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WPI biologist's discovery gives evolution clues and may affect drug interaction research

A WPI biologist has discovered that a key component in a worm's communication system can be repurposed to take on a different function, providing insights into the workings of evolution. This finding could have significant implications for drug interaction research, agricultural bio-engineering, and our understanding of genetic inherit...

SourceWorcester Polytechnic Institute·JournalNature Communications·DateAug 15, 2019

Leaping larvae! How do they do that without legs?

Researchers at Duke University discovered that gall midge larvae use a hydrostatic legless jumping mechanism, which allows them to launch themselves through the air with incredible speed and efficiency. This remarkable behavior is made possible by sticky patches of skin on the larva's body, similar to those found on geckos' feet.

SourceDuke University·JournalJournal of Experimental Biology·DateAug 8, 2019

Life is tough but so are worms -- thanks to mom

A Duke University study found that worm offspring of mothers who experienced nutrient stress during pregnancy were better equipped to handle starvation later on. This is due to changes in insulin signaling transmitted via eggs, which helped the larvae develop normally and avoid reproductive abnormalities.

SourceDuke University·JournalCurrent Biology·DateJul 8, 2019

Excellent catering: How a bacterium feeds an entire flatworm

A single bacterium supplies the gutless Paracatenula worm with lipids, proteins, sugars, fatty acids, vitamins, and other substances for energy and biomass production. The bacteria use chemosynthesis to convert carbon dioxide into organic compounds, which are then delivered to the host in small droplet-like vesicles.

SourceMax Planck Institute for Marine Microbiology·JournalProceedings of the National Academy of Sciences·DateApr 8, 2019

Biophysicists use machine learning to understand, predict dynamics of worm behavior

Researchers used an algorithm to model the decision-making of C. elegans in response to a sensory stimulus, achieving predictions that matched experimental results. The Sir Isaac platform demonstrated improved accuracy compared to prior models, offering insights into the potential of artificial intelligence in scientific discovery.

SourceEmory Health Sciences·JournalProceedings of the National Academy of Sciences·DateMar 27, 2019

Can you 'catch' cancer?

Research suggests that parasitic worms cause majority of cancers in poor countries due to chronic inflammation and toxic egg excretions. However, some species of helminths, like the 'hyper tapeworm', inhibit cancer growth and may even enhance host's immune response to tumors.

SourceFrontiers·JournalFrontiers in Medicine·DateMar 25, 2019

The genetics of regeneration

A team of researchers from Harvard University has discovered genetic switches that control the process of whole-body regeneration in animals. Using three-banded panther worms, they found that a non-coding DNA section activates a 'master control gene' called early growth response (EGR), which controls various processes by switching othe...

SourceHarvard University·JournalScience·DateMar 14, 2019

What can worms tell us about human aging?

Researchers have developed a community-agreed model of worm metabolism, which has been re-optimised for relevance to metabolic changes during ageing. The model predicts that Oxaloacetate production becomes limiting in aged worms, potentially leading to extended lifespan by up to 20%.

SourceBabraham Institute·JournalFrontiers in Molecular Biosciences·DateFeb 6, 2019

Adaptive models capture complexity of the brain and behavior

Scientists parse animal behavior into digestible chunks using an adaptive model, spotting subtleties that would have otherwise been missed. The study found that complex dynamics can be broken down into simple linear patterns, allowing for the quantification of brain states and movement behaviors in various organisms.

SourceOkinawa Institute of Science and Technology (OIST) Graduate University·JournalProceedings of the National Academy of Sciences·DateJan 31, 2019

Neuron death in ALS more complex than previously thought

Researchers have discovered that two types of motor neurons die in ALS patients through distinct mechanisms, potentially leading to the development of more targeted treatments. The study used worm models to investigate the degeneration of spinal and brain neurons in ALS, revealing new insights into the complex nature of the disease.

SourceBrown University·JournalPLOS Genetics·DateOct 9, 2018