Articles tagged with Liver
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In a groundbreaking operation, doctors at the University of Witwatersrand performed the world's first intentional liver transplant from an HIV-positive mother to her HIV-negative child. The successful transplant has raised hopes for using this method to save additional lives. However, the team is now unsure of the child's HIV status.
A new study found that a web-based intervention is an effective approach to manage lifestyle changes in patients with NAFLD, reducing weight, and improving dietary intake. The web-based program was compared to group counseling and showed similar effectiveness after two years.
Patients with non-alcoholic fatty liver disease (NAFLD) who consume moderate amounts of alcohol have a 36% decreased risk of early death, while heavy drinking increases the risk by 45%. The study suggests that moderate drinking may be beneficial for these patients.
Researchers at Johns Hopkins Medicine used an endoscopic procedure to deliver therapeutic genes to the liver via the common bile duct, demonstrating a safe and effective method for gene therapy. The technique, called ERCP, was found to be less invasive than traditional injection methods, with no biliary or liver injury observed.
Researchers found that obese patients who underwent a combined liver transplant and weight-loss surgery experienced significant weight loss maintenance and reduced metabolic complications. The study suggests that this dual approach is safe and effective over the long term for treating obesity-related liver disease.
A new six-year single-center study found a web-based program to be an effective approach to manage lifestyle changes in patients with NAFLD, comparable to group-based interventions. The web program reduced weight loss and improved liver health, suggesting counseling as a key therapeutic option until drugs are approved.
A new study reveals that CD26/DPP-4 is a key player in the regeneration of acute liver wounds and may serve as a valuable biomarker for detecting hepatic disease. The molecule's enzymatic activity was shown to increase with reduced liver immune cell population, suggesting its potential use in non-invasive diagnosis.
Alcohol consumption is common among patients with liver disease, associated with poor outcomes. The authors advocate for expanded treatment of alcohol use disorder in everyday clinical practice, including patients with advanced liver disease.
Researchers at the University of Illinois have discovered how damaged liver cells repair themselves by reprogramming into an early stage of postnatal organ development. The findings reveal that injured liver cells undergo partial reprogramming, which is regulated by a specific RNA-binding protein called ESRP2.
Research found that silver nanoparticles and soluble silver cause inflammation in zebrafish gills, with nanoparticles leading to longer-term effects. After exposure, fish recovered from the metal, but continued to exhibit altered gene expression levels.
Children awaiting livers from deceased donors face significant disadvantages due to the scoring system, which significantly underestimates their risk of death compared to adults. The Pediatric End-stage Liver Disease (PELD) score is incompatible with the Model for End-stage Liver Disease (MELD) score used for adults.
Two recent studies reveal that mitochondrial proteins are broken down more quickly in fatty liver cells, reducing their activity. Meanwhile, liver cells with fatty liver disease show signs of overworking, using triglycerides instead of glucose to make energy and increasing reactive oxygen byproducts, which can damage proteins.
Researchers identified caspase-2 as a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. The study found that an inhibitor of caspase-2 could provide an effective way to treat or prevent NASH, possibly even reversing early symptoms.
A new test predicts advanced fibrosis in NAFLD patients, accurately identifying 92% of those at risk. The tool uses the PRO-C3 biological marker and combines it with clinical information for highly accurate results.
Researchers at Cincinnati Children's Hospital Medical Center genetically deleted Ago2 from the livers of mice, stabilizing energy metabolism and preventing obesity and diabetes. The study provides a solid basis for further research into novel therapeutic approaches to treat chronic metabolic disorders.
Research by University of Manchester scientists found that genes regulating lungs and liver function change with the day-night cycle, impacting steroid side effects. Removing a specific molecule, Reverbα, altered gene expression and showed protective effects against fatty liver buildup.
Fatty liver disease is a complex condition that can lead to severe complications like type 2 diabetes and cardiovascular disease. A new review article proposes the use of new diagnostic and therapeutic approaches to enable specific risk prognosis and individualized treatment.
A new model developed by scientists at the University of Bristol aims to help farmers tackle multi-million losses due to liver fluke infestations. The model explicitly links liver fluke prevalence with key environmental drivers like soil moisture, enabling farmers to make informed decisions on grazing and treatment.
A study published in Royal Society Open Science found that Mongrel Mob members had low knowledge of viral hepatitis, leading to risky infection behaviors. The research also identified concerning liver health issues, including high rates of inflammation and damage.
Scientists discover TREM-1 amplifies inflammation, leading to liver scarring and cirrhosis. Targeting this receptor may prevent fibrosis and cancer development.
A study published in PLOS ONE found that restricting high-sucrose diet to active times reduced fat levels in rats. The research team limited the diet to nighttime, resulting in lower blood and liver fat compared to an unrestricted diet.
Researchers have successfully created 3D human liver tissue from human stem cells and implanted it into mice with liver disease, demonstrating improved liver function. The study showcases a promising approach to developing human liver tissue implants that could reduce the need for animal testing.
Researchers found that trehalose improves insulin sensitivity in mice by activating a gene called Aloxe3, which boosts calorie burning and reduces fat accumulation. Trehalose also has beneficial effects on the liver's metabolism, similar to fasting.
Researchers have discovered a potential alternative to liver transplant for patients with acute liver failure, which is triggered by liver injury and can be life-threatening. A new therapy using anti-cancer drugs has been shown to regenerate the liver in mouse models, preventing death from liver injury.
A new blood test can quickly detect early signs of liver disease in dogs, enabling prompt treatment and reducing the need for invasive biopsies. The test is based on insights from human patients and has been successfully tested on 250 dogs.
Research suggests ketogenic diets may cause an increased risk of Type 2 diabetes in the early stage of the diet, particularly through insulin resistance. The study found that fatty acids from a ketogenic diet can have signaling roles in the brain.
Advanced inflamed vascular plaques associated with progressive liver disease, supporting systemic effects of chronic unresolved inflammation. Researchers test oral delivery of omega-3 fatty acids to treat inflammation without unwanted side effects.
Researchers found that naked mole-rat breeders have changed aging rates, living longer than non-breeders due to higher resistance to muscle loss during aging. The study suggests that genetic mechanisms underlying social suppression of sexual maturation may contribute to their exceptional lifespan.
A new study found that injectable trace minerals alleviate inflammation and oxidative stress in lactating Holstein cows exposed to aflatoxin. The researchers discovered that the minerals increased liver concentrations of selenium and iron and boosted serum glutathione peroxidase activity.
A new study found that genetic variation in Caucasians with chronic hepatitis B infection increases the risk of severe liver damage and inflammation. Researchers identified a link between the STAT4 gene and liver fibrosis, suggesting that genetic factors may play a role in disease progression.
Researchers found that mice with obesity develop new liver circadian rhythms that impact fat accumulation and burning, suggesting a potential therapeutic strategy for treating obesity-related liver diseases. Administering drugs at specific times when PPAR-alpha is most active could enhance effectiveness and reduce toxicity.
Studies investigate how changes in gut bacteria and lipid metabolism may influence brain health and cognitive decline. Research suggests that altered plasmalogens production by the liver may result in reduced availability of critical lipids to the brain, contributing to impaired cognitive function and neurodegeneration in Alzheimer's.
Researchers found reduced levels of plasmalogens in the liver are associated with an increased risk of Alzheimer's disease, mild cognitive impairment, and other biomarkers of neurodegeneration. The study suggests that a deficiency in these lipids could lead to the eventual destruction of peroxisomes, increasing Alzheimer's risk.
A study found a 65% increase in cirrhosis deaths and a doubling of liver cancer deaths among US adults between 1999 and 2016. Young people aged 25-34 experienced the highest average annual increase in cirrhosis deaths, driven by alcohol-related liver disease.
A new study reveals a significant increase in liver deaths due to cirrhosis among young adults, with the highest fatalities among whites, American Indians, and Hispanics. The rise is attributed entirely to alcohol-related liver disease, highlighting the need for prevention strategies such as taxes on alcohol and reducing marketing.
A TGen-led study has found a link between DNA methylation and non-alcoholic fatty liver disease (NAFLD) in obese patients. The research identified four genes that may represent potential targets for new therapeutics.
Researchers at BIDMC developed the BE3A score to predict improvement in liver function after DAA therapy for patients with decompensated cirrhosis. The online scoring system assesses 5 baseline factors to provide a shared decision-making tool for physicians and patients.
Researchers at UCalgary have discovered that the antidepressant mirtazapine may be an effective treatment for PBC, a rare and incurable liver disease. The study found that patients taking mirtazapine showed improved health outcomes compared to those without depression.
Researchers have identified specific lipid species in the blood and liver that correlate with healthy or fatty liver states. These findings suggest that measuring individual lipid species may provide a more accurate diagnosis of metabolic diseases such as NAFLD, diabetes, obesity, and metabolic syndrome.
Researchers have developed genetically humanized mice that can be persistently infected with Hepatitis Delta Virus (HDV), a common cause of liver fibrosis and cancer. The mice were able to rid themselves of the virus before showing any liver damage, making them an ideal model for testing new treatments.
A new compound, DPM-1001, has shown promise in reducing copper levels in cells and improving symptoms of Wilson's disease. The study confirmed that the compound is orally available and specifically targets copper, reducing unwanted side effects.
A study by ISGlobal reveals the presence of proteins from hypnozoites in circulating extracellular vesicles, providing a potential diagnostic tool for asymptomatic patients. This breakthrough could help identify and stop malaria vivax transmission, an essential requirement to achieve the WHO's target of eliminating malaria by 2030.
Researchers identified a compound called phenylacetic acid (PAA) produced by gut bacteria linked to the early onset of Non-Alcoholic Fatty Liver Disease (NAFLD). The study suggests PAA could be used as a biological marker in the clinic to identify patients at increased risk of disease.
A TGen-led study has identified significant gene expression patterns associated with obesity-related NASH inflammation and fibrosis. The researchers discovered 176 genes specific to fibrosis, revealing three cellular pathways and 16 previously associated genes.
Researchers developed a new ultrasound technology, time-harmonic elastography, to diagnose liver fibrosis in obese adolescents without invasive biopsies. The technology accurately distinguishes between patients with no or mild fibrosis and those with moderate or advanced fibrosis.
A new approach for treating liver cirrhosis has been found with aleglitazar, which reduces inflammation and portal hypertension in rats with cirrhosis. Aleglitazar suppresses inflammation, vasoconstriction, angiogenesis, and tumor necrosis factor overproduction in cirrhotic rats.
A new decision-making tool called the BE3A score assesses 5 factors to predict improvement in liver function for patients with decompensated cirrhosis. The scoring system will aid physicians in shared decision-making about HCV treatment, particularly for those awaiting liver transplantation.
A new study finds that video consultations between primary care physicians and specialists improve liver disease care and increase patient survival rates. Patients who participated in these consultations had a 54% higher survival rate compared to those without access to virtual consultations.
A new study by the University of Pennsylvania School of Medicine found that private insurers deny coverage for life-saving hepatitis C drugs at a rate of 52.4%, while Medicaid and Medicare deny treatment at 34.5% and 14.7% respectively. The high denial rates may be due to varying restrictions on reimbursements among states.
Researchers discovered a naturally occurring antibody that binds to oxidized phospholipids, blocking inflammation and preventing arterial plaque formation. The antibody protected mice from atherosclerosis, aortic stenosis, hepatic steatosis, and prolonged their lives.
A new Canadian guideline recommends screening for hepatitis C virus (HCV) in people born between 1945 and 1975 due to high rates of infection. The guideline also advocates for curative therapy for all individuals affected by HCV, aiming to prevent premature death.
Researchers propose using viruses to restore normal functioning of cells' nuclei, potentially eradicating unwanted effects of aging. Wrinkled nuclear membranes may be responsible for metabolic diseases such as diabetes and fatty liver disease.
Researchers found that gut bacteria can control antitumor immune responses in the liver by regulating bile acid metabolism and NKT cell accumulation. This discovery has implications for understanding liver cancer mechanisms and potential therapeutic approaches.
Researchers created a 'quick and robust' blood test that can detect liver fibrosis, the first stage of liver scarring, from a blood sample in 30-45 minutes. The new method uses polymers coated with fluorescent dyes to bind to blood proteins, offering a simple and inexpensive way to diagnose disease.
A new blood test can detect liver damage in 30-45 minutes, distinguishing between healthy and damaged individuals. The test could lead to earlier treatment and potentially save millions of lives.
Scientists at the University of Edinburgh have developed a lab-based system for studying Non-Alcoholic Fatty Liver Disease (NAFLD), the most common cause of liver disease in the developed world. The new tool enables researchers to investigate biological mechanisms and develop effective treatments.
Researchers at the University of Colorado Anschutz Medical Campus have shed light on intestinal failure-associated liver disease, a condition that affects people relying on IV nutrition due to intestinal damage. The study suggests three possible new targets for drug intervention to prevent or treat the disease.
A new study reveals that a malaria parasite manipulates liver cells to survive and reproduce, building strength before invading red blood cells. Disrupting this process by targeting the aquaporin-3 protein may lead to new treatments for malaria before symptoms appear.
Liver transplant centers are increasingly accepting transplants for patients with severe alcoholic hepatitis, showing positive outcomes and high one-year survival rates of over 90%. Centers use selective criteria to evaluate candidates, assessing medical history, social support, and psychiatric disorders.
A team led by CSHL Professor Douglas Fearon found that dormant cancer cells are already in the liver before surgery, expressing MHC1 and CK19 markers. In a post-operative stress-induced state, these cells re-express markers and begin to divide, forming seeds of metastatic lesions.