Articles tagged with Cartilage
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Researchers successfully engineered human cartilage using tissue engineering methods, demonstrating potential for therapeutic applications. The study also found that osteogenic protein-1 enhances cartilage production when added to chondrocytes on scaffolds.
Researchers at Duke University have found that lubricin helps reduce friction and maintain joint cartilage integrity, suggesting its potential as a treatment for osteoarthritis. The study used precise measurement of biomechanical properties to compare lubricin-deficient joints to normal ones.
Duke University researchers developed a three-dimensional fabric scaffold for cartilage repair using patient stem cells. The new technology could treat larger areas of cartilage damage and provide more effective results than current therapies.
Researchers found that etanercept, a TNF inhibitor, had no impact on new cartilage or bone formation in mice with spontaneous arthritis. The study suggests that joint fusion and joint inflammation are separate processes, which should be considered as distinct therapeutic targets.
Scientists have uncovered the molecular structure of cartilage's collagen fibrils, a key factor in osteoarthritis. The discovery could lead to treatments that prevent fibril deterioration and ultimately alleviate joint pain.
Men with knee osteoarthritis who smoke experience greater cartilage loss and more severe pain than non-smokers. Smoking is a potentially modifiable risk factor for worsening knee osteoarthritis.
A recent study published in Annals of the Rheumatic Diseases found that smokers are more likely to experience severe cartilage loss and knee pain due to osteoarthritis. Smokers were also significantly more likely to report greater pain severity than non-smokers.
Bioengineering researchers at UC San Diego have shown that sliding forces on cartilage surfaces increase the production of proteoglycan 4, an important step towards growing healthy joint tissue. This discovery has significant implications for the treatment of osteoarthritis and the development of artificial joints.
Researchers have developed a noninvasive imaging technique that uses a contrast agent and microcomputed tomography to image cartilage in osteoarthritis research. The technique, dubbed EPIC-microCT, reveals information about cartilage thickness and composition, allowing for the monitoring of osteoarthritis progression and treatment.
A study published in Proceedings of the National Academy of Sciences reveals that SOX9 and RUNX2 are two master transcription factors involved in differentiating skeletal progenitor cells into bone or cartilage. The researchers found that SOX9 appears to be the dominant player, suppressing RUNX2 activity to promote cartilage formation.
Researchers at the University of Bristol successfully regenerated cartilage in injured knees using bioengineered tissue implants. The study showed that engineered cartilage tissue can grow and mature even in knees affected by osteoarthritis, offering a promising approach to treating joint damage.
A recent study published in American Journal of Roentgenology found that higher strength MRI can detect shoulder cartilage tears with high accuracy, allowing doctors to diagnose and treat the condition without surgery. This non-invasive approach has significant benefits for patients, especially athletes who are prone to such injuries.
Research reveals cartilage cells can die outside the direct impact zone due to leukocyte-mediated damage. Anti-CD18 antibodies and desferoxamine show promise in blocking this process.
Researchers at Duke University Medical Center have developed a novel growth factor that significantly improves the ability of human fat-derived stem cells to be transformed into cartilage cells. The growth factor, BMP-6, stimulates the production of key biochemical markers of cartilage cell proliferation, suggesting potential for tissu...
Researchers identified adult human multipotent stem cells derived from the periosteum, which can regenerate cartilage, muscle, and bone. The study showed that these cells can contribute to muscle regeneration and form cartilage when implanted into a joint surface defect.
A recent study conducted by Virginia Tech researchers found that the Swedish Autologous Chondrocyte Implantation (ACI) method produces repairs with excellent durability. The study, which used a controlled biotribology device, compared the wear of ACI-repaired cartilage to normal cartilage from the same joint.
Researchers at Rice University have developed a self-assembly method to grow dime-sized disks of cartilage with properties approaching native tissue. The technique uses only donor cells, eliminating rejection risks, and has been refined to produce virtually identical cartilage in terms of mechanical and biochemical makeup.
A study found a strong association between meniscal malposition, meniscal tears, and cartilage loss in knee OA. Meniscal damage increased the risk of cartilage loss, particularly in the medial tibiofemoral joint.
Researchers found that lampreys, long thought to be evolutionary outliers, use the same essential protein to build cartilage as all other vertebrates, including humans. The discovery sheds light on the early origins of vertebrate skeletal development and challenges traditional views on vertebrate evolution.
The study revealed that radiologists can use four radiologic signs to prospectively identify radial meniscal tears, increasing detection sensitivity from 37% to 89%. Repairing damaged cartilage is preferred over removal when possible.
Researchers found that genetically engineered muscle-derived stem cells (MDSC-B4) improved cartilage repair in rats, with well-integrated repaired tissue at 8, 12, and 24 weeks after surgery. The study also showed that MDSC-B4 could differentiate into chondrogenic cells depending on the type of medium they grew in.
Researchers at Imperial College London have directed embryonic stem cells to become cartilage cells, showing potential for growing new cartilage for transplantation. This breakthrough technique could also be used in cosmetic and reconstructive surgery, offering a new solution for joint replacements and other medical problems.
A study found that moderate exercise can improve knee cartilage strength and elasticity, reducing the progression of osteoarthritis. Regular physical activity has been shown to reduce knee pain and stiffness, as well as improve functional performance tests.
Researchers identified a novel syndrome marked by rapid cartilage debonding and stripping away from bone in an affected family. The condition causes joints to be exceptionally susceptible to shattering, despite being diagnosed with various disorders in the past.
Researchers found that pomegranate fruit extracts inhibit the overproduction of MMP enzymes in human cartilage cells, slowing cartilage degradation in osteoarthritis. The findings suggest a potential therapeutic effect for consuming pomegranate fruit extract to protect cartilage.
MDCT arthrography outperforms MRI in detecting cartilage problems, offering better 3D evaluation and tissue contrast. The study suggests MDCT arthrography as a prominent method for imaging patients with hip dysplasia.
Athanasiou receives the inaugural award from ASME for his groundbreaking research and mentorship in bioengineering. He has published over 150 papers, holds 25 patents, and founded three companies with FDA-approved products.
Researchers developed a simple test to quantify loss of lubrication after knee injury, which has important implications for preventing osteoarthritis. The study found that lubricin completely disappeared from rabbits in three weeks and greater friction was observed in patients with injured knees.
A clinical trial by Mayo Clinic found that shark cartilage did not demonstrate any efficacy in patients with advanced breast or colorectal cancers. In fact, some quality of life measurements worsened among patients treated with shark cartilage.
Research by University of Utah Health reveals that overweight and obese individuals are at least three times more likely to tear their meniscus, while the most obese face a 25 times greater risk. The study's findings have significant implications for meniscal surgeries and the nation's medical costs.
New cartilage repair techniques have been shown to improve knee function and reduce pain in patients. Studies using osteochondral allografts and microfracture procedures resulted in better outcomes, including increased knee function and reduced pain, after a minimum of two years.
Researchers found that mice lacking type VI collagen developed osteoarthritis at a rate five times greater than those with a functioning gene. The study provides new insights into the role of type VI collagen in cartilage health and its impact on osteoarthritis development.
Research identifies DDR2 as critical signaling molecule in osteoarthritis progression, leading to increased MMP-13 expression and cartilage degradation. The study suggests that DDR2 inhibitors may slow down osteoarthritis progression, offering a potential new approach for treatment.
Researchers have developed an injectable gel that can speed up the repair of torn cartilage. The biodegradable material is composed of hyaluronic acid and can be hardened with ultraviolet light or visible light, creating a growth environment for cartilage-producing cells to grow new cartilage.
Researchers at Rice University aim to create implantable TMJ discs grown from patient cells, offering a potential alternative to transplantation. The goal is to provide a treatment option for the nearly 11 million Americans suffering from TMJ disorders.
A study by Johns Hopkins University biologist Gary K. Ostrander reveals over 40 examples of shark tumors, debunking the myth that sharks don't get cancer. The research warns against pseudoscientific claims and calls for increased scientific literacy and critical thinking skills.
A mouse model of osteoarthritis has been developed, revealing that bone morphogenetic protein (BMP) signaling is essential for the maintenance of healthy articular cartilage. The study found that inactivating BMP signaling in mice led to severe arthritis, mimicking human osteoarthritis conditions.
Researchers found a strong correlation between a peptide fragment of type II collagen (CTX-II) and the prevalence and progression of osteoarthritis (OA), particularly at the knee and hip. CTX-II levels were associated with increased risk and severity of OA, including rapid joint destruction.
The study reveals a mechanism by which cell signals induce specific patterns of cartilage and bone formation in the vertebrate head. The findings provide insight into craniofacial syndromes such as DiGeorge Syndrome, highlighting the importance of local, interconnected strategies of development.
A new clinical syndrome has been discovered that leads to severe osteoarthritis, characterized by cartilage breakdown and the presence of specific FRZB gene mutations. The study sheds light on the genetic mechanisms underlying this complex disease, with potential implications for treatment and prevention.
Researchers develop a novel treatment to stimulate natural cartilage tissue growth in knee joint defects, providing a potential solution for osteoarthritis treatment. The hyaluronan-based polymer creates a protective cap and enables new cartilage tissue to grow, filling the defect and promoting healing.
Researchers at Duke University Medical Center have successfully reprogrammed human fat cells to become adult stem cells capable of forming bone, cartilage, and other cell types, providing a promising new approach for treating diseases such as osteoarthritis.
A study found that piercing ear cartilage increased the risk of infection compared to lobe piercing. The authors identified 7 confirmed Pseudomonas aeruginosa infections and 18 suspected cases, with most treated ineffectively with antibiotics.
Labral tears in hip cartilage have been identified as a common injury among professional golfers, with MRI scans revealing significant damage. Eight pro golfers underwent successful arthroscopic surgery to repair labral injuries, marking a significant shift towards earlier diagnosis and treatment of hip pain.
Researchers at the University of Illinois Chicago have successfully created a human-shaped articular condyle using adult stem cells. The tissue-engineered structure retained both bone-like tissue underneath and cartilage-like tissue on top, similar to a natural articular condyle.
The study found that inhibiting PKR prevents the production and activation of enzymes that break down connective tissue and the release of proteoglycan from cartilage. This suggests that PKR is involved in the molecular pathways that contribute to arthritis progression.
Rice University researchers aim to develop new, noninvasive treatment options for damaged cartilage by using patient's own bone marrow cells to grow more cartilage. The goal is to create a biodegradable scaffold that promotes cartilage formation and avoids problems associated with current therapies like allografting.
A study published in Arthritis & Rheumatism reveals that cartilage oligometic matrix protein (COMP) is present in blacks, with average levels higher in patients and men than in whites. COMP may serve as a biomarker for osteoarthritis progression.
Researchers at Rice University are working on growing replacement cartilage for the meniscus, a kidney-shaped wedge of cartilage that cushions stress in the knee joint. By developing methods to simulate mechanical conditions and grow tissue in precise shapes, they aim to create more effective treatments for osteoarthritis.
Researchers at Duke University Medical Center have found that oxygen levels play a crucial role in transforming adult stem cells from fat into cartilage cells. Under low-oxygen conditions, the stem cells differentiate into chondrocytes, which can potentially repair damaged cartilage.
Researchers at Johns Hopkins University have successfully created cartilage-like tissue using adult stem cells in a minimally invasive procedure. The technique involves injecting a fluid filled with stem cells and nutrients into damaged tissue, where it hardens into a stable gel that can be replaced by new bone or cartilage.
Researchers found that 84% of patients experienced improved airways and symptoms after the laser procedure, which lasted 6-8 minutes. The cartilage recovered its shape over several weeks, providing an alternative to traditional surgery for reducing morbidity and economic impact.
Researchers at Case Western Reserve University discovered kinks in the aggrecan protein, a submolecular root of arthritis. The study shows that these kinks may be more susceptible to enzymes that degrade cartilage in osteoarthritis, providing a link between structure and function.
A new MIT technique involves growing cartilage cells within a novel gel, which is then delivered to damaged joints. The engineered tissue has mechanical and biochemical properties similar to native cartilage.
A new study by Duke University researchers found that even small degrees of malalignment in knee surgery patients can cause dramatic alterations in pressures within the joint. Proper alignment is crucial for preventing future development of severe arthritis.
The study provides direct measurements of nanoscale forces between cartilage molecules and a tiny probe tip, shedding light on the complex biocomposite material's behavior. The results reveal a mix of electrical repulsive and steric forces contributing to its unique properties.
Dr. Stephen B. Trippel's research involves articular cartilage repair through the use of a naturally occurring growth factor, with laboratory results encouraging for repairing musculo-skeletal tissue. The technique combines gene therapy and tissue engineering to stimulate cartilage-cell growth.
Scientists have successfully implanted cartilage made from stem cells in mice, showing promise for repairing damaged tissues. The study uses fat cells to produce cartilage-like cells that can be used as implants to treat injuries and diseases.
Researchers have developed a new x-ray technique called diffraction enhanced imaging (DEI) that can image cartilage and detect early stages of osteoarthritis. This technology has the potential to improve diagnosis and treatment of the disease, which affects over half of the nation's elderly.
Researchers at Cardiff University discover that Cod Liver Oil's Omega-3 fatty acids can slow cartilage degradation and inflammation, offering a potential cure for osteoarthritis. The study suggests that taking Cod Liver Oil in early adulthood may prevent the onset of osteoarthritis and reduce its symptoms.