Articles tagged with Placenta
Research led by Queen Mary University of London finds air pollution particles, including metals, in placentas of 15 London women, suggesting a link between maternal inhalation and fetal exposure. The study highlights the need for further research to fully understand the effects of air pollution on fetal development.
A new discovery in regenerative medicine may lead to new treatments for placenta complications during pregnancy. Researchers at Monash University and Duke-NUS have developed a method to create induced trophoblast stem cells (iTSCs) that can be used to make placenta cells.
Researchers found that COVID-19 virus invades placenta in cases with and without fetal infection, highlighting its protective role. The study also reveals unique cell surface proteins responsible for viral entry, paving the way for novel prevention and treatment strategies.
Researchers developed a machine learning approach to examine placentas, decreasing healthcare costs and allowing more women to be informed of their health risks. The algorithm can identify diseased blood vessels indicating preeclampsia risk with high accuracy.
A new study has shown that Zika virus can create a robust inflammatory environment in the placenta, leading to pathological changes and impact on fetal development. The findings provide valuable insights into mother-to-baby transmission of Zika virus and may lead to the development of detection methods and treatments.
Researchers found that opioid use during pregnancy can negatively affect the placenta's structure, reducing cells that produce essential by-products for normal brain development. The study also identified specific genetic expression differences between female and male placentas in response to maternal oxycodone exposure.
A DNA twist separates double helix into a single strand, regulating placental growth and development. The sixth base of DNA, N6-methyladenine, stabilizes this structure, controlling cell fate.
Researchers found persistent DNA damage in placentas of mice with cohesin mutations, leading to senescence and pro-inflammatory cytokines affecting embryonic growth. Targeting cytokine signaling may be a way to protect the health of the placenta and promote healthy pregnancies.
Researchers used MRI to investigate blood flow to the placenta in healthy and pre-eclampsia pregnancies, identifying differences in blood flow and a new phenomenon called the 'uteroplacental pump'. This finding could help explain why babies born to mothers with pre-eclampsia are often small and premature.
High-resolution imaging of human placenta reveals uniform oxygenation levels and efficient blood flow, while also discovering rapid draining from veins and utero-placental pump contractions that facilitate better circulation and fetal growth. These findings improve placental models and optimize MRI protocols for better diagnosis.
A recent study presents an automatic method to detect and segment the intrauterine cavity using artificial intelligence and deep learning techniques on MRI data from 71 pregnancies. The proposed method achieves high segmentation performance, highlighting its potential for use in daily clinical practice as a surgical planning method.
A new study found that COVID-19-positive pregnant women's placentas showed signs of injury, including abnormal blood flow between mothers and babies. This could lead to increased monitoring during pregnancy, including non-stress tests and growth ultrasounds.
Brazilian researchers found Zika virus can infect multiple regions of the placenta, highlighting the need to collect and store samples properly. Diagnostic tests must consider these regions to ensure accurate results.
Researchers at USF Health discovered how a large human non-protein coding gene regulates epithelial-to-mesenchymal transition, a process crucial for placental implantation and fetal growth. Activating this microRNA cluster inhibited EMT, while reduced expression led to increased invasion and tumor-like behavior.
Researchers found bisphenol S, a BPA alternative, can negatively affect the placenta and potentially a developing baby's brain. This chemical can lower serotonin production, compromising fetal brain development.
A study found that bisphenol S, a BPA substitute, causes changes in gene expression and neurotransmitter levels in the mouse placenta, similar to BPA. The findings suggest that BPS may be toxic to humans, despite some differences in human and mouse placentas
A research team at INRS has modeled the interaction of commonly used antidepressants with estrogen and aromatase, a key enzyme in fetal development. The study suggests that not all types of antidepressants have the same hormonal affinity, and some may be less harmful to the developing fetus.
A study published in PLOS ONE found that a common cold virus can infect cells from human placentas, suggesting a possible link between maternal infection and fetal lung infections. Researchers suspect RSV could attack lung tissue within the fetus, potentially predisposing offspring to asthma.
A rat study found that older mothers' male offspring are more likely to develop heart problems due to changes in placental development and function. The placenta plays a crucial role in supporting fetal growth, but older mothers' placentas show detrimental effects on male fetuses.
A team of researchers has developed an AI-powered system that can analyze placentas using computerized photographic image analysis, potentially improving health outcomes for mothers and babies. The system uses artificial intelligence to detect features linked to abnormalities and potential health risks.
Researchers developed a new imaging technique to track maternal blood flow to the placenta, identifying women at risk for complications such as preeclampsia and intrauterine growth restriction. The study found that women with reduced placental blood flow later developed one or more complications.
A study in experimental models found that allopregnanolone, a hormone produced by the placenta, is essential for normal fetal brain development. Insufficient production of this hormone can lead to autism-like behaviors and cerebellar abnormalities.
Researchers aim to prevent congenital toxoplasmosis by studying the molecular mechanisms of transmission and placenta development. The team will investigate how Toxoplasma gondii infection affects fetal development and explore potential treatments.
A team of researchers from the University of Vienna has shown that the widespread food estrogen zearalenone migrates through the placenta and is partially converted to other harmful substances. The study found that even small concentrations could have a greater impact on the embryo than previously assumed.
Researchers have discovered that zearalenone, a widespread food estrogen, can pass through the placenta and affect fetal development. The study found that even low concentrations of zearalenone can have a significant impact on the unborn child's hormonal balance.
A recent study found that African-American preterm births are associated with chronic inflammation of the placenta and underdeveloped vessels, leading to poor growth and increased risk of neurodevelopmental impairments. These abnormalities suggest that the fetus was not receiving enough oxygen and nutrients from the placenta.
A recent study found that women with malfunctioning natural killer cells may be at a higher risk of developing placental accreta. If confirmed in humans, this discovery could lead to new preventative measures and reduce the need for fertility-ending surgeries.
A study led by UC Riverside professor David Reznick found that female fish with placentas form new species twice as fast as those without, due to their ability to choose mates. This connection between mothering and evolution suggests a key role for females in shaping the formation of new species.
Research found that interferon production alters placental development, potentially causing serious complications. Interferon-induced transmembrane proteins block syncytin fusion activity, preventing viral entry but also hindering fetal growth.
A team of scientists at Duke University Medical Center has discovered a previously unidentified route for antibodies to be transferred from the mother to the fetus, which could lead to safer and more effective vaccines. This finding provides a potential way to control when and how certain antibodies are shared.
A study of over 600 infant genomes found that variations in the SLIT2 gene may contribute to premature births by activating the mother's immune system. The researchers also discovered a link between the SLIT2-ROBO1 signalling pathway and multiple pregnancy complications, including preeclampsia and ectopic pregnancy.
Researchers found that early alcohol exposure restricted placenta growth and blood vessel formation, leading to reduced nutrient delivery to the embryo. This study has significant implications for understanding pregnancy-associated conditions like fetal growth restriction.
Researchers at Mount Sinai have discovered Cdx2 cells, a type of placental stem cell, that can regenerate healthy heart cells after heart attacks in animal models. These cells have the ability to target injury sites and avoid rejection by the host immune system, making them promising for regenerative therapy.
Research finds that placental hormone allopregnanolone plays a crucial role in fetal brain development, and its disruption can lead to brain injuries associated with ASD. The study suggests that subtle changes in utero may set the stage for neurodevelopmental disorders later in life.
Researchers used 3D modeling to understand nutrient exchange in the human placenta, a process critical for fetal growth. The study found that terminal villi geometry determines solute exchange capacity between mother and fetus.
A major breakthrough in artificial womb technology has demonstrated its ability to support extremely preterm babies equivalent to a human fetus at 24 weeks of gestation. The study published in the American Journal of Obstetrics & Gynecology shows that the technology can maintain stable, growth-normal state for five days.
Researchers developed a microfluidic model of the placenta, allowing for the study of caffeine transport from mother to fetus. The model showed that some caffeine does pass through, raising questions about maternal intake and fetal exposure. Further studies aim to personalize the technology and explore effects on individual cells.
A study published in Environment International found that PFAS substances, commonly used in consumer products, accumulate in fetal tissue throughout pregnancy. The study also revealed higher levels of these chemicals in male fetuses than female, highlighting the need for further research on their effects.
Cambridge researchers have discovered that placentas can adapt to function properly despite poor diets or low oxygen during pregnancy, impacting on pregnancy outcomes and lifelong health. This adaptation helps the placenta transport sufficient oxygen and nutrients to the fetus, mitigating complications such as fetal growth restriction.
A new study has found that Rift Valley fever virus can cause high rates of stillbirth in pregnant rats and human tissue, with the virus evading the mother-child barrier more efficiently than other vertically transmitted viruses. The research aims to develop vaccines to prevent the virus from causing miscarriage and birth defects.
Researchers have developed 'mini-placentas', cellular models of the early stages of placenta formation, to study early pregnancy and reproductive disorders. These miniature functional models closely resemble normal first-trimester placentas and may provide insights into pre-eclampsia, miscarriage, and chromosomal abnormalities.
Researchers created a detailed atlas of fetal and maternal cells in the first trimester, revealing 20 distinct cell types and gene expression profiles. The findings could inform further research into pregnancy complications like preeclampsia and pre-term birth.
Research suggests Zika virus may use the same immune transfer route as dengue to infect Hofbauer cells in the placenta, leading to increased viral binding and entry. This finding has implications for understanding Zika's ability to cross the placental barrier.
Researchers mapped over 70,000 single cells at the uterus-placenta junction to understand maternal immune system modifications. This study provides a reference map for healthy pregnancy development, shedding light on disorders such as miscarriages and pre-eclampsia.
A study by ISGlobal and partners found that prenatal exposure to malaria significantly alters a newborn's innate immune response, particularly if the placenta is infected. This type of exposure may affect a baby's risk of developing malaria during their first year of life.
Research reveals a single missing gene in mothers leads to miscarriages due to placenta problems, including fewer blood vessels and altered shape. The study provides new insights into recurrent miscarriage in humans and lays the foundation for further research on placenta development.
Scientists successfully inserted human DNA into transgenic laboratory mice, allowing them to study the biology of preterm birth. They discovered a stress hormone called corticotrophin-releasing hormone (CRH) and its interaction with a transcription factor called DLX3 in the placenta.
New research finds tiny particles of carbon in placentas, suggesting air pollution can affect foetal development. The study reveals that sooty particles from the mother's lungs can reach the placenta via the bloodstream.
Scientists at TU Wien have successfully created an artificial placenta model that closely resembles the natural organ, providing new insights into the exchange of important substances between mother and child. The research uses a high-resolution 3D printing process to produce customized hydrogel membranes populated with placenta cells.
Scientists created a placenta-on-a-chip to study how bacterial infections trigger preterm birth. The device mimics the placental barrier's response to infection, potentially leading to new treatments for this condition.
Researchers found that genes associated with schizophrenia alter early brain development indirectly by influencing placenta health, leading to a fivefold increased risk of developing the disorder. The study also discovered a sex bias in schizophrenia incidence, with males more likely to be affected due to the placenta's role.
A study published in Applied and Environmental Microbiology found a surplus of pathogenic bacteria in placentas from premature births, supporting the hypothesis that maternal infection may cause preterm birth. The research also discovered evidence of placental bacteria in healthy pregnancies, challenging conventional wisdom.
Research finds that placental ALLO levels increase during pregnancy, especially in preterm births, which may affect fetal brain development. Higher ALLO levels have been linked to improved neurological outcomes in some cases.
A novel marmoset model of human Zika virus infection offers new opportunities for understanding the virus's impact on congenital disease in humans. The researchers found that infection of marmoset dams recapitulates the human infection more faithfully than other animal models.
A large study found no increased risk of serious health problems in babies born to mothers who consumed their placentas. The research also identified some motivations behind the practice, including a desire to prevent postpartum depression.
Scientists have discovered higher levels of humanin in placentas of women who gave birth to underweight infants. This protein may play a role in protecting the fetus during placental failure. The study highlights the importance of understanding the causes of low birthweight and its potential impact on adult health.
A new study reveals that 68% of genetic mutations causing fetal death affect the placenta, highlighting its critical role in development. Placental defects often occur alongside brain, heart, and circulation issues.
Researchers at the University of Pennsylvania have demonstrated the feasibility of their organ-on-a-chip platform in studying drug transport across the human placental barrier. The study found that the placenta-on-a-chip successfully emulated the protective mechanism against toxic drugs, paving the way for its use as a screening platform.
Research suggests that C-sections are associated with a decreased risk of urinary incontinence and pelvic prolapse, but an increased risk of asthma, obesity, and pregnancy complications. The study analyzed data from over 29 million participants and found mixed results on the long-term effects of C-sections.
Exposure to a widely used flame retardant chemical mixture can disrupt placental function, leading to altered production of the neurotransmitter serotonin. This study found evidence of endocrine, inflammatory and neurotransmitter signaling pathway disruption in placentas.