Articles tagged with Lungs
Researchers have identified a common molecular disease pathway explaining how diverse non-infectious and infectious agents like anthrax, lung plague, SARS, and H5N1 avian influenza can cause severe lung failure with similar pathologies. Oxidative stress triggers the innate immune system, leading to severe lung damage.
A two-part series explores chronic cough, defined as a cough lasting longer than eight weeks, affecting 9-33% of the population. The causes are diverse, including airway diseases and cardiovascular conditions, and often go undiagnosed or misdiagnosed as idiopathic.
Researchers have developed tests that diagnose, predict or monitor cancer risks without invasive tissue sampling. Oral epithelium can be used as a surrogate tissue to assess molecular damage to the lungs, allowing for convenient biomonitoring methods.
Research found a strong link between engine exhaust and pneumonia deaths, with 35 local authorities accounting for over 15,000 excess deaths, equivalent to the annual death toll from London smog. The study suggests that pollutants directly damage lung tissue, increasing risk of progressive lung diseases such as COPD.
Patients with cystic fibrosis who develop life-threatening lung infections pose significant challenges for lung transplantation. The success rate of lung transplants in these patients is lower compared to those without such infections, sparking debate about whether to allocate donor lungs to them.
During WWII, physiologists developed altitude chambers to study high-altitude effects on humans. They trained animals to parachute and discovered techniques to prevent decompression sickness and hypoxia. These innovations paved the way for pressurized aircraft and safer air travel.
Experimental work on utilizing donor organs from cardiac arrested donors shows promise in addressing the critical organ shortage for lung and possibly heart transplantation. Strategies for organ preservation during transport, such as Ex-Vivo Lung Perfusion (EVLP) and Organ Care System (OCS), are also being discussed.
Researchers present data on gene-based blood testing that may help reduce immunosuppression and predict cardiac allograft rejection. Non-invasive molecular testing of routine blood samples provides information on the immune, inflammatory, and injury status of transplanted hearts before tissue damage occurs.
Researchers link atherosclerosis to widespread organ damage and discover potential targets for treatment. The study found that biochemical signals in arteries can contribute to harm in the lungs, liver, and other organs.
The National Institutes of Health has awarded contracts to develop new mechanical circulatory support devices for children with congenital heart defects. These devices are designed to decrease wait list mortality and improve efficiency of organ utilization in pediatric patients.
Workers exposed to low levels of an asbestos-like mineral from Montana vermiculite are at increased risk for lung disease today. A 25-year follow-up study found that even low cumulative exposure can cause changes in the lining around the lungs.
A study published in the American Journal of Preventive Medicine found that after-school programs increased moderate-to-vigorous physical activity among middle school girls by 80 calories a week. The intervention also reduced sedentary behavior by 8.2 minutes per day.
Researchers discovered that alligators use a combination of muscles to shift their lungs and maneuver in the water. This unique ability allows them to dive, surface, and roll sideways without creating disturbance. The study highlights the importance of specialized muscles in aquatic animals for navigation and stealth.
The March of Dimes has awarded $3.5 million to scientists studying the role of genes and heredity in premature births. The organization aims to understand the causes of preterm birth, which affects over half a million babies annually.
Researchers are investigating how biomechanical forces affect blood vessel growth in the lungs of babies with congenital heart disease. The study aims to understand the mechanisms behind this phenomenon and potentially develop improved treatments for affected children.
Researchers discuss the potential for developing new therapies for idiopathic pulmonary fibrosis by targeting abnormal embryonic pathways. The treatment imperative for cardiac interventions in older patients also drives this need for innovative treatments.
Bilateral lung transplantation in younger patients with end-stage COPD provides longer survival than single lung transplantation, with median survival times of 6.41 and 4.59 years, respectively. This finding holds true even after adjusting for pre-transplant characteristics.
A study found that genetic variations modifying MBL2 expression are associated with more severe CF symptoms, including faster lung decline in patients deficient in the protein. This may lead to new approaches for treating those at risk of increased disease severity.
Recovery from flu leaves lungs vulnerable to pneumonia-causing bacteria due to immune system suppression. This 'protection mechanism' may also affect response to environmental allergens.
Researchers found that black patients with COPD were less likely to receive a lung transplant and more likely to die or be removed from the transplant list than white patients. Despite differences in insurance, socioeconomic status, and cardiovascular risk factors, these disparities persisted.
A new study found that a 'lung open ventilation' strategy combining low tidal volumes, recruitment maneuvers, and high PEEP levels reduced the rates of severe persistent low oxygen levels and needed rescue therapies. The study also showed improved lung function and reduced organ failure duration.
Researchers at Northwestern University found that high CO2 levels impair lung function and increase the risk of edema. The study suggests reducing CO2 levels to improve treatment outcomes for patients with respiratory distress.
A new UCLA Medical Center study shows that select patients age 65 and older can safely undergo lung transplantation with acceptable outcomes. The study found similar survival rates between younger and older patients, suggesting that age should not preclude patients from the procedure.
A study found that secondhand smoke exposure is associated with decreased lung function in individuals with cystic fibrosis. Certain mutations in the CFTR gene determine the magnitude of this effect, suggesting a potential role for gene-environment interactions in worsening lung outcomes.
Researchers discovered that mast cells in the lungs release renin, an enzyme that helps trigger bronchoconstriction, a hallmark of asthma. This finding suggests potential new targets for treatment against asthma and other respiratory diseases.
A study found that severe asthma is characterized by air trapping and incomplete reversibility with bronchodilator treatment. This suggests a distinct physiological difference between severe and non-severe asthma, potentially leading to new treatment approaches.
Researchers at Johns Hopkins Medicine discovered that secondhand smoke exposure can weaken lung function in patients with cystic fibrosis. The study found that even a small genetic change can double the negative effects of secondhand smoke on lung function, accelerating reduced lung function and lifespan.
Researchers have discovered that cigarette smoke depletes the Sirtuin (SIRT1) gene, which protects against premature aging and inflammation. Testing antioxidant resveratrol may help restore this gene to prevent lung damage and diseases like COPD and lung cancer.
Researchers at the University of Cincinnati discovered that increased numbers of neutrophil cells in the lungs of IPF patients are associated with a 30% increased risk of mortality. This finding may lead to more accurate diagnoses and improved treatment options for those affected by idiopathic pulmonary fibrosis.
Researchers have made significant advances in treating and diagnosing LAM through the use of sirolimus and serum VEGF-D test, showing improved lung function and reduced tumor growth. These studies provide hope for patients suffering from this deadly disease, paving the way for targeted therapies.
Researchers found that Gas6 protein increases cell signaling in response to Epo treatment and treats both chronic and acute anemia in mice. Additionally, mice deficient in Gas6 have decreased sensitivity to Epo and reduced ability to recover from anemia.
Researchers found that sirolimus reduced angiomyolipoma size by nearly 50% in TSC and LAM patients. Lung function also improved in LAM patients, with a 10-15% increase in expiratory air flow.
Researchers found that IETM is the arch-criminal in HPS development, leading to increased NO and CO production and vascular abnormalities. The study suggests that targeting LPS may be effective in preventing and treating HPS.
Researchers compared computed tomographic pulmonary angiography (CTPA) to conventional lungs scans for excluding pulmonary embolism. While CTPA detected more clots, it also resulted in a higher rate of venous thromboembolism diagnoses. The study suggests that CTPA may be a safe and reliable alternative to ventilation-perfusion scanning.
Research shows preemies' reduced lung function persists beyond infancy, contributing to increased risk of respiratory illnesses. Maternal tobacco smoking also linked to lower lung function in both full-term and preterm infants.
Exposure to traffic pollution may increase respiratory problems and reduce lung volumes in children with asthma. Living in areas with high road density also increased respiratory symptoms in asthmatic children, even if they didn't have pre-existing conditions.
Researchers at Massachusetts General Hospital have discovered a crucial molecular pathway underlying idiopathic pulmonary fibrosis (IPF), a deadly lung disease. The study found that lysoposphatidic acid (LPA) and its receptor LPA1 play a key role in attracting fibroblasts, leading to scarring of lung tissue.
A new study by Imperial College London found that diesel exhaust fumes increase asthmatic symptoms, reduce lung capacity, and cause inflammation in people with mild and moderate asthma. The research measured air quality and lung function in volunteers walking along Oxford Street, where only diesel-powered vehicles are allowed.
A CU-Boulder technology has been used to identify unexpected bacteria strains in the lung fluid of Denver children suffering from cystic fibrosis. The method uses nucleic acid gene sequencing to rapidly detect and classify pathogens found in the lungs, identifying over 60 species of bacteria in samples from 28 patients.
A purified bacterial extract spray administered to laboratory mice provided powerful protection against all four major classes of pathogens, including anthrax and bubonic plague. The treatment was shown to stimulate a healthy immune response and increase antimicrobial polypeptides in the lung lining fluid.
A new system has been developed to classify rare lung diseases in infants, improving diagnosis and treatment outcomes. The system groups various lung diseases into distinct categories, allowing pathologists to diagnose children's lung disease more accurately.
A recent study found that chronic alcohol consumption by lung donors promotes scarring and airway injury after transplantation. The research, published in the American Journal of Respiratory and Critical Care Medicine, raises questions about human lung donors with a history of alcohol abuse.
A new study found that treatment with ibuprofen is associated with a significantly slower rate of decline in lung function in children and adolescents with cystic fibrosis. The study showed a 29 percent reduction in loss of lung function compared to those who did not use the anti-inflammatory drug.
A novel MRI technique has identified structural damage to the lungs caused by secondhand cigarette smoke. The study found that breathing secondhand smoke can injure your lungs, with 57% of smokers showing early lung damage.
A new study reveals that individuals with higher body mass index (BMI) experience greater drops in lung function after acute ozone exposure. The research found that underweight individuals have lower ozone-related drops in lung function, while overweight and obese individuals exhibit the greatest declines.
Researchers at the University of Utah Health found that lung transplantation rarely extends children's survival and can even increase their risk of dying. The study analyzed data from 514 patients with cystic fibrosis and found that only one patient showed a clear benefit from transplantation, while others were at a higher risk of death.
A study on lung transplantation for children with cystic fibrosis found no survival advantage for young patients, contradicting previous research. Pediatric pulmonologist Julian Allen calls for more judicious referrals and social support for families making decisions about treatment.
The American Thoracic Society has released new clinical standards for treating cystic fibrosis, focusing on aerosolized antibiotics and DNase for patients with moderate to severe lung disease. The guidelines aim to improve lung function, reduce exacerbations, and increase life expectancy.
Researchers identified a mechanism that represses dendritic cell function in melanoma, which could be targeted for treatment. A new approach to treating myotonia in individuals with DM1 was also discovered using morpholino antisense oligonucleotide.
Research reveals that statins cause skeletal muscle damage through the activity of the gene atrogin-1. Inhibiting this gene's function could help protect against the side effect. Separate studies also link low levels of protein SHGB to metabolic syndrome and show how excess sugar contributes to its development.
A team of researchers has made a breakthrough in understanding the mechanisms that regulate hemoglobin's ability to transport oxygen. By using sophisticated atomic calculation techniques, they have identified the factors that control hemoglobin's affinity for oxygen, which can now be used to design alterations of its structure.
Researchers at Johns Hopkins Medicine found that heart transplant recipients who receive commonly used blood-vessel-opening drugs can achieve similar survival rates as those without high pressure. The study of 10,331 patients showed a reduced survival rate for those who did not respond to therapy. These findings bring new hope to hundr...
Researchers found that computer-aided detection (CAD) combined with multi-detector computed tomography (MDCT) improves radiologists' ability to detect solid lung nodules. CAD successfully matched 91.3% of nodules detected in both exams, and reduced reading time for radiologists.
A recent study found that breastfed babies with asthmatic mothers had lower airflows and no improved lung growth, suggesting a potential link between breastfeeding and increased risk of asthma. In contrast, non-asthmatic mothers' milk may promote lung development.
A study published in the Journal of the National Cancer Institute found that treatment with a vitamin A derivative called retinoic acid reduced the growth of lung cells in former heavy smokers. The researchers also found that the treatment slowed down cell growth in the parabasal layer of lung cells, but not in the basal layer.
A prospective study found that quality of life surpasses classic predictors like disease stage and tumor size in determining survival. Patients with better quality of life scores had a significantly higher rate of survival.
Researchers at Mayo Clinic Jacksonville found that partial breast irradiation can expose as much lung and heart tissue to potentially toxic radiation as whole breast irradiation. This suggests that both methods carry equivalent risks and benefits.
A study found that a pharmaceutical monoclonal antibody can prevent pulmonary fibrosis, a serious side effect of radiation therapy for advanced lung cancer. This breakthrough may lead to more effective radiation therapies and extend patients' lives.
A team of doctors at the University of Bonn performed the first-ever prenatal surgery to treat premature rupture of the fetal membrane. The operation successfully stimulated lung growth in Miriam, who was born after five days with almost doubled lung volume. Her case will be published in Fetal Diagnosis and Therapy on October 29th.
A study found that valsartan reduces Alzheimer's disease-like symptoms in mice by lowering brain beta-amyloid protein levels. A new virotherapeutic also shows promise in treating cancer by selectively targeting cancer cells.