Weight Gain
Articles tagged with Weight Gain
Study shows use of obesity drugs alongside behavioral intervention is associated with reduced “food noise”
People who have lost weight using tirzepatide are seven times more likely to maintain their weight loss if they continue on the maximum dose compared to those who stop treatment
Simple ‘gut reset’ procedure may prevent weight rebound following GLP-1 discontinuation
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
Postmenopausal white women with genetic risk regain weight two times faster
A new study has found that postmenopausal white women with higher genetic risk of obesity regained weight about two times faster than those with lower genetic risk. Despite this difference, Black women in the study regained weight at a similar rate, regardless of their genetic risk.
Adaptive mobile health intervention to reduce excess gestational weight gain
A cluster-randomized trial found that an adaptive mobile health intervention effectively reduced the rate of gestational weight gain and total gestational weight gain among pregnant patients with overweight or obesity. The study suggests that technology-based interventions can be a valuable tool in managing excess weight during pregnancy.
$3.4 million grant to improve weight-management programs
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
What happens when patients stop taking GLP-1 drugs? New Cleveland Clinic study reveals real world insights
A Cleveland Clinic analysis of nearly 8,000 patients found that discontinuing semaglutide and tirzepatide does not lead to significant weight regain in clinical practice. Many patients successfully stabilized their weight after one year through alternative treatments and therapeutic lifestyle interventions.
GLP-1RA switching and treatment persistence in adults without diabetes
A large cohort study found that fewer than 1 in 4 adults with overweight or obesity without diabetes remained on GLP-1RA treatment after 12 months. Treatment switching between GLP-1RA agents was common, reflecting active therapy management and the emergence of new formulations and weight management agents.
Patients regain weight rapidly after stopping weight loss drugs – but still keep off a quarter of weight lost
Patients who stop taking weight loss drugs like Ozempic and Wegovy experience rapid weight regain of up to 60% within a year, but sustain around 25% of lost weight. Researchers found that individuals may maintain healthier eating habits even after treatment ends.
Prevalence of youth overweight, obesity, and severe obesity
The study found excess adiposity remained highly prevalent among US youths in 2024, with certain racial and ethnic subgroups affected more. The prevalence of severe obesity was also higher for these subgroups.
Pennington Biomedical’s Dr. Catherine Prater awarded postdoctoral fellowship from the American Heart Association
Dr. Catherine Prater's research project aims to improve prediction models and uncover metabolic markers that explain individual differences in weight gain. She will use machine learning techniques to train and test prediction models using existing clinical trial data.
Stopping weight loss drugs linked to weight regain and reversal of heart health markers
A systematic review finds that stopping weight loss drugs leads to rapid weight regain, reversing heart health markers in under two years. Average monthly weight gain is 0.4kg, with all cardiometabolic risk markers projected to return to pre-treatment levels within 1.4 years.
The gut bacteria that put the brakes on weight gain in mice
Researchers identified a specific type of gut bacteria, Turicibacter, that promotes metabolic health and reduces weight gain in mice. The bacterium produces fatty molecules that are absorbed by the small intestine, improving ceramide levels and preventing excessive weight gain.
Gestational weight gain and pregnancy outcomes after GLP-1 receptor agonist discontinuation
A study found that women with obesity who stopped using GLP-1 receptor agonists experienced more gestational weight gain and a higher risk of preterm delivery, gestational diabetes, and hypertensive disorders. The research suggests that discontinuation of these medications may impact pregnancy outcomes.
Cardiometabolic parameter change by weight regain on tirzepatide withdrawal in adults with obesity
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
Two thirds of women experience too much or too little weight gain in pregnancy
A review of 1.6 million women found that two-thirds experience excessive or inadequate weight gain during pregnancy, associated with complications such as preterm birth and large birth weight. The study supports the development of global healthy growth and weight gain standards to improve outcomes for mothers and babies worldwide.
Study: Metformin new standard of care to manage weight gain side effect of certain bipolar medications
A study published in The Lancet Psychiatry found that metformin can help manage weight gain in overweight or obese youth taking medication for bipolar disorder, making it a potential standard of care treatment. The MOBILITY trial showed modest but significant benefits of metformin over no treatment, with well-tolerated side effects.
Doctor exposes critical treatment gap leaving eating disorder patients “stuck in the cracks” of healthcare system
A doctor warns of critical treatment gaps in eating disorders, highlighting the dangers of ignoring physical warning signs and behavioral indicators. Dr. Jennifer Gaudiani advocates for integrated medical and psychological care to address the urgent need for effective treatment.
Community health worker support for Hispanic and Latino individuals receiving hemodialysis
A culturally tailored community health worker intervention modestly lowered interdialytic weight gain and improved dialysis adherence among Hispanic and Latino patients with hemodialysis-dependent kidney failure. This study suggests that such interventions can enhance patient outcomes for these vulnerable populations.
Study confirms that inactive parents contribute to sedentary behavior in their children
A study by São Paulo State University found a direct association between adults' levels of physical activity and their children's sedentary behavior. Children of inactive parents tend to be more sedentary, but when mothers and fathers maintain an active routine, their children usually follow suit.
Proportion of obesity-related conditions attributable to obesity and overweight in US youth
A recent study found that large portions of obesity-related conditions in US adolescents and young adults are attributable to obesity. Treating and preventing obesity may reduce these conditions and associated costs. The researchers emphasize the importance of addressing childhood obesity to prevent future health issues.
New study finds hidden body fat is linked to faster heart ageing
A new study found that excessive visceral fat is linked to faster ageing of the heart, with a genetic predisposition to female-type fat in women potentially slowing heart ageing. Researchers also discovered that artificial intelligence analysis of images revealed signs of organ ageing, including tissue stiffness and inflammation.
GLP-1 receptor agonists and cancer risk in adults with obesity
A retrospective cohort study found that GLP-1 receptor agonists may reduce overall cancer risk, including lower risks of endometrial and ovarian cancers, among patients with obesity or overweight. However, these medications may also increase the risk of kidney cancer, highlighting the need for longer-term follow-up.
Impact of a weight loss intervention on 1-year weight change in women with stage II/III breast cancer
A telephone-based weight loss intervention significantly reduced weight in breast cancer patients with overweight and obesity. The study suggests that this intervention may improve disease outcomes, warranting further investigation in future trials.
Teens with higher blood levels of PFAS regain more weight after bariatric surgery, study finds
A new study found that adolescents with higher blood levels of per- and polyfluoroalkyl substances (PFAS) prior to bariatric surgery regained more weight and had greater increases in waist circumference up to five years after surgery. Researchers believe PFAS exposure disrupts endocrine and metabolic processes, leading to weight regain.
Health: Anti-obesity medications associated with weight rebound post-treatment
A meta-analysis published in BMC Medicine found that patients prescribed anti-obesity medications may experience a significant weight gain after stopping their prescription. The study analyzed data from 11 randomised trials and suggests that six approved anti-obesity medications are associated with weight regain after treatment cessation.
Genetic test predicts obesity in childhood
A new genetic test can predict adulthood obesity in early childhood, allowing for targeted preventative strategies. The test was developed using data from over five million people and found to be twice as effective as previous tests at predicting obesity risk.
Which factors affect the success of popular prescription weight loss drugs in individuals?
A study of 679 patients found that longer GLP-1RA treatment, not having diabetes, and higher body fat were associated with better weight reduction. Higher muscle mass and metabolic rate also contributed to successful weight loss in patients with overweight or obesity.
Weight loss in midlife, chronic disease incidence, and all-cause mortality during extended follow-up
Sustained midlife weight loss was associated with lower chronic disease incidence and decreased all-cause mortality. The study's findings suggest that maintaining a healthy weight during middle age can have long-term health benefits.
Glucagon-like peptide 1 receptor agonists and mental health
GLP1-RA treatment is associated with improvements in quality of life, restrained eating, and emotional eating behavior. The treatment also provides reassurance regarding its psychiatric safety profile.
First five years of a child’s life provide a critical window of opportunity for preventing overweight and obesity, Dutch study suggests
A child's body mass index (BMI) at six years old is a strong predictor of their risk of overweight or obesity at 18. Reaching a healthier weight before six can reduce this risk, but returning to it later does not have the same effect.
Bigger bellies in childhood linked to development of metabolic and heart health risk by 10 years old
A Danish study found that adverse waist-to-height ratio trajectories in childhood are associated with increased cardiometabolic risk at age 10. Children with gradually increasing central obesity showed early signs of metabolic and cardiovascular risk, including elevated blood pressure and insulin resistance.
The combination of significant weight gain and late motherhood greatly increases a woman’s risk of breast cancer, UK study finds
A UK study of 48,417 women found that significant weight gain after age 20 and late first pregnancy increase the risk of breast cancer. Women who experienced early first pregnancy were found to have greater weight gain during adulthood than those with a late first pregnancy.
Prenatal and perinatal factors of life’s essential 8 cardiovascular health trajectories
A cohort study found associations between pre-pregnancy overweight, smoking during pregnancy, and formula-feeding with adverse cardiovascular health trajectories in early childhood. The study suggests that addressing these factors through interventions may optimize cardiovascular health in children.
Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity
The study estimates that expanded Medicare coverage for GLP-1RAs would increase access to these treatments and reduce obesity-related comorbidities. However, this would come with substantial costs over a decade, projected at $8 billion, highlighting the need for further price reductions and cost-saving strategies.
Maternal childhood trauma may lead to early metabolic changes in male children
A study of 352 newborn pairs found that maternal childhood trauma can lead to excessive weight gain in male children as early as the first two months of life. This may increase future risk of obesity and diabetes, highlighting a potential intergenerational effect.
3-year study of tirzepatide shows that most patients only gain 5% or less from their lowest or ‘nadir’ weight
A new analysis of the SURMOUNT-1 trial found that around two-thirds of participants regained only 5% or less of their lowest weight over three years. The study suggests that most patients receiving tirzepatide had a relatively stable weight journey, with limited weight regain after reaching their nadir weight.
Oral semaglutide vastly reduces heart attacks, strokes in people with type 2 diabetes
A new clinical trial found that oral semaglutide can significantly reduce cardiovascular events in people with type 2 diabetes and pre-existing cardiovascular disease. The medication decreased the risk of major cardiac events by 14% compared to placebo, with nonfatal myocardial infarction seeing the greatest reductions in risk.
Scientists discover why obesity takes away the pleasure of eating
A high-fat diet reduces neurotensin, a brain peptide that interacts with the dopamine network, leading to reduced pleasure in eating. Boosting neurotensin levels restores pleasure and promotes weight loss in mice, offering new avenues for addressing obesity.
Rise in kidney disease underscores critical heart-kidney connection
Chronic kidney disease rates increased by 24% globally from 1990 to 2021, linked to higher cardiovascular disease risk. Collaborative care and screening for cardiovascular-kidney-metabolic syndrome can reduce mortality and improve patient lives.
Do lifetime body weight patterns affect kidney cancer risk?
New research suggests that maintaining a healthy weight throughout life and losing weight later in life may reduce the risk of kidney cancer. Higher BMI at various ages across adulthood was associated with increased risks of developing different types of kidney cancer, including renal cell carcinoma, papillary RCC, and chromophobe RCC.
Weight loss protects – even when weight is regained
A Swedish study of over 1,300 participants found that losing a significant amount of weight still offers protection against health issues like cancer and cardiovascular disease, even if some weight is regained. However, regaining weight can increase the risk of microvascular disease and other health problems.
Bottle feeding toddlers to sleep linked to dental decay and excess weight
New research strengthens evidence against bottle feeding in bed for toddlers, linking it to increased risk of dental cavities and overweight. Parents are advised to stop using bottles before naps and at bedtime by age 12 months to prevent these health issues.
Weight loss increases risk of death for obese adults
A recent study published in Heart journal found that extreme weight fluctuations significantly increase the risk of death among obese individuals with cardiovascular disease. Both weight loss and gain above 10kg raise mortality risk, highlighting the importance of maintaining a stable weight even within the obese range.
Scientists identify genes that make humans and Labradors more likely to become obese
Researchers found that dogs carrying the genetic variant DENND1B had higher body fat content, while humans also carry this gene linked to obesity. The study highlights the importance of fundamental brain pathways in regulating appetite and body weight.
Taking semaglutide before bariatric surgery does not improve weight loss or safety
A study of 350 patients found that taking semaglutide before bariatric surgery did not increase total weight loss and had similar health outcomes to surgery alone. Researchers suggest a surgery-first strategy may lead to better obesity treatment outcomes.
Obesity starts in the brain
A recent study found that a brief consumption of highly processed foods can alter the brain's sensitivity to insulin in healthy individuals, potentially leading to obesity and type 2 diabetes. This effect was observed even after returning to a balanced diet for one week.
Demonstrates the relationship between antidepressants and weight gain
A recent study published in Frontiers in Psychiatry reveals a strong link between antidepressant use and weight gain, with an average 2% increase in body weight among participants. The study highlights the need to consider this association when prescribing antidepressants and monitor weight changes accordingly.
Biological clock plays critical role in driving teens’ late-day eating habits
Researchers discovered that adolescents with higher body mass indexes consumed more calories later in the day than their peers of healthy weight. The study controlled for environmental and behavioral influences to isolate the role of the circadian system in shaping eating patterns.
Biological clock plays critical role in driving teens’ late eating habits
Researchers found that teens with obesity consumed more calories in the late afternoon and early evening compared to their peers of healthy weight. The study, published in PNAS, demonstrates that the body's biological clock directly impacts food intake throughout the day.
Yo-yo dieting may significantly increase kidney disease risk in people with type 1 diabetes
A new study found that yo-yo dieting significantly increases the risk of kidney disease in people with type 1 diabetes. Participants who experienced greater weight fluctuations had a 40% decline in estimated glomerular filtration rate and were more likely to exhibit increased albuminuria.
Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists among us adults with overweight or obesity
A cohort study found that patients without type 2 diabetes had higher discontinuation rates and lower reinitiation rates of GLP-1 receptor agonist therapy. Inequities in access and adherence to effective treatments exacerbate disparities in obesity.
Calorie labelling leads to modest reductions in selection and consumption
A new Cochrane review found that calorie labelling in supermarkets, restaurants, and other food outlets leads to a small reduction in the calories people select and purchase. The average reduction was 1.8%, equating to around two almonds per 600-calorie meal.
Yes, college students gain holiday weight too—but in the form of muscle not fat
A new study reveals that college students and older adults gain weight during the holiday season, but in different ways. College students add muscle mass, while older adults gain fat. This finding highlights the importance of understanding weight and health across major life stages.
Weight changes and heart failure risk after breast cancer development
A nationwide cohort study in Korea found that postdiagnosis weight gain is associated with an increased risk of heart failure after breast cancer development. Effective weight intervention can protect cardiovascular health, particularly within the first few years after diagnosis.
Does an infant breast milk supplement commonly used in Sweden contribute to childhood obesity?
Research found that infants given milk cereal drinks after six months old experience early rapid weight gain but not higher body mass index or waist-to-height ratio. Early rapid weight gain is predictive of later adiposity, regardless of supplement consumption.
Study finds tonsil removal not linked to undesirable weight gain, contrary to popular belief
Researchers found no correlation between adenotonsillectomies and undesirable weight gain in children with mild sleep-disordered breathing. The study used data from a clinical trial involving 458 children and showed that adenotonsillectomy improved symptoms, blood pressure, and quality of life but not primary neurodevelopmental outcomes.
Eating dark chocolate linked with reduced risk of type 2 diabetes
A new study from Harvard T.H. Chan School of Public Health found that consuming at least five ounces of dark chocolate per week may lower the risk of developing type 2 diabetes by up to 21%. Dark chocolate's rich polyphenols are believed to offset the negative effects of saturated fat and sugar on weight gain and diabetes.
Paternal weight influences baby’s size at birth, study finds
A Brazilian study of 89 father-mother-baby triads found that paternal overweight is linked to lower birth weight and may influence the baby's health in adulthood. The research suggests that fathers should prioritize healthy habits during pregnancy to support fetal development.