Articles tagged with Uterus
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A third family welcomes a baby after participating in a landmark uterus transplant clinical trial at Baylor University Medical Center. The successful birth is the largest program in the world, having performed a total of 20 uterus transplants.
A study led by Massachusetts General Hospital researchers reveals that Misr2+ cells play a critical role in forming a healthy uterus. The cells, which express the receptor for Mullerian Inhibiting Substance (MIS), are found to continue expressing MIS past sexual differentiation, contributing to uterine development.
Researchers discovered an endometrial receptor that recognizes sperm molecules, allowing them to survive and potentially increasing fertility rates. This 'secret handshake' interaction may adjust the female's immune response and help sperm overcome the leukocytic reaction.
Researchers are analyzing the genes of hundreds of females with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome to identify genetic causes. The study aims to improve genetic counseling and potential treatment for this condition, which affects about 7-10% of women.
A decade-long study found that vaginal childbirth substantially increases the probability of developing pelvic floor disorders, such as urinary incontinence and uterine prolapse, later in life. The study also identified delivery modes associated with higher risk, including spontaneous vaginal delivery and operative vaginal delivery.
Researchers found that hysterectomy in rats with intact ovaries led to a memory deficit, suggesting the uterus may have functions beyond reproduction. The study tested rats with different types of menopause surgical interventions and found that only those with just the uterus removed had a negative effect on working memory.
A recent rat study published in the Endocrine Society's journal found that hysterectomy can cause short-term memory loss in rats. Removing the ovaries alongside the uterus did not result in a similar impairment, suggesting a unique negative effect of hysterectomy on brain function.
Researchers have successfully performed the world's first uterus transplant from a deceased donor, allowing a woman with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome to give birth. The recipient received immunosuppression drugs and had a healthy pregnancy, resulting in the birth of a baby girl via caesarean section.
Researchers mapped over 70,000 single cells at the uterus-placenta junction to understand maternal immune system modifications. This study provides a reference map for healthy pregnancy development, shedding light on disorders such as miscarriages and pre-eclampsia.
Researchers at Northwestern Medicine have successfully reprogrammed induced pluripotent stem cells into healthy uterine cells for potential treatment of endometriosis. The study marks a significant step towards treating the painful and persistent gynecological disease, which affects approximately 10% of women worldwide.
Researchers at Linköping University found that uterus transplantation with living donors is ethically comparable to altruistic surrogacy, citing potential pressures on donors and lack of research on child outcomes. The study suggests that decision-makers should consider the parallels between the two practices.
Researchers found that women who underwent failed outpatient sterilization procedures were more likely to experience a live birth and less likely to have an ectopic pregnancy compared to those who had surgical options. The study, published in Obstetrics & Gynecology, included data from nearly 1,000 pregnancies after sterilization failure.
Eight children have been born to mothers who received fertilized eggs after a uterus transplant, marking significant progress in the field. A new project focuses on robot-assisted operations, aiming to improve patient outcomes and reduce complications.
Research suggests uterine fluid informs the fetus of its mother's world, affecting embryonic development and long-term health. Studies have shown that maternal environmental exposures can leave epigenetic tags on fetal DNA.
A new study published in Radiology found that uterine fibroid embolization (UFE) can help restore fertility in women with uterine fibroids. After an average follow-up of six years, 41.5% of women who underwent the procedure became pregnant and gave birth to 150 babies.
Researchers at Baylor College of Medicine discovered that follistatin promotes decidualization and supports embryo implantation. In a mouse model, female mice lacking follistatin produced fewer pups and failed to attach embryos to the uterine wall.
Researchers at KU Leuven have successfully grown three-dimensional cultures of the endometrium in a laboratory dish, shedding light on the monthly menstrual cycle and its regulation by female hormones. The new technique enables the study of diseases such as endometrial atrophy and cancer, as well as drug discovery and screening.
Scientists at the University of Cambridge have successfully grown miniature functional models of the womb lining in culture, providing a major step forward in understanding the changes that occur during the menstrual cycle and early pregnancy. The findings may lead to new insights into endometriosis and fertility treatments.
Researchers suggest that Michelangelo's famous chapel contains hidden symbols associated with female reproductive organs, such as the uterus and fallopian tubes. The study, published in Clinical Anatomy, provides a previously unavailable interpretation of one of Michelangelo's major works.
A phase 3 trial found that a natural combined estradiol-progesterone capsule significantly decreased moderate to severe hot flashes in postmenopausal women. The treatment was well-tolerated with minimal side effects, presenting an alternative to unregulated hormone therapies.
New research identifies physiological changes in the body that could explain why older mothers are more likely to experience complicated births. The study found that maternal age influences the structure of the uterus, leading to impaired muscle contraction properties, reduced sensitivity to oxytocin, and altered hormonal signals.
Researchers discovered that NLRP2 is specifically produced by egg cells and becomes more important to fertility as the mice age. The study suggests that mutations in NLRP2 may give rise to early menopause and other conditions associated with maternal fertility decline.
A new study reveals that 43% of women with unexplained infertility are infected with the HHV-6A virus, which activates immune cells and produces cytokines making it harder for a fertilized egg to implant. The finding could lead to treatments improving outcomes for infertile women.
New research reveals that fetal BPA exposure alters the uterine epigenome, affecting almost 1,000 genes regulated by estrogen. This changes lead to an increased risk of estrogen-related diseases such as infertility and breast cancer in offspring.
A team of researchers at Washington University in St. Louis has developed the first 3D multiscale mathematical model of uterine contractions, which may aid in predicting preterm birth. The model precisely replicates the electrical activity in the uterus during a contraction using data from magnetomyography measurements.
Scientists have identified a uterine trigger called hypoxia-induced force increase (HIFI) that allows muscle cells to adapt to low oxygen levels, leading to stronger contractions in labor. This discovery could help resolve issues of prolonged labor and emergency cesareans.
A psychological evaluation of nine women who received a uterus from live donors indicates they adjusted psychologically well to their new life situation during the first year. Three of the seven remaining women have delivered healthy babies, with most reporting improved relationships with their donor and increased hope for a family.
Swedish clinicians have successfully performed live births after uterus transplantation, paving the way for new treatments. The long research journey of the Swedish uterus transplant project has led to preliminary results that offer hope for women who lack a functional uterus.
A new University of Adelaide study discovered an association between contact with seminal fluid and the development of endometriosis. The research found that seminal fluid enhances the survival and growth of endometriosis lesions, potentially increasing the risk of progression in women.
A recent study is comparing the direct and indirect costs of three minimally invasive fibroid treatments: global fibroid ablation, myomectomy, and uterine artery embolization. The TRUST Study aims to determine which treatment offers the best balance between cost and benefits for women seeking to preserve their uterus.
Researchers at the University of Manchester have identified a possible cause of IVF failure in some women, which may be treated with therapies targeting microRNA-145 and its effects on IGF1R. The study's findings suggest that manipulating this biological process could lead to improved rates of embryo attachment during implantation.
A recent study has clarified how proteins influence the direction of egg transportation in the fallopian tube, a crucial component of the reproductive system. Researchers found that protein Celsr1 is essential for proper transportation by controlling cell shape and ciliary movement.
A 47 million-year-old horse fossil in Germany preserves the uterus and an unborn foal, revealing that early horses had a similar reproductive system to modern horses. The discovery provides valuable insights into the evolution of equine reproduction.
The world's first child was born from a transplanted uterus, marking a major step forward in treating uterine factor infertility. The baby boy was delivered via caesarean section due to preeclampsia, but is developing normally and the mother and child are doing well.
A study published in JAMA examined the prevalence of underlying cancer in women undergoing minimally invasive hysterectomy using morcellation. The researchers found uterine cancers present in 27 per 10,000 women at the time of the procedure, with advanced age associated with underlying cancer and endometrial hyperplasia.
Research published in Nature Communications reveals a faulty electrical switch in the uterus of overweight women, causing irregular contractions and increasing the risk of caesarean sections. This breakthrough discovery sheds light on the mechanism behind labour complications in overweight women, paving the way for potential treatments.
A team of Swedish researchers led by Professor Mats Brännström have successfully performed nine uterus transplants using live donors, a breakthrough in treating uterine infertility. The transplants involved five mother-daughter pairs and four close relatives, with no blood transfusions required during surgery.
Researchers found that fetal surgery activates a mother's T cells, which normally reject foreign organs. In mice, this activation leads to preterm labor and fetal death. The study provides possible clues to the high rate of preterm labor after human fetal surgery.
De Vita is working with collaborative partners to determine the elastic and viscoelastic properties of uterosacral and cardinal ligaments. Her research could transform surgical reconstruction methods for female sufferers, establishing new guidelines and biocompatible grafts.
A recent Mayo Clinic survey found that uterine fibroids significantly impact the quality of life and workplace performance of women, with African-American women experiencing more severe symptoms and delayed diagnosis. The study highlights the need for better treatment options and increased awareness about this common public health issue.
Scientists have created a mouse model that may reveal useful targets for new adenomyosis treatments. The model is based on the beta-catenin protein, which causes changes in cells leading to the disease.
A Yale University study reveals that nearly 50,000 unnecessary deaths among women aged 50-69 with hysterectomies could have been avoided if they used estrogen-only therapy instead of combined hormone therapy. The decline in estrogen usage was linked to the 2002 WHI study's findings on women with a uterus, but not those without one.
Researchers found that smoking reduces the production of a key gene called BAD in Fallopian tubes, creating an environment conducive to ectopic pregnancies. This finding may lead to new ways to prevent and diagnose ectopic pregnancies.
A study using pregnant mice found that BPA exposure changes the way genes respond to estrogen in adulthood, potentially explaining increased incidence of estrogen-related disorders. This can lead to conditions like uterine fibroids and endometriosis.
Postmenopausal women who have had a hysterectomy may experience stiffer arteries, increasing the risk of cardiovascular disease. Hormonal changes and decreased estrogen levels after menopause may contribute to this effect.
Scientists at the Max Planck Institute for Heart and Lung Research have elucidated the action mechanism of castor oil, revealing that ricinoleic acid activates the EP3 receptor to stimulate intestinal activity and labour. This discovery could lead to a reassessment of its clinical use and potentially open new areas of application.
Researchers at the University of Cincinnati found evidence that BPA can alter the structure of the uterus, leading to increased susceptibility to pyometra, a potentially deadly infection. In animal models, exposure to BPA induced immune cell numbers in the uteri, which were five-fold higher than control animals.
A new study reveals that precise regulation of myosin phosphorylation is crucial for uterine activity during labor. The researchers discovered that specific amino acids are phosphorylated to control uterine contractions, providing insights into premature births and failed inductions.
Researchers at the University of Liverpool found that diabetic pregnant women experience weaker uterine contractions, increasing the risk of emergency caesarean births. Calcium levels in the uterus are also significantly reduced in these women, leading to poorly contracting muscles.
A study on free-living female Alpine marmots found that prenatal testosterone exposure gives females an edge in a population, allowing them to become more aggressive and dominant. This is contrary to previous findings in other species, where being exposed to males can make females less reproductively successful.
A study published in Nature Genetics reveals that genetic parasites invaded the mammalian genome over 100 million years ago and transformed reproductive biology. This led to the development of the placenta, which nurtures young within the womb.
A recent study has identified DEDD protein as essential for the formation of a functional decidua in mice. Defective DEDD function may be responsible for female infertility. The researchers suggest further investigation into the relationship between DEDD dysfunction and infertility in women.
Researchers at Yale School of Medicine have discovered that exposure to Bisphenol A (BPA) during pregnancy causes permanent abnormalities in the uterus of offspring. The study found that BPA exposure permanently alters gene expression and DNA modification in the uterus, leading to hyper-responsiveness to estrogens.
Researchers discovered that pomegranate seed extract's beta-sitosterol increases calcium levels in uterine muscle cells, stimulating contractions. This finding could lead to new ways of treating dysfunctional labour and improve pregnancy outcomes worldwide.
Researchers found uterus sparing surgery to be an effective treatment option for women with pelvic organ prolapse, with 82.97% patient satisfaction rates. The study also showed minimal persisting symptoms, with sexual activity maintained in 95.5% of patients.
A Tel Aviv University researcher is studying how the uterus contracts before embryo implantation, suggesting optimal timing and positioning can improve IVF success rates. The research aims to reduce the risk of multiple births and genetic diseases in IVF babies.
Mayo Clinic researchers studied 816 women who underwent global endometrial ablation (GEA) to assess its effectiveness in reducing menstrual bleeding. They found that only 16% of patients required hysterectomy five years after the procedure, which is nearly half of what was previously reported.
Scientists have discovered that prostacyclin stimulates the activation of uterine muscles, leading to strong contractions during labor. This finding may help develop therapies for preventing preterm labor, a serious complication of pregnancy.
Researchers at Yale University identified a key regulatory link in the evolution of pregnancy involving the altered function of HoxA-11 protein. This finding revolutionizes our understanding of how pregnancy evolved in mammals, highlighting a crucial genetic switch that tempered the immune system and allowed for internal development.
Researchers found that women with smaller uteri are at higher risk of premature twins, leading to increased foetal mortality and medical complications. Using transvaginal ultrasound to measure uterine height can help medical professionals make informed decisions about embryo transfer.