Articles tagged with Stomach
Scientists have discovered a group of four proteins responsible for generating Helicobacter pylori's characteristic curvature, enabling its survival in the acidic stomach environment. Laboratory-engineered mutant strains lacking these proteins fail to twist properly and are unable to colonize the stomach.
Researchers have made significant advancements in diagnosing and treating Barrett's esophagus and inflammatory bowel disease. A new study found that endoscopic radiofrequency ablation can effectively eliminate the condition in most instances, with five-year durability outcomes showing 46 of 50 patients remained free of disease.
Research found that dark-roasted coffee, including espresso and French roast, may be less irritating to the stomach due to its high content of N-methylpyridium (NMP), a substance that reduces acid production. This discovery could lead to new, stomach-friendly brews with the rich taste and aroma of regular coffee.
A new Cochrane Systematic Review suggests that stomach wrap operations are more effective in reducing symptoms of severe acid reflux than acid suppression tablets. The study found significant improvement in symptoms shortly after surgery compared to drug treatment.
Scientists develop a mathematical model of a three-cell microcircuit in a chicken's brain, revealing an elegant compromise between abstraction and complexity. The model reduces the system to one equation with two parameters, shedding light on why it's difficult to understand the brain using traditional methods.
Researchers found that Erbitux, a cancer treatment drug, reversed symptoms of Ménétrier's disease in nearly half of patients. The study provides new hope for those suffering from this rare condition.
A study published in the World Journal of Gastroenterology investigated whether children can tolerate surgery without fasting. The results showed that children can handle the stress of surgery when fed up to 2 hours before surgery, indicating no significant difference between short and long periods of fasting.
A study found that Laysan albatrosses nesting on Kure Atoll and Oahu ingested significantly different amounts of plastic, with those on Kure Atoll consuming almost ten times the amount. The birds' stomach contents revealed a wide range of plastic items, including Asian characters indicating their likely origin.
Researchers at the University of Gothenburg have identified a protein called MUC1 as an important part of the body's defense against Helicobacter pylori. Genetic variations in MUC1 molecules may contribute to why some people are more ill than others with stomach ulcers and stomach cancer.
Research reveals that obstructive sleep apnea (OSA) patients often have additional gastrointestinal (GI) tract conditions. A study of 42 adult OSA patients found pathological GI findings in 83.3% of cases, with hiatus hernia being the most common condition.
Researchers have discovered a group of substances that block flavodoxin, a key protein for H. pylori survival, offering promise for new specific antibiotics against the bacteria that causes stomach ulcers and other diseases worldwide.
A phase III randomised controlled trial found that famotidine reduces the development of stomach ulcers by 90% and upper-intestinal ulcers by 95% compared to placebo. The study also showed fewer adverse events in the famotidine group.
A recent study suggests that gastrin is an essential cofactor for Helicobacter-associated gastric corpus carcinogenesis in mice. High levels of gastrin lead to the development of stomach cancer, while absence of gastrin increases tumor numbers in the gastric antrum.
Researchers found that gastrin stimulates gastric acid secretion and plays a significant role in the development of Helicobacter-induced stomach cancer. High levels of gastrin may increase cancer risk, while low levels may lead to more tumors in specific parts of the stomach.
Researchers found that Helicobacter pylori is not transmitted through drinking water but rather through vomit and faeces, suggesting simple isolation and hygiene measures can prevent its spread. The study suggests isolating vomiting patients, especially children, for a short period can help prevent the bacterium's transmission.
Researchers at Mayo Clinic found that low doses of carbon monoxide can reverse gastroparesis, a common complication in diabetes. The study showed that carbon monoxide normalizes gastric functioning without increasing oxidative stress or HO1 expression.
Researchers found that glutamine supplementation can lower inflammation in stomach tissue infected with H. pylori bacteria, a primary cause of stomach cancer. The study suggests a potential new treatment option for stomach ulcers and gastric cancers.
Researchers have developed a new yogurt that fights stomach ulcer bacteria with almost vaccine-like effects. The yogurt contains an antibody that reduces bacterial activity, offering a potential alternative to antibiotics for treating gastritis and stomach ulcers.
Researchers developed a non-invasive diagnostic tool using serum biomarker tests to differentiate between healthy and diseased stomach mucosa. The European GastroPanel examination, combined with pepsinogen assays, showed high accuracy in detecting gastric atrophy and peptic ulcer diseases.
Two non-surgical treatments for gastroesophageal reflux disease (GERD) have been found to be effective in reducing medication use and improving symptoms, according to a recent study. Radiofrequency therapy appears effective for reducing heartburn and cough, while full-thickness plication may be beneficial for patients with regurgitation.
Simple clinical and laboratory tests can identify low-risk stomach bleed patients who can be safely managed as outpatients. This approach reduces hospital admissions by 71% without adverse effects on patient care.
Cognitive neuroscientists successfully created an illusion of body-swapping by manipulating sensory impressions, allowing subjects to perceive a mannequin's body as their own. This discovery sheds light on how the brain constructs an internal image of the body and has potential practical uses in VR applications.
A recent study discovered that Helicobacter pylori bacteria can be found in the mouths of people with halitosis without showing signs of stomach disease. The researchers found a significant association between the presence of H. pylori and periodontal disease, which is also a cause of bad breath.
Researchers at University of Cincinnati discovered a gene that helps control stomach acid production, which could lead to new therapies for overproduction. The study found that eliminating the Slc26a9 transporter gene stops acid secretion in the stomach.
Research detects ER-alpha and PR isoforms in Mongolian gerbil stomach, but their regulation by E2 and P4 varies between tissues. The study sheds light on the mechanisms behind these receptors' roles in gastric health.
Takeda's investigational PPI TAK-390MR demonstrates higher healing rates than lansoprazole among patients with more severe grades of erosive esophagitis. The drug combines dexlansoprazole with a Dual Delayed Release formulation, designed to provide extended duration of acid suppression.
Researchers have found a potential solution for diabetic gastroparesis by increasing production of a key molecule in the digestive process. The study, published in Gastroenterology, shows that a red blood cell derivative can restore normal gastric emptying and improve glucose control.
A new type of stent design prevents bleeding due to mechanical mucosal lesions. Individual stent designing alleviates late complications associated with stent treatment, leading to successful outcomes in palliative stent implantation.
A study found that individuals with diabetes and those with larger stomach pouches are less likely to successfully lose weight after gastric bypass surgery. The researchers examined data from 361 patients who underwent the procedure between 2003 and 2006.
A new study reveals that H. pylori bacteria can exploit stomach cells to protect themselves from the immune system, increasing the risk of stomach cancer. The bacteria's interaction with gastric cells triggers a receptor called Decay-accelerating factor (DAF), which reduces immune damage and promotes chronic inflammation.
A randomized controlled trial found that removing H. pylori bacteria from stomachs of post-operative stomach cancer patients can significantly reduce the risk of stomach cancer redeveloping. The study showed a two-thirds reduction in metachronous gastric cancer development between eradication and control groups.
Researchers at the University of Illinois Chicago are developing string probe tests to diagnose eosinophilic esophagitis, a condition where defense cells attack the esophagus. The test uses a swallowed string with gelatin capsule to measure inflammatory proteins and replace repeat endoscopies.
The American Society for Gastrointestinal Endoscopy (ASGE) has issued guidelines on the role of endoscopy in bariatric surgery patients. The guidelines emphasize the importance of preoperative endoscopy to detect lesions that may affect surgery and postoperative symptoms or conditions, such as nausea, vomiting, and abdominal pain.
A new study led by NYU Langone Medical Center researchers found that children who carry Helicobacter pylori are nearly 59% less likely to have asthma. The bacteria, which has co-existed with humans for at least 50,000 years, may strengthen the immune system and reduce the risk of allergic reactions.
A study of two naturally mummified corpses found remnants of Helicobacter pylori bacteria in gastric tissue from North American mummies. The research suggests that H. pylori infection occurred in native populations around 1350AD in the area now known as Mexico.
A new implantable device blocks stomach nerve signals, resulting in significant weight loss in obese participants. The study found that a quarter of patients lost over 25% of their excess weight and three patients lost more than 30%. A follow-up double-blinded study will be conducted to assess the device's true effectiveness.
Scientists have isolated a new bacterium, Helicobacter suis, in pigs' stomachs using a pioneering technique. The bacterium is associated with stomach ulcers in pigs, which may cause sudden death, and has been linked to an increased risk of infection in humans who are close to the animals.
Researchers at the University of Illinois have identified a novel toxin receptor for H. pylori, allowing the bacterium to survive in the human stomach. The discovery provides valuable insights into the mechanisms of H. pylori's survival and may lead to new therapeutic strategies.
A new study reveals that ghrelin hormone enhances the brain's response to food-related cues, making food more attractive. The hormone targets regions involved in reward and motivation, similar to those affected by drug addiction.
Scientists at University College London have identified two cell proteins that relax the gut and help accommodate large meals. The P2Y1 and P2Y11 receptor proteins could provide a new approach to combatting weight gain by preventing stomach expansion.
A brain-imaging study found that overweight people's brains respond differently to feelings of fullness, with reduced activation in areas signaling satiety. Treatments targeting these circuits may help control chronic overeating, according to the authors.
Researchers at Penn State developed a novel surgical technique using a Z-shaped incision to access the stomach, promising reduced bleeding and complication rates. The technique has potential applications in minimally invasive surgeries, such as intestinal bypass surgery and organ biopsies.
A rare stomach cancer case report highlights histochemistry's diagnostic value for carcinosarcomas. The study finds epithelial components expressing cytokeratin 18, EMA, and CEA positivity, while mesenchymal components show vimentin staining without muscular or neural differentiation.
A study presented at the American Heart Association conference found that keeping Halloween candy wrappers visible reduces consumption by nearly half. By moving candy dishes away from tempting areas or controlling portion sizes, parents can help their kids develop healthier eating habits during the holiday.
Researchers found that gastric bypass patients are at risk of developing small intestinal bacterial overgrowth (SIBO) and malabsorption of vitamins, minerals, and micronutrients. This can lead to conditions like osteopenia, osteoporosis, and osteomalacia.
Researchers have discovered gastric progenitor cells in mouse stomachs, which can give rise to all functional stomach glands. This discovery may aid understanding of normal cell turnover and potentially open doors for investigating gastric cancer origins.
Research reveals that fat in the stomach converts vitamin C from an inhibitor to a promoter of nitrosamines, potentially increasing cancer risk. Vitamin C levels were significantly boosted when fat was added, contradicting previous findings that supplements fail to reduce cancer risk.
A study led by Stanford surgeon John Morton found that patients who undergo gastric bypass surgery are more sensitive to alcohol, reaching higher breath-alcohol levels and taking longer to sober. This altered metabolism may contribute to an increased risk of addiction.
High-salt diets may increase the risk of severe gastric disease by inducing gene activity in H. pylori, making it more virulent. The study found that bacterial cells exposed to high salt concentrations exhibited morphological changes and increased transcription of virulence genes.
A recent study found that a virulent strain of H. pylori may help protect children from developing asthma, with those carrying the strain being 40% less likely to have had asthma before age 15. The microbe was also associated with protection against ragweed and other allergies in younger adults.
Researchers found that fats in the stomach reduce vitamin C's ability to protect against cancer-forming compounds. The presence of lipids overrides the antioxidant effect, allowing harmful nitrosating species to form.
A study led by doctors at Beth Israel Deaconess Medical Center shows that patients treated with the endoscopic Plicator procedure experience a sustained reduction in gastro esophageal reflux disease (GERD) symptoms and medication use. Over half of the patients were able to stop medication completely three years post-procedure.
A more restrictive drug coverage policy in British Columbia resulted in lower upper gastrointestinal bleeding rates compared to Ontario. The study suggests that limiting access to NSAIDs like coxibs can protect the population from adverse effects.
Researchers identified brain circuits motivating desire to overeat in obese individuals, linked to the same circuits that cause addicted individuals to crave drugs. The study found significant changes in brain metabolism associated with emotional behaviors and eating habits.
A recent study found a possible link between the use of proton pump inhibitors and an increased risk of community-acquired Clostridium difficile-associated disease. The research, published in the Canadian Medical Association Journal, suggests that patients who have been prescribed these medications may be more likely to develop CDAD.
A computer model of the stomach revealed a narrow path, dubbed the Magenstrasse, where food exits rapidly and particles are processed differently. This discovery may explain observed high variability in drug initiation time and have important implications for drug delivery and digestion.
A new enzyme, prolyl endoprotease (PEP), has been identified that can efficiently degrade gluten in the human stomach, a process previously impossible. This breakthrough offers potential relief to those with celiac disease, who currently rely on a strict gluten-free diet.
A study of 75 healthy college students found that those who were led to expect considerable nausea fared better than those who weren't. Preparation can have a profound impact on how patients respond to nausea, with the results suggesting that informed expectations may help reduce symptoms and stomach activity.
A 12-month study showed that NEXIUM maintained normal acid production levels in most patients with Zollinger-Ellison syndrome. Most participants controlled their acid output after just 10 days, and no ulcers or erosive esophagitis were observed at the end of the year.
Researchers have identified a stomach receptor for Helicobacter pylori, a common gut bacteria that causes peptic ulcers and gastric cancer. The discovery suggests that drugs targeting this receptor could prevent or treat these diseases.