A study in mice suggests that transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack by dampening gene activation linked to negative effects. The transplantation method could help researchers understand the mechanisms behind this protective effect and potentially lead to therapeutic applications.
SourceOhio State University·JournalInternational Journal of Obesity·TypeExperimental study·DateDec 15, 2021
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Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
SourceShibaura Institute of Technology·JournalNutrients·TypeExperimental study·DateDec 13, 2021
Researchers discovered that naked mole-rats rapidly decrease uncoupling protein 1 (UCP1) in brown adipose tissue to conserve energy in hypoxia. This mechanism may hold secrets for humans to survive and thrive in low-oxygen environments, particularly in relation to diseases like stroke and chronic pulmonary disorders.
SourceUniversity of Ottawa·JournalNature Communications·DateNov 24, 2021
A recent study by the University of California - San Diego team discovered that glycogen regulates and promotes fat metabolism, helping to balance energy intake and expenditure. The research suggests modulating glycogen metabolism in fat cells could provide new approaches for weight loss and improved metabolic health.
SourceUniversity of California - San Diego·JournalNature·DateOct 27, 2021
Researchers found that young male winter swimmers had better thermoregulation and higher heat loss due to frequent sauna exposure. They also showed increased brown fat tissue activity, particularly in response to cold exposure.
SourceCell Press·JournalCell Reports Medicine·TypeExperimental study·DateOct 11, 2021
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A study led by McMaster University scientists found that chlorpyrifos slows down the burning of calories in brown adipose tissue of mice, leading to weight gain and obesity. This process, known as diet-induced thermogenesis, is critical for regulating calorie storage and metabolism.
SourceMcMaster University·JournalNature Communications·TypeExperimental study·DateAug 27, 2021
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
SourceMedical College of Georgia at Augusta University·JournalNature Communications·DateAug 10, 2021
A new study reveals that secretin hormone induces satiation by activating brown adipose tissue, leading to increased glucose uptake and elevated energy expenditure. This mechanism has significant implications for weight control and metabolic disorders.
SourceUniversity of Turku·JournalNature Metabolism·DateJun 22, 2021
A new study suggests that increasing a protein in brown adipose tissue remodels white fat to lower diabetes risk. The research found that genetically engineered mice with extra protein had lower blood sugar and insulin sensitivity.
SourceUT Southwestern Medical Center·JournalNature Communications·DateJun 4, 2021
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A study published in Nature Metabolism reveals that vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced energy-burning brown fat cells. This finding could lead to the development of new therapies targeting obesity and metabolic disorders by increasing overall energy expenditure.
SourceJoslin Diabetes Center·JournalNature Metabolism·DateApr 12, 2021
The Masonic Medical Research Institute has developed a novel technique for isolating brown fat cells, which can help study the relationship between brown fat cells and other cell types. This breakthrough could lead to better understanding of diseases and generate innovative cures and treatments.
SourceMasonic Medical Research Institute·JournalJournal of Visualized Experiments·DateMar 15, 2021
A study of 52,000 participants found that those with detectable brown fat were less likely to suffer cardiac and metabolic conditions. Brown fat burns energy, and its presence was linked to lower risk of hypertension, congestive heart failure, and coronary artery disease.
SourceRockefeller University·JournalNature Medicine·DateJan 4, 2021
Brown fat, a biological fuel that increases metabolic rate and decreases fat storage, continues to grow and divide after birth, according to Masonic Medical Research Institute researchers. This finding has major implications, as scientists can try to increase brown fat cells to prevent or reduce obesity.
SourceMasonic Medical Research Institute·JournalScientific Reports·DateDec 11, 2020
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Researchers found that cold temperatures increase vitamin A levels, stimulating the conversion of white into brown adipose tissue and enhancing fat burning. This 'fat transformation' is a potential approach for novel obesity therapeutics.
SourceMedical University of Vienna·JournalMolecular Metabolism·DateOct 21, 2020
Researchers found that beta2-adrenergic receptors in brown fat cells stimulate thermogenesis, a process that burns calories and improves insulin sensitivity. The discovery could lead to new treatments for obesity and type 2 diabetes.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell Metabolism·DateAug 5, 2020
Researchers at the University of Bonn identified a receptor that regulates two side effects of aging: increased abdominal girth and shrinking muscles. The A2B receptor is found in mice and human cell cultures, and its activation increases heat generation and muscle growth.
SourceUniversity of Bonn·JournalCell Metabolism·DateJun 25, 2020
A new metabolism regulation system was found in brown adipose tissue using the kallikrein-kinin hormonal system, which can help prevent damaging effects of excessive activation. This discovery could lead to strategies for moderating thermogenic activity in pathological situations like cancer.
SourceUniversity of Barcelona·JournalNature Communications·DateMay 7, 2020
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that short-term cold exposure increased energy expenditure and improved fatty acid profiles in individuals with active brown fat. People with brown fat burned 15% more calories than those without, highlighting the organ's potential as a ta...
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateApr 28, 2020
A study published in Science Advances found that exercise during pregnancy stimulates the production of brown adipose tissue in fetuses, leading to improved metabolic health and reduced obesity. The findings suggest that physically fit women exercising during pregnancy may be setting their children up for better fitness too.
SourceWashington State University·JournalScience Advances·DateApr 17, 2020
Researchers discovered a novel pathway that boosts brown fat cell's heat-generating capacity without increasing fat accumulation. This finding suggests that activating this pathway may benefit people with obesity, diabetes, and related metabolic diseases.
SourceJoslin Diabetes Center·JournalNature Communications·DateApr 6, 2020
Researchers have discovered a molecular accelerator of leptin action in the brain called Sh2b1, which promotes the stimulation of the sympathetic nervous system and activates brown fat. This activation increases energy expenditure and protects against obesity and metabolic disease.
SourceMichigan Medicine - University of Michigan·JournalNature Communications·DateMar 31, 2020
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Researchers have discovered a new mechanism by which mitochondria and endoplasmic reticulum communicate in brown fat cells, affecting heat production and leading to dysfunctional mitochondria. Without this complex, mice become cold-sensitive and develop abnormal lipid droplets.
SourceMichigan Medicine - University of Michigan·JournalScience·DateMar 30, 2020
Researchers have discovered that blocking the iRhom2 protein increases energy consumption in fat depots, protecting against fat accumulation and inflammation. The study found no deleterious side effects, suggesting iRhom2 blocking may be a promising treatment for obesity.
SourceInstituto Gulbenkian de Ciencia·JournalMolecular Metabolism·DateJan 10, 2020
Researchers discovered that an extract from ginseng can induce Enterococcus faecalis, which produces myristoleic acid to activate brown adipose tissue and reduce adiposity. Increasing BAT activity could be a novel therapeutic approach for obesity and related diseases.
SourceChinese Academy of Sciences Headquarters·JournalGut·DateNov 21, 2019
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Scientists at Scripps Research Institute have discovered a little-known protein that plays a crucial role in managing glucose and insulin levels in the body. The protein, PGRMC2, acts as a chaperone for heme, a molecule essential for cellular processes, and its absence is linked to obesity and metabolic diseases.
SourceScripps Research Institute·JournalNature·DateNov 20, 2019
Researchers at the University of Copenhagen have mapped proteins secreted by adult human brown and white fat cells, revealing they send distinct signals to the rest of the body. Brown fat plays a key role in regulating the cellular immune system, while white fat promotes tissue plasticity.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell Metabolism·DateOct 25, 2019
Researchers have discovered that a lipid produced by brown adipose tissue, called 12-HEPE, helps reduce blood sugar levels in obese mice. The study found that 12-HEPE promotes glucose uptake into both skeletal muscle and brown adipose tissue, leading to improved glucose tolerance.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCell Metabolism·DateSep 27, 2019
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Researchers at Rutgers University have found that brown fat can filter and remove branched-chain amino acids (BCAAs) from the blood, which are linked to diabetes and obesity. The study suggests that environmental factors such as cold temperatures or spicy foods may be able to control BCAA uptake by brown fat.
Research at Kobe University reveals that protein secretions by skin cells, keratinocytes, regulate the differentiation of subsurface skin fat cells into white or brown adipose tissue. The study found that suppressing growth factor proteins BMP2 and FGF21 can decrease white fat cell numbers and increase brown fat cells.
SourceKobe University·JournalJournal of Investigative Dermatology·DateJul 25, 2019
Research suggests that humans have lost the ability to shunt fat cells toward beige or brown fat, leading to an increased reliance on calorie-storing white fat. This shift may have provided an energy advantage for human brain growth, but also contributes to modern obesity.
SourceDuke University·JournalGenome Biology and Evolution·DateJun 26, 2019
Researchers at the University of Nottingham discovered that drinking coffee can stimulate 'brown fat', increasing body heat and burning calories. This could be a key to tackling obesity and diabetes. The study used thermal imaging to trace brown fat reserves and found that caffeine had a direct effect on its functions.
SourceUniversity of Nottingham·JournalScientific Reports·DateJun 24, 2019
Researchers found that mirabegron accelerates atheroclerosis in mice by activating brown fat, potentially increasing the risk of cardiovascular disease and stroke in humans. The study suggests patients with cardiovascular disease or mutations affecting LDL removal should exercise caution when using this drug.
SourceKarolinska Institutet·JournalProceedings of the National Academy of Sciences·DateMay 13, 2019
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Research reveals that cholesterol-lowering statin drugs decrease the formation of brown adipose tissue in adults. Brown adipose tissue plays a crucial role in regulating body temperature and insulin sensitivity. The study found that people taking statins have significantly lower rates of brown adipose tissue compared to non-statins users.
A new study suggests that a molecule called BMP8b could be used as a drug to increase the amount of brown fat in humans and make it more active. In mice, increasing BMP8b levels changed some white fat into brown fat, leading to increased energy burn and lower risk of heart attack. Further research is needed to confirm its effectiveness.
SourceUniversity of Cambridge·JournalNature Communications·DateNov 26, 2018
Researchers discovered that secretin stimulates appetite suppression and increased brown fat heat production in mice. Human volunteers showed similar results, suggesting a link between secretin and satiation. This finding may lead to new approaches for treating obesity.
A new method, DITE, has been developed to accurately measure temperature in fat-containing tissues. The method was tested using fluorescent thermometers and achieved precise results, providing potential insights into the characterization of brown adipose tissue in vivo.
SourceChinese Academy of Sciences Headquarters·JournalMagnetic Resonance in Medicine·DateSep 19, 2018
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers discover gene H19 has a unique protective effect against the development of overweight and related diseases. Genes from mothers primarily lead to the development of brown fat tissue, which has a protective effect against obesity.
SourceUniversity of Southern Denmark·JournalNature Communications·DateSep 6, 2018
Researchers at TUM demonstrated that food increases thermogenesis in brown fat, contrary to the long-held assumption that it only responds to cold. This discovery could lead to new ways to prevent obesity and diabetes.
SourceTechnical University of Munich (TUM)·JournalCell Metabolism·DateAug 29, 2018
A new study by CU researchers has identified histone deacetylase 11 (HDAC11) as a potential therapeutic target for treating obesity and diabetes. Deleting HDAC11 in mice stimulates the formation of brown adipose tissue, leading to increased energy expenditure and a reduction in white adipose tissue.
SourceUniversity of Colorado Anschutz Medical Campus·JournalJCI Insight·DateAug 9, 2018
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Researchers at BIDMC have shown that altering brown fat tissue can significantly impact skeletal muscle function, leading to reduced exercise performance. The findings suggest that myostatin, a hormone normally silenced in brown adipose tissue, plays a crucial role in regulating muscle function.
SourceBeth Israel Deaconess Medical Center·JournalCell Metabolism·DateAug 2, 2018
Researchers at Columbia University have developed a method to directly convert white fat to brown fat outside the body and then reimplant it in a patient. This technique uses fat-grafting procedures commonly performed by plastic surgeons, which is potentially safer than existing methods that use pharmaceuticals or chronic cold exposure.
SourceColumbia University School of Engineering and Applied Science·JournalScientific Reports·DateAug 1, 2018
Researchers have identified P38 alpha as a crucial protein in activating brown fat cells to burn excess fat and eliminate the risk of obesity and related diseases. The study found that mice genetically modified to lack P38 alpha were protected against obesity, diabetes, and fatty liver disease.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalPLOS Biology·DateJul 18, 2018
Research shows that ambient temperature before conception influences offspring's brown adipose tissue activity and protection against excess weight and metabolic disorders. This epigenetic mechanism may explain why people in cold regions have higher levels of brown fat.
SourceETH Zurich·JournalNature Medicine·DateJul 9, 2018
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A new study reveals that having a meal increases oxygen consumption in human brown adipose tissue (BAT) as much as cold exposure does. This finding suggests that eating may be an effective way to activate BAT and support metabolic health.
SourceUniversity of Turku·JournalCell Metabolism·DateJun 20, 2018
Researchers investigated brown fat cells after whitening, finding they are more likely to die than white adipocytes. Whitened fat tissue also shows increased inflammation and macrophages. The ketogenic diet regulates metabolites but not brain levels, suggesting changes in plasma metabolism may not always cross the blood-brain barrier.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalJournal of Lipid Research·DateJun 13, 2018
Researchers found that cardiolipin production in brown fat cells increases calorie-burning and improves insulin sensitivity. Low levels of cardiolipin are linked to obesity and type 2 diabetes.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell Metabolism·DateJun 1, 2018
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Researchers developed a microdialysis technique to measure brown fat's chemical make-up, discovering its activation under both cold and warm conditions. The findings offer potential targets for therapies boosting brown fat's energy-burning power for weight loss.
SourceUniversity of Edinburgh·JournalCell Metabolism·DateMay 24, 2018
A new study by Ohio State University reveals that a lipid released from brown fat, called lipokine, surges in the bloodstream after exercise. This finding suggests that burning of brown fat and this lipid play an important role in the metabolic benefits of exercise.
SourceOhio State University·JournalCell Metabolism·DateMay 1, 2018
Researchers identified a lipid that circulates in the blood after exercise and exposure to cold, which may help reduce triglyceride levels and improve cardiovascular health. The lipid, called 12,13-diHOME, is produced by brown fat and promotes the uptake of fatty acids into working muscles during exercise.
SourceCell Press·JournalCell Metabolism·DateMay 1, 2018
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Researchers at Joslin Diabetes Center have discovered a hormone in fat that boosts metabolism during exercise and cold exposure. The hormone, 12,13-diHOME, is released from brown fat and offers beneficial metabolic effects. Further studies are underway to understand its role in obesity and metabolic disease.
SourceJoslin Diabetes Center·JournalCell Metabolism·DateMay 1, 2018
Researchers find gamma delta T cells in fat play a crucial role in regulating body temperature and protecting against cold shock. These immune cells, known as gd T cells, help turn white fat into brown fat to generate heat, leading to potential weight loss therapies for obesity patients.
SourceTrinity College Dublin·JournalNature Immunology·DateApr 24, 2018
A new study by the University of Nottingham found that lower temperatures can activate the formation of 'good' brown adipose tissue (BAT) in adults. This discovery could lead to new ways of controlling diseases such as diabetes and obesity.
SourceUniversity of Nottingham·JournalScientific Reports·DateMar 21, 2018
Salk researchers discovered how the ERRγ molecule gives brown fat its energy-expending identity, which could lead to new therapies for obesity and related diseases. The study found that the molecule is active in brown fat cells and plays a crucial role in maintaining their ability to burn energy.
Researchers have developed a new non-invasive method to measure the metabolic activity of brown adipose tissue, making it easier to verify its heat generation. The method uses multispectral optoacoustic tomography (MSOT) to visualize changes in oxygenated and deoxygenated hemoglobin, allowing scientists to study its effects on energy b...
SourceTechnical University of Munich (TUM)·JournalCell Metabolism·DateMar 12, 2018
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Researchers at the University of California, Berkeley, found that brown fat cells can be activated to burn calories when stimulated, similar to how muscle cells work. The team identified a potential pathway to trigger this activation and hopes to develop drugs to stimulate brown fat function.
SourceUniversity of California - Berkeley·JournalCell Metabolism·DateMar 6, 2018
Researchers have discovered an enzyme called SNRK that regulates inflammation in white fat tissue and promotes brown fat metabolism. This finding suggests a potential new target for therapies aimed at curbing obesity and its complications.
A study published in Nature Communications identifies MKK6 as a key protein controlling white-to-brown fat conversion. This process enables lipids to be burned for heat instead of stored, potentially reducing obesity. Mice lacking MKK6 exhibit reduced body weight and protection against obesity.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalNature Communications·DateOct 11, 2017
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A study by Georgia State University researchers found that brown fat's role in generating heat is more complex than previously thought. They discovered that lipolysis, which breaks down stored fat, is not essential for heat production in response to cold exposure, but rather regulates fuel selection and white fat browning.
SourceGeorgia State University·JournalCell Metabolism·DateOct 5, 2017
Researchers at WashU Medicine have identified a way to convert white fat into beige fat, a type of fat that burns calories and protects against obesity. By blocking a specific protein in white fat cells, scientists can induce the production of beige fat, leading to weight loss and improved metabolic health.
A new medicated skin patch has been developed that can transform white fat into brown fat locally, increasing metabolism and reducing fat. The patch was tested in obese mice with significant results, including a 20% reduction in treated side fat and lower fasting blood glucose levels.
SourceColumbia University Irving Medical Center·JournalACS Nano·DateSep 15, 2017