Articles tagged with Dorsal Root Ganglion
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Nageotte nodules, previously largely ignored in research, are abundant in sensory ganglia of individuals with diabetic neuropathy and composed mainly of satellite glia and non-myelinating Schwann cells. These clusters may represent a target for drugs that protect nerves or help manage diabetic neuropathy.
Researchers at Florida Atlantic University's Schmidt College of Medicine have developed a handheld ultrasound device to treat neuropathic pain. The device uses low-intensity focused ultrasound to target specific areas of the nervous system, offering a non-invasive and non-opioid-based treatment option.
Researchers discovered stem cells in mouse dorsal root ganglia (DRG) with the potential to regenerate lost sensory neurons and glia. These cells, known as satellite glia, can become activated and generate new glia and, to a lesser extent, neurons after injury.
A study published in Journal of Neuroscience reveals that FLRT3 protein, involved in neuron development and cell adhesion, is also critical for pain sensitization. High levels of FLRT3 protein were found in the dorsal horn following nerve injury, leading to touch sensitivity and mechanical allodynia.
The study implanted 125I seeds into rat dorsal root ganglia to provide relief for neuropathic pain. Results showed elevated mechanical pain threshold without influencing motor functions, suggesting neuronal microdamage as the primary mechanism. The findings have potential implications for developing novel pain management therapies.
After sciatic nerve injury, microRNA-214 targets srGAP3 in rat DRG primary neurons. This relationship affects axon guidance and neural regeneration.
A study found that co-culturing dorsal root ganglion neurons with type-2 astrocytes increases neuronal survival rates and process lengths. However, the effect is weaker compared to type-1 astrocytes and oligodendrocyte precursor cells.
A study published in Neural Regeneration Research found that substance P and calcitonin gene-related peptide expression increased significantly in dorsal root ganglia after sciatic nerve injury, peaking at 7 days post-injury. This increase suggests these neuropeptides may serve as an index for evaluating early peripheral nerve injury.
Researchers identified a family of proteins called Mrgprs that functions as itch receptors in a rare subset of nerve cells. The study found that MrgprA3 is the primary itch receptor for chloroquine, leading to potential new treatments for nonallergic itch.