Bonn researchers found higher numbers of type 3 innate lymphoid cells in duodenum tissue of FAP patients, producing interleukin-17A which stimulates ROS production and DNA damage. This suggests a local environment favoring cancer development, prompting a new approach to preventing duodenal cancer.
A study published in the Journal of the American College of Surgeons found that gastric bypass surgery results in high rates of Type-2 diabetes remission five years after the operation, even after patients regain a significant amount of weight. In contrast, patients who underwent sleeve gastrectomy and regained their weight were five t...
A study from MedUni Vienna found that macrophages in the duodenum control iron absorption by degrading transferrin. This discovery may lead to new treatment options for inflammatory bowel diseases and intestinal infections.
A retrospective study found that elevated CA 19-9 and CEA levels were associated with worsened outcomes in duodenal adenocarcinoma patients. The study, which included 68 patients, suggests that these tumor markers may show promise as prognostic tools for this rare malignancy.
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Research led by Diego Bohórquez at Duke University has identified the cells responsible for sensing sugar in the gut. These neuropod cells produce neurotransmitters that transmit signals to the brain, allowing animals to distinguish between real sugar and artificial sweetener.
The Duodenum Intestine-Chip, a living product from Emulate, Inc., was shown to accurately recreate key functions of the human duodenum. The chip demonstrated superior functionality compared to organoids alone in terms of global transcriptomic profile and physiological function.