Articles tagged with Zebrafish
A new study published in Nature Communications identifies the cells and genes necessary to make liver ducts in zebrafish, which could lead to the development of new treatments for Alagille syndrome. The research team discovered that Jagged signals come from an unexpected cell type, endoderm-derived cells within the liver itself, stimul...
Researchers found a direct connection between deletions in two genes in the 16p11.2 region of human chromosome 16 and certain brain and body traits, including seizures, hyperactivity, and obesity. The study suggests that multiple genes interact to produce various characteristics.
Jessica Blackburn, a University of Kentucky Markey Cancer Center researcher, has received a $1.5 million NIH New Innovator Award to study leukemia relapse in zebrafish models and patient samples.
A University of Queensland team has made a breakthrough in understanding the vestibular system, which controls balance and movement. Using optical tweezers, they were able to activate the vestibular system without the animal moving, allowing for the study of neural circuits in the brain that mediate vestibular perception.
Researchers found that mechanical tension plays a crucial role in the regeneration of zebrafish hearts, with supersized cells leading the way and smaller cells multiplying to cover the surface. The study's findings open up new possibilities for developing bioengineering approaches to human heart disease.
Researchers developed a method to trace the history of beta-cells in zebrafish, revealing dynamic sub-populations with different developmental histories. These findings have implications for understanding diabetes progression and developing effective strategies for beta-cell regeneration and protection.
Researchers have developed a system allowing zebrafish to self-administer doses of hydrocodone, leading to increased drug-seeking behavior and signs of anxiety. The study provides a new approach to explore the biological pathways behind addiction and withdrawal.
Scientists have developed a system called FreemoVR, which immerses freely-moving animals in a reactive, three-dimensional world controlled by a computer. This allows researchers to study complex interactions of neurons in different brain regions while maintaining natural sensory input and feedback.
Researchers studied zebrafish to understand how early life affects brain development and behavior in adults, finding that visual environment influences spontaneous brain activity. Dark rearing also reduced the larvae's ability to catch prey, suggesting environmental input impacts brain wiring and behavior.
Zebrafish deficient in vitamin E have impaired behavioral development and increased mortality rates, suggesting a link to human neurological health. Dietary supplementation with vitamin E later in life does not fully resolve these issues.
Researchers have pinpointed key molecules that prompt damaged nerve fibres in zebrafish to regenerate themselves. Understanding these signals could hold clues for therapies to help heal the spinal cord after injury.
Researchers at Johns Hopkins Medicine discovered that controlling the immune system's cell reactivity to injury can accelerate eye tissue regeneration in zebrafish. This finding may lead to new strategies for combating degenerative eye diseases in humans.
Research reveals that the left habenula is crucial for rapid recovery from fear-induced immobilization in zebrafish larvae. The study also sheds light on the development and function of the habenular region in regulating fear responses, anxiety, and mood.
Researchers at the University of Minnesota and Smithsonian Conservation Biology Institute have developed a new method for preserving zebrafish embryos using gold nanotechnology and lasers. This breakthrough technique has significant implications for human health, wildlife conservation, and aquaculture.
Researchers have successfully cryopreserved and revived zebrafish embryos using a novel method involving plasmonic gold nanoparticles. The technique has the potential to be applied to other species with similar embryonic sizes and structures, offering a breakthrough in preserving aquatic biodiversity.
Researchers have identified a specific gene mutation in myopathy, a type of muscle disease, and found it plays an essential role in muscle fibre integrity. The study uses a zebrafish model to provide new insights into the genetic basis of the disease.
Researchers at DGIST have successfully measured zebrafish's multi-channel electroencephalogram (EEG) using a non-invasive method. This breakthrough enables precise observation and study on the generation of EEG in specific areas of the brain, with potential applications in developing new drugs for epilepsy syndrome.
A specific protein called prokineticin 2 plays a critical role in setting the correct balance between sleep and wakefulness in response to light and darkness. The study found that Prok2 suppresses the awakening effect of light and the sedating effect of darkness, suggesting a new mechanism for regulating sleep behavior.
A research team created 3D models to analyze zebrafish behavior, revealing significant compromises in 2D-scored behaviors. The study confirmed that 3D approaches underestimate locomotion and overestimate spatial preference, leading to false positives and false negatives.
Researchers found that Vitamin D3 stimulates lipid metabolism through VDR-RXR heterodimers, activating Pgc1a for mitochondrial biogenesis and oxidative metabolism. This study reveals a basal nonskeletal effect of ancient VD/VDR signaling in teleosts.
Researchers at Carnegie Institution develop a method to visualize and measure lipids in real-time as they are metabolized by living fish. This breakthrough allows for a better understanding of cellular functions and the role of lipids in health problems such as cardiovascular disease and diabetes.
Scientists at the University of Queensland have identified a new type of lymphatic brain cell in zebrafish that surrounds the brain and clears damaging cellular waste. This discovery provides insight into how the brain forms and functions, potentially leading to new treatments for neurological diseases like stroke and dementia.
Researchers at Japan's National Institute of Genetics discovered a direct neural link connecting the brain's visual system to its feeding center, linking visual perception of food to feeding motivation. This study, using genetically engineered zebrafish, shows that 'eating with the eyes' is deeply rooted in evolution.
Researchers have found that pain relief medication can ease the discomfort of zebrafish larvae, offering a potential replacement for adult fish used in scientific research. This breakthrough reduces animal suffering and paves the way for more humane testing methods.
Researchers have determined that fluorescent granular perithelial cells, which protect the brain against diseases, arise from endothelial cells in the circulatory system. This finding may contribute to understanding cognitive decline of aging and HIV infection of brain cells.
Researchers have identified a key gene in zebrafish that causes congenital blindness, which could hold the key to treating a similar disease in humans. The study found that the gene affects cone photoreceptors and leads to degeneration without impacting rod cells.
Researchers have successfully visualized the development of blood vessels in zebrafish embryos without labels or contrast agents, enabling better understanding of brain and cardiovascular diseases. The new study uses optical resolution photoacoustic microscopy to provide three-dimensional images with high spatial resolution.
Michigan State University is using a $727,000 grant from the National Institutes of Health to study the connection between fish genes and human medicine. The team, led by Ingo Braasch, is focusing on the spotted gar, a fish with a similar genome to humans and zebrafish.
Dowling-Degos disease patients with PSENEN gene mutations display unusual pigment cell behavior in zebrafish, leading to similar skin patterns. The discovery provides new insights into the causes of acne inversa and its link to the genetic disorder.
Scientists have identified GABA as a signal that triggers self-repair in fish retinas. They believe this could be the key to regenerating human retinas, naturally repairing damage caused by degenerative diseases. The researchers are now pursuing further studies with mice and zebrafish to confirm their findings.
Researchers discovered that decreased levels of neurotransmitter gamma-aminobutyric acid (GABA) trigger the retina to produce stem cells in zebrafish, shedding light on retinal regeneration. The finding informs efforts to restore vision in people who are blind and has implications for regenerative medicine.
Scientists have examined the globin gene cluster in zebrafish to understand 3D genome folding and its relationship to gene expression. They found that adult and embryonic globin genes are spatially separated in the genome, with distinct chromatin domains and organization.
Short bowel syndrome results in significant changes to gene expression, including increased cell proliferation and immune response. The study provides a map of these alterations, potentially leading to new therapies for SBS patients.
Researchers studying zebrafish found that early improvements in balance emerge from growing ability to execute quick swims in response to instability. Zebrafish learn to correct movements and become more stable over time.
A team of researchers from NYU Tandon School of Engineering has developed a 3D platform to simulate zebrafish behavior, which can potentially replace animal testing in certain types of research. The model was calibrated on real-life data and allows for rapid simulations that reduce the need for animal subjects.
DBA's molecular mechanisms involve ribosomal protein deficiency, leading to p53 pathway activation and microRNA34A-mediated decreased red blood cell formation. Exogenous nucleosides may alleviate symptoms by reducing DNA damage response and increasing energy metabolism.
Researchers have successfully used Bdellovibrio bacteriovorus, a predatory bacterium, to clear multi-drug resistant Shigella infections in zebrafish. The bacteria works alongside the host's immune system, showing promise as a living antibiotic for tackling drug-resistant Gram-negative bacterial infections.
A University of Pittsburgh researcher has successfully regenerates heart tissues in mice using components from zebrafish, a skill lost among humans and other mammals. Human heart cells have also shown promising results in vitro, paving the way for potential treatments for heart disease.
Researchers found that common probiotic Lactobacillus plantarum decreases stress-related behavior and anxiety in zebrafish, leading to increased signaling of neurotransmitters. Probiotics may have a positive impact on human stress levels, as their effects on the central nervous system are being studied.
This study proposes zebrafish as a model to predict EDCs effects on humans. Key genes vitellogenin and aromatase cytochrome P450 were monitored in zebrafish to detect EDC presence, offering new mechanisms for reproductive status alteration.
A new study published in PLOS Biology found that a program teaching biology through raising zebrafish from embryos improves students' knowledge of scientific concepts and their attitudes towards science. The program, BioEYES, was shown to be particularly effective in engaging underrepresented minorities.
A five-year study found BioEYES significantly improves elementary, middle school, and high school students' science knowledge and positive attitudes towards science. The program increased students' ability to imagine themselves as scientists, with the greatest effect on attitude changes among younger students.
The BioEYES program using live zebrafish teaches basic scientific principles and increases students' science knowledge and positive attitudes. Elementary students showed the greatest attitude changes.
Researchers at Duke University have identified a crucial protein, CTGF, essential for spinal cord regeneration in zebrafish. By introducing the human version of CTGF, they were able to boost regeneration and improve swimming abilities in fish.
Scientists have found a key protein, connective tissue growth factor A (ctgfa), that facilitates spinal cord regeneration in zebrafish. The protein promotes the formation of bridges across damaged tissue, leading to improved healing outcomes.
Researchers at MDI Biological Laboratory found that early-life stress increases adult vulnerability to diseases like arthritis, asthma, cancer, diabetes, heart disease, and mental illness. Chronic exposure to cortisol in zebrafish embryos leads to abnormal immune systems and signs of chronic inflammation.
Researchers at NYU Tandon School of Engineering discovered zebrafish are more attracted to 3D-moving robotic models of themselves than other stimuli. The team used a controllable robotic platform to study freshwater fish behavior, exploring mechanisms behind human disorders like anxiety and schizophrenia.
A new study published in Cell Reports identifies two proteins relevant to Alzheimer's disease, Interleukin-4 and STAT6, which play a crucial role in neural stem cell proliferation and formation of new neurons. This discovery offers hope for the development of regenerative therapies for Alzheimer's.
A recent study suggests that manipulating the immune response in adult zebrafish brains could lead to the activation of neural stem cells and the proliferation of new neurons. This finding has significant implications for the potential development of novel therapies against Alzheimer's disease.
A study led by Duke University researchers found that blocking the production of a key receptor can reduce the toxicity of cigarette smoke on zebrafish embryos. The receptors were found to play a role in early embryonic development, particularly the formation of bone, heart and muscle tissues.
Systems biologist Jan Philipp Junker and molecular geneticist Gaetano Gargiulo have each received a €1.5 million ERC Starting Grant to study cellular processes in zebrafish and glioblastoma, respectively. Their research aims to understand the mechanisms behind variable phenomena in developmental biology.
Researchers used live zebrafish and 3D microscopy to track interactions between gut bacteria, finding that mechanical contractions play a vital role in shaping communities of intestinal microbiota. This discovery offers new insights into the problems experienced by humans with Hirschsprung's disease.
Scientists have discovered that zebrafish are susceptible to arthritis, mirroring the condition in humans and other mammals. The study uses zebrafish as a model to accelerate therapeutic research into preventing or easing osteoarthritis.
Researchers have discovered specific cell types and mechanisms responsible for orientation selectivity in the retina of zebrafish, shedding light on how we perceive and recognize visual stimuli. The study reveals that mutating a key protein called Teneurin-3 leads to a loss of orientation selectivity in neurons.
Researchers found that eliminating α-synuclein protein protects zebrafish from ziram-induced dopamine loss and provides potential treatment for pesticide-exposed Parkinson's patients. This study supports the approach of targeting α-synuclein to slow or stop disease progression in most people with Parkinson's.
Researchers found that repairing mutated cilia genes restored cerebrospinal fluid flow and prevented spinal curves from developing in zebrafish. If translatable to humans, the study could lead to a non-surgical approach for treating idiopathic scoliosis.
Researchers discuss zebrafish as a model system for studying normal hematopoiesis and blood disorders. The review highlights the knowledge gained from studies of zebrafish, including large-scale forward genetic screens and modeling of human genes to create transgenic zebrafish.
Researchers discovered that macrophages can grab and repair broken blood vessel ends in zebrafish brains, suggesting a potential natural repair mechanism for microbleeds. This process, observed over three hours, involved adhesion molecules and mechanical traction forces.
A deep-brain structure called the habenula contains two neural circuits that influence whether a fight will be won or lost in zebrafish. The circuits regulate surrender or continuing aggression based on activity levels in different sub-regions, suggesting a dynamic mechanism for determining fight outcomes.
Researchers used whole-brain imaging to study larval zebrafish behavior in plain surroundings. They found alternating left and right turn states in the brain, leading to spontaneous chaining of turns that deviate from random walks.