Articles tagged with Hippocampus
Researchers at UCLA have discovered a key molecular mechanism behind memory linking and identified an FDA-approved drug that can restore this brain function in middle-aged mice. The study suggests a potential early intervention for dementia and strengthening human memory in middle age.
Researchers found that genes expressed in the brains of fearless birds differ from those of fearful birds, influencing their behavior and adaptation to new environments. This study provides insights into the genetic basis of fear and boldness in wild animals, potentially leading to novel approaches for addressing anxiety disorders.
A study found a connection between learning and memory deficits in children with Joubert Syndrome and defects in the hippocampus. The researchers used animal models to create a genetic mutation that mimicked the human disease, revealing key findings about the role of primary cilia in brain development.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
The brain detects unwanted memories and proactively inhibits them using the anterior cingulate cortex (ACC). If inhibition fails, the ACC triggers a reactive alarm to alert other regions to stop the intrusion. This study sheds light on the neural mechanisms of controlling intrusive thoughts.
When the eyes land on a face, certain cells in the amygdala react and trigger memory-making activity. Theta wave activity is also reset or restarted, preparing the hippocampus to receive new socially relevant information.
Researchers at Florida Atlantic University found that mice can perceive the difference between a picture of an object and the actual 3D object, employing higher-order cognitive processes. The study suggests that mice's hippocampus plays a significant role in associating memories with visual stimuli.
Researchers found that brains from patients with Alzheimer's disease had higher levels of the protein Fli-1 and fewer pericytes lining their smallest blood vessels, leading to leakage. Blocking Fli-1 improved memory in mice, suggesting a promising new approach to treating the disease.
Scientists demonstrate a definitive link between mitochondrial oxidative damage and cognitive dysfunction in Alzheimer's disease using a transgenic mouse model. The study found that Aβ1-42 aggregation in the hippocampus caused cognitive impairment, while oxidation led to mitochondrial dysfunction.
Researchers discovered that toxic goiter causes shrinkage in central brain regions, such as the hippocampus and amygdala, which can lead to mental symptoms. The study provides key insights for patients with Graves' disease, a common form of hyperthyroidism.
Researchers discovered increased activity in the hippocampus during anesthesia and sleep, preceding Alzheimer's symptoms by years. This abnormality may enable early diagnosis and treatment of the disease.
Researchers found that moderate aerobic cycling improved auditory verbal learning and processing speed, as well as increased volumes of the hippocampus and cerebellar cortex. The study suggests exercise interventions may be an attractive option for improving cognitive function in individuals with traumatic brain injury.
Researchers found that prenatal exposure to nicotine and its by-products produces long-term effects on sleep and stress-response in mice. This early-life exposure can lead to alterations in the hippocampus, a sensitive structure that develops after birth.
New research published in JNeurosci reveals that impaired cognition can be part of normal aging, rather than an early sign of Alzheimer's. Cognitively frail adults showed brain structure and activity similar to healthy controls, suggesting lifestyle factors like physical activity and education may play a role.
A team of researchers at Duke University found that surprise can disrupt the stability of patterns in the hippocampus, leading to more false memories. This study has implications for understanding learning and memory, as well as how people recall events and faces.
Researchers at Göttingen University have developed a new X-ray imaging method to detect changes in neuronal cell nuclei, indicating altered activity of neurons. This technique enabled the identification of changes in neurons in Alzheimer's disease.
Researchers have found that stimulating the anterior thalamus can increase memory-related brain activity and restore memory function in rats with MTT lesions. The study suggests that therapies targeting this region could help recover memory in patients with brain injury, challenging previous notions of memory recovery.
A new study published in iScience reveals that fat cells play a central role in cognitive decline and neurodegeneration by controlling the systemic response to brain function. Targeting fat cells may improve outcomes for neurodegenerative disorders, according to researchers at Marshall University.
Researchers at the University of California, Davis, have discovered brain activation in sleeping two-year-olds when played words they had previously learned. The study found activation in the hippocampus and anterior medial temporal lobe, indicating that these regions are crucial for laying down initial memories for words.
Researchers used functional MRI to image the hippocampus of volunteers learning and recalling short stories, finding that coherent memories are woven together. The study suggests the hippocampus brings pieces together across time to form connected, narrative memories.
A study published in Communications Biology reveals that chronic hyperglycemia in diabetes impairs working memory performance by altering the connection between key brain regions. Researchers found that areas critical for forming and retrieving memories were over-connected, leading to errors in remembering correct information.
Researchers at Mount Sinai Hospital are testing a novel light therapy to slow Alzheimer's debilitating effects, aiming to improve both cognition and sleep. The treatment involves flashing pulses of light designed to enhance electrical brain waves and reset the sleep-wake cycle.
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
Researchers mapped the molecular mechanisms of primate hippocampal aging, identifying key cell types and molecules affected by age. The study provides a valuable resource for diagnostic biomarkers and therapeutic targets for neurodegenerative diseases.
Researchers discovered that stimulating environments preserve a young DNA methylation landscape in the aged mouse hippocampus, leading to greater neuroplasticity. This finding suggests that active lives may help preserve mental fitness in old age, with implications for human brain health and disease prevention.
Research found human hippocampal neurons fire during specific moments in time, encoding information about the time and order of events. These neurons contribute to episodic memories by tracking time and sequence of events.
A new Northwestern University study reveals that the hippocampus is not just essential for long-term memory but also supports short-term memory and guides decision-making. The findings suggest that the hippocampus uses short-term memory to inform where we look, priming our visual system to learn and reevaluate our environment on the fly.
Researchers at UIC's Center for Alcohol Research in Epigenetics have discovered a key regulator of gene expression and anhedonia during alcohol withdrawal. Blocking STAT3 activity alleviates withdrawal-induced depression in rats, and similar results are seen in human postmortem hippocampus samples of individuals with alcohol use disorder.
Researchers at the Weizmann Institute of Science used fruit bats to study navigation in an experimental setup that emulates their natural environment. They found that a single neuron can represent multiple place fields and that the size of each field changes according to location, resolving the discrepancy between traditional models.
Researchers from the University of Sussex found that blood flow and oxygen levels in the hippocampus are lower than those in other brain regions, making it vulnerable to damage. Increasing blood flow in the hippocampus may be effective in preventing damage from happening.
A study led by Genevieve Konopka and Bradley C. Lega found significant differences in gene activity between the anterior and posterior portions of the hippocampus, with genes associated with mood disorders active in the anterior portion and cognitive disorders in the posterior portion.
Scientists have uncovered the molecular structure of three major complexes of glutamate receptors in the hippocampus, a region crucial for memory and learning. The discovery has significant implications for treating epilepsy and seizure disorders, as it enables the development of targeted drugs to modulate specific receptor activity.
Researchers developed a neural implant that monitors brain activity in multiple areas simultaneously. The study reveals two-way communication between the hippocampus and cerebral cortex during learning and memory formation, tied to sharp-wave ripples.
A study published in PLOS Biology found that different general anesthetics have varying effects on the brain's hippocampus, a region essential for memory formation. Isoflurane resulted in undisrupted memory formation in mice, while other anesthetics caused significant changes in brain activity and stability of synaptic connections.
Researchers measured brain activity in first-time Japanese language students and found initial boosts followed by reductions as skills improved. Brain regions such as the grammar center, comprehension area, and auditory processing areas showed increased activation during early stages.
A team at Osaka City University has found that the subiculum sorts and routes spatial information from the hippocampus to specific regions of the brain, enabling smooth navigation. This discovery could shed light on disorders such as dementia and improve our understanding of brain function.
Researchers identified two new genes linked to Alzheimer's disease, PTPN9 and PCDHA4, in a study of gene expression in the hippocampus. The findings suggest that these genes contribute to the progression of the disease through pathways related to plaque formation and cell death.
A new study suggests that prenatal BPA exposure may be responsible for the male bias in autism spectrum disorder. The research found that BPA altered the expression of several genes in the hippocampus in a sex-dependent pattern, leading to decreased neuronal viability and impaired learning/memory in male offspring.
Researchers used focused ultrasound to improve delivery of IVIg to the hippocampus, increasing antibodies and neurogenesis by four-fold in a mouse model of Alzheimer's. This technique may help boost the efficacy of immunotherapy for AD treatment.
Scientists have developed a new imaging technology to study the brain's deep structures at high resolution. The technology, called adaptive optics two-photon endomicroscopy, enables in vivo imaging of deep brain structures and sheds light on brain functions.
A new study has confirmed the long-suspected link between sleep apnea and Alzheimer's disease, identifying identical signs of brain damage in both conditions. The research found amyloid plaques, a known indicator of Alzheimer's, in the brains of people with obstructive sleep apnea.
Researchers have identified how brain cells work together to join up memories of separate experiences, allowing us to make educated guesses. The process happens in a region of the brain called the hippocampus and is also linked to creativity.
Researchers found that brain function remapping is impaired in Alzheimer's disease patients, causing spatial memory impairment. Improving brain remapping function may reverse spatial memory impairment using deep brain stimulation methods.
Research reveals that lower-income families experience reduced memory and language abilities in children due to smaller anterior hippocampus development. The study also suggests that higher income thresholds beyond $75,000 may not provide additional cognitive benefits.
Researchers at UMass Amherst have identified a new regulatory role for CaMKII, a protein involved in calcium signaling, in the brain's memory center. They found that the hub domain of CaMKII plays a crucial role in tuning its sensitivity to calcium, opening up new avenues for investigation and potential therapeutic targets.
A new CSU study found that physical stress at work is linked to faster brain aging and poorer memory in older adults. Those who reported high levels of physical stress had smaller hippocampal volumes and performed poorly on memory tasks.
Researchers from Florida State University have uncovered new information about how Alzheimer's disease affects the brain during sleep. The study found that the interaction between two brain regions may contribute to symptoms experienced by patients, such as impaired memory and cognition. This discovery could lead to a better understand...
Researchers used sub-millimeter brain implants to determine which brain areas are responsible for facial and scene recognition. The study found that the medial parietal cortex plays a crucial role in identifying faces and places, working together with traditional memory regions to facilitate recognition.
Researchers found that when hippocampal neurons are already firing at high rates before seeing a word, participants are more successful in encoding and remembering the word later. This suggests that the hippocampus may have a specific mode for facilitating memory formation.
Researchers at the Picower Institute for Learning and Memory discovered that the lateral septum tracks rewards with an emphasis on location. This brain region plays a crucial role in filtering and converting raw information about location into reward-specific output.
Disruption of hippocampal activity with TMS impairs future imagining and creative thinking abilities in young adults. Reduced activity in the hippocampus is linked to decreased future imagining and divergent thinking.
Researchers found sets of cells in the hippocampus activated during similar types of experiences, such as trying new foods or visiting a restaurant. These 'lap-encoding cells' are distinct from memory cells that store specific locations and may help the brain interpret novel situations and learn new information.
Scientists from Boston University's Center for Systems Neuroscience found that scents trigger memories even years later and can reinvigorate forgotten details. The study suggests using odors as a therapeutic tool to treat PTSD and other mental health conditions.
A study by DZNE researchers found that a good blood supply to the hippocampus is crucial for healthy memory performance. Participants with doubly supplied hippocampi showed improved cognitive scores compared to those with single-supplied hippocampi or microbleeding, suggesting better oxygen delivery may be key.
A brain imaging study found that PTSD patients have a deficiency in mechanisms that suppress and regulate memory activity, particularly in the hippocampus. The study suggests that these dysfunctioning systems contribute to the persistence of intrusive memories.
Trigeminal nerve and hippocampus volumes predict successful surgical treatment outcomes, with non-responders showing larger intracranial volume and contralateral hippocampus volume. The study suggests that neuroanatomical features may be key to understanding chronic pain resistance.
Researchers at the University of Alberta have identified a crucial role for the nucleus reuniens in coordinating memory consolidation during slow-wave sleep. The study suggests that this area may play an essential part in turning short-term memories into long-term ones.
A National Institutes of Health-funded study found that coordinated brain activation, including 'replay' events, helps rats learn how to navigate toward goals. Reverse replay is crucial for reflecting on past paths, while forward replay supports planning for future choices.
Rat pups exposed to infant maltreatment exhibit elevated stress-hormone levels, amygdala, hippocampus, and social behavior deficits. These changes are influenced by the presence or absence of a nurturing mother, highlighting specific effects of stress and social context on brain and behavioral development.