, enhancing the body's regenerative potential and repairing various tissues.
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
A yearlong randomized controlled trial found that daily prune consumption slowed bone loss connected to osteoporosis. Participants who ate at least four to six prunes every day maintained bone density and bone strength.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
Researchers at Texas A&M University have discovered a new technique for tissue regeneration using mineral-based nanomaterials inspired by ancient medical practices. The approach aims to induce natural bone formation, reducing the need for invasive procedures and long-term medication, and promoting improved quality of life.
Scientists have developed a novel maleic acid-treated bacterial cellulose gel that significantly improves bone repair outcomes. The gel's enhanced biocompatibility and osteogenic gene expression promote cell proliferation and differentiation, paving the way for potential applications in tissue engineering.
Fossilized bone fragments from Western and Central Europe have been identified as belonging to gigantic ichthyosaurs due to their unique microstructure. The discovery sheds new light on an ongoing debate among paleontologists, suggesting that these massive sea creatures could have reached lengths similar to the modern blue whale.
A study found that early Mesozoic animals, including dinosaurs, grew quickly around 230 million years ago. This feature is not unique to dinosaurs but was shared by several non-dinosaur reptiles as well.
Scientists from Tokyo Medical and Dental University have created Opto-RANK, a light-activated form of RANK that can induce osteoclast differentiation. The treatment approach uses blue light activation to stimulate local bone resorption, making it a promising tool for treating abnormal calcification diseases and orthodontic issues.
A study from Lund University found that a ceramic bone substitute injection improves the strength of bone anchors and enhances peri-implant bone formation. The treatment combination shows promising results in increasing bone tissue density by up to 10% six months after surgery.
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
Researchers at the University of Basel have developed a system that combines three functions: cutting bone, controlling depth, and differentiating tissue types. This autonomous system uses three lasers to make precise incisions with minimal human interference.
A study published in the American Journal of Human Biology found that COVID-19 has negatively impacted bone tissue, particularly among young adults. The research indicates a significant decrease in bone mineral density during the pandemic compared to pre-pandemic measurements.
Researchers at Washington State University have created implantable metals that can kill 87% of bacteria causing staph infections in lab tests. The 3D-printed materials combine titanium with copper and tantalum, offering inherent antibacterial response and improved bone tissue integration.
Researchers at Johns Hopkins Medicine created a machine learning model to calculate percent necrosis in osteosarcoma patients after chemotherapy. The model achieved an 85% positive correlation with musculoskeletal pathologist results, increasing accuracy to 99% when one outlier was removed. This could help provide patients with earlier...
Scientists from Central South University develop a novel approach to address bacterial infection in bone transplantation by enriching H2O2 and amplifying the Fenton reaction. The technique enhances biocompatibility and safety, promising reduced transplant failures and post-operative complications.
Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.
Researchers found evidence of intentional post-mortem modifications to human remains, including fractures and scrapes, at a cave in southern Spain. These alterations suggest that the ancient humans reused and repurposed their own burial sites for practical purposes.
Researchers discuss the essential role of macrophages in metastatic growth of lung colonies in melanoma, highlighting their importance in clearing challenges to tissue integrity and promoting growth-related processes. The authors emphasize the need for targeted therapies against macrophages to combat untreatable metastasis.
Researchers developed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering, demonstrating potential for clinical applications. The scaffolds can reconstruct desired tissue EM through non-invasive ultrasonic stimulation, promoting cell adhesion and osteogenic differentiation.
The technique has the potential to overcome major shortcomings associated with conventional bioprinting, allowing real-time wound treatment and immediate anastomosis with native tissue. However, challenges remain, including integration with surrounding tissues and limited access to defect sites in articular joints.
A 225-million-year-old Brazilian fossil provides the oldest evidence of air sacs in dinosaurs, which enabled these creatures to grow into giants. The discovery sheds light on how these structures evolved over time, contradicting previous assumptions about their development.
African spiny mice have been found to produce bone plates similar to those of armadillos, a discovery that challenges previous understanding of mammalian armor. The plates, known as osteoderms, provide protection and are distinct from scales found in other animals.
A study found that sleeve gastrectomy decreases bone mineral density and strength in adolescents and young adults. Participants who underwent weight loss surgery lost significant amounts of weight and experienced reductions in abdominal fat tissue and muscle mass.
Researchers developed a novel approach that promotes bone regeneration in mice without implantation of bone tissue or biomaterials. By carefully stretching the skull along its sutures, they activated skeletal stem cells that reside in these wiggly seams, repairing damage to the skull that would not have healed on its own.
Researchers identified key Hox genes as controllers of stem cells involved in both forming and repairing bone. Increasing the activity of these genes restored fracture repair capacity in aging mice by 32.5%, highlighting their potential for treating bone-healing deficiencies.
Researchers at Shenzhen University have developed a compact fiber optical nanomechanical probe (FONP) to measure in vivo biomechanical properties of tissue and even single cells. The high-precision mechanical sensing system enables accurate measurements with spring constants as low as 2.1 nanonewtons.
Researchers at MLU and partners developed a new process coating implant materials with a gene-activated biomaterial that induces stem cells to produce bone tissue. This method, published in Advanced Healthcare Materials, stimulates bone healing in a targeted manner with fewer side effects than existing methods.
Researchers developed a bioactive gel from cow mucus that promotes bone formation and blood vessel growth, potentially replacing traditional bone grafting methods. The gel interacts with the immune system to enhance healing of bone defects.
A 319-million-year-old fossilized fish has provided the oldest example of a well-preserved vertebrate brain, shedding new light on the neural anatomy and early evolution of ray-finned fishes. The discovery reveals that brain evolution in these animals unfolded more complexly than previously thought.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
Researchers compared zebrafish and medaka bones, finding medaka lacks bone cells but retains water-absorbing Proteoglycans. The study suggests a new explanation for why some bones respond better to stress than others.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
Researchers found evidence of fibrolamellar bone in early tetrapod Whatcheeria, suggesting rapid juvenile growth. This contradicts the long-held assumption that slow growth was ancestral for tetrapods, and instead reveals a more complex life history.
UCF researchers have designed a cerium oxide nanoparticle to protect bones against radiation damage from cancer therapy. The treatment also improves bone regeneration and kills cancer cells, reducing the risk of bone fractures and tissue damage.