Researchers at Johns Hopkins and the University of Michigan have developed a treatment that helps spinal cord nerves regrow after injury. Using an enzyme called sialidase, they increased the number of new nerve fibers in injured rats by more than twice, compared to untreated controls.
Researchers at UW-Madison are developing cell transplant techniques to repair damaged myelin and protect nerve fibers in multiple sclerosis. The $3.4 million grant will support the use of human stem cells and minocycline, an antibiotic with anti-inflammatory properties.
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Researchers have discovered that an experimental drug can reverse the loss of nerve fibres in Parkinson's Disease. The study found that dopamine-containing nerve fibres had sprouted back in the brain, leading to improved motor function and sustained benefits even after treatment cessation.
The study found a strong link between nerve damage and the presence of molecules Nav.1.6 and NCX, which can lead to permanent and irreparable damage in MS. The researchers hope to design new therapies that will protect vulnerable nerve fibers.
Researchers found that a combination therapy using Schwann cells and cyclic AMP (cAMP) promotes axonal growth and functional recovery after spinal cord injury. The treatment preserved and elevated cAMP levels in nerve cells and myelinated nerve fibers, leading to better locomotion and coordination in rats.
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Researchers found that patients with multiple sclerosis who experience high levels of fatigue have widespread axonal damage in their brains. The study suggests that the nerve damage may be the underlying cause of fatigue, rather than other factors like conduction block or inflammatory mediators.
A single application of high-concentration capsaicin patches has been shown to provide significant long-term pain relief for patients with postherpetic neuralgia, a condition that often persists for years. The patch-based treatment avoids systemic side effects associated with traditional treatments.