Articles tagged with Zebrafish
Researchers have designed a simple and efficient platform to discover new drugs treating spinal cord lesions using zebrafish, accelerating the translation period from discovery to clinics. The platform has identified a molecule with motor recovery properties in zebrafish larvae and showed efficacy in spinal cord injury models in rodents.
Researchers at Harvard University discovered zebrafish choose mating over fleeing a threat when exposed to pheromone cues. This decision is controlled by specific brain regions responding to reproductive hormones.
New research reveals that epigenetic changes in humans and zebrafish, a tiny fish species, are conserved for over 400 million years. The study found that genes linked to cancer development are silenced early in human embryos, similar to zebrafish, suggesting an ancient mechanism controlling these genes.
Researchers from the University of Sheffield have discovered spherical structures in zebrafish brains containing nitric oxide, potentially linked to genetic forms of stroke. The study provides new insights into neurological and cardiovascular research.
Researchers found that an anti-malarial drug called artemisinin can help sensory cells of the inner ear recognize and transport essential proteins to specialized membranes. This could lead to new therapeutic options for people with Usher syndrome, a common genetic cause of hearing loss.
Researchers used zebrafish to study the effects of a genetic mutation linked to brain disorders such as autism and schizophrenia. The study found that the mutation caused clustering of cellular interactions, leading to disrupted normal development and brain health.
Researchers discovered that V1 neurons in fish spinal cords inhibit slow muscle activity during high-speed swimming. This mechanism enables fast swimming by preventing disturbance from slow muscle activity.
A new zebrafish model has been developed to visualize drug responses at single-cell resolution in live animals, identifying a promising treatment for rhabdomyosarcoma. The model allows for the assessment of combination therapies and direct visualization of drug responses, reducing costs and time required for clinical trials.
Researchers have discovered an unexpected role for the gene GRIK5 in linking vascular biology to eye disease, utilizing biobanks, electronic health records, and zebrafish. The study found reduced expression of GRIK5 associated with 18 different eye diseases, including retinal detachment, cataract, and glaucoma.
Scientists discovered eight distinct cell populations in zebrafish brains that proliferate in response to amyloid-β aggregates, a hallmark of Alzheimer's disease. These populations may serve as potential targets for inducing regeneration and developing new treatments for humans.
A portable scientific microscope nicknamed Flamingo will make its way from Madison to Boston for collaboration and research. The project aims to democratize expensive high-end microscopy, bringing it cost-free to campuses and labs where access may be scarce.
Researchers found that longer-lived sperm in a male's ejaculate produce offspring with longer and healthier lifespans. This study has important implications for evolutionary biology and assisted fertilization technologies, such as IVF in humans.
Researchers have found a link between autism, serotonin levels and digestive issues in zebrafish. By replicating a mutation in the SHANK3 gene, they discovered a drastic reduction in serotonin-producing cells, which may lead to treatments for gastrointestinal symptoms.
Research in zebrafish reveals that clock genes determine daily behavioral rhythms and activity levels. The study found that eliminating these genes reduces energy supply, leading to lower locomotion and more resting behavior.
A new software, idtracker.ai, can identify up to 150 individual fish with high accuracy, extracting valuable data for understanding group behavior. The AI-powered system uses deep learning neural networks and conventional algorithms to recognize unique features of each zebrafish.
Researchers at the Norwegian University of Science and Technology have found that cilia are essential for normal brain development and functioning. In zebrafish larvae, groups of cells with cilia create a stable directional flow of cerebrospinal fluid within individual ventricles.
During zebrafish development, a region of the embryo switches from viscous to liquid, allowing it to take shape. The study found that this process is mediated by cell division and regulated by non-canonical Wnt signaling pathway.
Administration of fluoxetine to zebrafish embryos reduced cortisol levels in three subsequent generations, affecting gene expression and steroid production pathways. The antidepressant's impact on offspring was more pronounced in males than females.
Scientists from the University of Sheffield have created zebrafish that carry the genetic change known to cause motor neurone disease. This breakthrough will accelerate pioneering research and experimental drug trials, which could lead to new treatments for the devastating neurogenerative disorder.
A new gene, slincR, discovered in zebrafish could help explain human susceptibility to chemicals. The study found that the gene regulates sox9b, a crucial gene in human development.
Researchers discovered large immune cells called macrophages play a vital role in repairing damaged nerve connections in zebrafish. These molecules dampen inflammation at the injury site, enabling nerve cells to bridge gaps and repair lost connections.
Researchers identified a novel anti-inflammatory bacterial protein, Aeromonas immune modulator (AimA), that reduces gut inflammation and delays death by septic shock in zebrafish. The study suggests that AimA acts as a mutualism factor, promoting both bacterial colonization and host survival.
Researchers have developed a novel testing system using zebrafish larvae to filter out substances with unwanted side effects. They found over 500 substances that modulated appetite, with most having specific effects without interfering with known systems.
Zebrafish models have been developed to study the intricate molecular pathways underlying mucosal melanomas. The research identified a previously unrecognized tumor suppressor, SPRED1, and its interplay with oncogene KIT. These findings hold promise for developing precision cancer therapies for this rare and aggressive form of melanoma.
Scientists developed zebrafish with genetic mutations to study Saethre-Chotzen syndrome, a common form of craniosynostosis. The study revealed abnormal stem cell development leading to premature suture fusion and disrupted skull growth.
Researchers at OIST and Vietnam Academy of Science and Technology have decoded the entire genome of the striped catfish, revealing new details about its evolutionary lineage and genes related to disease resistance. The genome data will enable aquaculturists to develop molecular markers for optimal breeding
Researchers have developed gene-edited zebrafish models using CRISPR/Cas9, enabling precise point mutations to replicate human disease-associated genetic variants. This advancement improves the efficiency of disease modeling and opens new doors for understanding genetic disorders.
The NIH has awarded a $3.3-million grant to Carnegie Institution scientist Steven Farber to identify new pharmaceuticals for combatting cardiovascular disease. Using genetically engineered zebrafish with glowing lipoproteins, the team aims to find compounds that lower ApoB levels and reduce disease risk.
Researchers are using laser marking systems and light sheet microscopy to track individual cells in zebrafish development, aiming to create a complete cellular blueprint. The project has the potential to revolutionize regenerative biology by precisely defining cell roles in complex organisms.
A new open-source electronic husbandry repository has been developed to manage zebrafish colonies, capturing demographic metadata and tracking fish mortality and fertilization. The cloud-based system is accessible via an everyday smartphone, enhancing reproducibility in science.
Scientists at Boston Children's Hospital have identified a potential new treatment for adenoid cystic carcinoma by targeting the MYB gene in zebrafish. The study found that retinoic acid derivatives effectively shut off the MYB gene, slowing tumor growth and validating its efficacy in human cells.
Researchers found that zebrafish with specific personalities outperformed those based on coloration patterns in terms of reproductive parameters. The study suggests that pairing animals by personality can boost fitness and inform conservation efforts.
A new mathematical model explains the formation of zebrafish stripes by highlighting the crucial role of a single pigment cell type. The model shows that iridophores lead the process, providing redundancies to ensure reliable stripe formation even when cellular processes go wrong.
Researchers discovered a link between the protocadherin 17 gene and abnormal brain-eye muscle connections in zebrafish, which may contribute to strabismus. The study suggests that Pcdh17 protein plays a crucial role in positioning neurons correctly in the brain and extending axons to target muscles.
Researchers detected high levels of sunscreen chemicals in Shenzhen waters and found they affect zebrafish embryo development. The effects vary depending on the chemical combination and exposure duration.
Researchers identified brain cells crucial for zebrafish socialization, mirroring human social behavior problems seen in autism and schizophrenia. The study's findings provide a new avenue for research on the biological underpinnings of social behavior.
Researchers established zebrafish mutants of four PIH-protein genes and found specific dynein subtypes are required for each PIH protein's function. The study demonstrates distinct roles of PIH proteins in axonemal dynein assembly, which may explain cilia motility defects.
A recent study by University of Queensland researchers has uncovered a new brain pathway that enables zebrafish to detect and respond to visual threats from predators. The findings reveal that the thalamus plays a crucial role in processing visual information, which is then transmitted to other parts of the brain for escape responses.
Researchers discovered a genetic link between left-right brain asymmetry and melatonin production in fish, shedding light on pineal gland function. The study found that a protein called Bsx controls the development of the pineal complex, leading to disrupted sleep-wake cycles.
Researchers from North Carolina State University and Oregon State University have identified a genetic difference in zebrafish that is tied to differing responses to the same environmental chemical. The study found an association between the gene Sox7 and varying responses to abamectin, a commonly used antiparasitic.
Researchers at University of Oregon and Oregon State University found that biocompatible gold nanoparticles and surfactants become toxic when combined in a synergistic way, causing 88% mortality rate in zebrafish embryos. The study's new delivery system could serve as an early screening method to detect toxicity and ensure product safety.
The Flamingo project provides a portable and shareable light sheet microscope, addressing the challenges of accessing high-powered microscopy technologies. Labs can configure experiments remotely and mail the device to other labs for use, at no cost to users.
Researchers discovered that zebrafish use a near-360 degree view to detect threatening silhouettes in black-and-white and seek out food by detecting UV light scattering. Their unique four-color vision system is unlike any other vertebrate, with half of their neurons dedicated to eyes that are substantial metabolic investments.
In certain fish and frogs, cellular umbrellas shade fragile stem cells from the sun's harmful rays. This discovery highlights an important tool some aquatic animals use to keep crucial blood-cell-producing stem cells safe.
Researchers have developed a system to profile every cell in developing zebrafish and frog embryos, revealing the comprehensive landscape of gene expression events that mark new cell states and types. This work provides a significant resource for studying developmental biology and disease.
Researchers at the National Institute of Genetics have elucidated a neuronal population essential for fear conditioning in zebrafish, revealing a functional equivalent of the amygdala in mammals. This discovery has significant implications for understanding fundamental neural circuits and their evolution.
A CNIC-coordinated project will investigate the oxidative phosphorylation system (OXPHOS) and its structural heterogeneity, with potential implications for metabolic plasticity. Researchers from various countries and specialties will collaborate to develop new methods and gain a deeper understanding of this fundamental biological process.
Dr. Juhyun Lee is using a $154,000 grant from the American Heart Association to develop a microscope that can capture 3-D motion and track gene development in zebrafish. This research could lead to identifying heart abnormalities and diagnosing congenital conditions for potential treatment with gene therapy.
Artificial organelles have been integrated into the cells of living zebrafish embryos, enabling controlled release of pharmaceutical compounds. This innovative approach shows promise for treating diseases and reducing side effects.
Researchers discover protein CEP128 regulates critical cellular processes, including heart development, and its inactivity causes severe malformations in zebrafish. Human cells also show similar effect, providing potential insights into treatments for birth defects and diseases.
Researchers found adult fish change swimming trajectories in response to a change in the Earth magnetic field, even without visible light. They identified a candidate region in the brain that could lead to the discovery of magnetic receptor cells.
Using a stab injury model in adult zebrafish, researchers discovered that neural stem cells can regenerate brain tissues in the optic tectum. New neurons were generated from radial glia through Wnt signaling, providing insights into regenerative processes and potential applications for human CNS restoration.
Researchers found that fish survive polluted stormwater but still suffer sensory damage, affecting food detection, predator sensing, and navigation. Soil-based filtering systems like rain gardens show promise in improving survival, but the benefit varies among species.
A study by CNIC scientists discovered that cardiomyocytes from the innermost heart regions can contribute to the regeneration of the external heart wall in zebrafish. This finding reveals a new way to rebuild a damaged heart and has implications for human heart regeneration.
Researchers at NYU Tandon School of Engineering have created a bioinspired robotic replica that can interact in three dimensions with live zebrafish. The system allows the robot to watch and mimic the behavior of live fish in real-time, promoting social interactions.
Researchers at RIKEN Brain Science Institute identify a neuronal pathway that enables zebrafish to avoid carbon dioxide. The team found that the trigeminal sensory neurons and the habenula play critical roles in detecting carbon dioxide. These findings shed light on the neurobiology behind avoidance behaviors in animals.
Researchers at Oregon State University discovered that exposure to valproic acid, a migraine treatment, causes characteristics similar to autism spectrum disorder (ASD) in zebrafish. The study validated zebrafish as a model for studying ASD and its causes, providing a faster and more efficient alternative to traditional rodent models.
Researchers found zebrafish larvae use 13 different patterns of movement combined in sequences to respond to situations, revealing the 'Lego pieces' of complex behaviors. The study's objective computational method revealed novel features of behavior that are not obvious from human observation.
Researchers discovered that zebrafish exhibit significant spatial memory impairment after a blow to the head, with slower reaction times to familiar environments. Genetic analysis identified key genes involved in brain cell proliferation and migration, offering new insights into potential human recovery strategies.
Researchers at Case Western Reserve University discovered a gene that helps zebrafish convert water motion into electrical impulses, similar to human hearing. The shared gene allows fish to sense water flow direction and may also inform future studies on human hair cell mechanotransduction.