Articles tagged with Soft Tissue
A new study found that obstructive sleep apnea causes widespread changes in gene activity in mice, affecting up to 16% of genes, particularly in lung tissue. The findings may lead to diagnostic and therapeutic approaches, including blood tests tracking dysregulated gene products.
A study from the University of Chicago uses machine learning to record intricate tongue movements and neural activity, revealing that brain patterns can accurately predict 3D tongue shape. This breakthrough could lead to brain-computer interface-based prosthetics for restoring lost functions of feeding and speech.
A multicenter study found diabetes to be associated with post-reconstruction limb loss and racial disparities in wound infection rates. The study also revealed that vascular interventions prior to reconstruction correlated with higher complication rates, as did free flap types, which led to longer hospital stays.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
The NRG Oncology combined trial results indicate that pathologic complete response (pCR) is associated with improved survival outcomes for patients with localized soft tissue sarcoma. pCR can be used as a prognostic factor for clinical outcomes in future STS research, with patients achieving higher overall and disease-free survival rates.
Researchers found that increasing melanin levels in human skin reduces Cherenkov emission intensity, while blood concentration affects different color channels. The study suggests using multispectral signatures to correct attenuated signals based on patient's blood volume or skin color.
A Tohoku University study found that soft gingiva is more likely to cause inflammation, hindering the development of collagen fibers. This discovery has implications for the development of advanced biomaterials and microdevices to control local inflammation.
A study found that a commercial water purifier may have caused Mycobacterium abscessus infections in 4 cardiac surgery patients due to chlorine depletion. The hospital's water system was contaminated via municipal water, emphasizing the importance of monitoring and preventing mycobacteria.
A new AR system using HoloLens enables doctors to perform transperineal prostate interventions with high accuracy and flexibility. The system provides a 3D immersive experience, allowing doctors to guide needles to their target with ease.
Researchers at the University of Tokyo found that a specialized wing structure called the propatagium evolved in non-avian dinosaurs, paving the way for modern birds to fly. The discovery, based on statistical analyses of arm joints, helps fill gaps in knowledge about bird flight origins.
Researchers found that strengthening hip abductor muscles can provide effective compensation for weaknesses in knee extensor muscles, leading to improved mobility in people with below-the-knee amputations. The study tested the hypothesis in eight military personnel who had undergone a lower limb amputation and showed promising results.
Researchers at Shenzhen University have developed a compact fiber optical nanomechanical probe (FONP) to measure in vivo biomechanical properties of tissue and even single cells. The high-precision mechanical sensing system enables accurate measurements with spring constants as low as 2.1 nanonewtons.
The University of Oklahoma engineer is developing a novel endoscopic optical imaging technique to provide real-time visualizations for needle-based medical interventions. This technology aims to improve the precision of needle placement, reducing complications and improving treatment efficacy.
A 319-million-year-old fossilized fish has provided the oldest example of a well-preserved vertebrate brain, shedding new light on the neural anatomy and early evolution of ray-finned fishes. The discovery reveals that brain evolution in these animals unfolded more complexly than previously thought.
A new electromagnetic device has established a new standard of precision in mechanobiology research, enabling high-precision measurements of soft biological tissues. The device allows for the mechanical testing of human biopsy samples and has shown enhanced reliability with errors below 15%.
Researchers found that EWS::FLI1 induces Slit2 expression, which activates Robo receptors and enhances Ewing sarcoma growth. Silencing Slit2 strongly inhibited Ewing sarcoma cell growth, providing an opportunity for targeted therapy.
Researchers at Imperial College London have designed a low-cost external fixator for broken bones, made from stainless steel and aluminium, which can be manufactured locally. The device has shown similar stiffness to commercial devices in cadaver leg bones and is being tested in Gaza, Sri Lanka, and Ukraine.
Researchers developed an injectable hydrogel that inhibits common bacteria and promotes tissue regrowth, treating infections around prosthetics. The gel has a porous structure, excellent injectability, and rapid self-healing properties.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
A modelling study published in Scientific Reports found that diplodocid tails were unlikely to create a supersonic boom due to their slow movement speed. The authors simulated tail movements using a model and found that adding hypothetical structures to the end of the tail did not allow it to reach the speed of sound without breaking.
University of Virginia engineers develop a Minecraft-like, voxelated approach to create complicated structures comparable to human tissues and organs. They use droplets as the basic building blocks, assembling them into 3D constructs with precise location, composition, and properties.
Patients with non-metastatic soft tissue sarcoma can safely receive hypofractionated treatment over three weeks instead of five, achieving similar tumor control and no increased risk of wound complications. The study found comparable rates of major wound complications between the two treatment courses.
A study published in BMJ Open found that quad bike injuries among children are significantly more severe and common than car injuries. The research highlights the need for public education campaigns to educate on ATV-related injuries, particularly in young riders.
Researchers discovered that specific tissue chemistry governs the likelihood of organs being preserved in fossils. The study found that a decaying fish's internal organs decompose in a 'soup' together, and their pH levels determine whether they'll be replaced by minerals.
Researchers discover gene AVIL responsible for deadly brain tumor also causes two forms of childhood cancer, rhabdomyosarcoma. Blocking AVIL activity prevents formation of the disease in lab samples and mouse models.
A new study found that coral spawning events at deeper depths occur at lower intensities than those in shallow waters. The researchers suggest that deep reefs may more often rely on shallow-reef corals to survive.
Researchers have developed a new type of prosthetic using microfluidics-enabled soft robotics that promises to greatly reduce skin ulcerations and pain in patients who have had an amputation between the ankle and knee. The prosthesis uses integrated pneumatic actuators to control fit, reducing volume changes and pressure ulcers.
A 58-year-old woman from Armenia suffered from severe finger pain for over 40 years when knitting, which was later revealed to be caused by a rare benign glomus tumor under her fingernail. The tumor was successfully removed in a 30-minute operation, restoring the patient's quality of life and allowing her to return to her hobby.
Adding diffusion-weighted MRI to conventional MRI enhances the differentiation of locally recurrent tumor and post-surgical fibrosis in pancreatic ductal adenocarcinoma resection. The study found higher sensitivity with DWI, facilitating earlier detection of recurrences.
Researchers at Lehigh University developed a new method to accurately gauge healing progress of bone fractures using 3D models. The model identifies the cutoff point between soft tissue and bone, allowing for more precise predictions of bone behavior during the healing process.
Researchers at UMass Amherst developed a new theory that allows for precise prediction of soft material failure. The breakthrough has major implications for polymer engineering and manufacturing, enabling the design of more efficient products.
GeniPhys Inc. has received a two-year, $974,349 Small Business Innovation Research (SBIR) grant from the National Science Foundation to advance the commercialization of its initial product, Collymer Self Assembling Scaffold (Collymer SAS). The grant will be used to scale up manufacturing capabilities and file key regulatory submissions...
The integration of optical sensing into orthopedic surgical devices has the potential to increase accuracy and improve outcomes in musculoskeletal repair. Researchers explore various types of optical sensing, including spectroscopy and imaging, to address unmet clinical needs in orthopedic surgery.
A prospective study found that MRI outperformed conventional tests and FDG PET/CT for various staging endpoints in SCLC. Whole-body MRI and FDG PET/MRI were more accurate than FDG PET/CT for assessing local invasion extent.
Scientists have created a new imaging method that can detect microscopic soft tissue damage in animal spines, which may lead to improved treatments for lower back pain. The technique uses fluorescent molecules to target denatured collagen and produce precise 3D maps of spinal damage.
A LSU Health New Orleans study reports a nearly 70% decrease in morphine milligram equivalent (MME) per discharge opioid prescriptions for patients who underwent common lower extremity surgical procedures. The study also found a significant decline in new opioid prescriptions, from 50% in 2013 to 19.3% in 2018.
Researchers developed a tool to investigate cause of death when skeletonised remains are recovered, providing a breakthrough in forensic lightning pathology. The study identified unique markers of lightning damage deep within the human skeleton, allowing for recognition of lightning strikes even when only dry bone survives.
Leiomyosarcomas are diverse, rare, and aggressive mesenchymal soft tissue sarcomas. Epigenetic profiling identified differential DNA methylation and gene expression patterns associated with subtypes. These findings suggest epigenetic profiles can be used to stratify patients and apply targeted therapies.
Researchers have developed 3D-printed tissue scaffolds that degrade harmlessly while promoting tissue regeneration. The scaffolds showed excellent biocompatibility and the ability to support cell migration, ingrowth of tissues, and revascularisation.
Researchers at Virginia Tech created soft electronics that can sustain damage without losing electrical conductivity. The materials are stretchy, recyclable, and reusable, making them ideal for emerging technologies like wearables and soft robotics.
Researchers have formulated a facial soft tissue thickness dataset for adult chimpanzees, providing a foundation for reconstructing the faces of ancient hominids. The dataset and regression equations will help reduce variability in reconstructions, offering a more accurate representation of our human ancestors.
Researchers evaluate expression of TAZ and YAP, the p53-MDM2 axis, and RABL6A in sarcomas, finding that elevated YAP and TAZ independently predict worse overall and progression-free survival. Network analysis reveals a possible functional relationship between biomarkers.
Using bioprinting, researchers successfully repaired traumatic injuries to the skin and bones of the face and skull in a rat model. The technique involved printing both bone and soft tissue layers, achieving 100% closure of soft tissue in four weeks and 80% closure of bone in six weeks.
Well-preserved fossils from 547 million-year-old remains have enabled researchers to trace the ancestry of some of the world's earliest animals further back than ever before. The study has uncovered a link between Cambrian Explosion animals and one of their early ancestors.
A new genus and species of ichthyosaur, Thalassodraco etchesi, has been discovered in the UK, measuring 2m in length and dating back to the Late Jurassic period. The specimen was found buried head-first in limestone, preserving its soft tissues and providing valuable insights into the biology of these marine reptiles.
A University of Sydney team has developed a plasma technology to attach hydrogels to polymeric materials, allowing for better interaction with surrounding tissue. The technology has shown promising results in tests using biomolecules found in the body.
Researchers have created a technology to print tissues directly in the body, using a specially-formulated bio-ink that can be crosslinked safely using visible light. This breakthrough enables minimally-invasive laparoscopic options for tissue repair and engineering, saving time and cost.
Researchers at UMass Amherst have outlined high-priority goals and opportunities for advancing knowledge on cavitation science, which occurs in soft materials and tissues during traumatic brain injury. The team proposes using cavitation as a unique tool to understand soft tissues and develop new medical devices.
Researchers at ETH Zurich developed a new substance that inhibits the growth of calcium phosphate crystals, preventing vascular calcification. The molecule is structurally related to IP6 and has been shown to be stable and effective in vitro and in disease models.
A study published in British Journal of Clinical Pharmacology found that statin use for as little as 91 days increased the risk of skin and soft tissue infections. Statin use was also associated with a higher risk of developing diabetes, which is a significant risk factor for these infections.
Researchers at Johns Hopkins Medicine have created a synthetic soft tissue substitute that encourages growth of new tissue and blood vessels. The material, well-tolerated and retaining its shape, may lessen the need for implants or grafts in reconstructive surgeries.
Researchers discovered that corals with thicker soft tissues can recover more quickly from bleaching due to the presence of beneficial algae. The stored energy in these tissues helps corals survive until environmental factors improve.
The team developed a transparent, waterproof, and conductive material that can repair itself in both air and water environments. This innovation has the potential to reduce electronic waste by enabling devices to perform self-repair functions.
Researchers studied the digestive tracts of wombats and found that elastic properties of intestinal walls allow for cube formation. Wombats use cube-shaped poop to mark their home ranges and communicate with other wombats.
Researchers at Yale University discovered chemicals that preserve dinosaur soft tissues under specific conditions, such as oxidative environments. These preserved structures are comparable to Advanced Glycoxidation and Lipoxidation end products (AGEs and ALEs), which are resistant to decay and degradation.
A study of nearly 600 women with breast cancer found that autologous fat transfer did not increase rates of cancer relapse after five years. While the study did not show significant differences, it highlights the potential benefits of this technique for correcting deformities after breast cancer surgery.
A Swedish study has successfully imaged the soft tissue of an ancient Egyptian mummy's hand using a novel CT technique called phase-contrast imaging. This technique enhances contrast and allows for detailed analysis of soft tissues, opening up new opportunities for paleopathology research.
This study evaluated perioral soft tissue changes after orthognathic surgery using 3D CT scans. Significant post-operative changes were observed in nasolabial and mentolabial angles, while lip width remained unchanged.
A new imaging technique using bioinspired camera technology will measure changes in the UCL during loading, providing insight into damage accumulation. The technique aims to improve microstructural evaluation of soft tissues and study biological damage in rotator cuff tendons.
PharmaMar will present data on Yondelis and lurbinectedin, showcasing clinical advances in soft tissue sarcoma, breast cancer, and small-cell lung cancer. The company's molecules have demonstrated efficacy and safety in various studies, including a phase III trial for small-cell lung cancer.