Articles tagged with Cartilage
Tel Aviv University scientists apply industrial monitoring technique to diagnose diseases like osteoarthritis and assess the efficacy of medications. Bio-ferrography detects nanometer-sized particles, providing objective and quantitative results for early disease detection and orthopedic implant evaluation.
A team of researchers has discovered that lubricin, a synovial fluid glycoprotein, reduces wear to bone cartilage. This discovery has significant implications for the treatment of osteoarthritis, the most common form of joint disease.
Materials scientists from Jena University have created a cellulose implant that can trigger the regeneration of cartilage produced naturally in the body. The implant, which consists of a sponge-like structure with two different surfaces, is designed to adhere to bone and stimulate cartilage growth.
Researchers have discovered that dinosaurs had thick layers of cartilage in their joints, which may have made them considerably taller than originally estimated. This study has implications for understanding dinosaur posture and speed.
Researchers at New York University have developed a new sodium MRI method that can detect osteoarthritis in its early stages. By analyzing the concentration of sodium ions in cartilage, this non-invasive technique provides a clear map of glycosaminoglycan (GAG) distribution, essential for diagnosing and monitoring diseases.
Suncica Canic develops computer models to simulate stent interactions with blood and cells, improving stent compatibility and reducing complications. Her research aims to help doctors choose the right stents for their patients and optimize stent design for specific procedures.
Researchers identify options for restoring joint lubrication to potentially prevent OA. The study found that injecting lubricin into the traumatized joint limits cartilage deterioration and encourages the joint to produce its own lubricin.
Researchers identify neogenin as a crucial protein in skeletal development, which can disrupt cartilage and bone formation if mutated. This finding offers new insight into treating osteoarthritis and provides potential therapeutic targets.
Researchers at Rice University aim to develop an injectable mix of polymers and adult stem cells to regenerate articular cartilage in injured knees and joints. The team hopes to find the optimal formulation of MSCs and growth factors for regenerating new cartilage.
A recent study found that subchondral bone mineral density positively predicts cartilage defect development at the medial tibial site, but not cartilage loss. Researchers believe subchondral bone changes and loss of cartilage contribute to osteoarthritis, a condition affecting millions worldwide.
Researchers found that cryo-preserved amniotic membrane is useful as a scaffold for growing human chondrocytes and repairing human cartilage injuries. The membrane bonds well with native cartilage, forming tissue with high cellular density.
A large Phase III randomized trial of shark cartilage as a cancer agent found no survival benefit for patients with advanced non-small cell lung cancer. The study enrolled 379 newly-diagnosed patients and did not meet its primary endpoint: survival.
Researchers design a bioactive nanomaterial that activates bone marrow stem cells to produce natural cartilage. The treatment shows promise in repairing damaged joints with better results than conventional microfracture procedures.
Researchers developed a computer program that accurately measures the meniscus in radiology images, providing potential biomarkers for osteoarthritis. The program's automated measurements are as reliable or more reliable than human interpretations, completing tasks in minutes rather than hours.
Recent enhancements to Autologous Chondrocyte Implantation (ACI) therapy, such as matrix-assisted ACI (MACI), show promise in repairing cartilaginous tissue. These therapies may help delay or prevent the need for total joint replacement in OA patients.
A new surgical technique using synthetic, dissolving plates has shown to effectively repair nasal septum defects with minimal long-term complications. The study found that 93.2% of patients achieved a straight nasal septum and improved nasal airway function after surgery.
A study found that middle-aged men and women who engage in high levels of physical activity are at greater risk for developing knee abnormalities and osteoarthritis. High-impact activities like running and jumping carry a greater risk, while low-impact activities like swimming and cycling may protect against disease.
A study of 357 patients who underwent rhinoplasty using irradiated homologous costal cartilage found low complication rates, including 3.25% warping, infection, or resorption. Patient satisfaction was high at 94.2%, making this graft material a reliable alternative to autologous cartilage.
Research suggests that diabetes accelerates bone loss and impairs fracture healing due to increased levels of inflammatory molecules like TNF-α. This can lead to delayed bone fracture healing and an increased risk of fractures in diabetics.
The new journal will publish full-length original manuscripts on all types of cartilage, including articular, tracheal/bronchial, and intervertebral disc fibrocartilage. It aims to bridge a gap in the literature by focusing on both clinical and basic science perspectives of cartilage research and repair.
Researchers have discovered a potential treatment for osteoarthritis using parathyroid hormone, which may regenerate lost cartilage in joints. The treatment delays cartilage loss and improves its volume in diseased joints, offering hope for patients with joint injuries.
Researchers at Boston University have developed new computer tomography contrast agents that selectively bind to glycosaminoglycans in articular cartilage, improving visualization and sensitivity for diagnosing osteoarthritis. The study's findings show that these cationic agents are three times more sensitive than current contrast agents.
A new study identifies vascular cell adhesion molecule 1 (VCAM-1) as a strong predictor of hip and knee joint replacement due to severe osteoarthritis. Elevated VCAM-1 levels were found in individuals who underwent joint replacement, mirroring active cartilage damage or an inflammatory component in OA.
A recent study published in Radiology found that obesity is strongly associated with an increased risk of rapid cartilage loss in the knees. The study, which analyzed data from over 3,000 participants, identified baseline BMI as a key predictor of rapid cartilage loss.
Researchers at Hospital for Special Surgery have developed a biodegradable scaffold to treat patients with damaged knee cartilage. The study found that the plug demonstrated predictable maturation on imaging studies and showed encouraging properties similar to native articular cartilage.
Two new techniques using lab-grown cells have shown promise in treating ankle injuries that don't respond to initial treatment. Autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) eliminate the need for osteotomy in some cases, reducing morbidity.
MIT engineers have developed a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into joints. The technology has shown promise in small defects and could offer a more effective, less expensive, and easier alternative to current treatments for sports injuries and arthritis.
Researchers are assessing a new surgical procedure for regenerating cartilage in damaged knee joints. The Cartilage Autograft Implantation System (CAIS) involves extracting healthy tissue and implanting it into the damaged area, potentially producing tougher hyaline cartilage.
A new study identifies chondrogenic progenitor cells (CPCs) in late-stage osteoarthritis cartilage with migratory capabilities and tissue-specific stem cell characteristics. The CPCs may be recruited to degenerating cartilage, offering a potential regenerative therapy for arthritis.
Researchers discovered that aging causes a dramatic drop in COX-2 enzyme levels, leading to reduced stem cell differentiation into cartilage and decreased bone formation. The study found that manipulating the COX-2 pathway with experimental drugs can rescue healing ability lost with age.
A new study found that stronger quadriceps muscles protect against cartilage loss in the lateral compartment of the patellofemoral joint, a site of frequent cartilage loss and pain in patients with knee OA. Greater quadriceps strength also showed to have less knee pain and better physical function than those with weaker muscles.
Scripps research scientists discover that loss of HMGB2 protein causes progressive cartilage deterioration, a hallmark of osteoarthritis. The study provides a promising avenue for new treatment options and may lead to prevention or reversal of the disease.
A mouse model study reveals that a mutated Hoxd13 protein directly induces extra digits and indirectly promotes cartilage formation, leading to syndpolydactyly. Intrauterine treatment with retinoic acid restores normal digit formation.
Scientists at the University of Liverpool will use models and tissue samples to understand ochronosis development. A potential therapy may be developed if the underlying mechanisms are understood, reducing arthritis risk for Alkaptonuria sufferers.
Eben Alsberg, a biomedical engineering professor at Case Western Reserve University, has received the Ellison Medical Foundation New Scholar in Aging award. The award provides funding for his project to develop novel microenvironmental technology to rescue chondrogenic potential of mesenchymal stem cells from aged individuals.
A team of researchers has developed a pacemaker to stimulate the muscles that control breathing in horses. This technology may also benefit humans with laryngeal paralysis or those who undergo laryngeal transplants. The study's findings provide insights into the coordination of movement and breathing in equines.
Researchers at Tel Aviv University and New York University have developed a non-invasive MRI technique that detects the earliest signs of osteoarthritis, enabling early diagnosis and treatment. The test is cost-effective and can provide results within one day.
A team of researchers found definitive genetic proof of how osteoarthritis destroys joint cartilage in nearly 21 million aging Americans. The study used genetically engineered mice to show that high levels of beta-catenin lead to cartilage destruction and bony growths, providing a new foundation for treating OA.
A new medical imaging technology could provide a long-awaited test for early diagnosis of osteoarthritis, allowing doctors to prevent or reduce permanent damage. The method uses modified MRI to determine the concentration of glycosaminoglycan, a biomarker for OA and cartilage disorders.
Researchers at OHSU discovered males from a strain of mice called MRL/MpJ have the innate ability to repair their own knee cartilage. Cartilage injuries heal poorly in humans, leading to osteoarthritis, which affects one quarter of the adult population by 2020.
A new surgical technique called joint distraction has been shown to promote cartilage repair in patients with severe knee osteoarthritis. The study found that patients experienced significant improvements in functional ability and pain scores, with cartilage volume and thickness increasing by up to 50% and 40%, respectively.
Bioengineers at Rice University have developed a method to stimulate cartilage cell growth using intense pressure, resulting in tissue with nearly all properties of natural cartilage. The new process has potential for treating arthritis and repairing damaged tissues, but further testing is needed.
Researchers at Brown University have developed a method to regenerate cartilage naturally by creating a synthetic surface that attracts cartilage-forming cells. The team, led by Thomas Webster, uses carbon nanotubes to stimulate cell growth through electrical pulses, which appears to enhance cartilage regeneration.
A study by Rush University Medical Center found that the Z-plasty technique significantly improves nasal airflow and reduces recovery time compared to traditional open rhinoplasty. The minimally invasive procedure shows promise as an effective treatment option for patients with internal nasal valve collapse.
A microarray screening study revealed significant gene expression changes in adult human joint cartilage after injury. The study identified the Wnt-16 signaling pathway as a key player in the molecular response, which may be relevant to osteoarthritis progression.
Researchers have identified a cell that can produce enough of a person's own cartilage to treat cartilage lesions and mark the onset of osteoarthritis. This breakthrough could lead to effective transplantation of transplanted cells into damaged joints, overcoming current limitations in treating arthritis.
Researchers at the University of Wisconsin-Madison studied embryonic chick feet to understand digit growth. They found that phalanges form from mesenchymal cells, not cartilage, and are shaped by complex signals from genes. This discovery may help explain bradydactyly conditions in humans.
A toxic pollutant found in cigarette smoke, benzo(a)pyrene (BaP), has been shown to slow bone healing by interfering with the process of stem cells becoming cartilage cells. This delay can lead to chronic pain and disability.
Researchers found that mice without lubricin experienced early wear and increased friction in their joints, highlighting the protein's role as a boundary lubricant. The study's findings suggest injecting lubricin or its close cousin could prevent wear in joints, reducing the need for joint replacement surgery.
A study found that 82% of entheses have a synovio-entheseal complex (SEC), which is involved in triggering inflammation in OA. The SEC's formation is linked to fibrocartilage degeneration and cell clustering, suggesting a novel mechanism for synovial inflammation.
A clinical trial aims to identify individuals at risk of osteoarthritis through the analysis of Smurf2 enzyme expression in cartilage cells. The study seeks to develop a diagnostic test and potential injection to prevent or slow disease progression.
Regular physical activity is linked to increased tibial cartilage volume and reduced cartilage defects in healthy adults. Moderate exercise also shows promise in lowering the incidence of bone marrow lesions, a potential indicator of knee OA progression.
Researchers have successfully grown cartilage-like cells from human embryonic stem cells using the Rice method. The study's results mimic different types of cartilage found in the human body, such as hyaline articular cartilage and fibrocartilage.
Experts emphasize evidence-based approach to treating osteoarthritis, citing benefits of coxibs and NSAIDs despite gastrointestinal and cardiovascular risks. The OARSI international COX-2 workshop 2007 provided guidance on safe use of these agents.
Researchers found that oral calcitonin effectively protects against articular cartilage degradation and surface erosions in ovariectomized rats, a model for postmenopausal women. Calcitonin worked better than estrogen therapy, preventing cartilage erosions completely.
The University of Delaware has received a $11 million grant from the NIH to conduct translational research on osteoarthritis, focusing on tissue mechanics and biomechanics. A unique mentoring program will also support women biomedical researchers at UD.
A large Phase III study found that shark cartilage extract AE-941 has no benefit when combined with chemotherapy and radiation for patients with advanced non-small cell lung cancer. The study did not meet its primary endpoint: survival, and the researchers cast major skepticism on the efficacy of shark cartilage products.
Researchers used dGEMRIC MRI to measure GAG distribution and correlate it with indentation stiffness. The study found a significant relationship between the dGEMRIC index and mechanical stiffness, suggesting its potential as a predictive measure of cartilage stiffness in osteoarthritis patients.
New research led by Gregory Jay at Brown University shows that protein lubricin, not just hyaluronate, is crucial for protecting joints from wear and reducing arthritis risk. The study found that adding lubricin to supplements could restore elasticity in synovial fluid.
A low-tech operation called symphysiotomy, performed under local anesthesia, can increase the size of the pelvic outlet and permit vaginal delivery of the baby. This procedure has been largely abandoned in developed countries due to its simplicity and effectiveness in addressing maternal mortality in Africa.