Articles tagged with Lymph Nodes
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Researchers at Stanford Medicine identified unique patterns of immune cells in breast cancer patients' lymph nodes that predict clinical outcome and can identify tumor spread. The study found that immune changes within these lymph nodes predicted clinical outcome even better than their tumor invasion status.
Researchers found that the 'immune profile' of axillary lymph nodes can independently predict breast cancer recurrence. The study showed that immune cell numbers and composition in these nodes correlated with disease-free survival, outperforming other clinical parameters.
A study published in JAMA Network found that a diagnostic strategy combining Transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) and mediastinoscopy can identify more patients with tumor invasion or lymph node metastases, reducing unnecessary thoracotomies by 16%.
Research discovers T-cell 'traffic control' system that prevents autoimmune disease and rejection of transplanted organs, promising new treatment for multiple sclerosis and transplant rejection. The system is controlled by a fat-like compound called S1P, which can be blocked with experimental drugs to prevent excessive T cell activity.
A study of 580 women found that nearly half experienced persistent lymphedema, a condition causing fluid buildup in arms and hands. Lymphedema affects quality of life, requiring lifestyle changes such as compression garments.
Fine-needle aspiration of axillary lymph nodes has been shown to be a safe and effective alternative to sentinel lymph node biopsy or axillary dissection for patients with suspected breast cancer. The procedure allows for precise treatment and can help avoid unnecessary surgeries, saving money and time.
A clinical trial found that systematic aortic and pelvic lymphadenectomy improved progression-free survival, but not overall survival, in patients with advanced ovarian cancer. The procedure did not significantly increase median overall survival duration.
Research at Massachusetts General Hospital found that tumor cells use VEGF-A to stimulate growth of new lymphatic vessels, allowing them to spread to lymph nodes more easily. The study's results suggest that targeting this process could be a promising approach for preventing the further spread of metastatic cancer.
Researchers at Ohio State University discovered that precursors to natural killer cells are found in lymph nodes, not bone marrow. This finding may offer new insights into manipulating NK cells to enhance immune responses to cancer.
A recent study found that only 37% of patients with colorectal cancer received adequate lymph node evaluation, highlighting the need for improved surgical care and pathologic assessment. Additionally, research on non-Hodgkin lymphoma and obesity suggests no association between body mass index and overall risk of either disease.
Cancer researchers have developed a new method to delay dendritic cell activation, extending the time when immune cells can detect and attack cancer. By using a drug that links molecules, the approach prolongs the activity of dendritic cells, which are key to cancer vaccines.
Researchers found that 39% of healthy patients with mesenteric lymph nodes had no evidence of disease one year after their initial examination. Follow-up imaging is not necessary for patients with multiple small nodes scattered throughout the abdomen.
A new technique detects lymph node metastases in cancer patients using nanoparticles and MRI, providing unprecedented accuracy and potentially sparing unnecessary surgery. The method involves tracking nodes with magnetic particles, identifying patterns for normal and malignant nodes, and generating a 3D reconstruction of the lymph nodes.
A validation study has shown that a 70-gene signature is more effective than current standard criteria in predicting the time to distant metastasis and overall survival in breast cancer patients. The results have the potential to reduce chemotherapy prescriptions by up to 20% and improve quality of life for many women with breast cancer.
A new biopsy technique combining ultrasound and fine needle aspiration can reliably determine whether lymph nodes are malignant in women with breast cancer. The method allows for the identification of cancerous nodes without the need for sentinel lymph node sampling or axillary node dissection, saving patients from additional surgery.
A new study by the Schepens Eye Research Institute reveals a previously unknown connection that stimulates immune response in the eye and other parts of the body. By blocking VEGFR-3 growth factor, researchers can arrest the rejection process, leading to improved survival rates for corneal transplant patients.
Researchers explore alternative biomarkers for prostate cancer using immune responses to AMACR, while a new RNA interference strategy shows potential in silencing PLK1 genes. The latest AJCC breast cancer staging system revision also influences false-negative rates.
A study published in Journal of Clinical Oncology found that extended lymph node dissection does not increase long-term survival among gastric cancer patients, potentially increasing morbidity and hospital mortality. The procedure may only be beneficial if safe and effective alternatives can be developed.
A new nomogram developed by Memorial Sloan Kettering Cancer Center accurately predicts the likelihood of axillary lymph node metastasis in breast cancer patients. The model considers various pathological factors, including tumor size and type, estrogen-receptor status, and detection methods.
Researchers at Duke University discovered that mast cells trigger both the innate and adaptive immune responses by releasing TNF, which recruits infection-fighting T-cells and induces antibody production. This finding redefines how the immune system functions and may lead to new therapeutics for disease protection.
Researchers developed a new method to detect melanoma in lymph nodes using molecular analysis, revealing 25% of cancer-free patients had undetectable metastases. The study found patients with multiple markers were more likely to develop recurrence and die from the disease.
A study found that PET scans can detect activation of lymph nodes in HIV-infected individuals, suggesting potential targets for treatment. Researchers propose using PET scans to locate active nodes and target them with radiation or removal.
Researchers found distinct lymphoid tissue activation patterns in patients with acute, mid-stage, and late HIV-1 disease. PET scans showed predictable sequence of lymph node involvement, suggesting potential for treatment interruptions during active node removal.
Researchers discovered a group of breast cancer tumors unrelated to typical patterns, with no clear link between tumor size and axillary lymph node cancer. This finding has significant implications for early diagnosis and treatment of women carrying the BRCA1 gene mutation.
A study found that examining lymph nodes in women with early-stage uterine cancer can prevent unnecessary radiation therapy and improve treatment outcomes. The researchers analyzed data from 144 women diagnosed with grade 1 endometrial cancer, finding that lymph node removal saved patients from unneeded radiation therapy in 22 cases.
A new contrast agent has been shown to be 92% accurate in identifying malignant disease using MR imaging, outperforming CT scans in diagnosing testicular cancer metastases. The agent enhances lymph node signal intensity, allowing for earlier detection of disease.
A study found that 11C-Choline PET scans were more sensitive in detecting pelvic lymph node tumors and accurately staged their development, with an overall accuracy of 93%. This technique shows promise as a safe, non-invasive method for prostate cancer patients
A new study reveals that sentinel lymph node mapping can be safely performed on patients with melanoma in the delicate head and neck area, allowing for early detection of cancer spread. The technique has been shown to accurately stage patients and identify those who need further treatment, potentially improving survival rates.
Women with stage IIIb cervical cancer may benefit from different treatments depending on the spread of their disease, according to a new study. The research found that women whose cancer had not spread to lymph nodes had the highest survival rates, while those with upper chest lymph node involvement typically died within months.
Researchers use new microscopy techniques to observe immune cell behavior in living tissues, revealing prolonged contact between T cells and dendritic cells. This study paves the way for future work on T-cell activation and provides a new glimpse into key steps in early immune responses.
A study published in the Journal of Clinical Oncology found PET scans to be more accurate than CT scans in detecting cervical cancer spread. The imaging method reveals metabolic differences between cancer cells and normal tissue, identifying abnormal lymph nodes.
A new diagnostic tool is highly accurate in detecting cancer spread in women with vulva cancer, potentially sparing them from debilitating lymph node removal. Researchers found that 27 out of 59 patients had cancer spread, and the procedure could spare up to 80% of women from this procedure.
A retrospective study published in Cancer journal shows an inverse correlation between the number of lymph nodes and 5-year survival rates. Patients with 20 or more tumor-free lymph nodes had a 4.33 times greater relative risk of dying from metastatic breast cancer, compared to those with fewer than 20.
The Comprehensive Cancer Center at Wake Forest University has been approved to participate in a national breast cancer study evaluating the effects of sentinel node biopsy versus standard axillary dissection. The trial aims to determine if removing only the sentinel node impacts cancer control and survival.
A University of Iowa-led study found that women with Stage I breast cancer who did not receive axillary node dissections had significantly worse 10-year survival rates compared to those who underwent the procedure. The analysis suggests that many women with early-stage disease are not receiving this crucial treatment, which may impact ...
A new test developed by USC scientists and colleagues can accurately detect hidden breast cancer cells in lymph nodes, improving the detection of metastases. This breakthrough enables customized treatments tailored to individual patients' characteristics, such as tumor size and hormone receptor status.
A UCSF study reports that melanoma patients with cancer spread to their sentinel lymph nodes have a greater chance of experiencing disease recurrence and mortality. The study found that patients with negative SLN biopsies had lower rates of disease recurrence and mortality.
Researchers found that axillary lymph node dissection, a common surgery used to determine the extent of disease in early stage breast cancer patients, may not benefit a large number of them. The study concluded that knowing lymph node status was unlikely to affect survival and may not be worth the risks associated with the surgery.
The new technique allows doctors to find the sentinel lymph node, reducing swelling and side effects. In over 90% of cases, the sentinel lymph node is found, offering women more effective treatment with fewer complications.