Articles tagged with Lymph Nodes
Researchers at UT Arlington are developing tissue-engineered artificial lymph nodes that can attract prostate cancer cells, allowing for more targeted treatments and potentially longer patient survival. The technology, led by Liping Tang, could also help identify the biological signals that enable cancer to migrate throughout the body.
The study reveals IL-37's role in regulating the adaptive immune system by inhibiting antigen recognition. This allows for potential manipulation of IL-37 levels to sensitize or desensitize the immune system in various diseases.
Research found that post-operative radiation therapy improved overall survival for patients with resected NSCLC, with a median survival time of 42 months compared to 38 months without PORT. Factors associated with better survival included female gender, adenocarcinoma histology, and younger age.
Researchers at Wayne State University are working on a grant-funded project to design molecular vaccines for Type 1 diabetes and other autoimmune diseases. They aim to use a novel approach called 'hitchhiking' to deliver therapeutics to specific sites in the lymph nodes.
Researchers at Duke Medicine and Duke-NUS Graduate Medical School Singapore detail how Yersinia pestis bacteria hitchhike on immune cells in lymph nodes to spread the bubonic plague. New therapies that block host immune function show promise in preventing infection and improving survival.
A new minimally invasive technique using endoscopic biopsy of lymph nodes has been shown to be sensitive and accurate in staging non-small cell lung cancer. The approach avoids the need for surgical mediastinal staging, reducing complications and improving patient outcomes.
Researchers identified racial disparities in the use of sentinel lymph node biopsy (SLNB) among black and white women with early-stage breast cancer. Black women were 12% less likely to undergo SLNB, contributing to higher risk for lymphedema compared to white patients.
A Mayo Clinic study found that ultrasound images of underarm lymph nodes are more accurate in overweight and obese breast cancer patients than in those with a normal body mass index. The research suggests that soft fatty tissue can be compressed during ultrasounds, leading to better specificity and accuracy for these patients.
New research finds that radiotherapy after mastectomy reduces recurrence and death rates for women with early breast cancer in 1-3 positive lymph nodes. The study, which analyzed data from 3786 women, shows a significant benefit of radiotherapy regardless of chemotherapy or hormonal therapy use.
A decade-long study confirmed the effectiveness of lymphatic mapping and sentinel-node biopsy in detecting melanoma's early spread to lymph nodes, significantly prolonging patients' survival rates. The technique spares patients from unnecessary surgery and substantial costs for those with non-spreading tumors.
Researchers found that patients with high tumor cell density in sentinel lymph nodes are more likely to die from melanoma within 5 years. A new model predicts patient survival more accurately, identifying those at high risk for progression and those with excellent long-term outcomes.
A study found that women who had more frequent screening mammography had a significantly lower rate of lymph node positivity, improving patient prognosis. The researchers suggest that following guidelines recommending annual screening beginning at age 40 may benefit breast cancer patients.
A new study suggests that treatment of pelvic nodes individualized by including sentinel nodes can be easily integrated into an IMRT-based strategy, correctly covering individual pelvic nodes without nodal recurrence. The study's findings indicate low toxicity and efficacy, justifying further evaluation.
Researchers found that posterior intercostal lymph nodes have predictive power for mesothelioma patients, with patients without cancer in these nodes having significantly longer overall survival rates. The study suggests including these lymph nodes in the mesothelioma staging system.
A Mayo Clinic-led study found that a less-invasive procedure called sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91% of patients with node-positive breast cancer who received chemotherapy before their surgery. The procedure removed only a few lymph nodes, reducing surgical complications.
Researchers found a 12.6% false-negative rate with SLN surgery, exceeding the prespecified threshold for patient selection. The study suggests that greater sensitivity is needed to support the use of SLN surgery as an alternative to ALND in patients with cN1 disease.
A conservative approach to removing lymph nodes during breast cancer surgery is associated with less harm and similar results to more radical procedures. The study found that avoiding axillary surgery can reduce complications and morbidity in patients.
A new study has found that treating chest lymph nodes in early breast cancer patients improves overall survival without increasing side effects. The research involved 4004 patients from 43 centres and found that irradiating the IM-MS lymph nodes gave a better patient outcome than radiation therapy to the breast/thoracic wall alone.
Researchers at Helmholtz Centre for Infection Research found that lymph nodes in certain locations produce more regulatory T cells, which mediate tolerance to harmless substances. This 'location-specific memory' is crucial for maintaining the balance of the immune system and preventing autoimmune diseases.
A QUT study found that extensive breast cancer surgery is linked to an increased risk of developing arm lymphoedema. The study revealed one in five women may be diagnosed with the condition, which can cause anxiety, depression, and emotional distress.
Researchers at Lund University found that lymph nodes provide a more accurate picture of breast cancer prognosis than breast tissue alone. Analyzing the proliferation, hormone receptor status, and HER2 status of lymph nodes showed significantly improved results in predicting metastases and disease recurrence.
A phase III non-inferiority trial found that axillary radiotherapy provides excellent regional control and reduces the risk of lymphoedema compared to axillary lymph node dissection. The study also showed no significant differences in overall or disease-free survival between the two treatment arms.
The study found that lymph node volumes were estimated at 30% lower in low-dose scans compared to high-dose scans. Lung nodule volume was also significantly affected, with 46% lower volumes in low-dose scans.
A new imaging dye has been shown to effectively detect and map cancers in lymph nodes, improving staging accuracy. The radioactive dye successfully identified cancerous lymph nodes, detecting 94% of malignancies compared to the standard blue dye's 76%.
A new study found that 75% of women who had arm node removal surgery worried about getting lymphedema, despite only 19% developing it. Most patients adopted multiple risk-reducing behaviors, which were not supported by data.
A new surgical technique has been developed at the University of California - San Diego School of Medicine, using fluorescently labeled molecules to spot cancer invasion in lymph nodes. This allows surgeons to identify cancerous tissue during surgery, saving healthy tissue and reducing unnecessary removal of lymph nodes.
A new study conducted by Mayo Clinic reveals that sentinel lymph node surgery can accurately identify residual breast cancer in lymph nodes after chemotherapy, with a success rate of 91%. The procedure removed only a few lymph nodes, reducing surgical complications, and found complete eradication of cancer in 40% of patients.
A new study reports that endoscopic mastoscopic axillary lymph node dissection (MALND) reduces blood loss, pain, and swelling compared to conventional surgery. MALND also shows promise in reducing distant metastasis rates and improving aesthetic outcomes.
Researchers found that the risk of rectal cancer spreading to lymph nodes increases with age, with younger patients being more likely to have affected nodes. The study suggests that doctors should hunt aggressively for lymph node involvement in younger patients.
A study analyzing the International Mesothelioma Interest Group (IMIG) staging system for malignant pleural mesothelioma (MPM) reveals areas for potential revision. The current system distinguishes among T and N categories, but qualitative T descriptors may not be applicable to clinical staging.
Researchers at University of Pittsburgh School of Medicine showed that liver cells, thymus tissue and insulin-producing pancreatic islet cells can thrive in lymph nodes despite being displaced from their natural sites. This could lead to cell-based alternatives to whole organ transplantation.
A new CT linked technique improved the detection of positive sentinel lymph nodes and increased disease-free survival rates among melanoma patients. The study found that patients who underwent preoperative SPECT/CT imaging had a higher rate of metastatic node detection and longer disease-free survival.
Researchers found evidence that melanoma manifests differently in children than in adults, particularly with regard to the likelihood and significance of lymph node metastases. Despite higher rates of metastases to sentinel nodes, survival rates for children are comparable or better than those for adults.
Researchers found that high F-18-FDG uptake in axillary lymph nodes before treatment can predict disease-free survival in invasive ductal breast cancer patients. A nodal SUVmax of 2.8 was identified as the optimal cutoff for predicting disease-free survival.
A new study recommends that breast cancer patients with a positive ultrasound-guided axillary node biopsy undergo an axillary dissection due to more extensive disease. Patients with a negative biopsy can instead have a sentinel lymph node biopsy.
Researchers at Moffitt Cancer Center are developing 'designer lymph nodes' that use gene-modified cells to produce a pre-planned immunologic response for cancer patients. These innovative nodes aim to rebuild and augment the immune system, overcoming dysfunction caused by tumors or treatments.
A new study found that a protein called SIX1 plays a critical role in early stage metastasis, especially lymphatic metastasis, in breast cancer. The study identified the SIX1-VEGF-C pathway as an important signaling pathway involved in breast cancer metastasis.
Photoacoustic tomography allows scientists to see deep beneath the skin with high contrast, revealing tissue oxygen use and cancer biomarkers. The technique enables non-invasive imaging for breast cancer staging, early chemotherapy response monitoring, melanoma detection, and gastrointestinal tract visualization.
Dr. Kari Alitalo receives the award for his outstanding contributions to lymphatic science and advancement of VEGF-C lymph node transplant research, which shows promise in treating lymphedema and improving lymphatic function.
Cancer cells losing cadherin-11 protein spread to nearby organs and structures like lymph nodes. Researchers propose recovering protein activity could slow tumour growth and decrease metastases.
Researchers discovered that nonsteroidal anti-inflammatory drugs (NSAIDS) inhibit tumor metastasis by reducing lymphatic vessel dilation and prostaglandin pathways. This mechanism provides a potential target for cancer treatment.
Scientists at Duke University Medical Center created nanoparticles that target lymph nodes to greatly enhance vaccine responses. The particles mimic natural mast cell granules and provide a timed release of inflammatory mediators, stimulating effective immune reactions in mice vaccinated with the influenza A virus.
A rare type of HIV-infection, group N, has been diagnosed in a man in France who recently travelled to Togo, marking the first detection outside Cameroon. The patient exhibited severe clinical manifestations and early decline in CD4 cell count, but responded well to antiretroviral treatment.
A study by Fox Chase Cancer Center found that sentinel lymph node biopsy can predict cancer recurrence and guide treatment for Merkel cell carcinoma patients. The procedure led to lower risk of cancer recurrence and improved survival rates in two-year follow-up.
Researchers have developed a virtual fly-through 3D imaging technique that accurately detects regional lymph node metastases in non-small cell lung cancer patients. The method achieved an 81% diagnostic accuracy rate, making it a promising tool for non-invasive diagnosis.
Dr. Giuliano was awarded the Brinker Award for Scientific Distinction for his pioneering findings on lymph node removal and his contributions to less invasive breast surgery. His research has led to improved quality of life for women with breast cancer and reduced side effects from breast surgery.
A significant increase in lymph node evaluation during colon cancer operations occurred over two decades, but this was not associated with a corresponding rise in node-positive cancers. Patients with high lymph node evaluation experienced lower relative hazard of death.
A study on natural killer cells in wild mice found that these mice have higher numbers of NK cells compared to lab mice, suggesting a closer representation of human immune systems. The findings support the hypothesis that environmental factors are needed to fully represent the immune system.
A new study from the University of Michigan Comprehensive Cancer Center confirms that sentinel lymph node biopsy is a safe and effective way to determine the status of regional nodal basins for head and neck melanoma patients. The procedure was found to be accurate in identifying cancerous nodes, with only 4% false-negative results.
A study found no association between occult metastases in lymph nodes and overall survival among women with early-stage breast cancer. Researchers detected micro-metastases using immunohistochemical staining but did not find significant impact on death or recurrence rates.
A new study published in Journal of the American Medical Association found that removing lymph nodes due to microscopic cancer cells has no impact on survival outcomes for women with early-stage breast cancer. The study, conducted by Cedars-Sinai Medical Center, challenged the common approach to treating early-stage breast cancer.
A new study published in the Journal of Thoracic Oncology found that endosonography followed by surgical staging significantly improved the quality of life for lung cancer patients. The study, which compared two strategies for mediastinal staging, showed no significant difference in costs between the two approaches.
Researchers at UC Davis discovered that Lyme disease bacteria accumulate in lymph nodes, triggering a strong immune response but one that is not effective against the infection. The study suggests that B. burgdorferi has developed a novel strategy to subvert the immune system, allowing it to both provoke and evade an effective response.
A new study found that adding radiation therapy to breast-conserving surgery improves disease-free survival and reduces cancer recurrence in women with early breast cancer. The treatment significantly lowered the rate of recurrences in the breast and lymph nodes, as well as in other parts of the body.
A recent study published in The Journal of Nuclear Medicine found that PET scans can help determine earlier if treatment for tuberculosis is working or if the disease is multidrug-resistant. This technology has the potential to become a valuable clinical adjunct to genotypic and phenotypic tests, improving patient outcomes.
The sentinel node procedure has evolved to limit surgical overtreatment, but isolated tumor cells and micrometastases have led to increased surgeries. Current studies examine the role of radiotherapy, pathologic protocols, and prognostic impact of these findings on breast cancer patients.
A new study suggests that less invasive lymph-node biopsy can accurately diagnose lymph node status in patients with early stage endometrial cancer, reducing the risk of surgical complications. The procedure has been shown to be safe and effective, with a negative predictive value of 97% and sensitivity of 84%.
Small-screen detected lung cancers with maxSUV of 2.0 or smaller nodules than 10mm have low risk of nodal metastases, suggesting some patients can avoid invasive procedures. This reduces operating time and morbidity associated with lymph node dissection.
Scientists at the University of California, San Diego are creating a new technique for identifying critical lymph nodes in breast cancer patients. By injecting fluorescent microbubbles into the tumor and imaging them with ultrasound, doctors can pinpoint the sentinel lymph node without surgery.
A study found that removing only the first lymph node (sentinel lymph node dissection) did not impact overall survival for women with early-stage breast cancer. The use of this method resulted in fewer complications compared to more extensive axillary lymph node dissection.