Articles tagged with Liver
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Researchers identified the first genetic defect linked to biliary atresia, a mysterious liver disease causing liver transplantation in children. The study found five patients with disabling mutations in the gene PKD1L1, which was also linked to heterotaxy and congenital heart disease.
Researchers have identified six proteins associated with early-stage non-alcoholic fatty liver disease (NAFLD), a condition that can progress to end-stage liver cirrhosis. The discovery of protein PIGR as a candidate biomarker for liver damage tests offers a promising new diagnostic tool.
A team of researchers has identified biomarkers in the blood that can predict the accumulation of toxic fats in the liver, a sign of early fatty liver disease. The discovery has the potential to lead to a blood test to detect those at risk of advanced fatty liver disease and could represent a new approach in precision medicine.
A new study confirms that obesity impairs vitamin D conversion in the liver, affecting its major form in the blood. This finding highlights the need for targeted treatment approaches, such as calcidiol, to address vitamin D insufficiency in obese individuals.
Researchers identified a genetic mutation in the PKD1L1 gene linked to Biliary atresia, a devastating condition that affects many children. The study found five patients with two copies of mutations and three additional patients with one mutation, providing new insights into the cause of the disease.
Researchers at TIFR have identified molecular mechanisms that allow the liver to adapt to nutrient intake after fasting. These 'fed-microRNAs' inhibit protein synthesis, maintaining blood glucose levels. The study's findings offer potential therapeutic targets for metabolic diseases.
The HOPE in Action Multicenter Liver Study is evaluating the safety and efficacy of transplanting livers from HIV-positive donors to HIV-positive recipients. Researchers will monitor participants for signs of organ rejection, failure, and HIV-related complications, as well as track their psychological and social responses.
The study found that livers from older donors (70 and older) decreased in use despite improvements in liver graft loss and death among recipients of these older liver grafts. This suggests it may be reasonable to expand the donor pool with broader use of liver grafts from older donors.
A new study published in the Journal of Hepatology has identified a pathway connecting some antiretroviral (ARV) drugs with liver disease. The research suggests that ARV drugs interact with the pregnane X receptor, stimulating fatty acid uptake and cholesterol synthesis in the liver.
The University of Warwick has identified the enzyme DGAT1, which controls how much fat is added to particles released by the liver. Inhibiting this enzyme allowed scientists to 'slim down' particles and load them with less fat, reducing the amount of 'bad' cholesterol in the blood.
A recent study found that the MELD score does not fully identify patients with life-threatening syndrome ACLF-3, which involves multiple organ-system failures. ACLF-3 patients have a higher risk of being removed from the waitlist or dying while waiting for a transplant.
A 15-year study found a significant increase in US liver transplants for alcohol-associated liver disease, but with lower five-year survival rates compared to other liver conditions. The study suggests changing attitudes towards sobriety length may be driving this trend.
A study found that supplementing mouse moms with nicotinamide riboside increases the quantity and quality of their milk, resulting in long-lasting physical and behavioral advantages in their offspring. The pups benefited from improved metabolic health, better motor coordination, learning and memory, and resilience to stress.
A randomized clinical study found that a diet low in free sugars significantly improved nonalcoholic fatty liver disease (NAFLD) in adolescent boys. The study showed a reduction in NAFLD from 25% to 17% in the intervention group, compared to a 20% reduction in the usual diet group.
The proportion of U.S. liver transplants for alcohol-associated liver disease (ALD) has doubled in the last 15 years, with a shift away from the six-month abstinence rule contributing to the increase. Despite this, ALD patients still appear to be disadvantaged in transplant access.
Researchers found that a low-sugar diet resulted in significant improvement in nonalcoholic fatty liver disease (NAFLD) in adolescent boys. The study showed a 31% reduction in liver fat in the low-free sugar diet group compared to the typical diet group.
Researchers at UNIST have discovered that endotrophin plays a crucial role in producing a pathological microenvironment in liver tissues of chronic liver disease. ETP levels are associated with metabolic dysfunction and systemic insulin resistance, making it a potential diagnostic marker and therapeutic target.
A study published in The BMJ found that people with the most common genetic disorder in northern Europe are associated with substantially higher levels of disease than previously thought. The faulty genes often lead to serious health problems, including haemochromatosis and liver disease.
Researchers have developed a new model to study the health effects of metabolic protein AMPK, revealing its potential as a treatment for nonalcoholic fatty liver disease and other diseases. By activating AMPK in mice with fatty liver disease, scientists found that it lowered liver fat and protected against weight gain and obesity.
Researchers analyzed national data and found that African-American transplant recipients lived 4.75 years longer on average if their livers were donated by someone of the same race. The study suggests a possible way to improve survival rates for this patient population, which typically faces poorer outcomes with liver cancer.
Research suggests that PCSK9 inhibitors can protect against NAFLD by inducing degradation of hepatic HNF1a protein, insulin resistance, and other mechanisms. The use of PCSK9 inhibitors also ameliorates NAFLD independently of low-density lipoprotein cholesterol level reduction.
A nurse-led specialist clinic in GP surgeries has been shown to diagnose twice as many cases of liver disease than usual care. Simple tests, such as liver stiffness measurements and blood samples, detected nearly half of the patients as having some form of liver disease, including cirrhosis and fatty liver disease.
A new study by USC researchers reveals that a fatty diet can trigger changes in the immune system leading to non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease. The study identified a novel type of reparative macrophage that counteracts inflammation, offering potential pathways for future therapies.
Researchers at Technical University of Munich discovered that immune cells attacking liver sinusoidal endothelial cells disrupts the organ's blood and nutrient supply, leading to overwhelming damage. A new perforin inhibitor agent has been identified to prevent this lethal process.
A new study published in Radiology found that MRI effective for monitoring liver fat levels in obese patients undergoing weight loss treatments. The study assessed liver fat before and after bariatric surgery using quantitative chemical shift-encoded MRI, showing a significant decrease in liver fat content after six to ten months.
Researchers identified optimal recipients for split liver transplants, including children weighing under 10 kilograms and those with rare diseases. Split liver transplants were found to have similar outcomes as whole liver transplants when adjusting for variables such as donor age and recipient health.
A diet rich in green leafy vegetables, especially those high in inorganic nitrate like spinach and rocket, may prevent liver steatosis. Researchers found that increased nitrate intake reduced fat accumulation in the liver and improved insulin/glucose homeostasis in mice with type 2 diabetes.
A recent study by RUDN medics revealed critical spread rates of five types of viral hepatitis in Somalia, with 18.9% of residents infected with hepatitis B and higher rates for hepatitis A and E. The researchers emphasize the need for immediate action to address this global health crisis.
The study investigates the interplay between microRNAs and targeted genes in cellular homeostasis of adult zebrafish, highlighting two types of miRNA unique to each organ. MicroRNAs regulating fundamental processes are common to both liver and gut, while those specific to either organ regulate distinct biological processes.
Researchers have discovered a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease mimicking methylmalonic acidemia. FGF21 levels can predict liver severity and inform treatment decisions. The study may also shed light on common disorders like fatty liver disease and obesity.
Researchers at Boston University have made significant progress in understanding the molecular mechanisms underlying HDL formation. They discovered a crucial interaction between apolipoprotein A-I and ABCA1 proteins, which enables the formation of nascent HDL particles.
A study found that a gene mutation believed to have protected people from the bubonic plague may also protect HIV patients with hepatitis C from fatal liver scarring. Researchers matched patients with and without the CCR5-delta 32 gene mutation and found that those with the mutation had less fibrosis progression.
A new study reveals that liver macrophages do not contain infectious forms of HIV and are unlikely to replicate the infection on their own. The findings narrow potential treatment targets for HIV-infected people taking long-term antiretroviral therapy.
The Woods Hole Oceanographic Institution has documented a dramatic rebound in flounder health due to decades of remediation efforts, including a sewage treatment plant and discharge tunnel project. The number of liver tumors among winter flounder has decreased significantly since the late 1980s.
University of Michigan researchers have developed a new building block that can serve as a safer alternative for the development of new medicines. The novel compound is produced using visible light and does not produce harmful metabolites like traditional anilines.
Researchers found that yelloweye rockfish have difficulty removing toxic mercury from sensitive liver cells, which can cause damage. The study highlights the potential risks of contaminants on this threatened species, with conservation efforts underway to protect them.
Researchers found that perceiving food activates the liver to prepare for nutrient uptake, including rapid signaling cascades that prime the endoplasmic reticulum for protein synthesis. This study may hold implications for understanding obesity and diabetes connections through protein folding and insulin release.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about how liver cell communication affects disease progression. By studying the dialogue between hepatocytes and macrophages, they found that a specific ketone body metabolite helps protect against tissue fibrosis in non-alcoholic fatty liver...
A new study found a clear negative correlation between climate factors and alcohol consumption, with colder regions and areas with less sunlight experiencing higher drinking rates. Climate is also tied to binge drinking and the prevalence of alcoholic liver disease, which claims many lives in patients with prolonged excessive alcohol use.
Researchers found that hepatitis B virus (HBV)-associated acute liver failure results from an uncommon encounter between a highly mutated HBV variant and an unusual immune response in the patient's liver. By analyzing liver samples, they discovered new mechanisms about the disease, providing insights into its development.
Researchers have identified a heterogeneous pattern on liver ultrasounds as a predictor of advanced liver disease in cystic fibrosis patients. Children aged 10 years old are at the average age of diagnosis, and 25% develop advanced liver disease within four years.
Research reveals epigenetic changes in IGFBP2 gene influence type 2 diabetes risk. Higher IGFBP2 levels in blood lower diabetes risk.
Grickscheit aims to develop an 'off-the-shelf' stem cell-based therapy that might not require immunosuppression, a substantial step forward for metabolic liver disease. The UPLiFT investigation will test the effective dose and regimen of the therapy.
Researchers found three genetic variations linked to increased liver fat, which could lead to new treatment options for non-alcoholic fatty liver disease (NAFLD). The study, led by Westmead Institute for Medical Research, identified the mechanisms behind hepatic steatosis, a major risk factor for NAFLD.
Researchers identified 14 genetic variants associated with fat storage patterns and their impact on metabolic risk. These genetic factors tend to protect against diabetes, heart disease, and hypertension when stored under the skin, rather than in organs like the liver.
A recent study found that young plasma has a protective effect on liver damage caused by ischemia reperfusion injury in experimental animals. The study's results demonstrate the therapeutic potential of blood from young animals to prevent age-related phenomena.
Researchers have discovered interleukin IL-22 as a new target to inhibit the progression of liver disease and prevent cancer. The study reveals how IL-22 accelerates fibrosis during chronic hepatitis by amplifying the signal of the fibrogenic cytokine TGF-β.
Scientists have discovered a way to increase NAD+ levels in the kidney and liver by blocking an enzyme, ACMSD, which limits its production. This breakthrough has shown promise for treating liver and kidney diseases, with enhanced mitochondrial function and improved health outcomes.
Advanced liver disease patients who accept liver transplants from older donors (over 70 years old) have a reduced risk of death, regardless of their Model for End-stage Liver Disease score. The study found nearly a twofold decrease in mortality beyond 90 days with acceptance of an older donor.
Scientists have created a comprehensive map of individual human liver cells, identifying 20 distinct cell populations and new aspects of the liver's immunobiology. The study, published in Nature Communications, reveals new insights into the liver's cellular landscape and its impact on disease.
A recent study found that liver transplant survival rates have improved significantly among older adults, with a notable increase in recipients aged 65-69 and those aged 80 or over. The one-year acute rejection rate decreased by 30%, and the risk of death was 57% lower compared to earlier years.
Research shows ALD patients have worse outcomes in intensive care unit (ICU) with lower survival rates and higher risk of emergency hospital admissions. The study emphasizes the need for better community services for alcohol addiction and management of long-term conditions.
Researchers discovered that mast cells release histamine from the gut, triggering the formation of oleoylethanolamide, which stimulates ketogenesis and supports brain and muscle function during prolonged fasts or intense exercise. This finding challenges the long-held assumption that mast cells are solely responsible for allergic respo...
A new study reveals that protein kinase C epsilon (PKCε) is acting from fat tissue to worsen disease, pointing to a new function in this dynamic organ. Fat tissue reveals striking differences in cell shape and size in the presence and absence of PKCε.
A new study found that clay supplements can improve the immune response of dairy cows to aflatoxin exposure, leading to reduced inflammation and increased liver functionality. Cows fed higher doses of clay produced more milk with lower levels of aflatoxin M1.
University of Houston biologist Michihisa Umetani has discovered a protein partnership that protects blood vessels from danger. His work aims to target the Liver X Receptor (LXR) for new medicines to prevent atherosclerosis, offering a potential solution to severe side effects associated with current treatments.
Researchers at ETH Zurich successfully heal genetic disease phenylketonuria in mice using a modified CRISPR/Cas9 system. The technique achieved a high correction rate of up to 60% and restored normal levels of phenylalanine, eliminating the disorder's symptoms.
Scientists have performed prenatal gene editing in laboratory animals to prevent a lethal metabolic disorder, offering the potential to treat human congenital diseases before birth. Using CRISPR-Cas9 and base editor 3, researchers reduced cholesterol levels and improved liver function in mice with genetic mutations.
Scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth. Using CRISPR-Cas9 and base editor 3, researchers reduced cholesterol levels and improved liver function in mice treated in utero.
A new preclinical study shows that PET imaging with the 18F-FAC radiotracer can image T cells in the liver, potentially reducing biopsies and improving treatment. The approach could lead to personalized treatment of patients with immune-related liver disease.