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Scavenging molecule provides long-term protection against nerve agents in rodents

A new bioscavenger molecule has been developed to protect against toxic nerve agents, providing up to five days of protection and near-total safety against sarin. The therapy represents a major breakthrough in the field and could have translational potential for medical and military applications.

SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Translational Medicine·DateJan 2, 2019

Dim light may make us dumber

Researchers found that dim light exposure led to significant reductions in brain-derived neurotrophic factor and dendritic spines, impairing learning and memory performance. Bright light exposure, on the other hand, showed improvement in spatial task performance, with full recovery after a break.

SourceMichigan State University·JournalHippocampus·DateFeb 5, 2018

Are amoebae safe harbors for plague?

Plague bacteria survive and replicate for up to 48 hours inside an amoeba, replicating and thriving in a way most bacteria do not. The discovery sheds new light on the persistence of plague outbreaks, which can smolder for years before re-emerging with a vengeance.

SourceColorado State University·JournalEmerging Infectious Diseases·DateJan 16, 2018

For rodents, seeing is believing

Researchers found that rats use local visual cues more than idiothetic cues when navigating through identical environments in darkness. Place cell activity indicated that animals were unaware of separate environments, suggesting reliance on visual cues over directional sense.

SourceRuhr-University Bochum·JournalFrontiers in Behavioral Neuroscience·DateJul 6, 2017

Woodrats can't stomach favorite foods at high temps

A study by University of Utah researchers found that woodrats' livers are less efficient at breaking down toxins at higher temperatures, potentially affecting their diet and ecosystem. The reduction in liver function may be due to a tradeoff between thermoregulation and detoxification, leading to changes in gene expression and metabolism.

SourceUniversity of Utah·JournalMolecular Ecology·DateJun 27, 2017

Rare fossil discovery raises questions

Researchers have uncovered adult and juvenile remains of a giant rodent species (Isostylomys laurdillardi) in Uruguay, raising questions about its classification. The study suggests that previously found fossils were from the same species as the newly discovered adults.

SourceTaylor & Francis Group·JournalJournal of Systematic Palaeontology·DateFeb 22, 2017

Poison warmed over

Researchers found that warmer temperatures reduce desert woodrats' ability to eat their normal diet of toxic creosote bushes. This could lead to animals changing their diets, relocating to cooler habitats or going extinct in local areas.

New species discovered: Hog-nose rat

Scientists have discovered a new genus and species of shrew rat on Sulawesi Island in Indonesia, featuring an extremely large nose, long hind legs, and unusual dental characteristics. The Hog-nosed rat is genetically distinct from other rodents and has a weak jaw musculature, indicating a diet that does not require vigorous chewing.

SourceLouisiana State University·JournalJournal of Mammalogy·DateOct 6, 2015

Island rodents take on nightmarish proportions

Researchers analyzed size data for over 1,000 rodent populations to identify those that evolved into unusually large or small sizes. The study found that islands are home to more extreme cases of size variation, with rodents on islands weighing among the top or bottom 2.5 percent for their species.

Interdependence explained

A UCSB ecologist examines how human disturbance affects landscape and wildlife, revealing links between conservation and human health. She finds that land-use change increases plague transmission by moving rodents closer to human habitats, while environmental conditions affect flea infestations.

SourceUniversity of California - Santa Barbara·JournalAmerican Journal of Tropical Medicine and Hygiene·DateMar 9, 2015

Giant rodent used incisors like tusks

A new study led by scientists at the University of York found that the largest fossil rodent, Josephoartigasia monesi, used its incisors for activities other than biting, such as digging and defense. The rodent's powerful bite was estimated to be around 1400 N, but its incisors could withstand almost three times that force.

SourceUniversity of York·JournalJournal of Anatomy·DateFeb 3, 2015

Fecal transplants let packrats eat poison

Researchers found that bacteria in the gut, rather than liver enzymes, are crucial for allowing herbivores to feed on toxic plants. Fecal transplants with microbes from creosote-eaters enabled woodrats to eat toxic creosote bushes, confirming their importance in adapting to new diets.

SourceUniversity of Utah·JournalEcology Letters·DateJul 20, 2014

A tale of 2 species

Researchers investigate why only 14 percent of woodrat hybrids have genetic signatures from both desert and Bryant's woodrats. Habitat differences and mating conflicts are found to be key factors limiting hybridization in closely-related species.

SourceWildlife Conservation Society·JournalEvolution·DateMar 27, 2014

Rats control appetite for poison

A new University of Utah study reveals that woodrats that eat a variety of toxic plants can limit their toxin intake more effectively than those that specialize in one plant. By increasing time between meals, reducing meal size, and drinking more water, generalist woodrats regulate their toxin exposure.

SourceUniversity of Utah·JournalFunctional Ecology·DateAug 8, 2011

Do-it-yourself brain repair following stroke

Perlecan domain V protects nerve cells from death and promotes blood vessel growth after stroke, enhancing brain repair. Elevated levels of perlecan domain V were detected in rodent models of stroke, suggesting it may provide a nontoxic therapy to improve stroke outcomes.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateJul 11, 2011

Now that's what I call a rat

The CSIRO Australia team has found the remains of a massive 6 kg rat, which survived until around 1000-2000 years ago. The discovery highlights the importance of conserving biodiversity among rodents, such as rats, which play key roles in ecosystems.

How mice and humans differ immunologically

Researchers identified TLR9 expression patterns as a key factor in determining molecule toxicity between mice and humans. In mice, other immune cells expressing TLR9 were responsible for TNF-alpha production, leading to severe lung inflammation and toxicity.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 10, 2009

How glucocorticoid drugs protect the heart

Researchers found that glucocorticoids induce production of PGD2, which protects rodent hearts from ischemia/reperfusion injury. Synthetic glucocorticoids may be more beneficial for humans following a heart attack than traditional ones.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateMay 18, 2009