A new study reveals that inhibiting autophagy in mice leads to an increase in brown fat cells and a reduction in body mass. The researchers conclude that autophagy has a crucial role in regulating the formation of distinct fat cell types, providing a potential avenue for treating obesity.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateOct 12, 2009
Researchers at Dana-Farber Cancer Institute engineered mouse cells to produce brown fat, a natural energy-burning type of fat that counteracts obesity. Transplanted into adult mice, the synthetic brown fat precursors burned excess energy at a high rate.
SourceDana-Farber Cancer Institute·JournalNature·DateJul 29, 2009
Researchers found that adults, particularly young women, have functional brown adipose tissue, which burns calories and generates heat. Three ounces of brown fat can burn hundreds of calories per day.
Researchers have found that cold and brown fat cells play a significant role in metabolism, raising the prospect of a new method for treating obesity. The discovery suggests that increasing fat burn could be a more effective approach than solely reducing energy intake.
SourceUniversity of Gothenburg·JournalNew England Journal of Medicine·DateApr 16, 2009
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Researchers at the Joslin Diabetes Center have demonstrated that adult humans still have a type of 'good' fat called brown fat, which is active in burning calories and using energy. Brown fat was found to be more common in thin adults with normal blood glucose levels, but less likely to be present in those who were overweight or obese.
SourceJoslin Diabetes Center·JournalNew England Journal of Medicine·DateApr 8, 2009
Researchers have discovered novel prion infectivity in white and brown fat tissues of mice, shedding new light on the pathogenesis of prion diseases. This finding may have significant implications for preventing prion infection in animals and humans, particularly in ruminants suspected of exposure to or infection with prions.
Researchers at Joslin Diabetes Center identified a protein called BMP-7 that induces the formation and function of brown fat cells. This discovery may lead to new treatments or prevention strategies for obesity and its associated diseases.
Researchers at Dana-Farber Cancer Institute discovered a molecular switch that can convert muscle precursor cells into brown fat cells, which burn calories and release energy. The breakthrough could lead to new treatments for obesity by activating the calorie-burning process in the body.
SourceDana-Farber Cancer Institute·JournalNature·DateAug 20, 2008
Researchers discover how PRDM16 regulates fat cells to favor brown adipose tissue (BAT) formation, which can help counteract obesity and diabetes. The findings provide insight into the molecular mechanisms behind BAT specification and hold promise for therapeutic treatments.
SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateMay 14, 2008
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Researchers at New York Medical College discovered a link between bird lack of brown fat and dinosaur extinction. The study found that birds' inability to generate heat may have contributed to the demise of dinosaurs.
SourceNew York Medical College·JournalBMC Biology·DateApr 23, 2008
Researchers at Dana-Farber Cancer Institute have identified a gene and protein known as PRDM16 that controls the production of brown fat, a type of adipose tissue that generates heat and counters obesity. The study suggests that turning up this switch in humans could be a new strategy for treating overweight and obesity.
SourceDana-Farber Cancer Institute·JournalCell Metabolism·DateJul 10, 2007
Researchers identified genetic and cellular mechanisms that enable mice with high-fat diets to resist obesity and diabetes, suggesting a role for brown fat cells. The study may lead to new therapies for obesity and prevention of type 2 diabetes.
SourceJoslin Diabetes Center·JournalProceedings of the National Academy of Sciences·DateMar 1, 2007
New research reveals that the UCP1 gene was inactivated 20 million years ago in pigs, causing them to lose the ability to use brown fat for body heat. As a result, piglets shudder to maintain their body temperature.
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Researchers at Saint Louis University School of Medicine found that heated blankets can significantly reduce false-positives in cancer scans caused by brown adipose tissue. The blankets reduced the uptake of tracer by 62%, compared to 30% with traditional drugs.
Researchers identified genes that govern the development of brown fat cells, which burn energy and generate heat. The discovery may lead to new tools to fight obesity by targeting specific genes with drugs or agents.
SourceJoslin Diabetes Center·JournalNature Cell Biology·DateMay 25, 2005
Researchers at Imperial College London have discovered a key to tackling obesity in humans by studying the thermal regulation system of newborn lambs. The study found that a molecular switch controls the transformation of brown fat into normal white fat, and that activating this switch could potentially lead to new weight loss techniques.
Diet-induced thermogenesis is an intricate system of communications masterminded by the brain that produces heat and helps prevent obesity. By removing beta adrenergic receptors, researchers found that mice fed a high-fat diet grew massively obese, highlighting the importance of this pathway in preventing weight gain.
SourceBeth Israel Deaconess Medical Center·JournalScience·DateAug 1, 2002