Researchers have developed a novel portable and low-cost macroscopic mapping system for all-optical cardiac electrophysiology using optogenetics and machine vision cameras. The system can stimulate and image engineered networks of human heart cells, providing insights into cardiac wave function and stability.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateJan 11, 2023
Researchers at the University of Missouri are developing a wearable heart monitor using a breathable material with antibacterial and antiviral properties. The device will track heart health via dual signals, providing continuous monitoring for early detection of heart disease.
Researchers at the University of Houston have developed a protocol to reprogram human heart cells into specialized cells that conduct electricity, enabling rhythmic heartbeat and repair diseased hearts. The discovery could lead to improved cardiac function and new pharmacological therapies for heart diseases.
SourceUniversity of Houston·JournaliScience·DateNov 21, 2022
Researchers found a longer PR interval and prolonged QT duration in genetically modified pig hearts after transplantation into humans, indicating signs of electrical disease. The study provides a foundation for future research to better understand xenotransplantation's effects on the heart's electrical system.
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Researchers found that adult heart cells have fewer communication pathways called nuclear pores, which may protect against harmful signals but prevent regeneration. This discovery sheds light on why adult hearts do not regenerate like newborn mice and human hearts.
SourceUniversity of Pittsburgh·JournalDevelopmental Cell·TypeExperimental study·DateOct 24, 2022
A recent study led by Dr. Luis Cuello and Alain J. Labro found that a known Shaker channel mutation differs structurally from its human counterparts, with implications for drug development and ion transport mechanisms. The research reveals a unique conformation of the W434F mutant that is distinct from wild-type channels.
SourceTexas Tech University Health Sciences Center·JournalScience Advances·TypeObservational study·DateOct 11, 2022
A large Kaiser Permanente study found that most patients with a thoracic aortic aneurysm less than 5.5 cm are not at high risk of experiencing dissection or requiring surgery. The study's findings support the current consensus guidelines recommending surgery for patients with larger aneurysms.
SourceKaiser Permanente·JournalJAMA Cardiology·DateOct 5, 2022
Researchers discover that oxytocin stimulates stem cells to migrate and develop into cardiomyocytes in zebrafish and human cell cultures. This could lead to the regeneration of damaged hearts after a heart attack. The study found that oxytocin also activates EpiPCs, which can replenish lost cardiomyocytes.
SourceFrontiers·JournalFrontiers in Cell and Developmental Biology·TypeExperimental study·DateSep 30, 2022
Researchers have successfully visualized stable spiral waves in human ventricles using high-resolution optical mapping, providing new insights into the complex behavior of the heart during conditions like fibrillation. This breakthrough could lead to the development of new therapies for treating arrhythmias.
SourceGeorgia Institute of Technology·JournalHeart Rhythm·TypeExperimental study·DateSep 7, 2022
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers use human tissue models to study myocardial infarction, a leading cause of mortality worldwide. These models allow for early detection of discrepancies between animal and human responses, enabling faster and safer clinical trials.
SourceAmerican Institute of Physics·JournalBiophysics Reviews·DateAug 30, 2022
A study by CNIC scientists has identified a key role for the MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy. Inhibition of p38α promotes an unexpected activation of the other branch of the pathway, consisting of the proteins MKK3, p38γ, and p38δ. This activation induces another key pathway in cardiac hypertrophy, the mTOR pathway.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournaleLife·TypeExperimental study·DateAug 16, 2022
Researchers at RCSI University have created a new lab-based model to test devices for heart failure with preserved ejection fraction. The model enables testing of the left atrium and ventricle, two independently controlled chambers that simulate blood flow during the resting phase.
SourceRCSI·JournalFrontiers in Cardiovascular Medicine·DateJul 26, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
University of Toronto researchers develop a lab-grown model of the human left heart ventricle made with living heart cells. The bioartificial tissue construct beats strongly enough to pump fluid inside a bioreactor and offers new possibilities for studying heart diseases and testing potential therapies. Future work aims to increase the...
SourceUniversity of Toronto Faculty of Applied Science & Engineering·JournalAdvanced Biology·DateJul 11, 2022
Bioengineers from Harvard John A. Paulson School of Engineering and Applied Sciences create first biohybrid model of human ventricles with helically aligned beating cardiac cells, increasing blood pumping efficiency by up to 50%. The model was made possible using Focused Rotary Jet Spinning (FRJS), a new method of additive textile manu...
SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalScience·DateJul 8, 2022
Researchers at the University of Houston have made a groundbreaking discovery in repairing and regenerating heart muscle cells in mice. The technology uses synthetic mRNA to deliver mutated transcription factors, which increases the replication of cardiomyocytes. This finding has the potential to become a powerful clinical strategy for...
SourceUniversity of Houston·JournalThe Journal of Cardiovascular Aging·TypeExperimental study·DateJun 16, 2022
Researchers discovered a new gene, ZBTB11, that drives heart muscle cell degeneration in arrhythmogenic cardiomyopathy. The gene's activity induces damage to neighboring heart cells, a key process in the disease.
SourceHubrecht Institute·JournalCardiovascular Research·TypeObservational study·DateMay 24, 2022
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A new study published in Open Heart found that patients with asymptomatic severe aortic stenosis benefit from early valve replacement surgery to prevent irreversible heart muscle damage. The research showed that timing of surgery is crucial in reducing mortality and hospitalization rates.
SourceUniversity of East Anglia·JournalOpen Heart·TypeMeta-analysis·DateMay 17, 2022
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
SourceTechnical University of Munich (TUM)·JournalNature Cell Biology·TypeExperimental study·DateMay 12, 2022
Researchers aim to improve pediatric heart transplant outcomes by identifying how certain drugs work and developing new medications to prevent damage to transplanted hearts. The studies will focus on a recently identified population of immune cells, MAIT cells, to adjust medication dosages and minimize side effects.
Researchers have engineered a tiny living heart chamber replica to study disease progression and test new treatments. The miniPUMP device mimics the real organ's mechanics, allowing for accurate tracking of how the heart grows in embryos and studying the impact of disease.
SourceBoston University·JournalScience Advances·DateApr 22, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A Cleveland Clinic-led trial found that an experimental 'gene silencing' therapy significantly reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 96%-98%. The therapy targets the gene responsible for Lp(a) production and has shown strong efficacy with no major safety concerns reported.
SourceCleveland Clinic·JournalJournal of the American Medical Association·DateApr 3, 2022
The trial evaluated the use of mavacamten as an alternative to heart surgery or alcohol septal ablation for treating hypertrophic cardiomyopathy. Findings showed significant reduction in left ventricular outflow tract pressure gradient and improvements in quality-of-life measures.
A multidisciplinary research team from the University of Pittsburgh seeks to improve vascular graft integration by developing fully biodegradable tissue-engineered vascular grafts. The goal is to keep compliance-matched as it degrades and remodels, reducing long-term graft failure rates.
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
SourceMedical College of Georgia at Augusta University·JournalCirculation·DateJan 14, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Recent clinical trials showed promising results with cardiosphere-derived cells, improving heart parameters in patients with Duchenne muscular dystrophy. Researchers investigate using cell-derived products like exosomes to boost endogenous repair pathways, while aiming to reverse cardiomyocytes' proliferation limitations.
SourceUniversity of Alabama at Birmingham·JournalJournal of the American College of Cardiology·TypeLiterature review·DateNov 29, 2021
A randomized trial comparing plug-based and suture-based vascular closure techniques after TAVR found that the plug-based technique had a shorter time to hemostasis but higher access-site complications. The study, CHOICE-CLOSURE, reported similar mortality rates between both groups.
SourceCardiovascular Research Foundation·JournalCirculation·DateNov 8, 2021
Scientists at Lewis Katz School of Medicine discovered that reintroducing the protein LIN28 into adult heart stem cells improves their chances of survival. This breakthrough could lead to new treatments for heart disease using stem cell therapy.
SourceTemple University Health System·JournalRedox Biology·DateOct 21, 2021
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Atrial fibrillation screening in 75- and 76-year-olds may significantly reduce the risk of stroke, severe bleeding, and death. The study, published in The Lancet, found that at least 2,300 cases of stroke or death could be avoided per year with national screening.
SourceKarolinska Institutet·JournalThe Lancet·TypeRandomized controlled/clinical trial·DateAug 29, 2021
A new study found that 44% of micro-arteries from patients had abnormal myogenic tone, associated with excessive caldesmon presence and poor cell alignment. This abnormality affects blood supply within the heart and other organs, impacting quality of life and life expectancy.
SourceUniversity of Bristol·JournalCardiovascular Research·TypeObservational study·DateAug 9, 2021
Researchers have successfully grown sesame-seed-sized heart models using human pluripotent stem cells, which spontaneously self-organize into a hollow chamber without experimental scaffolds. The cardioids' wall-like tissue contracts rhythmically to squeeze liquid around the inside cavity, mimicking natural development.
A team of scientists from Loyola University Chicago's Stritch School of Medicine have discovered a critical component for renewing the heart's molecular motor, which breaks down in heart failure. Restoring BAG3 levels could strengthen the heart as a potential treatment for heart failure.
SourceLoyola Medicine·JournalNature Communications·DateMay 19, 2021
A team of researchers has created the first full-size 3D bioprinted human heart model using their FRESH technique, mimicking the elasticity of cardiac tissue. The model can be manipulated like real tissue, enabling surgeons to practice and improve their skills before actual surgery.
SourceCollege of Engineering, Carnegie Mellon University·JournalACS Biomaterials Science & Engineering·DateNov 18, 2020
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers have created the first atlas of human heart cells, detailing nearly half a million cells and their functions. The database provides a new basis for studying heart disease, which is the leading cause of death worldwide.
SourceHoward Hughes Medical Institute·JournalNature·DateSep 24, 2020
Scientists have documented all cell types and genes in healthy human hearts, paving the way for targeted treatments. This single-cell atlas will help understand heart disease and develop new therapies by correcting genetic mutations.
SourceUniversity of Alberta Faculty of Medicine & Dentistry·JournalNature·DateSep 24, 2020
Researchers analyzed almost half a million individual cells to build the most extensive cell atlas of the human heart, revealing diverse cell types and intricate networks. The study promises to enable better understanding of heart disease and guide development of highly individualized treatments.
Scientists created a comprehensive atlas of healthy human heart cells, revealing unique cell types and communication networks. The map will aid in understanding cardiovascular disease and developing personalized therapies.
SourceWellcome Trust Sanger Institute·JournalNature·DateSep 24, 2020
A collaborative study by Masonic Medical Research Institute and leading institutions reveals a comprehensive map of the human heart's cellular diversity. The findings provide valuable knowledge gaps about heart composition and function, shedding light on genetic risk factors for cardiac health.
SourceMasonic Medical Research Institute·JournalCirculation·DateSep 16, 2020
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Adenovirus, a common cold virus, can disrupt the heart's electrical system, leading to arrhythmias and sudden cardiac death. Researchers used induced pluripotent stem cell-derived cardiomyocytes to confirm the virus's impact on the heart's ability to communicate with its neighbors.
SourceVirginia Tech·JournalThe FASEB Journal·DateJun 22, 2020
Researchers Vera Tiesler and Guilhem Olivier examine the techniques and devices used in human heart extractions, shedding light on the relationship between ritual violence and cosmological interpretations. Their study reveals three distinct extraction methods and provides a framework for analyzing sacrificial rituals in other ancient s...
SourceUniversity of Chicago Press Journals·JournalCurrent Anthropology·DateApr 23, 2020
Researchers have developed an atomic magnetometer that can map the electrical conductivity of the human heart with high resolution. This technology has the potential to diagnose diseases such as atrial fibrillation without invasive procedures.
SourceAmerican Institute of Physics·JournalApplied Physics Letters·DateMar 31, 2020
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A study found that spaceflight affects human heart cells' gene expression, but these changes largely revert to normal upon return to Earth. The researchers used induced pluripotent stem cell-derived cardiomyocytes and observed significant changes in gene expression related to mitochondrial function.
SourceCell Press·JournalStem Cell Reports·DateNov 7, 2019
A recent study led by the University of Hong Kong found that all 17 languages analysed convey information at similar rates, with an average rate of 39 bits per second. This challenges traditional notions of language efficiency and suggests that all human beings share universal cognitive capacities in their language abilities.
SourceThe University of Hong Kong·JournalScience Advances·DateOct 10, 2019
A study found that human hearts have evolved to handle sustained endurance activity, while sedentary lifestyles lead to more 'ape-like' hearts and increased hypertension. Researchers compared heart function in apes and four groups of humans with varying activity levels.
SourceMassachusetts General Hospital·JournalProceedings of the National Academy of Sciences·DateSep 16, 2019
A study analyzing humans, chimpanzees, and gorillas reveals the human heart adapts to endurance activities by becoming larger, longer, and more elastic. However, there is a trade-off between these adaptations, making it harder for individuals with one type of adaptation to cope with the other.
SourceUniversity of British Columbia Okanagan campus·JournalProceedings of the National Academy of Sciences·DateSep 16, 2019
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
The study reveals that humans developed longer ventricles and larger chamber sizes due to endurance exercise, contrasting with great apes' shorter intense bursts of resistance. This suggests a trade-off between pressure and volume in the human heart's evolution.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateSep 16, 2019
A team of researchers from Carnegie Mellon University has developed a new technique to 3D bioprint tissue scaffolds out of collagen, allowing them to overcome challenges associated with existing methods and achieve unprecedented resolution and fidelity. The technique, known as Freeform Reversible Embedding of Suspended Hydrogels (FRESH...
SourceCollege of Engineering, Carnegie Mellon University·JournalScience·DateAug 1, 2019
A team of researchers has discovered unknown mini-proteins in the human heart, which were previously unknown. The proteins are used for energy production and could hold promise for treating heart disease.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalCell·DateMay 30, 2019
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers used an experimental therapy to block fibronectin protein, reducing scarred muscle tissue and saving mouse models from heart failure. The treatment restored function in damaged heart cells and reduced fibrosis.
SourceCincinnati Children's Hospital Medical Center·JournalCirculation·DateApr 13, 2018
Columbia University engineers develop a novel approach to growing mature human heart muscle from blood-derived stem cells, achieving critical hallmarks of adult human heart function in just four weeks. The technique involves applying physical conditioning and electromechanical stimulation to drive rapid maturation of the tissue.
SourceColumbia University School of Engineering and Applied Science·JournalNature·DateApr 4, 2018
Researchers at Columbia University created adult-like cardiac model using induced pluripotent stem cells with electric and mechanical stimulation. The resulting tissue mimics the human heart's behavior after just four weeks of culture.
SourceNIH/National Institute of Biomedical Imaging & Bioengineering·JournalNature·DateApr 4, 2018
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Biomedical engineers at Duke University have successfully grown a fully functional artificial human heart muscle large enough to patch over damaged tissue. The breakthrough enables therapies to replace lost muscle after a heart attack, which currently leaves patients with scar tissue that cannot transmit electrical signals or contract.
SourceDuke University·JournalNature Communications·DateNov 28, 2017
A team of researchers has created the first atlas of the healthy human heart's protein composition, which will aid in identifying differences between healthy and diseased hearts. The study found that despite functional differences between the right and left halves of the heart, they share similar protein compositions.
SourceTechnical University of Munich (TUM)·JournalNature Communications·DateNov 14, 2017
Researchers at ETH Zurich developed a soft artificial heart made from silicone that mimics the human heart's form and function. The device lasts only 3,000 beats but paves the way for future improvements in artificial hearts.
Researchers found olfactory receptors in human heart muscle that react to fatty acids, reducing heart rate and contraction force. A blocker for the receptor has been developed to mitigate negative effects on diabetic patients and those with increased heart rates.
SourceRuhr-University Bochum·JournalBasic Research in Cardiology·DateFeb 8, 2017
Researchers at the University of Bonn and Johns Hopkins University have developed a new method to stop life-threatening cardiac arrhythmia using light stimuli. The technique shows promise as an alternative to painful electric defibrillation, with potential for implantable optical defibrillators in the future.
SourceUniversity of Bonn·JournalJournal of Clinical Investigation·DateSep 12, 2016
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A team of University of Houston researchers has identified novel regulators of heart formation, including microRNAs, which can convert human fibroblasts into heart muscles. These findings hold promise for treating human heart attack and subsequent heart failure within the next five to 10 years.
SourceUniversity of Houston·JournalProceedings of the National Academy of Sciences·DateAug 9, 2016
A team of researchers at Massachusetts General Hospital has successfully regenerated functional heart muscle in decellularized human hearts using stem-cell derived cells. The study involved the use of induced pluripotent stem cells (iPSCs) reprogrammed from skin cells, which were then differentiated into cardiac muscle cells and reseed...
SourceMassachusetts General Hospital·JournalCirculation Research·DateMar 11, 2016
A new study from Karolinska Institutet shows that the mouse heart generates a substantial number of muscle cells early in life, as does the human heart. After the neonatal period, the generation of new heart muscle cells stops and the heart growth mainly occurs by size increase of muscle cells.
SourceKarolinska Institutet·JournalCell·DateNov 5, 2015
Duke researchers discovered a gene called Raf that acts as a switch to turn on Yorkie, making fly hearts grow bigger. The study sheds light on the genetic circuitry of signals governing growth and may help understand how human hearts respond to disease.
SourceDuke University·JournalScience Signaling·DateFeb 3, 2015
Researchers analyzed 50 years of hit songs to identify key themes for advertisers, finding emotional content resonates with mass audiences. The study identified 12 key themes, including loss, desire, and aspiration, which can be used to craft successful advertisements.
SourceNorth Carolina State University·JournalJournal of Advertising Research·DateMar 18, 2014
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.