Articles tagged with Hippocampus
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Researchers shed light on TIMP2's role in regulating hippocampal plasticity and function, which decreases with age. Targeting the extracellular matrix may improve plasticity in the brain, offering new directions for mitigating neurodegenerative disorders.
Researchers at HHMI's Janelia Research Campus have discovered that rats can think about places and objects not in front of them, generating specific neural activity patterns in the hippocampus. This ability is fundamental to remembering past events and imagining future scenarios, indicating that animals possess a form of imagination.
Researchers at Karolinska Institutet have discovered that a metabolic increase in the hippocampus is an early indicator of Alzheimer's disease. The study found that changes in mitochondrial metabolism precede synaptic disorganization and impaired autophagy, highlighting potential new methods for early intervention.
A Cornell University-led study has separated the role of the hippocampus in two functions of memory, which are crucial for associating time, place, and past experiences with future actions. The breakthrough has significant implications for treating memory and learning issues found in Alzheimer's disease and dementia.
Researchers found that electrical signals in the hippocampus differ immediately before recalling true and false memories. The study used epilepsy patients to measure neural activity leading up to correct or false recall, revealing a reduction in low-frequency activity associated with contextual similarity.
Researchers discovered protein p53's role in regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice. Lowering p53 levels led to changes in gene expressions related to behavior, while elevated p53 levels were linked to positive learning outcomes.
A recent study published in Geroscience found that trigonelline, a plant alkaloid in coffee, significantly improved spatial learning and memory performance in senescence-accelerated mice. The researchers also identified the underlying molecular mechanisms, including reduced neuroinflammation and increased neurotransmitter release.
A Northwestern University study found that endogenous cannabinoid molecules released by the brain during stress can calm it down. These molecules activate the same receptors as THC and may provide a natural coping response to stress.
Researchers found that individuals with higher body mass indexes have impaired connections between the hippocampus and hypothalamus, leading to an inability to control eating habits. The study suggests that targeting this brain circuit may lead to new treatments for obesity and related disordered eating conditions.
Researchers at MPFI discovered Protein Kinase C delta's (PKCd) role in regulating cell-wide gene expression through synaptic plasticity. The study found that PKCd activates biochemical reactions that spread throughout the neuron, influencing gene transcription and memory formation.
Researchers propose a new mathematical neural network theory that consolidates memories to the neocortex if they improve generalization. This view contradicts the classical understanding of systems consolidation, which assumes all memories move from the hippocampus to the neocortex over time.
A study found that social isolation is associated with a decrease in hippocampal volume, poorer cognitive performance, and an increased risk of developing conditions like Alzheimer's dementia. Conversely, maintaining a healthy social network can help preserve brain structure and function.
Researchers at the Institute for Basic Science have identified specific neurons in the hippocampus that allow us to recognize individual social counterparts and update their value through interactions. The dorsal CA1 region plays a crucial role in this process, enabling long-term memories of individuals to be formed.
A study found that excitatory-inhibitory imbalance, characterized by higher glutamate levels and lower GABA levels, precedes psychosis in individuals with 22q11.2 deletion syndrome. This imbalance is associated with hippocampal atrophy and cognitive decline.
Researchers used AI to study how the hippocampus produces varied replay types efficiently and their purpose. The model showed that sequences are prioritized stochastically according to familiarity and reward positions.
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
Researchers found that right hippocampal theta power hierarchically encodes the distance between current position and goal destination. The study used intracranial electroencephalography recordings from epilepsy patients performing a virtual navigation task.
A study by Universitat Autonoma de Barcelona finds that a hypocaloric diet attenuates brain changes associated with age-associated memory loss. The results show improved spatial object recognition test scores and reduced neuronal loss and inflammatory activity in the hippocampus.
Researchers found that psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity. The study's results improve our understanding of the restorative effects of psilocybin on the brain and may lead to alternative treatments for PTSD.
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
Researchers found that exercise releases chemical signals that promote neuronal development in the hippocampus, a crucial area for learning and memory. Astrocytes play a critical role in mediating the effects of exercise on brain health, helping to regulate neuronal activity and prevent hyperexcitability.
HBP researchers develop a robotic platform capable of learning as humans do while navigating around a space. The simulated hippocampus alters its own synaptic connections to remember paths, a marked improvement over current methods relying on deep learning.
Researchers have identified α5-GABAARs on interneurons as key receptors regulating memory formation in the hippocampus. Selectively knocking out these receptors from interneurons impaired spatial memory, while leaving pyramidal neurons unaffected.
Research at the University of Massachusetts Amherst shows that circadian disruption from jet lag can harm adult neurogenesis, which supports learning and memory. The study found that the Cryptochrome 1 gene regulates this process and that misalignment can lead to adverse health effects such as dementia and mental illness.
Researchers used functional MRI scanners to monitor brains of subjects watching real-life videos, finding that different parts of the brain work together to understand and remember situations. The study suggests the brain creates mental sketches of people that can be transposed from one location to another.
Researchers used virtual reality to study how memories are selected for long-term storage, revealing the anterior thalamus as a crucial stopover site. Stimulating this region enhanced memory consolidation, while inhibiting it hindered long-term retention.
Researchers have created a high-resolution, single-cell model of the human hippocampus CA1 area using data from the BigBrain Atlas. The model replicates the structure and architecture of the neurons, as well as their connectivity. This advancement in neuroscience has potential applications for modeling other brain regions.
A new study published in Current Biology found that the hippocampus and prefrontal cortex must synchronize their neural assemblies to support memory encoding, maintenance, and recall. Disruption of this synchronization leads to memory loss, presenting a viable target for therapeutic interventions.
Researchers found that suppressing AMPKα1 but not AMPKα2 isoforms improved aging-related impairments in mice. The study revealed novel insights into the roles of AMPK signaling pathway in cognitive aging.
A study published in NEJM Evidence found that seizures can be predicted at least 35 minutes before onset in patients with temporal lobe epilepsy. This breakthrough discovery has significant implications for developing more effective therapies for this common seizure disorder, which affects over 50 million people globally.
Researchers at UTHealth Houston received $15 million in NIH BRAIN grants to study brain processes related to speech, epilepsy, and reading. A new minimally invasive device will be developed to record brain activity during speech, while another project aims to disrupt seizures using neuromodulation.
Researchers found that platelet depletion increased amyloid plaque size and neuronal damage in APP-PS1 mice. However, platelets may have a beneficial role in limiting plaque growth and attenuating neuritic dystrophy at advanced stages of Alzheimer's disease.
Researchers use movie clips to study mouse brain activity, revealing novel ways to diagnose learning and memory disorders. The discovery points to new ways to tackle Alzheimer's and improve artificial intelligence.
Researchers developed a blood-based test that predicts Alzheimer's disease risk by analyzing changes in brain cell growth and division. The study found that the body's circulatory system can modulate the formation of new brain cells, and that this process occurs 3.5 years before a clinical diagnosis.
Researchers developed HippoCamera, a new smartphone app that significantly improves memory recall by boosting attention to daily events. Users record videos and audio descriptions of everyday experiences, which are then replayed to reinforce memory consolidation.
Researchers found that neurons in the hippocampus represent space in a nonlinear hyperbolic geometry that grows outward exponentially with time spent exploring an environment. This discovery provides valuable methods for analyzing data on neurocognitive disorders involving learning and memory.
Researchers found that remote fear memories are permanently stored in connections between memory neurons in the prefrontal cortex. The study suggests that a dysregulation of fear memory consolidation can lead to chronic maladaptive fear in PTSD, affecting about 6% of the population.
During sleep, brain regions synchronize to create motor memory by reviewing trials and errors of a given action. The study found that the
Small cell clusters in hippocampus are vital for fear-based memories, while sleep helps stabilize these clusters to improve memory. The study uses immediate early gene imaging to visualize active cells throughout the entire rat hippocampus.
Researchers created a detailed map of the hippocampus's connections to the rest of the brain, finding fewer links with frontal lobes but more with visual networks. This discovery may change how we think about human memory and cognition, potentially shedding light on why some primates excel at certain memory tasks.
The Human Brain Project researchers have developed a unique method called 3D Polarised Light Imaging (3D-PLI) to visualize nerve fibers at microscopic resolution. By combining different experimental methods and integrating data into multilevel atlases, the team gained new insights into brain connectivity.
Researchers discovered a new daily rhythm in inhibitory synapses, which rebalance brain activity to consolidate new information into long-lasting memories during sleep. The study suggests that wakefulness strengthens inhibitory synapses, enhancing memory formation.
A new theory by UMass Amherst sleep scientist Rebecca Spencer suggests that young children's brain development, not age, determines when and why they stop napping. The hippocampus, a memory area of the brain, plays a critical role in nap transitions.
A study published in Neurology found that eating omega-3 fatty acids can protect the brain from aging and cognitive decline in midlife. The research, conducted by the University of Texas Health Science Center at San Antonio, suggests that even small amounts of omega-3s can have a significant impact on brain health.
Researchers at Boston University have found a way to manipulate emotional memories using optogenetics, allowing them to rewrite and reduce the potency of negative memories. The study reveals that positive and negative memories are stored in distinct regions of the brain and communicate through different pathways.
Ascoli and Adam propose a novel data-driven methodology using neuroscience experimental knowledge and computer science advances. The study aims to benchmark learning rules in a spiking neural network simulation of the CA3-CA1 region, exploring dynamic synaptic plasticity and fixed neuroanatomy.
A study from UniSA researchers found associations between metabolic profiles and adverse brain findings, including lower hippocampal and grey matter volumes. People with metabolic profiles linked to obesity were more likely to have higher accumulation of iron in the brain.
A study found that aberrant expression of MAO-B causes both peripheral and neuroinflammation in RA patients, leading to joint pain and cognitive impairment. Administering an MAO-B inhibitor called KDS2010 improved both joint inflammation and cognitive function in a RA animal model.
Researchers found that stressed mice exhibited decreased neuron excitability in the dorsal hippocampus, which may drive social avoidance, while resilient mice showed increased excitability. This difference was linked to changes in stress hormone receptors and HCN1 protein expression.
A Brazilian-American research team has identified a subtype of inhibitory interneurons that can gauge speed with great precision. These neurons are more stable than excitatory neurons and may be linked to spatial memory and the ability to remember routes or locations.
Research finds that a single dose of alcohol permanently changes brain structure and function, leading to increased risk of addiction. The study used fruit flies and mice models to show that ethanol-induced changes in mitochondrial dynamics and synapse balance contribute to long-lasting behavioral changes.
Scientists at Harvard Medical School have made a breakthrough in understanding how the brain forms spatial maps. A new study reveals that the gene Fos plays a crucial role in this process, helping the brain use specialized navigation cells to form and maintain stable representations of the environment. The findings provide new insights...
Research reveals that physical activity has a noticeable effect on almost all brain regions, with higher intensity and duration increasing brain volume and cortical thickness. The hippocampus, a key memory center, benefits most from physical activity, which can help counteract age-related loss of brain matter.
Researchers investigate astrocyte production in the brain, discovering distinct dynamics in different parts of the cortex. The study suggests that early exposure to specific genes regulates stem cell behavior, leading to variations in astrocyte generation.
A study found that individuals with less hippocampus engagement are more likely to develop severe posttraumatic stress disorder (PTSD) symptoms. Those who exhibit greater defensive reactions to potentially threatening events also showed increased PTSD risk.
Research suggests that individuals with PTSD exhibit decreased activity in the hippocampus, leading to impaired threat reactivity and memory formation. This study reveals a significant interaction between hippocampal activity and physiological arousal in predicting PTSD symptoms.
Researchers discovered that hippocampal place cells represent direction and distance to a goal in addition to current location. A vector field provides signal towards the goal, aiding flexible navigation.
Researchers at UCLA have discovered a key molecular mechanism behind memory linking and identified an FDA-approved drug that can restore this brain function in middle-aged mice. The study suggests a potential early intervention for dementia and strengthening human memory in middle age.
Researchers found that genes expressed in the brains of fearless birds differ from those of fearful birds, influencing their behavior and adaptation to new environments. This study provides insights into the genetic basis of fear and boldness in wild animals, potentially leading to novel approaches for addressing anxiety disorders.
A study found a connection between learning and memory deficits in children with Joubert Syndrome and defects in the hippocampus. The researchers used animal models to create a genetic mutation that mimicked the human disease, revealing key findings about the role of primary cilia in brain development.