Articles tagged with Brain Tissue
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Researchers have discovered a common thread between multiple neurodegenerative diseases, including Alzheimer's, dementia with Lewy bodies, and frontotemporal lobar degeneration. A protein called TMEM106B forms fibrils in diseased brain tissue, potentially hobbling cells.
Researchers developed a new imaging approach called VascuViz to visualize blood vessels at different spatial scales. The method enables detailed mathematical models and complementary images to clarify the role of blood flow in health and disease, advancing our understanding of tissues throughout the body.
Researchers from Tel Aviv University found that hyperbaric oxygen therapy (HBOT) relieves PTSD symptoms in treatment-resistant veterans, improving brain function and microstructure. The breakthrough study provides new hope for PTSD sufferers, offering an objective diagnostic tool and potential long-term improvements.
A team of researchers from MIT created a comprehensive atlas of cerebrovascular cells in human brain tissue, identifying 11 subtypes and their functions. The study reveals differences between healthy and diseased cells, potentially leading to new targets for treating Huntington's disease.
Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
Scientists demonstrate a definitive link between mitochondrial oxidative damage and cognitive dysfunction in Alzheimer's disease using a transgenic mouse model. The study found that Aβ1-42 aggregation in the hippocampus caused cognitive impairment, while oxidation led to mitochondrial dysfunction.
Scientists at University College London have developed a novel cancer therapy using magnetic seeds guided by an MRI scanner to heat and destroy tumours. The therapy, called MINIMA, has the potential to precisely treat hard-to-reach cancers with minimal side effects.
Scientists have mapped the tau interactome, showing that mutant tau impacts mitochondria function in human neurons. The study also reveals a mechanism for tau release from neurons and its binding to mitochondrial proteins, which may inform future studies on preventing diseased tau spread.
Researchers have created a compact and affordable device for recording brain activity, offering research-grade signal quality and customizable configuration. The device has the potential to help people with epilepsy detect impending seizures and those with limited mobility regain control over their limbs.
A new wearable headset, Kernel Flow, monitors brain activity using time-domain fNIRS. The system can record high-resolution brain signals from across the brain with performance similar to conventional systems.
A ketogenic diet has been shown to improve spatial memory and visual memory, lower brain inflammation indices, and cause less neuronal death in individuals with traumatic brain injuries. The diet may also slow down the rate of cellular aging, offering hope for those suffering from this condition.
A comprehensive study of exercise performed at different times of the day has identified distinct health-promoting signaling molecules produced by the body in an organ-specific manner. The findings suggest that exercising at the right time can optimize health benefits, particularly for individuals at risk of obesity and type 2 diabetes.
A new tissue expansion method, eMAP, has been developed to improve neural imaging. It allows for the imaging of proteins at neural connections, enabling the measurement of their relative distances and abundance. The technology facilitates high-throughput analysis and enables multiscale imaging of synapses along whole neuronal branches.
Researchers found that zika virus injections destroyed brain tumors in mice and reduced tumor size in cerebral organoids, with immune cells alerting the system to its existence. This approach opens up prospects for virotherapy treatment of central nervous system tumors.
Lesions in white matter carry messages between neurons, damaging it and leading to cognitive deficits. Researchers found that strain on ventricular walls explains where lesions develop in the aging brain.
Researchers at Göttingen University have developed a new X-ray imaging method to detect changes in neuronal cell nuclei, indicating altered activity of neurons. This technique enabled the identification of changes in neurons in Alzheimer's disease.
A study published in Brain Pathology found elevated levels of tau protein in the brains of people with ALS who carry a mutation in the C9orf72 gene. The researchers also identified new genetic mutations in the tau gene and discovered that the ratio of different forms of tau protein may be an indicator of disease progression.
Researchers found that human neurons have a lower density of ion channels compared to other mammals, suggesting an evolutionary adaptation for energy efficiency. This difference in channel density may enable the human brain to allocate more resources to complex cognitive processes.
Researchers at Massachusetts General Hospital discovered that reducing abnormal tau can reverse mitochondrial dysfunction and oxidative stress in ALS. By targeting tau with a specific degrader, the study suggests a promising new treatment strategy for this degenerative disease.
Researchers at Newcastle University have found that increased levels of ceramides and alpha-synuclein protein in extracellular vesicles could help diagnose Lewy body dementia and test treatment effectiveness. The findings may lead to a more accurate diagnosis for the over 100,000 people affected by the disease.
Recent research highlights microglia's involvement in Alzheimer's development and progression. A better understanding of microglial dysfunction may help explore signs and mechanisms of the disease, as well as enable microglia as a potential therapeutic target.
Dampwood termites exhibit brain changes in anticipation of cognitive demand, specifically in visual processing regions. This experience-expectant plasticity is seen before the individual molts into a king or queen, highlighting the insects' adaptability and unique role within the colony.
University of Illinois Chicago researchers discovered a function of mammalian target of rapamycin complex 2 in an antiviral defense mechanism, limiting HSV-1 virus infection through rapid activation of antiviral immunity. The protein complex protects the host by preventing encephalitis and possible death due to HSV-1 infection.
Researchers at TTUHSC have identified novel targets for treating stroke, focusing on enhancing neurolysin activity. The study discovered small molecules that can selectively enhance the activity of neurolysin, which showed promise in reducing damage to the brain after a stroke.
Researchers at Hebrew University developed a novel approach to mapping brain white matter fiber architecture using Nissl staining. The technique, called Nissl-ST, reveals the hidden patterns and organization of glial cells in white matter, opening new avenues for studying brain development, aging, and neurodegenerative diseases.
A study by Purdue University researchers has discovered a way to use gene therapy to turn glial brain cells into neurons, restoring visual function. This process is more efficient and less damaging than stem cell therapy, offering new hope for patients who have lost vision or motor skills after a stroke.
Researchers at UC San Diego are developing higher-resolution sensor grids with increased density to improve diagnosis and treatment of drug-resistant epilepsy. The team plans to test these grids in pigs before conducting clinical trials, aiming to provide surgeons with a clearer picture of brain regions triggering seizures.
Rare fossils from the Cambrian period confirm the presence of an ancestral frontal domain in arthropods, which gives rise to crucial neural centers involved in decision-making and memory. The discovery also sheds new light on the evolutionary origin of visual systems in arthropods.
Researchers at Tel Aviv University successfully printed the first entirely active and viable glioblastoma tumor using a 3D printer. The 3D-bioprinted model includes functional blood vessels that simulate a real tumor, making it a promising tool for predicting treatment efficacy and drug development.
Researchers generated brain organoids containing functional optic cups from human induced pluripotent stem cells (iPSCs), demonstrating intrinsic self-patterning ability. The optic cups exhibited light sensitivity, diverse retinal cell types, and connectivity to brain regions.
A team from the Russian Quantum Center developed a novel solid-state supersensitive room-temperature magnetometer capable of registering weak electrical sources in the brain. The device successfully detected alpha rhythm, a sinusoidal electric current in the back of the brain, and showed higher sensitivity than existing systems.
A new study has found that chronic opioid use changes gene expression in the brains of people with opioid use disorder (OUD), suggesting proinflammatory signaling and synaptic remodeling. The affected genes involved in immune response and neuronal connections were also identified, offering new targets for treatment.
Researchers found that a mobile interventional stroke team treated patients faster and with better outcomes than standard care. Patients treated by the MIST team were more likely to be functionally independent at 90 days post-stroke.
Researchers at City of Hope developed a powerful miniature brain platform to study the causes of Alzheimer's disease and test dementia drugs in development. They used human stem cell technology to model sporadic Alzheimer's disease, finding that exposure to serum from blood can induce multiple symptoms.
Researchers mapped the molecular mechanisms of primate hippocampal aging, identifying key cell types and molecules affected by age. The study provides a valuable resource for diagnostic biomarkers and therapeutic targets for neurodegenerative diseases.
Researchers use X-rays to activate opsins in neurons, allowing for remote control of neural function and behavior. Scintillators emit visible light in response to X-ray irradiation, enabling the technique without tissue damage.
Researchers developed a non-invasive optical technique using spectroscopy to identify structural changes in the brain and diagnose Alzheimer's disease. The new technology has potential as a simple, completely non-invasive method of early detection and could also assess treatment effectiveness.
A team of MIT and Harvard University researchers has developed a modified version of two-photon imaging that can image deeper within tissue and perform the imaging much more quickly than what was previously possible. This technique allows for high-resolution images of structures such as blood vessels and individual neurons within the b...
Researchers have developed a new, noninvasive brain stimulation technique using magnetoelectric nanoparticles to stimulate deep brain function. The method is more efficient than traditional methods without invasive procedures, showing promise for treating various neurological conditions.
Researchers found that a protein associated with reduced heart disease also protects against Alzheimer's-like brain damage in mice. Increasing levels of LDL receptor may slow or stop cognitive decline, offering a promising treatment strategy for dementia.
Researchers mapped misfolded tau proteins' brain journey, finding they resist spread in certain areas. This discovery could lead to new therapies targeting specific brain regions.
A study in fruit flies and rat models reveals that traumatic brain injury disrupts nuclear transport machinery, leading to protein build-up and neurodegenerative diseases. Researchers identify a key enzyme and molecule involved in the process, highlighting a potential target for new treatments.
Researchers have developed a new technique called diffuse optical localization imaging (DOLI) that enables noninvasive imaging of the brain's microvasculature and neural activity at depths of up to 4 millimeters. This method uses the NIR-II window and is poised to bring new insight into how the brain works in health and disease.
Researchers have developed a new fluorescence microscopy technique that allows for high-resolution images of microcirculation in the brain without invasive surgical methods. This breakthrough has the potential to reveal new insights into neurological disorders and facilitate early detection and treatment.
A new study challenges the idea that gray matter is more important than white matter for cognitive health. Damage to dense structural connections in the brain was found to be a better predictor of poor outcomes than damage to functional hubs.
Scientists identify apoE protein's role in regulating immune-response molecules within neurons, leading to selective neurodegeneration. High levels of apoE trigger the expression of MHC-I genes, marking neurons for destruction and contributing to Alzheimer's disease progression.
Researchers at McGill University developed a novel approach using silicone and sugar to create the softest brain implant yet. The new implants have shown reduced inflammation and higher neuronal density compared to traditional hard implants.
Damage to densely-packed white matter regions is strongly associated with cognitive impairment compared to gray matter regions; this suggests that white matter hubs are crucial for cognition. The study's findings provide insights into how brain damage affects cognitive abilities and may help explain differences in cognitive decline.
Researchers developed a miniature light-sheet generator that can be implanted into a living animal's brain, enabling high-speed and high-contrast imaging of brain activity. The technology uses nanophotonic technology to create ultrathin silicon-based photonic neural probes that emit multiple addressable thin sheets of light.
A new study found no evidence of SARS-CoV-2 virus in COVID-19 patients' brains, despite significant pathological changes and neurological effects. Inflammation triggered by the virus may cause damage to the brain's blood vessels and lead to 'brain fog' in mild cases.
David C. Martin, a University of Delaware professor, is advancing novel polymeric materials to integrate electronics with human brain tissue. He has been named a Materials Research Society Fellow for his work on conjugated polymers for interfacing electronic biomedical devices with living tissue.
Researchers at the University of Georgia have developed a hydrogel, known as 'brain glue,' that mimics the composition and mechanics of the brain. The gel has been shown to protect against loss of brain tissue after severe TBI and may aid in functional neural repair.
Researchers at Charité - Universitätsmedizin Berlin have identified a new role for the protein drebrin in controlling scar formation and astrocyte reactivity following brain injury. This mechanism, which regulates membrane trafficking, may hold promise for treating neurological disorders such as Alzheimer's disease.
A new study has found that people with cerebral small vessel disease who have blood-brain barrier leakage have more brain tissue damage over two years than those with less leakage. The study also found a higher leakage rate at the start of the study resulted in more loss of tissue microstructure around brain lesions.
Researchers found that certain genes in inflammatory cells called glial cells increased their activity and grew longer appendages after death. This discovery challenges current understanding of post-mortem gene expression and cell activity, which may impact research on disorders like autism, schizophrenia, and Alzheimer's disease.
A new toolkit developed by researchers at the University of Houston, in collaboration with the National Institutes of Health, enables rapid drug development for brain diseases and injuries. The toolkit uses high-resolution imaging to analyze unhealthy brain tissue, revealing multiple biological processes at once.
Researchers at Ohio State University developed a technology called tissue nanotransfection (TNT) that reprograms skin cells into vascular cells to repair damaged brain tissue. In a mouse study, cells treated with this innovative cell therapy regained 90% of their motor function, showing promise for treating stroke patients.
Flat brain organoids grown on 3D-printed scaffolds show intrinsic gyrification, increasing size and surface-to-volume ratio and offering potential for biologically relevant systems. The results overcome shape limitations of previous spherical models, enabling consistent formation of neuroepithelial folding.
The new NINDS Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome provide a standardized approach to diagnose CTE's clinical manifestations during life. These criteria require substantial exposure to repetitive head impacts and progressive cognitive impairment or neurobehavioral dysregulation.
Researchers have developed an automated silicon-substrate ultra-microtome to improve the speed and quality of brain neural connection reconstruction. The device reduces manual collection skill requirement and ensures high-quality imaging without post-processing operations.