Articles tagged with Placenta
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Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
A Texas A&M study found that prenatal exposure to alcohol in males can lead to increased frequency of fetal development issues, including placental inefficiency and growth restriction. The research suggests that male behavior and environmental factors play a role in shaping fetal development beyond just genetics.
Researchers have detected the Delta variant of SARS-CoV-2 in the blood and placentas of women who experienced stillbirths and serious pregnancy complications. The study found that the virus was widely disseminated, causing severe inflammation of the placenta and leading to stillbirths.
The COVID-19 pandemic poses significant risks to pregnant women and their newborns, particularly due to viral-induced inflammation in the placenta. Studies have linked SARS-CoV-2 infection to adverse pregnancy outcomes, including stillbirth and severe neonatal illness, which may vary with specific circulating variants.
Scientists at the University of Missouri discovered that bisphenol A (BPA) exposure during pregnancy can negatively impact fetal brain development. MicroRNAs in the placenta play a key role in regulating cellular functions, including neural development. Researchers believe that microRNA packages could reach the brain through the placen...
A Rutgers study found that phthalates, commonly found in consumer products, can alter the production of essential placental hormones during pregnancy. Higher levels of phthalates have been linked to increased risk of preterm birth, gestational diabetes, and high blood pressure.
Researchers have developed a technique that analyzes cell-free RNA in a mother's blood to predict healthy pregnancy outcomes and detect potential complications like preeclampsia. The approach showed promise in identifying patterns of gene expression associated with a healthy pregnancy and predicting preeclampsia risk with high accuracy.
Researchers found that the fetus uses a signal called IGF2 to control nutrient supply from the placenta. The team discovered that only the paternal copy of the IGF2 gene is active, while the maternal copy inactivates it.
A study published in BMC Medicine found that maternal hypertension genes influence infant birth weight through effects on the placenta. The researchers analyzed fetal growth data and found a significant association between maternal genetic risk score and placental weight.
A new study suggests that unborn babies could contract Covid-19 if their gut is exposed to the SARS-CoV-2 virus. However, researchers say that this risk is extremely limited due to the placenta's protective shield. Vaccination against Covid-19 during pregnancy is still recommended as a way to protect the unborn baby.
A Québec research team studied the expression of three families of genes in the placenta and found associations with febrile seizure characteristics. The study, led by Professor Sarah Lippé, may help understand the underlying mechanisms of febrile seizures and their impact on children's cognitive development.
Research conducted by Mount Sinai Hospital reveals that cannabis exposure in utero can lead to higher levels of anxiety, aggression, and hyperactivity in children. Placental gene expression also shows lower immune-activating genes, predicting these outcomes.
Researchers at CNIC have identified the essential role of GPR126 in placental development, revealing its critical function in fetal growth and viability. The study also highlights a possible link between GPR126 dysfunction and pregnancy complications such as preeclampsia.
A new study published in Science Translational Medicine found that male placentas have increased immune activation and receive fewer anti-COVID antibodies from their mothers. This may help protect male fetuses but pose risks to the fetus and child.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
A new study found that maternal smoking during pregnancy is associated with changes in placental DNA methylation and poor birth outcomes. The research suggests that these epigenetic changes may affect fetal growth by altering the expression of genes involved in environmental responses, growth, and inflammation.
A review of scientific literature found pregnant women infected by SARS-CoV-2 have a higher risk of developing pre-eclampsia due to reduced ACE2 availability. ACE2 plays a crucial role in placental development, blood pressure control, and fetal development, making its impairment more susceptible to serious complications.
Researchers developed a prototype device that measures placental oxygen levels using near-infrared light, potentially diagnosing common pregnancy complications. The study found that women with anterior placenta and complications had lower placental oxygen levels compared to healthy pregnancies.
Researchers at Karolinska Institutet discovered industrial chemicals in the organs of fetuses conceived decades after many countries banned the substances. The study found that 15 out of 22 persistent organic pollutants were present in every organ, with four chemicals detected in all tissues in all fetuses.
Researchers found a direct link between placental mTOR and an infant's birthweight, with implications for obesity and Type 2 diabetes in adulthood. The study suggests that manipulating mTOR in the placenta can cause permanent impact on offspring health.
Researchers discovered that hormone biomarkers from the placenta can identify women at risk for pregnancy complications, which affect around one in ten pregnant women. The study found that these biomarkers are present from the first trimester and can lead to earlier diagnosis and treatment.
A new Northwestern Medicine study of placentas from vaccinated patients found no evidence of injury, supporting the safety of COVID-19 vaccines in pregnancy. The study adds to growing evidence that vaccination can protect fetuses without increasing harm.
A new ultrasound technique has been developed to detect fetal circulation problems in the placenta, allowing for earlier diagnosis and potential prevention of harm to the fetus. The study found that 16 women out of 40 tested had placentas with fetal circulation problems.
A Yale University study found that genetic factors control developmental abnormalities, including pregnancy loss and autism. Researchers examined placental data from nearly 50 sets of twins and discovered similar frequencies of abnormal cell growths in identical twins, suggesting genetics play a key role.
A study reveals that the mouse placenta's circadian clock regulates the expression and activity of ABCB1, a drug efflux transporter, in a 24h rhythm. This finding suggests that the timing of maternal treatment could be crucial to avoid non-desirable effects on foetal development during pregnancy.
A Yale University study found that pregnant women infected with COVID-19 are more likely to experience preterm births and neonatal problems due to a robust immune response in the placenta. The researchers also discovered that the virus's ACE2 receptors are present in most placentas during the first trimester, but disappear later.
Researchers successfully generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. The study provides strong evidence that the system is a good model for studying early embryo development, shedding light on the mechanisms of totipotency and the causes of early pregnancy loss.
A study in rats found that low womb oxygen can impair adult brain function and memory. Vitamin C supplements during pregnancy protected the offspring's brain health. The results suggest a potential preventative medicine approach for long-term brain health.
Biologists have discovered a new type of placental structure in animals, specifically in the group Cyclostomata from the phylum Bryozoa. This unique structure, called coenocytes, is formed through nuclear multiplication and cytoplasmic growth, unlike traditional cell fusion in animals.
A study published in Nature Genetics found that a specific histone modification, H2AK119ub1, acts as a marker for inherited DNA functional modifications from the mother. The researchers discovered that without this modification, fertilized embryos can experience miscarriages and enlarged placentas.
A recent study published in Biology of Sex Differences suggests that DHA supplementation during periods of high stress may reverse the negative impact of maternal stress on unborn males. Researchers found that exposure to prenatal distress decreased placenta and embryo weight in males but not females, while DHA groups showed a reversal...
The study confirms that the placenta is a 'dumping ground' for genetic defects, harboring mutations similar to childhood cancers. It tolerates major genetic flaws, unlike other human organs.
A genetic scoring study published in PNAS found that specific genes in the placenta can predict a baby's brain size at birth and its rate of cognitive development, which may lead to schizophrenia later in life. The study suggests that targeting placental health may reduce schizophrenia risk, particularly in males.
A new study by USF Health researchers has discovered that maternal decidual cells act as reservoirs for Zika virus transmission through the placenta. The study also found that tizoxanide can effectively inhibit Zika virus in these cells, offering promise for preventing perinatal transmission and its associated health problems.
A CU Anschutz study reveals associations between placental signaling and metabolic disease in children and adults, offering potential early intervention and diagnosis of conditions like diabetes and cardiovascular disease. Placenta function can illuminate future disease in adults and children.
A study found that a cell-surface estrogen receptor called GPER1 plays a critical role in protecting the fetus from maternal inflammation caused by viral infections. The researchers discovered that GPER1 helps to suppress type I interferon signaling, which can lead to serious developmental abnormalities and fetal death.
Researchers identified genes associated with decreased placental invasion and increased chemokine production in babies born with microcephaly. This finding provides insight into why only some babies exposed to Zika virus during pregnancy develop anomalies.
A portable device has been created to mimic the placenta's oxygenation role for pre-term newborns in respiratory distress. The artificial lung uses a fine membrane to release carbon dioxide and uptake oxygen while protecting blood from infection, improving survival rates and reducing brain damage.
Research led by Queen Mary University of London finds air pollution particles, including metals, in placentas of 15 London women, suggesting a link between maternal inhalation and fetal exposure. The study highlights the need for further research to fully understand the effects of air pollution on fetal development.
A new discovery in regenerative medicine may lead to new treatments for placenta complications during pregnancy. Researchers at Monash University and Duke-NUS have developed a method to create induced trophoblast stem cells (iTSCs) that can be used to make placenta cells.
Researchers found that COVID-19 virus invades placenta in cases with and without fetal infection, highlighting its protective role. The study also reveals unique cell surface proteins responsible for viral entry, paving the way for novel prevention and treatment strategies.
Researchers developed a machine learning approach to examine placentas, decreasing healthcare costs and allowing more women to be informed of their health risks. The algorithm can identify diseased blood vessels indicating preeclampsia risk with high accuracy.
A new study has shown that Zika virus can create a robust inflammatory environment in the placenta, leading to pathological changes and impact on fetal development. The findings provide valuable insights into mother-to-baby transmission of Zika virus and may lead to the development of detection methods and treatments.
Researchers found that opioid use during pregnancy can negatively affect the placenta's structure, reducing cells that produce essential by-products for normal brain development. The study also identified specific genetic expression differences between female and male placentas in response to maternal oxycodone exposure.
A DNA twist separates double helix into a single strand, regulating placental growth and development. The sixth base of DNA, N6-methyladenine, stabilizes this structure, controlling cell fate.
Researchers found persistent DNA damage in placentas of mice with cohesin mutations, leading to senescence and pro-inflammatory cytokines affecting embryonic growth. Targeting cytokine signaling may be a way to protect the health of the placenta and promote healthy pregnancies.
Researchers used MRI to investigate blood flow to the placenta in healthy and pre-eclampsia pregnancies, identifying differences in blood flow and a new phenomenon called the 'uteroplacental pump'. This finding could help explain why babies born to mothers with pre-eclampsia are often small and premature.
High-resolution imaging of human placenta reveals uniform oxygenation levels and efficient blood flow, while also discovering rapid draining from veins and utero-placental pump contractions that facilitate better circulation and fetal growth. These findings improve placental models and optimize MRI protocols for better diagnosis.
A new study found that COVID-19-positive pregnant women's placentas showed signs of injury, including abnormal blood flow between mothers and babies. This could lead to increased monitoring during pregnancy, including non-stress tests and growth ultrasounds.
A recent study presents an automatic method to detect and segment the intrauterine cavity using artificial intelligence and deep learning techniques on MRI data from 71 pregnancies. The proposed method achieves high segmentation performance, highlighting its potential for use in daily clinical practice as a surgical planning method.
Brazilian researchers found Zika virus can infect multiple regions of the placenta, highlighting the need to collect and store samples properly. Diagnostic tests must consider these regions to ensure accurate results.
Researchers at USF Health discovered how a large human non-protein coding gene regulates epithelial-to-mesenchymal transition, a process crucial for placental implantation and fetal growth. Activating this microRNA cluster inhibited EMT, while reduced expression led to increased invasion and tumor-like behavior.
Researchers found bisphenol S, a BPA alternative, can negatively affect the placenta and potentially a developing baby's brain. This chemical can lower serotonin production, compromising fetal brain development.
A study found that bisphenol S, a BPA substitute, causes changes in gene expression and neurotransmitter levels in the mouse placenta, similar to BPA. The findings suggest that BPS may be toxic to humans, despite some differences in human and mouse placentas
A research team at INRS has modeled the interaction of commonly used antidepressants with estrogen and aromatase, a key enzyme in fetal development. The study suggests that not all types of antidepressants have the same hormonal affinity, and some may be less harmful to the developing fetus.
A study published in PLOS ONE found that a common cold virus can infect cells from human placentas, suggesting a possible link between maternal infection and fetal lung infections. Researchers suspect RSV could attack lung tissue within the fetus, potentially predisposing offspring to asthma.
A rat study found that older mothers' male offspring are more likely to develop heart problems due to changes in placental development and function. The placenta plays a crucial role in supporting fetal growth, but older mothers' placentas show detrimental effects on male fetuses.
A team of researchers has developed an AI-powered system that can analyze placentas using computerized photographic image analysis, potentially improving health outcomes for mothers and babies. The system uses artificial intelligence to detect features linked to abnormalities and potential health risks.
Researchers developed a new imaging technique to track maternal blood flow to the placenta, identifying women at risk for complications such as preeclampsia and intrauterine growth restriction. The study found that women with reduced placental blood flow later developed one or more complications.
A study in experimental models found that allopregnanolone, a hormone produced by the placenta, is essential for normal fetal brain development. Insufficient production of this hormone can lead to autism-like behaviors and cerebellar abnormalities.