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Brown fat cells make 'spare tires' shrink

Scientists at the University of Bonn have discovered a way to turn on the 'natural heating system' in brown fat cells, which can lead to increased energy expenditure and reduced body weight. By activating this mechanism, it may be possible to fight obesity with fat.

SourceUniversity of Bonn·JournalScience Signaling·DateDec 1, 2009

Inhibiting the cellular process autophagy makes mice leaner

A new study reveals that inhibiting autophagy in mice leads to an increase in brown fat cells and a reduction in body mass. The researchers conclude that autophagy has a crucial role in regulating the formation of distinct fat cell types, providing a potential avenue for treating obesity.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateOct 12, 2009

Prion infectivity found in white and brown fat tissues of mice

Researchers have discovered novel prion infectivity in white and brown fat tissues of mice, shedding new light on the pathogenesis of prion diseases. This finding may have significant implications for preventing prion infection in animals and humans, particularly in ruminants suspected of exposure to or infection with prions.

SourcePLOS·JournalPLOS Pathogens·DateDec 4, 2008

Scientists find brown fat master switch

Researchers at Dana-Farber Cancer Institute have identified a gene and protein known as PRDM16 that controls the production of brown fat, a type of adipose tissue that generates heat and counters obesity. The study suggests that turning up this switch in humans could be a new strategy for treating overweight and obesity.

SourceDana-Farber Cancer Institute·JournalCell Metabolism·DateJul 10, 2007

Why piglets shudder to keep warm

New research reveals that the UCP1 gene was inactivated 20 million years ago in pigs, causing them to lose the ability to use brown fat for body heat. As a result, piglets shudder to maintain their body temperature.

SourcePLOS·JournalPLOS Genetics·DateAug 17, 2006