Ovaries

Large-scale Nordic study discovers link between polycystic ovary syndrome and heart disease

AI-driven wearable patches help identify undetected hormone disruption in unexplained infertility

Not all organs age alike: AI unveils the molecular impact of menopause across the female body

A new study reveals that menopause causes profound and uneven transformations across the female reproductive system, rather than a uniform decline. The research identified molecular signals associated with aging detectable in blood, allowing for non-invasive monitoring and earlier detection of risks.

Antifibrotic drug shows promise for premature ovarian insufficiency

Researchers found that an approved antifibrotic drug, finerenone, can reduce ovarian fibrosis and promote follicle growth in women with premature ovarian insufficiency. Clinical trials showed that finerenone improved follicle development and mature oocyte quality in women with POI.

Fecal transplants from older mice significantly improve ovarian function and fertility in younger mice

A new study reveals that fecal transplants from older female mice significantly improve ovarian function and fertility in young mice. The transplants show a direct link between the gut microbiome and ovarian health, with potential implications for fertility and overall health as women age.

Studies reveal Asian and Singaporean women with PCOS may experience longer reproductive lifespans and more favorable reproductive outcomes than peers without PCOS

Researchers found that Asian and Singaporean women with PCOS have better reproductive outcomes, including higher pregnancy rates and oocyte retrieval per cycle, compared to women without PCOS. Women with PCOS tend to maintain a higher ovarian reserve as they age, allowing for more robust responses to fertility treatment.

Embryo arrest in IVF linked to maternal age, not chromosomal abnormalities

A new study found that embryo arrest in IVF is more common with advancing maternal age but not directly related to chromosomal abnormalities. The research suggests two independent factors contribute to the number of euploid embryos available for transfer and overall ART success.

Why does female fertility decline so fast? The key is the ovary

Research reveals that ovarian aging is not just about egg quality, but also the surrounding cells and tissues. The study found that eggs cluster in pockets surrounded by egg-free zones, which decline in density with age, influencing egg lifespan and maturation.

Unusual case of rare ovarian tumor mimicking pregnancy with successful treatment outcome

A 36-year-old woman was diagnosed with non-gestational ovarian choriocarcinoma, a rare and aggressive tumor that shares symptoms with pregnancy. She received chemotherapy and showed complete response to treatment.

Stem cell treatment shows potential for restoring fertility in women with ovarian failure

Researchers evaluated the Stem Cell Regenera treatment in 145 women with ovarian failure, showing nearly 70% oocyte activation and 14% conception through IVF after treatment. The therapy stimulates ovarian activity, increasing conception chances in selected patients.

Moderate caloric restriction may slow ovarian aging in primates

A new study found that moderate caloric restriction can preserve youthful ovarian follicles and reduce age-related tissue stiffness in rhesus macaques. This suggests that lifestyle-based strategies may help delay the decline in reproductive function associated with aging.

Two WCM scientists receive inaugural Pershing Square Foundation Ovarian Cancer Challenge Grant

Weill Cornell Medicine researchers Dr. Juan R. Cubillos-Ruiz and Dr. David Lyden have been awarded a $750,000 grant to study ovarian cancer, with a focus on harnessing immune cells and detecting the disease earlier. Their research aims to develop innovative strategies for eliminating metastatic tumors and preventing recurrence.

Scientists create ‘mini-ovaries’ that may shed light on sex determination and infertility

Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.

Rare combination of ovarian tumors found in one patient

A new case report presents a highly unusual combination of two benign ovarian tumors: serous cystadenofibroma and collision lesions. Accurate preoperative diagnosis is critical for effective treatment planning, and this case emphasizes the need for personalized evaluation of each ovarian mass.

Ovary removal increases heart failure risk

A study found that women who underwent bilateral oophorectomy were more likely to develop heart failure later in life. The researchers suggest that early menopause may be a contributing factor to this increased risk, and recommend closer cardiovascular monitoring for women contemplating the procedure.

Cell atlas of the endometrium in women with PCOS may lead to better treatment

A new study reveals a cell atlas of the endometrium in women with PCOS, showing distinct differences in cellular composition and gene expression. The findings suggest that targeting specific cell types may lead to better treatment options for women with PCOS and related reproductive issues.

Pioneering work generates feline embryonic stem cells in boon for cats

Researchers at Osaka Metropolitan University have successfully generated feline embryonic stem cells, a major breakthrough for veterinary regenerative medicine. The high-quality stem cells can differentiate into various cell types and be transplanted to restore internal damage.

DNA methylation clocks may require tissue-specific adjustments for accurate aging estimates

A study found that DNA methylation clocks used in forensic science and epigenetics are less reliable when applied to non-blood tissues, such as lungs, colon, and kidneys. The researchers suggest that organ-specific epigenetic clocks may be needed to improve biological age prediction.

Women with ovarian removal have unique risk and resilience factors for Alzheimer disease

Researchers found that women who had both ovaries surgically removed before age 50 are at high risk of late-life Alzheimer's disease, with a fourfold increase in risk linked to the APOE4 allele. Hormone therapy reduces this risk by half in these women.

Clinical trial of device aims to induce ovulation in women with polycystic ovary syndrome

A clinical trial led by University of Oklahoma Health Sciences is investigating a new device designed to restore ovulation in women with polycystic ovary syndrome (PCOS)-related infertility. The REBALANCE trial aims to assess the safety and effectiveness of the device, which uses electrothermal energy to prompt ovulation.

Mayo Clinic researchers recommend alternatives to hysterectomy for uterine fibroids, according to study

Researchers at Mayo Clinic recommend minimally invasive treatment alternatives to hysterectomy for uterine fibroids, which can help women recover faster and reduce long-term risks. Early detection and treatment are key in reducing health disparities among Black women.

A mother’s health problems pose a risk to her children

A recent study found that children born to mothers with polycystic ovary syndrome (PCOS) are at a higher risk of lower birth weight, shorter stature, and smaller head circumference. The researchers believe that the placenta's inability to meet the baby's demands due to PCOS-related hormonal imbalances may be the cause.

Intraovarian PRP improves oocyte quality and embryo development in mouse models

Researchers have found that intraovarian PRP injection can improve the number and quality of blastocysts in POI mouse ovaries damaged by high doses of chemotherapy. The study also characterizes the protein content of PRP, suggesting its potential to enhance reproductive function.

New treatment extends ovarian function in older mice

Researchers discovered a novel treatment that extends ovarian function in older mice by improving maintenance of the ovaries and preventing key age-related changes. The treatment also fixes hormone production and overall health, alleviating symptoms such as bone loss, cardiovascular disease, and cognitive decline.

Fallopian tubes can be safely removed during sterilization

A study by the University of Gothenburg finds that removing Fallopian tubes during laparoscopic sterilization results in marginally more surgical complications than cutting them. The procedure may help protect against future ovarian cancer, a serious disease with limited early symptoms.

Evidence-based information combats misleading and false claims on the internet and social media about the anti-Mullerian hormone test

Researchers found that when given accurate information about the anti-Mullerian hormone test, women had less interest in taking the test compared to those who viewed misleading online claims. The study highlights the importance of providing evidence-based information to women seeking fertility treatment.

Egg cell maintenance: Long-lived proteins may be essential

A team of scientists from Max Planck Institute found that extremely long-lived proteins in the ovary play a crucial role in preserving fertility. These proteins, known as chaperones, help maintain cellular processes and prevent misfolded proteins from aggregating.

Removal of ovaries before menopause associated with reduced white matter integrity in brain

Researchers found that women who had their ovaries removed before menopause experience reduced white matter integrity in multiple brain regions. This reduction may contribute to an increased risk of cognitive decline and dementia later in life.

Redefining "hormonal": The new nonprofit empowering women

Hormonally.org provides free-to-access, evidence-based resources on women's hormonal health, empowering women to seek care, treatment, and support. The nonprofit addresses stigmas and misinformation surrounding women's hormonal issues, fostering a supportive online community for connection and shared decision-making.

Researchers uncover protein interactions controlling fertility in female mice

Researchers at the Francis Crick Institute have made significant discoveries about the proteins controlling fertility in female mice. By identifying a crucial protein called USP7, they found that it plays a vital role in maintaining ovarian function after birth.

Exposure to the sun's UV radiation may have a positive effect on fertility in women aged 30-40

A Tel Aviv University study found that women in this age group experience increased AMH secretion when exposed to UV radiation from the sun. This increase in hormone levels is associated with a positive effect on fertility.

Polycystic ovary syndrome tied to memory, thinking problems

People with polycystic ovary syndrome may experience lower memory and thinking skills, as well as subtle brain changes at midlife. Researchers found an association between the condition and cognitive decline, but additional research is needed to confirm these findings.

Multi-generational toxicant exposures show cumulative, inherited health effects

A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.

Gene expression atlas captures where ovulation can go awry

A gene expression atlas has been developed to map the complex cellular and molecular interactions that drive ovulation in mice. The findings reveal a previously unknown layer of selection that determines which follicles will release eggs, and highlight the importance of early differentiation markers for fertility management.

Systemic changes induced by ASCOT in plasma proteome of women with impaired ovarian reserves

Researchers found that ASCOT reverses some age-related protein expression changes, enriching processes related to the complement cascade and immune system in patients with poor ovarian response. In contrast, patients with premature ovarian insufficiency showed enrichment in responses to oxygen-containing compounds and growth hormones.

Brain cell discovery sparks hope for fertility treatments

Researchers found that kisspeptin neurons with dynorphin receptors are crucial for hormone secretion and ovulation. The study provides new insights into the central mechanism underlying reproduction and may lead to treatment of ovarian disorders.

TTUHSC’s Wilkerson to investigate links between pain and basal sex hormone levels

Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.

Mathematicians “thread the needle” to improve IVF success rates

Researchers redesigned IVF needles to reduce fluid flow damage to eggs, improving oocyte collection and IVF success rates. The study uses computer models and mathematical simulations to optimize the design, which has been successfully tested in cattle, with plans for human trials.

Menstrual cycle disorders may be linked to increased cardiovascular disease risk in women

Two reproductive health conditions, polycystic ovary syndrome and dysmenorrhea, are linked to increased cardiovascular disease risk in women. Studies suggest that girls with polycystic ovary syndrome have a 30% higher risk of high blood pressure, while women with dysmenorrhea are twice as likely to experience ischemic heart disease.

Researchers identify female sex determining gene in mice

A team of researchers has identified a key gene responsible for ovarian development in mice, shedding light on the early stages of sex determination. The -KTS variant of WT1 is essential for female gonad formation, regardless of XX or XY chromosomes, and may hold clues to understanding disorders of sex development.

Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature

Researchers found a total of 4,721 proteins altered with age in the murine ovary, including upregulated ECM proteins associated with fibrosis. Age-dependent changes also affect immune response pathways and unique immune cell populations.

Researchers uncover mechanism that links NAD+ to fertility problems

Scientists at Buck Institute reveal how NAD+ decline affects female reproductive function and longevity. Adding CD38 to the puzzle, they found that this enzyme degrades NAD+, accelerating aging processes. Targeting CD38 may offer new approaches to enhance fertility and overall healthspan.

New study in JAMA: unnecessary ovary removal in girls decreased significantly with use of a risk-stratification algorithm

A new study published in JAMA found that a consensus-based risk-stratification algorithm reduced unnecessary ovary removals in girls with benign masses from 16.1% to 8.4%. The algorithm accurately identified lesions highly likely to be benign, allowing for ovary-sparing surgery.

Four novel receptors may link endometrial cancer to PCOS

Researchers identified four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome, highlighting a major pathway involved in the increased EC risk in PCOS. The PI3K-AKT signaling pathway is consistent with a link between PCOS and EC.

Early ovary removal likely to accelerate aging process and health problems

A new study suggests that premenopausal bilateral oophorectomy may cause more chronic medical conditions, such as asthma and arthritis, and physical function decline late in midlife. Women who underwent the procedure before age 46 had increased risks of these conditions.

The protein protectors of fertility

Researchers from Osaka University have shed light on how certain proteins contribute to the formation of piRNAs, a type of RNA that protects the genome. Tejas plays a key role in recruiting Vas and Spn-E, facilitating nuage formation and piRNA processing.

More IVF babies born after egg collection in summer rather than in autumn

Researchers found a 30% higher likelihood of live births when eggs were collected in summer rather than autumn. They also discovered that bright sunshine on the day of egg collection increased the chances of a successful pregnancy.

Endometriosis linked to reduction in live births before diagnosis of the disease

A new study published in Human Reproduction found that women with endometriosis are more likely to experience a reduction in live births before receiving a definitive diagnosis. The research, which included over 18,000 women with surgically-confirmed endometriosis, showed that the number of first live births among these women was half ...

Fertility may decline early in women treated for Hodgkin lymphoma in childhood, but most who try for babies when they are young are successful

Research found that women treated for childhood Hodgkin lymphoma may experience declining fertility and longer wait times to become pregnant, but overall success rates are high. The majority of women in the study who had tried to become pregnant were successful, with some being able to conceive at a younger age.

Women with polycystic ovary syndrome may face increased risk of death

Research presented at ENDO 2023 found women with PCOS died 47% earlier than those without the condition. They were also at higher risk for deaths due to cardiovascular disease, tumors, diabetes, and lung infections.

How PCOS can affect the health of future generations of men

Sons of women with PCOS are two times more likely to develop obesity and have high levels of male hormones, leading to insulin resistance and type 2 diabetes. A mouse study confirms these findings, showing fat tissue and metabolism problems in the offspring despite a healthy diet.

Mouse study hints at specific brain receptor behind PCOS symptoms

A mouse study suggests that a specific brain receptor, the leptin receptor, may be involved in the development of PCOS symptoms. Researchers found that mice exposed to excess androgens prenatally had improved estrous cycles and regulation of their menstrual cycles, offering potential therapeutic targets for people with PCOS.

Risks of removing ovaries at benign hysterectomy may outweigh the benefits for women at low risk for ovarian cancer

Researchers found that removing ovaries during a benign hysterectomy increases the risk of hospitalization for cardiovascular disease in premenopausal women, but not necessarily for cancer. The study supports current recommendations to conserve ovaries in premenopausal patients at low risk for ovarian cancer.

How an autism gene contributes to infertility

A UC Riverside study identifies how a Fragile X gene mutation contributes to premature ovarian failure, leading to early infertility. Researchers found that the mutation affects neurons regulating reproduction in the brain and ovaries, causing an increase in hormone production and faster secretion rates.

Largest study to date of minipuberty identifies two new patterns of the reproductive hormone, AMH, in infant girls

Researchers have identified four distinct patterns of anti-Müllerian hormone (AMH) concentrations in infant girls, including two previously unknown patterns. These patterns may help researchers understand ovarian function and identify potential reproductive conditions earlier.

Removal of both ovaries in younger women associated with increased risk of Parkinson’s

Researchers at the Mayo Clinic found that surgical removal of both ovaries in women under 43 increases their risk of developing Parkinson's disease and parkinsonism. The study used health record data from the Rochester Epidemiology Project to analyze over 2,750 women who underwent bilateral oophorectomy.

Synchronizing ovulation with mating improves fertilization in “ultrasuperovulated” mice

Researchers from Kumamoto University found that synchronizing ovulation and mating in

Risk of cancer remains high for women over 50 with genetic BRCA1 or BRCA2 mutation

A new study found that women with BRCA1 or BRCA2 mutations have a cumulative risk of 49% developing any type of cancer after age 50. Risk-reducing surgeries like mastectomies and BSOs can lower this risk, but many women opt out despite elevated risk. Genetic testing is crucial for accurate risk assessment and personalized care.

Gameto licenses Wyss Institute tech to grow human ovaries in the lab

Scientists at the Wyss Institute and Gameto develop a living, fully human ovarian organoid that supports egg cell maturation and secretes sex hormones. This technology enables the study of human ovarian biology without tissue from patients and could lead to new treatments for infertility and ovarian cancer.

Study unlocks clues in mystery of naked mole-rats’ exceptional fertility

A new study reveals naked mole-rats produce eggs throughout their lives, contrary to the dogma that female mammals have a finite ovarian reserve. The research found that these rodents have exceptionally large numbers of egg cells and lower cell death rates compared to mice.