Articles tagged with Soft Tissue
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Researchers at the University of Texas at Arlington have developed a highly elastic biodegradable hydrogel for bio-printing of materials that mimic natural human soft tissues. The material can generate multiple types of human soft tissues, including skin, skeletal muscles, blood vessels, and heart muscles.
Researchers have developed high-density stretchable electrode grids for long-term stable neural recording, overcoming challenges in biocompatibility and mechanical properties. The breakthrough enables crucial applications in biomedical engineering, including diagnosing and treating neurological disorders such as epilepsy.
Researchers at Yale University have discovered a mineral signature that enables them to predict the presence of rare, soft-tissue preserving fossils. The study found that rocks rich in berthierine are more likely to contain Burgess Shale-type fossils.
A team of researchers led by Dr. Jonathan Vande Geest at the University of Pittsburgh has received a $673K NIH grant to construct biomimetic, small-diameter vascular grafts that mimic the body's own blood vessels.
Researchers have developed an optical ultrasound needle that provides unprecedented real-time imaging of soft tissues during keyhole procedures, reducing the risk of complications and improving surgical outcomes. The technology uses a miniature optical fibre to deliver light pulses, generating ultrasonic waves for image guidance.
Researchers have retrieved original pigment, beta-keratin and muscle proteins from a 54-million-year-old sea turtle hatchling, providing direct evidence that a pigmentation-based survival trait evolved in ancient sea turtles. The study confirms the preservation of multiple proteins over millions of years.
Researchers have developed a hybrid rigid-soft robotic arm for endoscopes with integrated sensing, flexibility, and multiple degrees of freedom. The device is powered by water and features a suction cup-inspired mechanism to safely interact with tissue.
Researchers developed flexible graphene and gold probes that can detect weak brain signals clearly, improving neural disease treatment and brain-machine interface capabilities. The new probes retain effective surface area despite shrinking size, paving the way for more convenient wireless versions.
A HKU palaeontologist and his team reconstructed the first highly detailed body outline of a feathered dinosaur using high-definition images of its preserved soft tissues. The technique, known as Laser-stimulated fluorescence (LSF), reveals the shape of the dinosaur's wings, legs and foot scales with unprecedented detail.
Professors Ateshian and Myers have made significant contributions to the fields of cartilage mechanics and soft tissue biomechanics. Ateshian's work focuses on developing better modalities for osteoarthritis treatment, while Myers studies the mechanics of the uterus and cervix to prevent premature births.
Researchers developed computer simulations demonstrating how lasers attack bacterial colonies, suggesting benefits for oral debridement and periodontal treatment. The study confirms the effectiveness of 810 nm diode lasers and 1064 nm Nd:YAG lasers in killing bacteria with minimal heating of surrounding tissue.
A multi-center study found significant survival gains in patients with high-risk soft tissue sarcoma of the trunk or extremities treated with neoadjuvant chemotherapy with an anthracycline plus ifosfamide. The regimen showed a 20% improvement in prognosis for these patients compared to those receiving histology-driven regimens.
Researchers at Hokkaido University have developed a new kind of hydrogel that bonds spontaneously and strongly to defected bones. The gel overcomes the problem of bonding with other surfaces by adding hydroxyapatite to its surface.
A new study reveals that biofilm formation is a common feature of group A streptococcus necrotizing soft tissue infections, leading to higher bacterial loads, extensive inflammation, and more severe tissue damage. Biofilm should be considered as a complicating factor of NSTI.
Researchers developed a supervised autonomous robot that excelled in open bowel surgery on pigs, potentially reducing complications and improving surgical outcomes. With further development, autonomous robotic surgery may take human error out of the operating room, benefiting patients undergoing soft tissue surgeries.
A Johns Hopkins University computer scientist has successfully programmed a robot to adjust to the subtle movement of soft tissues during surgery, promising improved safety and efficiency. The robotic system, called STAR, was compared with human surgeons and showed comparable performance in terms of suture spacing and seam leakage.
Research on 14,105 ACL reconstruction cases found that soft tissue allografts processed with high radiation or chemicals increased revision rates by 2-4 times compared to BPTB autografts. The study suggests that surgeons should consider the processing methods of allografts when making surgical decisions.
Researchers successfully reconstructed the internal structure of a compound eye from a predatory crustacean dating back 160 million years. This groundbreaking discovery reveals that soft tissue was preserved and provides new insights into the evolution of visual systems, challenging previous assumptions about fossil preservation.
A well-preserved 48-million-year-old horse-like fetus was discovered near Frankfurt, Germany, revealing significant details about the fossil record of a placental mammal. The study suggests that the reproductive system of early horses may have been highly developed during the Paleocene epoch.
A large prospective post-commercialization study in patients with advanced soft tissue sarcoma (STS) in Europe confirms the long-term anticancer activity of YONDELIS® (trabectedin). The median progression-free survival was 5.5 months, and durable responses were observed in 18 patients still on treatment.
PharmaMar presents new data for YONDELIS (trabectedin) in soft tissue sarcoma and solid tumors, including final overall survival analysis and real-world data from a large prospective phase IV study. Additionally, early clinical studies show synergistic activity for PM1183 in combination with paclitaxel or cisplatin.
Results from the EORTC trial 62072 show pazopanib improves progression-free survival in soft tissue sarcoma patients without affecting their health-related quality of life. The study provides valuable data on treatment outcomes and cost effectiveness for this patient population.
Scientists at Tel Aviv University have found that a tropical ascidian species can expel its digestive tract and rebuild it within 12 days. The study provides new insights into the organism's ability to eviscerate and regenerate its gut, shedding light on potential avenues for human soft-tissue regeneration research.
Researchers developed a compact synchrotron source that measures X-ray absorption, phase shifts, and scattering, allowing for the differentiation of healthy tissue from tumors. The new technology has improved soft tissue contrast, enabling quicker diagnoses in medical emergencies.
A large retrospective study of 885 patients with soft-tissue sarcoma found that YONDELIS treatment was effective, with median progression-free survival and overall survival of 4.4 and 12.2 months, respectively. Early administration as second-line therapy may optimize efficacy.
A study in Lancet Oncology suggests continued treatment with YONDELIS for advanced soft-tissue sarcoma patients who have not progressed after six courses improves progression-free survival. The results also indicate that a drug holiday may worsen outcomes.
A new standard of care for soft tissue sarcomas has been established through a study that shows image-guided radiotherapy can reduce long-term side effects while maintaining survival rates. The treatment delivers smaller radiation doses to tumors, minimizing exposure to surrounding healthy tissue.
A simple test called transcutaneous oximetry may predict which patients are most likely to experience wound-healing complications after surgery. Patients with lower oxygen levels before surgery were more likely to develop complications, highlighting the potential tool as a means of taking extra precautions.
Soft coral tissue has been found to protect reef skeletons from declining pH levels, potentially providing a new approach to preserving coral reefs. The study, published in PLOS One, highlights the resilience of soft corals and their potential role in maintaining the health of coral reefs.
Researchers develop protocol combining hard X-ray tomography and histology to visualize constricted vessels, enabling simulation of blood flow and targeted drug delivery. The method also characterizes soft tissues in the vicinity of calcified arteries with high precision.
The EORTC trial 62012 found that adding ifosfamide to doxorubicin improved median progression-free survival, but not overall survival or tumor shrinkage, in advanced soft tissue sarcoma patients. Combination chemotherapy also resulted in more overall responses compared to doxorubicin alone.
EORTC analysis confirms performance status, tumor grading, and hemoglobin levels as key predictors of long-term outcomes in pazopanib-treated patients. Long-term responders and survivors accounted for 36% and 34% of patients respectively.
A new study reveals that iron may play a role in preserving ancient tissues within dinosaur fossils, but also concealing them. Hemoglobin is identified as a key player in this process, which could lead to the recovery of more preserved tissues from well-preserved fossils.
A new study found that nail gun injuries are increasingly common, especially among young males in work settings. The researchers also noted that public consumers are at risk of injury from these devices.
Researchers found an association between living near pig farms and manure fertilizers with community-acquired MRSA infections. Approximately 11% of cases could be attributed to crop fields fertilized with swine manure.
The study found a significant decrease in invasive MRSA infections nationwide from 80,461 in 2011 to estimated 30,800 in 2005. This represents a 27.7% decline for healthcare-associated community-onset infections and a 54.2% drop for hospital-onset infections.
A LSUHSC study found significant racial and ethnic disparities in the incidence of soft tissue sarcomas among adolescents and young adults. The research revealed that African-American and Hispanic males were more likely to develop certain types of cancer, such as Kaposi sarcoma and liposarcoma.
A novel study in Arthritis Care & Research examines the medical response and imaging technologies used to treat Boston Marathon bombing victims. The study found that radiology resources should be used liberally to save lives and limbs in urgent situations like the Boston Marathon bombing.
A recent study found that orthopedic oncologists and surgical oncologists conducted only 52% of sarcoma surgeries, while general surgeons, plastic surgeons, and orthopedic surgeons performed the remaining 48%. This disparity may impact patient outcomes due to varying levels of expertise in removing deep-seated tumors.
Researchers at Case Western Reserve University have created a material that mimics the squid's beak to make medical devices safer and more comfortable. The new material has a mechanical gradient that acts as a shock absorber, reducing wear and tear on surrounding soft tissues.
The invasive spotted-wing vinegar fly (Drosophila suzukii) prefers sweet and soft fruits, posing a significant threat to US fruit crops. Researchers found that certain wild fruits may serve as reservoirs for this species, while other varieties are more likely to be infested.
Researchers discovered that blue light can selectively eradicate Pseudomonas aeruginosa infections of the skin and soft tissues, while preserving the outermost layer. This breakthrough could provide a potential non-toxic approach to treating resistant bacterial infections.
A careful approach to planning based on craniofacial surgery principles can help maximize patient outcomes in terms of facial form and function. Understanding the relationships between facial structure allows surgeons to compensate for missing bony or soft tissue landmarks, ensuring optimal positioning of the facial transplant.
A recent study published in JAMA found that the rate of community-onset MRSA infections has decreased significantly among US military personnel. Community-onset skin and soft tissue infections due to MRSA peaked at 62% in 2006 before declining annually, with a proportion of 52% in 2010.
Scientists have developed a new X-ray imaging method that improves contrast in computed tomography scans without increasing radiation dose. The technique, called grating interferometry, uses microstructures to enhance contrast and can be combined with clinical CT scanners.
Researchers at Queen's University have developed a soft tissue replacement technology using discarded human fat, showing promise in promoting natural soft tissue regeneration. The technology can be used to repair or replace damaged or missing soft tissue caused by various injuries or surgeries.
A new study found that modern low-energy handgun ammunition can inflict significant soft tissue damage, potentially causing infection and compartment syndrome. Orthopaedic surgeons should be aware of this powerful new ammunition to treat high-risk gunshot injuries properly.
A newly discovered fossil of a mosasaur, with well-preserved soft tissue, is providing scientists with unique insights into the biology of an extinct marine lizard. The study found that the mosasaur was able to minimize its frictional drag in the water and relied on its tail for propulsion.
A recent study found that the ultrasonic bone aspirator can be a useful tool for cosmetic rhinoplasty, allowing precise removal of bone without damaging surrounding soft tissue. The device showed a positive safety profile and early results warranting further investigation and use.
Researchers from Yale University discovered that a virus from the same family as rabies can target and kill soft tissue sarcomas. The oncolytic activity of VSV-rp30a was found to be effective against 12 out of 13 different sarcoma lines, with resistance overcome by interferon antagonizers.
Researchers developed a liquid composite material that can restore damaged soft tissue relatively safely and durably. The material, composed of biological and synthetic molecules, was tested in rats and humans, showing promise in facial reconstruction, particularly for soldiers' blast injuries.
A nearly $2 million NIH grant will help Nationwide Children's Hospital investigate biomarkers linked to hemangioma development and outcome. The study aims to understand the role of oxidant production in hemangioma formation.
Researchers have successfully imaged the internal tissues of a soft-bodied marine worm using micro-computed x-ray tomography (micro-CT) without dissection or destructive methods. This technique allows for high-definition images and three-dimensional rotating views, enabling detailed study of functional anatomy.
A Tel Aviv University researcher has developed a tool to measure tissue damage in the bed-ridden and paralyzed, aiming to alleviate discomfort and pain. The Soft Tissue Stress Monitor can detect when a load is too heavy, alerting caregivers to make adjustments to prevent permanent damage.
David Corr's $449,999 NSF CAREER award will support his research on harnessing cells' natural abilities to improve functional tissue engineering. He aims to develop fundamental understanding of environmental stimuli on cellular growth and fiber formation.
A study found that hand and feet massages provided consolation to 18 bereaved relatives, reducing feelings of loneliness and empty space. The massages helped participants balance grief with adapting to life after loss, promoting physical touch and closeness.
Researchers found significant changes in facial bones, particularly the jaw bone, occur with age and contribute to an aging appearance. The study suggests a two-step approach to facial rejuvenation: first restoring structure underneath before performing skin-tightening procedures.
Researchers at the University of Cincinnati are receiving a $3.75 million grant to study tendon development and create better repairs after injury using adult stem cells. The goal is to introduce signals that mimic normal tendon development during repair, leading to more effective soft tissue repairs.
Researchers at Purdue University have created a magnetic 'ferropaper' made from ordinary paper that can be used to make low-cost micromotors, tiny tweezers, and miniature speakers. The material is impregnated with iron oxide nanoparticles and can be controlled using a magnetic field.
Complicated skin and soft tissue infections (cSSTIs) require prompt treatment to prevent tissue destruction and minimize mortality. The new guidelines emphasize the importance of rapid diagnosis and initiation of antibiotic therapy, including surgical debridement for necrotizing infections.