Articles tagged with Dorsal Root Ganglion
Scientists have discovered the molecular characteristics of human sleeping nociceptors, which are key culprits in neuropathic pain. The findings provide a new framework for understanding the emergence of neuropathic pain at the molecular level and offer potential targets for developing targeted therapies.
Nageotte nodules, previously largely ignored in research, are abundant in sensory ganglia of individuals with diabetic neuropathy and composed mainly of satellite glia and non-myelinating Schwann cells. These clusters may represent a target for drugs that protect nerves or help manage diabetic neuropathy.
Researchers at Florida Atlantic University's Schmidt College of Medicine have developed a handheld ultrasound device to treat neuropathic pain. The device uses low-intensity focused ultrasound to target specific areas of the nervous system, offering a non-invasive and non-opioid-based treatment option.
Researchers discovered stem cells in mouse dorsal root ganglia (DRG) with the potential to regenerate lost sensory neurons and glia. These cells, known as satellite glia, can become activated and generate new glia and, to a lesser extent, neurons after injury.
A study published in Journal of Neuroscience reveals that FLRT3 protein, involved in neuron development and cell adhesion, is also critical for pain sensitization. High levels of FLRT3 protein were found in the dorsal horn following nerve injury, leading to touch sensitivity and mechanical allodynia.
The study implanted 125I seeds into rat dorsal root ganglia to provide relief for neuropathic pain. Results showed elevated mechanical pain threshold without influencing motor functions, suggesting neuronal microdamage as the primary mechanism. The findings have potential implications for developing novel pain management therapies.
After sciatic nerve injury, microRNA-214 targets srGAP3 in rat DRG primary neurons. This relationship affects axon guidance and neural regeneration.
A study found that co-culturing dorsal root ganglion neurons with type-2 astrocytes increases neuronal survival rates and process lengths. However, the effect is weaker compared to type-1 astrocytes and oligodendrocyte precursor cells.
A study published in Neural Regeneration Research found that substance P and calcitonin gene-related peptide expression increased significantly in dorsal root ganglia after sciatic nerve injury, peaking at 7 days post-injury. This increase suggests these neuropeptides may serve as an index for evaluating early peripheral nerve injury.
Researchers identified a family of proteins called Mrgprs that functions as itch receptors in a rare subset of nerve cells. The study found that MrgprA3 is the primary itch receptor for chloroquine, leading to potential new treatments for nonallergic itch.