Articles tagged with Striatum
A new atlas of the brain’s striatum has identified 31 subgroups of neurons, including those involved in addiction, depression, and schizophrenia. The atlas may help scientists develop new drugs to combat these conditions, particularly by targeting specific cell populations affected by Huntington’s disease.
A gene therapy platform successfully mapped the living brain noninvasively, using engineered proteins to track gene expression in different brain regions. This technology has the potential to reveal critical information about cellular activity and neurological disease progression.
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
A study found that rats' impulsive behavior and risky decision-making are shaped differently in males and females based on the timing of neural stimulation. The results highlight the importance of considering biological sex when developing treatments for disorders related to impulsivity and addiction.
A new study reveals how prenatal alcohol exposure impairs key brain cells and circuits, leading to cognitive inflexibility and increased risk of compulsive alcohol use. Researchers identified a specific brain cell affected by early alcohol exposure, providing a clear target for developing more effective treatments of FASD.
Researchers identified a dual learning system in the brain that enables habits to form and provides a scientific basis for breaking bad habits. The study suggests that replacing an action consistently can lead to the APE system forming a new habit, offering a potential strategy for overcoming addictions.
Researchers have discovered that the adult brain can generate new neurons that integrate into key motor circuits, potentially reversing damage in Huntington's disease. These newly generated cells replace lost neural networks and connect with complex brain networks responsible for motor control.
A recent study by Janelia researchers found that the striatum and motor cortex collaborate to specify movement parameters, contradicting traditional theories. This discovery sheds light on the role of the striatum in motor control and could lead to better understanding of movement disorders like Parkinson's and Huntington's.
Researchers discovered that mismatch repair genes are critical in eliciting damages to neurons vulnerable to Huntington's disease, triggering downstream pathologies and motor impairment. Targeting these genes may offer novel therapeutic approaches, including improving locomotor and gait deficits and reducing neuronal cell death.
Researchers at MIT have discovered additional brain pathways that modulate dopamine release, influencing movement and emotional decisions. The newly identified pathways appear to relay emotional information that helps shape motivation to take action.
Researchers map the conversion process from sucrose to bioactive glucomannan polysaccharides, pinpointing key genes involved in this transformation. This discovery sheds light on traditional Chinese medicine and may lead to more effective therapeutic agents.
Researchers discovered that brain regions, including anterior insula and striatum, are involved in the biased response to pleasure in people with bipolar disorder. In those with bipolar disorder, these brain regions show reduced communication, leading to a 'vicious cycle' of escalating mood and risk-taking behavior.
Researchers at EPFL have developed a novel non-invasive technique to target deep brain regions involved in neurological disorders. By applying low-level electrical stimulation on the scalp, they can selectively stimulate key brain regions without invasive procedures.
Researchers have discovered that neurochemicals influence neural activity, blood flow, and fMRI measurements. The study found that certain neurochemicals can cause constrictions in blood vessels, leading to negative fMRI signals.
A study by Pusan National University researchers found a significant association between Cutibacterium acnes and lichen striatus hypopigmentation, suggesting the potential for targeted therapy to reduce LS duration and hypopigmentation. The research team identified other likely candidates in skin microbiota imbalance.
Researchers at Northwestern University discovered that antipsychotic drugs interact with a different neuron type than scientists originally believed, which could lead to better treatments for schizophrenia. The study's findings suggest that the effect of antipsychotics on dopamine receptors has little bearing on their efficacy in humans.
Scientists found that cooling or warming the striatum region slows down or speeds up activity patterns, which correlates with rats' timing judgements. This provides evidence for the 'population clock hypothesis', suggesting that brains use decentralized and flexible sense of time.
Researchers at Texas A&M University found that substance use impairs cognitive flexibility by inhibiting specific neurons. Chronic cocaine or alcohol use alters the local inhibitory brain circuit, leading to decreased cognitive flexibility and increased risk of academic deficits and lower quality of life.
A study published in Brain found that disconnecting nerve pathways in the brain can lead to improved seizure freedom in patients with frontal lobe epilepsy. The research, involving 47 patients, revealed that cutting these connections resulted in 88% of patients being seizure-free after three years.
Researchers at Texas A&M University School of Medicine have identified a specific brain circuit that characterizes how fentanyl affects the brain. Suppressing negative emotional states may increase a person's chance of overcoming opioid use disorder.
Researchers identify vulnerable cell populations in the striatum, which contributes to loss of motor control and early mood disorders. Damage to striosomes may be responsible for mood disorders, while degeneration of matrix neurons likely contributes to motor decline.
A new study explores the relationship between fatty acid amide hydrolase (FAAH) levels and heavy drinking patterns in young adults. Lower FAAH activity was associated with more severe drinking, increased cravings, and reduced sensitivity to alcohol's negative effects.
Researchers at OHSU discovered adenosine effectively acts as a brake to dopamine, promoting balance in neuronal signaling. This finding suggests new avenues for drug development to treat Parkinson's disease symptoms by targeting the push-pull dynamic between dopamine and adenosine.
Researchers at Hebrew University have developed a new method using quantitative MRI to diagnose early-stage Parkinson's disease. This technique reveals biological changes in the brain, enabling early diagnosis and monitoring of treatment efficacy.
Research found that voluntary wheel running increased dopamine signaling in motor areas of mice. This increase remained even after exercise ended. The study suggests BDNF may catalyze increased dopamine signaling.
A new circuit model provides an explanation for how deep brain stimulation (DBS) relieves Parkinson's disease motor symptoms by interrupting a vicious cycle between the subthalamic nucleus and the striatum. The model suggests that DBS restores a balance with other rhythm frequencies, enabling better movement control.
A study published in Journal of Psychiatric Research found a significant biological difference between psychopaths and non-psychopaths, with psychopaths having a larger striatum region in the brain. This finding is linked to increased need for stimulation, impulsive behaviors, and higher likelihood of violent behavior.
A new MRI probe can monitor individual populations of neurons and reveal how they interact with each other. The technique uses genetically targeted probes to detect neural activity and provide a more precise picture of brain function.
A recent study published in Communications Biology found that the presence of the Bmal1 gene in the striatum affects alcohol consumption in both male and female mice, but in a sex-dependent manner. Males without the protein consumed more alcohol, while female mice with it consumed less.
A UC Riverside-led study found that treatment with the medication risperidone leads to increased activity of astrocytes in persons who stutter. This increase in activity may help reduce stuttering by blocking dopamine receptors in the striatum.
A team of UTSA researchers discovered long-range parvalbumin-expression neurons from the cortex to the striatum in mouse brains, challenging the exclusive local organization of cortical circuit neurons. This finding could lead to new treatments for epilepsy, PTSD, schizophrenia, and other mental conditions involving GABAergic neurons.
Researchers at UCLA discovered that the brain measures seconds by changing patterns of neural activity, with two distinct 'clocks' in different regions. The study found that mice could anticipate rewards based on scents associated with specific time intervals.
A recent study found that multitasking performance relies on the effective exchange of information between the putamen and cortical regions. After a week of practice, participants showed improved task performance and increased communication rates between these brain areas.
Dopamine released deep within the brain influences both nearby and distant brain regions, with significant effects found in the motor cortex and insular cortex. High dopamine concentrations promote longer periods of neuronal activity, suggesting a key function in learning and reward processing.
Researchers at Karolinska Institutet have discovered how different brain cell types in the striatum respond to sensory inputs and motor commands, shedding new light on how we align our movements with sensory feedback. The study reveals distinct receptor compositions and response patterns among five striatal neuron populations.
Researchers created a molecular 3D-map of nerve cells targeted by opioids in striatum, dividing it into subregions with spatiomolecular code. This knowledge may contribute to an increased understanding of normal reward processes and the effects of addictive substances on decision-making.
Researchers analyzed brain samples from two mutant HD gene positive individuals and found massive inflammation and similar gene expression patterns in the striatum compared to the prefrontal cortex. Unique patterns were also observed in the striatum, suggesting active neurogenesis during the disease process.
Researchers found significantly reduced mu-opioid receptor levels in schizophrenia patients' brains, contributing to negative feelings. This discovery provides a promising new lead for developing treatments for the condition.
Scientists at RIKEN Center for Brain Science found that impaired communication between the cortex and striatum can trigger absence epilepsy. Absence seizures, characterized by brief periods of lost consciousness, are associated with spike-wave discharges recorded on electrocorticograms.
Researchers found that the hippocampus uniquely represents bound features, such as faces and houses combined, which is essential for forming complex associations during learning. The study's findings have important implications for understanding how the brain's memory systems contribute to learning and decision-making.
MIT neuroscientists have developed tiny probes that can measure dopamine levels in the brain for more than a year. The sensors were implanted in animals and found to produce accurate readings for up to 393 days, opening up new possibilities for understanding dopamine's role in diseases such as Parkinson's.
Researchers at TGen and Circuit Therapeutics have developed new methods to examine medium spiny neurons in the striatum, a structure crucial for movement, decision-making, and action initiation. They identified Chrm4 as a potential therapeutic drug target, shedding light on how MSN cells contribute to neurodegenerative diseases.
A new study reveals that the brain relies on an exquisite balance between two populations of neurons in the striatum to control movement. The findings could help researchers develop new treatments for Parkinson's and Huntington's diseases by understanding how movement gets translated into desired action.
A WSU research study seeks to understand how sleep deprivation affects cognitive flexibility and develops new treatments for improved decision-making. The study uses a combination of human and animal experiments to identify brain processes involved in cognitive flexibility deficits.
Boosting learning from positive and negative feedback may prevent psychosis, according to researchers at the University of Missouri. Brain scans using functional magnetic resonance imaging can also identify markers for psychosis risk, helping mental health professionals better treat patients with psychoses.
Researchers isolated striosome neuron activity using optical neural imaging technology to shed light on their role in reinforcement learning. The study found that striosomal neurons fire more actively in response to odor cues associated with water rewards, indicating they are involved in anticipating the outcome of a stimulus.
Researchers trained visual neurons to control a computer-generated tone and a robotic arm using neuroplasticity. The connections from the cortex to the striatum were key to this learning, representing a feedback loop that may be essential for learning and memory throughout the brain.
Researchers found neurons that fire at the beginning and end of a behavior, marking the start and end of habits. The study sheds light on how the brain groups behaviors together into routines.
Researchers found that human neurochemical profiles are consistent with enhanced sensitivity to social cues, promoting monogamy and reducing within-group aggression. Elevated serotonin and neuropeptide Y levels may have encouraged male provisioning, while a dopamine-dominated striatum could have led to increased brain size and language.
Researchers at Columbia University and the Champalimaud Centre for the Unknown have discovered a map in the brain's striatum that guides animal movements. The study used miniature mobile microscopes to capture neural activity patterns of up to 300 neurons, revealing complex patterns of organization that reflect similarity in actions.
Researchers at Texas A&M University found that brain damage from stroke can increase an individual's preference for alcohol over water. The study used animal models and suggested that the brain's response to a stroke may play a role in increasing alcohol-seeking behavior.
A study published by the American Psychological Association found that individuals with a larger striatum in their brain may struggle with uncertainty, leading to anxiety disorders. The research suggests a relationship between an individual's ability to cope with uncertainty and the volume of gray matter within the brain.
A UCL-led study found that the brain responds weaker to money gained through immoral actions compared to those earned morally. The research identified a neural process that dampens the appeal of profiting at others' expense.
A UCLA study has identified a small cluster of brain cells that malfunction in Parkinson's disease, Huntington's disease, and Tourette syndrome. These support cells play a crucial role in encoding Pavlovian response and may hold the key to diagnosing and treating these disorders.
The new device, an array of tiny carbon electrodes, measures dopamine levels at millisecond timescales and can be used to monitor therapies aimed at boosting dopamine levels. The researchers found that dopamine levels vary greatly across the striatum, with implications for understanding learning and brain disorders.
Scripps Florida scientists have identified a specific signaling circuit in the brain involved in motor activity, which could lead to therapies for untreatable brain disorders. A protein interaction network helps control motor function by inhibiting dopamine signaling.
Adolescents' brains show enhanced connectivity between hippocampus and striatum, enabling better reinforcement learning and memory formation. This unique feature may be key to their ability to form powerful memories during adolescence.
New research suggests that teenagers' sensitivity to reward is an evolutionary adaptation to learn from their environment. The study found that adolescents outperformed adults in a picture-based game requiring learning from positive and negative reinforcement cues.
Researchers at Salk Institute created a comprehensive map of the striatum, a lesser-known brain structure that controls movement. The study reveals how patch and matrix neurons coordinate diverse functions, shedding light on long-standing questions about neurodegenerative diseases like Parkinson's.
A new study published in Biological Psychiatry suggests that inflammation can directly affect the brain's reward center, leading to changes in behavior similar to depression. The study found that patients with hepatitis C who received interferon-alpha treatment showed microstructural changes in their striatum, which was associated with...