Articles tagged with Brown Adipose Tissue
Joslin researchers have discovered that the hormone FGF21 stimulates the browning of white fat, leading to improved glucose metabolism and calorie burning. This finding has implications for the development of new medications for type 2 diabetes and obesity.
Researchers found that platelet-activating factor receptor (PAFR) deficiency leads to increased adiposity and weight gain in mice, causing brown fat dysfunction. This study suggests that regulating PAFR could lead to treatments for metabolic diseases.
A recent study published in Stem Cells has identified brown fat stem cells in adult humans, which may lead to new treatments for heart and endocrine disorders. The discovery could help increase the body's own ability to make brown fat or find novel ways to directly implant the cells into patients.
A team from Penn Medicine discovered that a protein called Rev-erb alpha, found in brown fat cells, regulates daily body temperature fluctuations and adaptability to environmental changes. This mechanism has implications for combating obesity, diabetes, and heart disease.
Researchers at UT Southwestern Medical Center discovered that brown fat cells are generated through new cell formation rather than converting white fat cells. This finding could lead to therapeutic strategies to activate precursor cells to produce more brown fat cells for weight management and related diseases.
Scientists at UTHealth Medical School developed a brown fat detection method that worked in an animal model, providing a new tool to fight obesity. The peptide probe can be used for whole-body imaging and localization of brown fat tissue.
Research identifies a link between the FTO gene and increased hunger-stimulating hormone production in individuals prone to obesity. Additionally, studies show that adult brown fat levels increase with cold exposure, which may provide a new strategy for combating obesity.
A new study published in Cell Metabolism suggests that cold exposure can accelerate the growth of atherosclerotic plaque in blood vessels, leading to increased risk of heart disease-related deaths. Brown fat activation has been linked to the formation of unstable plaques that can rupture and cause blockages in the heart and brain.
Researchers discovered a thermogenic secondary sexual character in male sea lampreys, producing heat through a rare type of fat. The 'rope tissue' plays a crucial role in courtship and mating, making it an essential component of the species' reproductive behavior.
Researchers at Sahlgrenska Academy, University of Gothenburg, have discovered two different kinds of brown fat cells in humans, which can burn energy and turn it into heat. The discovery offers new possibilities for developing methods to stimulate the brown fat tissue and prevent obesity.
Scientists at ETH Zurich demonstrated that white and brown fat cells can convert into each other, challenging current beliefs. This interconversion process is likely to occur in humans as well, offering a novel strategy for treating obesity by promoting brown fat formation.
Scientists decode a 'toggle switch' in mice that significantly stimulates fat burning by converting white fat cells into brown fat cells, potentially combating obesity.
Researchers found that human brown adipose tissue is abundant in deep neck regions and can be grown into functional cells. These findings open possibilities for studying BAT's role in metabolism and developing treatments to combat obesity.
Researchers have discovered that a protein switch called Ebf2 determines the development of brown fat cells, which are thought to counteract obesity by burning excess energy. The study found that Ebf2 regulates the binding activity of PPAR-gamma, a protein that regulates differentiation of developing cell types.
Researchers found a cross-talk between two types of brown fat that helps maintain body temperature and protect against diet-induced obesity. The study's findings may lead to new therapies that increase BAT formation to treat obesity.
Researchers have discovered a trigger that turns muscle stem cells into brown fat, a form of good fat associated with less obesity. The discovery, published in Cell Metabolism, provides hope for a potential obesity treatment using adult skeletal muscle stem cells.
Sanford-Burnham researchers discover that protein p62 plays a crucial role in balancing metabolism in fat tissue. When p62 is missing, the body's metabolic balance shifts towards 'bad' white fat and away from 'good' brown fat. This finding indicates that p62 could be an attractive target for new therapies aimed at curbing obesity.
Researchers discovered that brown fat transplants significantly decreased body weight and improved insulin sensitivity in mice fed high-fat diets. The study also found that the transplanted brown fat secreted hormones that mediated metabolic effects throughout the body.
Researchers performed brown fat transplants in mice to treat obesity, finding significant reductions in body weight and improvements in glucose metabolism. The transplanted brown fat secreted hormones that mediated metabolic effects throughout the body.
Research at Beth Israel Deaconess Medical Center has uncovered new insights into energy balance, a complex interchange between the brain's hypothalamus and energy expenditure. The study reveals that GABA neurotransmitter selectively drives energy expenditure and helps explain the fat-burning properties of brown fat.
Scientists have decoded signals that boost the burning of fat, focusing on the conversion of white fat cells into beige fat cells. Beige fat cells are efficient at converting energy from food into heat and can form from white fat cells.
Researchers at Columbia University Medical Center have identified a mechanism that can give energy-storing white fat some of the beneficial characteristics of energy-burning brown fat. By activating a cell receptor called ppar-gamma, scientists found that sirtuins boost metabolism by promoting the browning of white fat.
Scientists use thermal imaging to analyze brown fat reserves, which produce heat and aid in burning calories. The technique may help predict food labels' thermogenic index, aiding the fight against obesity.
Researchers identified a third type of fat cell, beige adipocytes, that can be activated to burn energy and generate heat in both mice and humans. Beige fat cells are genetically intermediate between white and brown fat, and respond to hormone irisin, which is released during exercise.
A new study by University of Iowa researchers shows that a natural substance found in apple peel can partially protect mice from obesity and some of its harmful effects. Ursolic acid increases muscle and brown fat in mice on a high-fat diet, leading to increased calorie burning and reduced obesity, pre-diabetes, and fatty liver disease.
Researchers at Joslin Diabetes Center found that cold exposure stimulates brown fat energy expenditure with fewer other systemic effects, suggesting a promising approach to treating obesity. The study disproves the use of ephedrine as a weight loss drug, which has side effects.
Researchers at the University of Cambridge have identified a protein called BMP8B that regulates brown fat activation in both brain and body tissues. Activating this protein may help support weight loss programs and prevent metabolic rate decrease.
Researchers at Brigham and Women's Hospital have identified a new candidate pathway for treating visceral obesity by manipulating vitamin A metabolism. By inhibiting the enzyme Aldh1a1, white fat cells can take on characteristics of brown fat, leading to reduced fat storage and improved metabolic health.
Scientists at UCSF have identified a protein called PRDM16 that can convert ordinary white fat cells into brown fat cells, which burn calories. This discovery makes PRDM16 a possible target for future obesity treatments.
Researchers found that an anti-cancer gene can help combat obesity and age-related diseases by activating brown fat, a type of tissue that burns off excess fat. A synthetic compound with the same effect has been developed, offering hope for a new drug to boost tumour suppressors or improve nutrient metabolism.
Researchers discovered that mice with an extra copy of the tumor suppressor Pten gene experience hyperactive brown fat, burning energy instead of storing it. This leads to improved metabolic balance, reduced insulin resistance, and lower liver fat, contributing to longer lifespan and cancer prevention.
A study found that young mice require a second round of heat-generating brown fat to survive after their mothers pass away. The findings also reveal that the babies are extremely sensitive to molecular-level effects that change gene dosage.
Researchers discovered that cardiac natriuretic peptides can convert white fat cells into brown fat cells in mice and humans, increasing energy usage and potentially aiding in weight loss. The study suggests a new approach to combating the obesity epidemic.
Research by Sheila Collins and colleagues found that cardiac natriuretic peptides cause white fat cells to take on characteristics of brown fat cells, increasing energy usage. In another study, Anne Müller's team identified a cellular mechanism by which Helicobacter pylori protects against asthma by modulating immune cells.
A team of researchers found that brown fat in adult men burns energy to generate body heat when exposed to cold temperatures, but not at warm temperatures. This discovery has significant implications for the human obesity epidemic, suggesting that increasing brown fat is unlikely to lead to weight loss and instead highlights the need f...
Researchers have found that brown fat in healthy adult men burns energy to generate body heat during cold exposure, but not at warm temperatures. This discovery has significant implications for combating the human obesity epidemic and suggests that increasing brown fat may not lead to weight loss.
A team of researchers at Dana-Farber Cancer Institute has isolated a natural hormone from muscle cells that triggers key health benefits of exercise. The protein, called irisin, has been shown to improve glucose tolerance and reduce white fat, promoting the development of 'good' brown fat.
New study reveals bacteria in large intestine slow down 'good' fat tissue activity, affecting energy usage and weight gain. Researchers found links between intestinal bacteria, gender differences in weight, and brown fat activity.
A team of researchers at UCSF has discovered that tiny immune cells called macrophages can switch on the brown fat in response to cold temperatures, inducing it to burn energy and produce heat. This finding suggests that the immune system plays a role in thermoregulation, potentially leading to new strategies for enhancing metabolism.
Scientists at UC Metabolic Diseases Institute discover that targeted inhibition of CB1 receptor can increase calorie burning in brown adipose tissue, leading to reduced body weight and blood glucose. Further study aims to find a safer and more effective drug strategy for glucose regulation and weight loss.
Researchers found that narcoleptic patients have a deficiency of the neuropeptide hormone orexin, leading to impaired brown fat activity. This can result in excessive weight gain despite reduced caloric intake.
Scientists at Sanford-Burnham discovered that orexin activates calorie-burning brown fat in mice, suggesting potential for new obesity treatments. The hormone is associated with increased energy expenditure and weight loss.
Researchers at Joslin Diabetes Center have identified two molecular pathways that activate brown fat, a type of fat that burns energy rather than storing it. The study provides new opportunities to stimulate brown fat growth, which could lead to the development of treatments for obesity and diabetes.
Researchers found that a socially engaging environment can convert white fat to brown fat, leading to increased energy expenditure and weight loss. The study suggests that social isolation may contribute to obesity, highlighting the importance of social engagement in maintaining a healthy metabolism.
Researchers at Ohio State University Medical Center found a biological switch that converts white fat to brown fat, leading to reduced abdominal fat mass and improved metabolism. The discovery uses environmental enrichment to activate a nerve and biochemical pathway that stimulates the transformation.
A study at Joslin Diabetes Center and Children's Hospital Boston found that 'good' brown fat is prevalent in leaner children, increasing until puberty and then declining. Boosting brown fat activity may be an effective approach to combating childhood obesity.
Research found that cortisol controls the recycling of bile acids, which are crucial for fat digestion. Without cortisol, mice lose weight and develop gallstones due to reduced bile acid levels. In humans with Addison's disease, cortisol deficiency also disrupts bile acid recycling.
Researchers found that reducing TGF-beta protein actions in mice converted white fat into brown fat-like cells with increased mitochondria, leading to calorie burning and reduced obesity. This discovery identifies a potential new approach to treating obesity and Type 2 diabetes.
Researchers discovered large amounts of brown fat in adults and found it can be grown in labs, burning substantial calories. The discovery suggests brown fat could be used to treat obesity and diabetes, but cannot replace traditional approaches.
Researchers at Johns Hopkins University have successfully transformed 'bad' white fat into 'good' brown fat in rats, reducing their calorie intake and weight. This breakthrough finding could lead to new obesity treatments for humans by targeting the transformation of white fat into brown fat.
Research suggests that reduced exposure to seasonal cold may contribute to rises in obesity due to minimized energy expenditure and reduced body heat production. Increased indoor temperatures may also lead to a loss of brown fat, reducing the body's capacity to burn energy.
Scientists at Joslin Diabetes Center have identified progenitor cells in mouse white fat tissue and skeletal muscle that can be transformed into brown fat cells. The study found that exposure to the protein BMP-7 and the diabetes drug rosiglitazone increased conversion rates, suggesting a potential for cell-based brown fat therapies.
Researchers discovered a genetic link between the gene CRTC3 and obesity. Mice lacking the gene were protected from weight gain on high-fat diets, suggesting that increased brown fat cells may control obesity. Human studies also found a higher incidence of obesity in individuals with an active version of the gene.
Research shows that deleting the ghrelin receptor but not the protein itself boosts the body's fat-burning thermostat in aging mice. This results in thinner mice with lower circulating lipids and increased heat production.
Researchers aim to create new therapeutics using novel insight into fat metabolism, targeting a type of fat cell that burns calories and reduces weight. The study builds on key discoveries about brown fat, a molecular furnace that generates heat by burning calories.
A recent study by UT Southwestern researchers suggests that the brain enzyme PI3 kinase plays a key role in regulating body heat and calorie burn after consuming high-fat meals. Mice with reduced PI3 kinase activity gained weight due to impaired thermogenic response, highlighting potential new targets for combating obesity.
A study by the Helmholtz Association found that COX-2 inflammation enzyme increases in white fat tissue after cold exposure, stimulating the formation of brown fat cells. The scientists also discovered that boosting COX-2 production in mice leads to a 20% reduction in body weight.
Researchers discover that mother's milk induces liver production of FGF21, a molecule that activates brown fat to increase body temperature. This phenomenon may have far-reaching consequences for metabolic health in adulthood.
Scientists at the University of Bonn have discovered a way to turn on the 'natural heating system' in brown fat cells, which can lead to increased energy expenditure and reduced body weight. By activating this mechanism, it may be possible to fight obesity with fat.
Scientists have discovered a direct link between insulin and core body temperature, finding that insulin injection in specific brain areas increases metabolism, brown adipose tissue activity, and core temperature. The study suggests a potential therapeutic area for future drug design and new insights into obesity and diabetes.