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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

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Time-keeping brain neurons discovered

Researchers have identified groups of neurons that precisely keep time in the primate brain, allowing for fine-scale control over actions. The discovery opens doors to investigations into how the brain produces and uses its natural time code.

MIT neuroscientists find neural stopwatch in the brain

Researchers identified populations of neurons coding time with extreme precision in the primate brain's prefrontal cortex and striatum. This fine-scale coverage enables precise timing of actions, such as speaking or driving a car.

Young adults may outgrow bipolar disorder

Researchers at the University of Missouri-Columbia found that nearly half of young adults diagnosed with bipolar disorder between ages 18-25 may recover by age 30. The study suggests a possible link to brain development and social changes during emerging adulthood.

Multitasking ability can be improved through training

New research from Vanderbilt University found that training increases brain processing speed and enhances multitasking efficiency. Through daily practice, individuals showed improved performance on simple tasks when completed separately or together.

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MIT: Long-distance brain waves focus attention

Researchers at MIT found that neurons in the prefrontal cortex fire in unison and send signals to the visual cortex to generate high-frequency waves associated with attention, learning, and consciousness. This neural synchrony enables communication between distant brain regions.

Activation of the prefrontal cortex improves working memory

A study by IDIBAPS reveals that prefrontal cortex activation improves working memory by reinforcing parietal cortex activity, enhancing short-term visual information retention. This innovative view opens up new research avenues, particularly for understanding and treating diseases affecting working memory.

Researchers capture wave of brain activity linked to anticipation

Scientists at Georgetown University Medical Center have documented brain activity in anticipation of music sequences, revealing a neural process that prepares the body to act. This finding sheds light on how humans predict motor activities and provides insight into cued associative learning.

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Stress-related disorders affect brain's processing of memory

Researchers used fMRI to find that patients with stress-related psychiatric disorders have abnormal brain activation in the prefrontal cortex and hippocampus, affecting memory suppression. This can lead to poor memory and increased anxiety due to lingering traumatic memories.

EEGs show brain differences between poor and rich kids

Researchers found that low-income children's brains function differently from those of high-income peers, with detectable differences in prefrontal cortex response to visual stimuli. This study provides a direct measure of brain activity and sheds light on the impact of socioeconomic status on brain development.

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Risk and reward compete in brain

A new imaging study reveals two distinct brain regions competing for control: one associated with risk aversion, the other with a desire for risk-taking. The prefrontal cortex plays a critical role in risk assessment.

Why delaying gratification is smart

A study found that participants with greater activation in the anterior prefrontal cortex, a key brain structure for short-term memory, scored higher on intelligence tests and exhibited better self-control. This neural link suggests that improving brain function in this area may lead to increased self-control.

Switching it up: How memory deals with a change in plans

Scientists at Johns Hopkins University found that two brain areas handle complex rules: the prefrontal cortex controls rule changes and parietal cortex controls number switches. This discovery may lead to enhanced understanding of mental illnesses with impaired rule-changing abilities.

When your memories can no longer be trusted

A new study by Dr. Martha Turner and colleagues found that patients with confabulation, a condition where memories are distorted after brain damage, all shared damage to the inferior medial prefrontal cortex. This discovery sheds light on how the human brain controls memory and distinguishes true from false recollections.

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Research suggests why scratching is so relieving

A study using functional MRI technology reveals that areas of the brain associated with unpleasant emotions and memories become less active during scratching, suggesting a possible explanation for its relieving effect. The findings may lead to new treatments for chronic itch, which affects over 30 million Americans.

Brain imaging and genetic studies link thinking patterns to addiction

Researchers identified brain regions that fire up more when people make impulsive decisions, a key finding linking thinking patterns to addiction. The study suggests raising dopamine levels may be an effective treatment for addiction, offering new approach to therapy and potential subtypes of alcoholics.

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Brain matures a few years late in ADHD, but follows normal pattern

Youth with ADHD exhibit delayed brain maturation in frontal cortex areas, which can affect higher-order executive control functions. However, the delay is most pronounced in regions at the front of the brain's outer mantle, supporting ability to control thinking, attention, and planning.

Forming social memories

Researchers have identified a specific region in the frontal cortex as key to recording and learning social information. This discovery may improve understanding of mechanisms behind mental disorders affecting social skills, such as schizophrenia and autism.

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The formation of social memories

Researchers have identified the medial prefrontal cortex as a crucial region in storing and recalling social memories. This finding opens new perspectives on understanding human recollections and mental disorders affecting social skills.

Prefrontal cortex loses neurons during adolescence

Researchers found that adolescence leads to a significant loss of neurons in the ventral prefrontal cortex, particularly in females, which challenges current models of brain development. This finding has implications for understanding human psychopathologies like schizophrenia and depression that often arise during late adolescence.

For easy tasks, brain preps and decides together

Researchers discovered that brain regions involved in spatial attention, planning movements, and decision-making activate simultaneously when preparing for a task. This preparation enables the brain to get a 'running start', leading to quicker responses. The study's findings have implications for understanding real-world tasks like dri...

Reading hidden intentions in the human brain

Scientists have successfully decoded brain patterns to determine an individual's chosen plan of action before execution, revealing a key role for the medial prefrontal cortex in reflecting mental states. This breakthrough uses functional magnetic resonance imaging (fMRI) to decode intentions from neural activity patterns.

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Experience sculpts brain circuitry to build resiliency to stress

Researchers found that experiencing control over a stressor immunizes a rat from developing depression-like syndrome when it later encounters uncontrollable stressors. The prefrontal cortex plays a crucial role in processing information about controllability and regulating responses to subsequent stressors.

Trying to control pain can be a double-edged sword, say scientists

Research shows that people who feel in control of their lives are less effective at coping with pain when it's beyond their control. Teaching psychological coping strategies helps reduce pain effects. The study suggests acceptance-based therapy may be a more effective approach to managing persistent pain.

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Human brain region functions like digital computer, says CU-Boulder professor

A region of the human brain believed to be critical to intellectual abilities functions much like a digital computer, according to CU-Boulder Professor Randall O'Reilly. The prefrontal cortex and basal ganglia operate by turning electrical signals into binary states and flexibly manipulating them, similar to digital computers.

Snap judgments decide a face's character, psychologist finds

Researchers conducted experiments on 200 people, finding that snap judgments about faces are formed rapidly, often before rational thought can influence the reaction. The study suggests that our intuitions about attraction and trust are among the fastest and most intuitive judgments we make.

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Where we change our mind

Researchers Wako Yoshida and Shin Ishii explored how different cortical regions function in solving partially observable decision-making problems. They found that the anterior prefrontal cortex is involved in belief maintenance, while the medial prefrontal cortex is involved in belief back-track processes.

The brain's executive is an 'event planner'

Researchers discovered that neurons in the lateral prefrontal cortex process information for future events to generate action plans, enabling monkeys to plan complex behaviors. The study provides new insights into the central function of behavioral planning in this higher brain region.

Lost in thought: Brain research

A recent study published in Neuron found that brain areas related to self-awareness are inactive when individuals focus on external tasks, and only active when both sensory experience and self-awareness are present. This suggests a new perspective on the role of self-awareness in perception.

Watching the brain switch off 'self'

Researchers used functional magnetic resonance imaging to study brain activity during sensory processing and introspection. They found that sensory processing activated the sensory cortex, while introspection activated the prefrontal cortex, which was silenced during intense sensory engagement.

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Cortex matures faster in youth with highest IQ

The study found that children with superior IQs have a cortex that thickens rapidly and peaks earlier than those with average or high IQs. The researchers suggest that this may be due to an extended critical period for development of high-level cognitive circuits.

People use separate brain mechanisms to make ambiguous and risky choices

Research finds activation of specific brain regions depends on participants' preferences for risk or ambiguity, shedding light on why people make risky choices. The study's results contribute to the emerging field of neuroeconomics, a new area of research that combines neuroscience and economics.

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Deep thoughts of a birdbrain

A new study reveals that neurons in a bird's brain region, analogous to the mammalian prefrontal cortex, selectively fire when birds are told to remember and stop firing when they are told to forget. This suggests that the avian brain may be capable of executive control, similar to humans.

Pitt Professor awarded competitive Sloan Research Fellowship

A Pitt professor has been awarded a prestigious Sloan Research Fellowship to study brain communication and its impact on mental disorders like schizophrenia. The two-year, $45,000 fellowship will fund his research into how brain areas interact during normal behaviors and how this interaction breaks down in schizophrenia.

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Brain scans reveal how gene may boost schizophrenia risk

A study found that increased activity in the prefrontal cortex predicts higher dopamine levels in the midbrain in individuals with the val COMT gene type, while decreased activity is seen in those with the met type. This suggests a 'tuning' model where dopamine regulates signal-to-noise ratios in brain cells.

Pathological gambling associated with brain impairments

Research suggests pathological gamblers exhibit altered decision-making functions and executive control, leading to long-term negative consequences. The study sheds light on the role of the prefrontal cortex in this neuropsychiatric disorder.

Study: Two brain systems regulate how we call for help

Research reveals that two brain systems, amygdala and right prefrontal cortex, play a crucial role in determining an individual's behavior and emotional expression when seeking help. The study found that animals with more secure relationships had increased activity in the right prefrontal cortex and decreased amygdala activity, while t...

Rat brain's executive hub quells alarm center if stress is controllable

A study by University of Colorado researchers found that rats with controlled stress exhibit reduced brainstem activation and behaviors similar to depression and anxiety. The prefrontal cortex sends inhibitory signals to the brainstem when stress is controllable, quelling alarm center activity.

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How the brain creates false memories

Researchers found that brain activity in the hippocampus and perirhinal cortex predicts accurate or false memories. Weak prefrontal cortex activity during misinformation phase indicates poorly placed details, creating false memories.

Stress impairs thinking via mania-linked enzyme

A new study reveals that stress activates the mania-linked enzyme PKC, leading to impaired cognitive functions in the prefrontal cortex and reduced memory-related cell firing. Inhibiting PKC may offer a fast-acting treatment for mania, with potential benefits for patients seeking emergency room care.

Perceptual decision-making hub pinpointed in human brain

Researchers at NIMH identified a brain region in the frontal cortex as the site of perceptual decision-making, which weighs competing signals from specialized visual processing areas. The discovery could explain why harder-to-identify images evoke slower responses in this area.

Imaging study shows brain maturing

A decade-long brain development study using MRI scans shows that higher-order brain centers, such as the prefrontal cortex, mature later in life. Gray matter wanes in a back-to-front wave as neural connections are pruned, with areas performing basic functions maturing earlier.

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Unsuspected brain region involved in side effects of diabetes drugs

Researchers discovered that the medial prefrontal cortex is activated during hypoglycemia, indicating a link between cognitive processes and innate physiological responses. This finding provides new understanding of how the brain functions during basic responses like those seen in hypoglycemia.