Articles tagged with Soft Tissue
Researchers developed a new mathematical model to understand wound healing, which found that surrounding tissue forces play a crucial role in closing wounds. The model predicts that these forces cause wounds to stretch or squish as they close, aligning with the natural direction of the tissue.
Researchers developed a novel method to precisely measure tissue deformation, providing highly accurate measurements to enhance compression-based apparel. The approach minimizes motion artifacts, offering actionable insights on material properties and garment design.
A new microfluidic chip design enabled precise control over interstitial flow and shear stress distribution, leading to sustained microvascular growth for over 12 days. The study found that rectangle chambers exhibited the highest network density due to uniform low shear stress, mimicking physiological capillary conditions.
Scientists at EPFL create a flexible auditory brainstem implant that closely conforms to the curved surface of the brainstem, enabling better tissue contact and reducing side effects. The device has been successfully demonstrated in macaques, showing promising results for high-resolution prosthetic hearing.
Jiawei Yang creates bioadhesives with two layers, a transparent solid hydrogel layer and a clear liquid adhesive layer, to provide fast, strong, stable, and deep adhesion in the body. The new bioadhesives have potential applications in treating Parkinson's disease, heart failure, and healing damaged cartilage.
MIT engineers have developed a way to grow artificial muscles that twitch and flex in multiple coordinated directions. This breakthrough allows for the creation of soft, wiggly robots with enhanced flexibility and range of motion.
Researchers at the University of Houston have developed a new technology that uses photon counting detectors to capture X-ray images with multiple energy levels simultaneously. This allows for more precise 3D visualization of different tissues and contrast agents, which can improve cancer detection and other medical applications.
Researchers found genetic changes not exclusive to tumours and skin patches, suggesting additional factors are necessary for tumour development. The study identified a pattern of mutations in the NF1 gene that may explain why nervous system tissues are commonly affected.
A study of Viking skulls using CT scans reveals a range of diseases including sinus and ear infections, osteoarthritis, and dental diseases. The results provide greater understanding of the health and wellbeing of the Viking population.
Researchers developed a durable de-icing surface inspired by human skin's layered structure, achieving exceptional performance with low ice adhesion strength. The surface design creates extensive wrinkling at the ice-substrate interface, allowing ice to shed under its own weight without external energy inputs.
Researchers at North Carolina State University found that soft tissue preservation in fossils does not seem to depend on the species, age or burial environment. The team was able to retrieve vessels from six dinosaur specimens, including four Tyrannosaurus rex and one Brachylophosaurus canadensis, using a suite of analytical tools.
A team led by Prof. Woo Young Jang developed a novel fluorescent probe to visualize cancer stem cells in complex samples, offering a new direction for cancer diagnostic imaging. This technology has significant implications for diagnosing and monitoring sarcomas.
Researchers aim to identify key mechanisms and molecular targets to prevent tumor progression in Rhabdomyosarcoma patients. The study focuses on the TAK1 protein, which plays a significant role in regulating cell growth, and its potential inhibition as a therapeutic approach.
Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.
A new research project funded by a $600,000 grant is exploring the mechanics behind episiotomies, with the goal of developing safer and more effective surgical practices. The study uses advanced experimental techniques and computational simulations to understand how incisions spread and potentially lead to tears.
A global team of scientists has made a groundbreaking discovery of a new skeletal tissue called lipocartilage, composed of fat-filled cells that provide super-stable internal support. This unique tissue has immense potential for treating facial defects, birth injuries, and cartilage-related conditions.
Researchers from the Keck School of Medicine of USC found an association between levels of manmade “forever chemicals” in drinking water and certain digestive, endocrine, respiratory, and mouth and throat cancers. The study estimated that PFAS contamination contributes to 6,864 cancer cases per year.
Researchers develop strategies to address mechanical and electrical properties, implantation, and multimodal functionality in hydrogel-based bioelectronics. The team explores conductive polymers, stimuli-responsive hydrogels, and wearable/implantable devices to create seamless human-body interfaces.
Researchers developed an ultra-compact transparent ultrasonic transducer for simultaneous high-resolution ultrasound and photoacoustic imaging. This technology improves diagnostic sensitivity by providing detailed information about tissue vasculature, thereby enhancing early cancer detection.
Researchers found lower incidence rates of soft tissue sarcomas among young U.S. active-duty military servicemen compared to the general population, likely due to better health and early detection within the military health system. In contrast, middle-aged servicemen showed higher rates, possibly due to greater cumulative exposure to t...
Researchers at Harvard University have developed a tissue-anchoring mechanism for medical devices, inspired by the circular hook-like attachment organ found in intestinal tapeworms. The device can be deployed in under 1 millisecond and anchors into soft tissue with minimal damage.
Researchers designed a millimeter-scale mechanism inspired by tapeworms to anchor small medical devices to soft tissues. The device, made of stainless steel and polyimide film, can be used in various medical applications and has potential for affixing sensors to marine organisms.
Researchers studied ovarian cancer cell migration patterns on soft and stiff surfaces, finding that epithelioid cells are more migratory than mesenchymal cells on stiffer matrices. The study used a novel software toolkit to analyze cell behavior over time, revealing a unique 'slip' movement pattern in epithelioid cells.
TU Graz researcher Gerhard A. Holzapfel leads a six-year project to develop AI-based methods for analyzing soft tissue mechanical properties using transcriptomics and microstructure imaging. The team aims to improve disease diagnosis and therapy in clinical practice.
A team of biomedical engineers from the University of Melbourne has developed a groundbreaking 3D printing system that can fabricate complex human tissues in just seconds. This technology significantly improves the potential to predict and develop new pharmaceutical therapies, reducing the need for animal testing.
Collymer is a regenerative collagen polymeric biomaterial designed for various medical applications. It can be engineered into materials with different shapes and properties to address unmet clinical needs in wound care, tissue reconstruction, aesthetics, orthopedics, and therapeutic cell delivery.
GeniPhys secures $500k NSF grant to support regulatory and commercial readiness of Collymer SAS for soft tissue restoration in advanced wound care. The technology promotes regenerative remodeling without inflammatory response, facilitating faster healing and tissue repair.
Researchers at EPFL have developed the e-Flower, a flower-shaped 3D microelectrode array that enables real-time recording of neural activity from 3D neural spheroids. This breakthrough technology allows for more accurate and gentle monitoring of brain cells, paving the way for further research on brain organoids.
Researchers developed a dissolvable microneedle patch to deliver immunomodulatory microparticles containing bifunctional molecules, such as azithromycin, to treat periodontitis. The patch demonstrated therapeutic outcomes by suppressing bacterial growth and modulating immune responses in both in vitro and in vivo studies.
Liheng Cai, a UVA engineering professor, has received a $1.9 million NIH grant to create advanced biomaterials that can be used to repair living tissues and build organ structures. His lab aims to develop polymers that mimic human biology and integrate healthy cells into the human body.
A new study uses nanoscopic 3-D imaging to analyze ancient bone samples, revealing insights into protein and tissue preservation during fossilization. The technique shows that Ice Age bones still retain original collagen protein frameworks, offering a potential proxy for screening specimen suitability for molecular sequencing.
A UVA research team has developed biomaterials with controlled mechanical properties matching those of various human tissues, representing a significant leap in bioprinting technologies. Their unique digital assembly of spherical particles (DASP) technique can deposit particles of biomaterial in a supporting matrix to build 3D structur...
Researchers studied the anatomy of mudskippers to understand their adaptations to life on land. They found that the fish's muscles in the pectoral fins are bigger and that some bone-connecting tendons were replaced by fascia tissue, providing stability and strength for walking.
The team, led by Professor Shoji Takeuchi, created a layer of skin that can bind to complex forms of humanoid robots, granting them increased mobility and self-healing abilities. The research has potential applications in the cosmetics industry, medical research, and robotics.
Researchers created a prototype of 'living bioelectronics', combining bacteria, sensors, and gel to integrate with living tissue. The device reduced inflammation and improved psoriasis-like symptoms in mice, offering potential for treating various skin conditions and injuries.
Researchers have developed a pressure-alternating shoe insole that provides periods of rest to the soft tissues, thereby reducing the risk of diabetic foot ulcers. This innovative technology aims to mitigate the risk of complications from poor circulation and foot sores.
Researchers developed a spring-like device that maximizes muscle contractions to power biohybrid robots. The new flexure design enables predictable and reliable movement, allowing engineers to build muscle-powered robots with increased precision and versatility.
A new study presents a novel surgical technique for treating Moebius syndrome, a rare condition that prevents smiling and affects social engagement. The technique involves utilizing the ipsilateral facial nerve to power gracilis free functional muscle transfer in select patients with residual facial nerve activity.
Researchers used machine learning tools to map distinct cellular configurations in soft tissue sarcomas, identifying correlations between cell types and clinical outcomes. The analysis uncovered three multicellular communities that correlated with patients' prognoses, potentially informing treatment decisions.
A team of UMass Amherst engineers has developed a tissue-like bioelectronic mesh system that can simultaneously measure the electrical signal and physical movement of cells in lab-grown human cardiac tissue. This breakthrough device allows researchers to observe how the heart's mechanical and electrical functions change during developm...
Researchers have discovered a way to stick hard and soft materials together using electricity, forming chemical bonds that can be easily reversed. This electroadhesion effect could enable the creation of biohybrid robots and improve biomedical implants.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
Researchers found that USP1 inhibits cdc42, increases EWS-FLI1 transcriptional output, and simulates Ewing sarcoma growth. A pharmacological inhibitor of USP1 activated cdc42 and inhibited Ewing sarcoma growth.
Researchers in Japan have developed a two-legged biohybrid robot that uses muscle tissues to achieve fine movements and efficiency. The robot can walk, stop, and make precise turning motions, paving the way for future advancements in robotics.
Researchers from MD Anderson Cancer Center reported a case of a patient with an exceptional response to pazopanib treatment for over 5 years. The study shows that pazopanib prevents or delays the progression of additional metastasis in EWSR1-NFATC2 positive sarcomas. Further studies are warranted.
Researchers have identified a 3D fragment of fossilized skin that is at least 21 million years older than previously described skin fossils. The ancient skin shares features with reptiles alive today, highlighting the importance of epidermis for survival in terrestrial environments.
Researchers at ADA Forsyth have discovered the regenerative properties of Resolvins, specifically RvE1, which promotes pulp regeneration and reduces bacterial invasion in dental pulp. The technology has far-reaching potential for regenerative medicine beyond oral health, including growing bones in other parts of the body.
Researchers found a tradeoff between fast growth and heat tolerance in corals, with thermally sensitive algae dominating faster growth but only in cooler water. This study helps predict reef futures and inform conservation strategies, highlighting the complexity of coral growth on a reef.
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
A team of researchers found that fibroblast cells cultured on substrates with varying degrees of stiffness exhibit changes in cell structure, function, and TGF-β activity, which regulates ECM architecture. This study provides insights into how mechanical forces influence wound healing and tissue development.
Postoperative wound infections in the head and neck region are common complications, with risk factors including age, smoking, and comorbidities. Aseptic operating conditions and peri/postoperative antibiotics can help minimize infection rates.
A new method for studying cancer cells' behavior on soft and stiff tissue environments has been developed, revealing crucial survival cues for cell growth. The study challenges the long-held assumption that cells prefer stiffer surfaces, opening up new possibilities for research in cancer biology and tissue engineering.
A team of researchers has developed a new visualization tool combining high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The technique, known as fluorescence lifetime (FLT) imaging, achieved an accuracy of over 97% in distinguishing tumor tissue from healthy tissue.
A University of Virginia team has developed a new analytical tool using hydrogels to cultivate vascular sprouting from mouse lung tissue, providing new insight into idiopathic pulmonary fibrosis. The research aims to understand the biomechanical and biochemical cues to blood vessels in the lungs during disease progression.
Researchers at University of Oxford have developed a miniaturized soft power source that can alter the activity of cultured human nerve cells, paving the way for miniature bio-integrated devices. The device uses internal ion gradients to generate energy, producing a current that persists for over 30 minutes.
Researchers developed tomoelastography, an imaging technique that maps tumor mechanical properties using MRI. Studies found consistent patterns between changes in tumor stiffness and increasing aggressiveness. The technique allows for precise measurement of tumor fluidity, enabling more accurate diagnoses and tailored treatment options.
A new method scans moving horses to produce an enhanced saddle-map, highlighting ideal areas for saddle placement to reduce pain and injury. The research identifies the most mobile areas of a horse's back as the least suitable for distributing pressure.
Researchers at MIT have created a metal-free, Jell-O-like material that can conduct electricity similarly to conventional metals. The material is made into a printable ink, which the researchers patterned into flexible, rubbery electrodes.
A study using digital reconstructions of Australopithecus afarensis muscles suggests that the 3.2 million-year-old 'Lucy' hominin could walk upright as efficiently as modern humans. The research, published in Royal Society Open Science, used open-source data on Lucy's fossil to create a detailed model of her lower body muscle structure.
Researchers detected Plasmodium falciparum, the deadliest form of malaria, in mummified tissues from Medici family members. The parasite was identified through microscopic and molecular analyses, revealing characteristic ring-shaped structures and Maurer's clefts.