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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Joslin study identifies 'good' energy burning fat in lean adults

Researchers at the Joslin Diabetes Center have demonstrated that adult humans still have a type of 'good' fat called brown fat, which is active in burning calories and using energy. Brown fat was found to be more common in thin adults with normal blood glucose levels, but less likely to be present in those who were overweight or obese.

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Prion infectivity found in white and brown fat tissues of mice

Researchers have discovered novel prion infectivity in white and brown fat tissues of mice, shedding new light on the pathogenesis of prion diseases. This finding may have significant implications for preventing prion infection in animals and humans, particularly in ruminants suspected of exposure to or infection with prions.

Making 'good' fat from muscle and vice versa

Researchers at Dana-Farber Cancer Institute discovered a molecular switch that can convert muscle precursor cells into brown fat cells, which burn calories and release energy. The breakthrough could lead to new treatments for obesity by activating the calorie-burning process in the body.

Joslin study identifies protein that produces 'good' fat

Researchers at Joslin Diabetes Center identified a protein called BMP-7 that induces the formation and function of brown fat cells. This discovery may lead to new treatments or prevention strategies for obesity and its associated diseases.

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Fat chance: Brown vs. white fat cell specification

Researchers discover how PRDM16 regulates fat cells to favor brown adipose tissue (BAT) formation, which can help counteract obesity and diabetes. The findings provide insight into the molecular mechanisms behind BAT specification and hold promise for therapeutic treatments.

Scientists find brown fat master switch

Researchers at Dana-Farber Cancer Institute have identified a gene and protein known as PRDM16 that controls the production of brown fat, a type of adipose tissue that generates heat and counters obesity. The study suggests that turning up this switch in humans could be a new strategy for treating overweight and obesity.

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Why piglets shudder to keep warm

New research reveals that the UCP1 gene was inactivated 20 million years ago in pigs, causing them to lose the ability to use brown fat for body heat. As a result, piglets shudder to maintain their body temperature.

Warm blanket lessens chances of false-positives in cancer scans

Researchers at Saint Louis University School of Medicine found that heated blankets can significantly reduce false-positives in cancer scans caused by brown adipose tissue. The blankets reduced the uptake of tracer by 62%, compared to 30% with traditional drugs.

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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.

Newborn lambs' central heating system could aid fat busting in humans

Researchers at Imperial College London have discovered a key to tackling obesity in humans by studying the thermal regulation system of newborn lambs. The study found that a molecular switch controls the transformation of brown fat into normal white fat, and that activating this switch could potentially lead to new weight loss techniques.

Researchers identify pathway that helps keep weight in check

Diet-induced thermogenesis is an intricate system of communications masterminded by the brain that produces heat and helps prevent obesity. By removing beta adrenergic receptors, researchers found that mice fed a high-fat diet grew massively obese, highlighting the importance of this pathway in preventing weight gain.