For fish, fear smells like sugar
Fish release a 'scary stuff' signal when injured, containing chondroitin sulfate that alerts nearby fish to flee. This discovery provides insight into the nature of fear in fish.
Zebrafish
Articles tagged with Zebrafish
Live from the thymus: T-cells on the move
Researchers at Max Planck Institute observe maturation of immune cells in live zebrafish embryos, finding they migrate into and out of thymus multiple times. This process is driven by chemokines alone and is independent of blood circulation.
UMass Amherst neurobiologists identify animal model for a deadly human metabolic disorder
Researchers created a zebrafish model to study Maple Syrup Urine Disease, which causes brain injury and severe dystonia. The model reveals abnormal swimming behavior and neurotransmitter imbalances, shedding light on disease mechanisms.
Gene mutation is linked to accumulation of fat, other lipids in liver
A study in zebrafish reveals that a gene mutation affects ketone body transport, leading to lipid accumulation in the liver. This discovery provides new insights into nonalcoholic fatty liver disease (NAFLD) and its link to energy metabolism.
Zebrafish may help speed drug discovery
Researchers use zebrafish to quickly assess potential compounds, reducing the number of candidates from 2,500 to 20-30 for further testing. This technology has the potential to revolutionize drug discovery by providing more thorough information about how compounds affect living organisms.
Long intervening non-coding RNAs play pivotal roles in brain development
Researchers identified conserved lincRNAs that affect brain development in zebrafish and found that their human versions have similar functions. The discovery provides a framework for studying lincRNAs, which are abundant but poorly understood molecules.
Fish may provide key to stopping disease spread, Wayne State University researcher says
A Wayne State University researcher is using zebrafish to study the spread of cholera and develop new treatments. The bacteria, Vibrio cholerae, can cause severe diarrhea and death if ingested by humans.
Testing antioxidant drugs is transparent
A team of scientists created a genetically modified zebrafish model that can visualize early events in human atherosclerosis. The model, which is efficient and cost-effective, allows researchers to test the potential effectiveness of new antioxidant and dietary therapies.
SourceUniversity of California - San Diego·JournalJournal of Clinical Investigation·DateNov 21, 2011
Mechanism uncovered for the establishment of vertebrate left–right asymmetry
A research team at the Hubrecht Institute demonstrates a mechanism by which left–right asymmetry in vertebrates is established and maintained. The study reveals a genetic midline 'barrier' that induces and maintains Nodal and BMP proteins to pattern the embryo along the left–right axis.
Growth hormone helps repair the zebrafish ear
Researchers found that growth hormone stimulates cell proliferation in zebrafish inner ears, particularly those of the utricle vestibular organ involved in balance. This discovery may lead to new treatments for human hair cell loss and ear injuries.
Repairing our inner clock with a 2-inch fish
A team of researchers has identified a common mechanism between humans and zebrafish that regulates the circadian system. The discovery, published in PLoS Biology, could lead to new treatments for mental illness, metabolic diseases, and sleep disorders.
Research in fish provides new clues about deadly form of liver cancer
Researchers used zebrafish to investigate the deadly form of liver cancer and uncovered a genetic signature that could aid in diagnosis. They also identified specific markers for early- and late-stage cancer, which may inform treatment regimes.
New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
Researchers have created a new model using striped zebrafish to screen drugs for Cushing disease, allowing for rapid identification of effective treatments. The model has already shown promise with one drug suppressing hormone secretion and cortisol levels.
SourceCedars-Sinai Medical Center·JournalProceedings of the National Academy of Sciences·DateMay 9, 2011
In a genetic research first, Mayo Clinic turns zebrafish genes off and on
Researchers at Mayo Clinic's Zebrafish Core Facility successfully switched individual genes on and off in zebrafish, allowing them to observe embryonic and juvenile development. This breakthrough enables the study of protein function and its relation to health problems like cancer, heart attacks, and addiction.
Scripps Research scientists create new genetic model of premature aging diseases
Researchers have developed a genetic model of premature aging disorders in zebrafish, which can be used to screen and develop compounds to treat these conditions. The model reveals that a specific gene mutation leads to accelerated aging in the fish, providing new insights into age-related diseases.
Neural guidance gene regulates liver development
Scientists have discovered that a gene regulating neuronal cell migration also plays a crucial role in liver organogenesis. The navigation gene nav3a optimizes cytoskeletal modulation, guiding cells to form the liver. Dysregulated expression of nav3a may be involved in human liver diseases.
Researchers use zebrafish to identify new gene linked to melanoma
Researchers have identified a new gene, SETDB1, that promotes the growth of melanoma and may play a role in up to 70 percent of malignant melanomas. The discovery was made using zebrafish and could lead to better therapeutic strategies for patients with melanoma.
2 new targets for melanoma therapies
Researchers found two new proteins that accelerate melanoma in zebrafish models, SETDB1 and DHODH, which could lead to new treatments. Leflunomide, an arthritis drug, also showed promise by blocking the production of RNA nucleic bases, a key step in cancer cell growth.
Earning its stripes
A new gene called SETDB1 has been found to promote melanoma growth and invasion in a zebrafish model. The researchers also discovered that SETDB1 is present at high levels in 70% of human melanoma samples, suggesting its potential role in the formation of most cases.
New research tool targets microRNA expression in zebrafish
Researchers have developed a novel method for measuring microRNA expression in specific tissues of developing zebrafish embryos. This technique uses digoxigenin-labeled riboprobes for in situ hybridization, enabling the study of miRNA's role in embryonic development and disease mechanisms.
What's in a name? Broadening the biological lexicon to bolster translational research
Developmental biologist Hazel Sive proposes using the term 'tool' to define biological systems that don't accurately recapitulate human disorders, but provide valuable insights. These 'tools' can be used in loss-of-function studies and screening for chemicals that affect gene activity, potentially leading to therapeutic targets.
SourceWhitehead Institute for Biomedical Research·JournalDisease Models & Mechanisms·DateMar 9, 2011
Wellcome Image Awards 2011
The Wellcome Image Awards 2011 highlight the diversity of images available through the Wellcome Library's image repository. The winners use various techniques to capture the wonder of medicine and the life sciences.
Mayo researchers, Rochester educators, students to present at science conference
A collaboration between Mayo Clinic and local educators has resulted in improved science test scores and increased participation in the Minnesota science fair. The project, InSciEd Out, introduced a new curriculum that incorporates zebrafish research into the classroom, with positive outcomes for grades six to eight.
UT researchers link algae to harmful estrogen-like compound in water
Researchers found that blue-green algae may produce an estrogen-like compound, disrupting reproductive hormones and affecting fish, plants, and human health. Exposure to the algal cells induced a response consistent with estrogen exposure in larval fish.
SourceUniversity of Tennessee at Knoxville·JournalEnvironmental Science & Technology·DateFeb 16, 2011
Researchers unlock the potential for exploring kidney regeneration
Researchers at Brigham and Women's Hospital have identified a progenitor cell in adult zebrafish kidneys that can be transplanted to generate new nephrons. This finding offers hope for improving kidney function and treating renal disease.
Zebrafish provide new hope for cancer treatment
Researchers used zebrafish to track the behavior of cancer cells and immune cells, discovering that cancer cells produce hydrogen peroxide to attract immune cells. This co-option of the immune system allows tumors to grow and spread, but blocking this interaction can prevent tumor formation.
Scientists find gene linked to congenital heart defect
Researchers at Princeton University discovered a gene, CCDC40, associated with congenital heart defects in humans. The gene controls right-to-left patterning and is also linked to respiratory disorders.
Zebrafish reveal exquisite workings of the brain
The study reveals the discovery of superficial interneurons, a type of inhibitory neuron that blocks communication about large stimuli, allowing small prey to be detected. The findings provide insights into the neural basis of tracking prey and offer new perspectives on brain function.
The zebrafish's neural circuit prevents it from biting off more than it can chew
Researchers have solved some of the mysteries of the zebrafish's neural circuit that underlies its vision. By analyzing the brain activity of retinal cells, they found that large visual stimuli are filtered out to prevent overreacting, while small moving objects activate the output neurons efficiently.
Zebrafish yield clues to how we process visual information
Scientists imaged individual neurons in zebrafish optic tectum, finding that strong activation leads to chasing motion, while weak activation results in no action. Inhibitory neurons play a key role in filtering out irrelevant signals.
NC State develops more precise genetic 'off switches'
Researchers at NC State University have developed a new methodology to precisely control and study gene function in localized areas of developing organisms. By using UV-light activated 'off switches' called morpholino oligonucleotides, scientists can now turn off specific genes only when exposed to UV light.
SourceNorth Carolina State University·JournalJournal of the American Chemical Society·DateOct 28, 2010
These dendritic cells are fishy, but that's a good thing
Researchers have identified dendritic cells in zebrafish, opening up new possibilities for studying the complexities of the human immune system. The discovery provides another model for investigating the mammalian immune system, particularly with regard to humans.
SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·DateSep 7, 2010
MIT creates technology for high-speed study of zebrafish larvae
Engineers at MIT develop a new technique to analyze zebrafish larvae in seconds, speeding up the process and enabling large-scale studies of human diseases. The technology uses high-resolution imaging to directly observe internal organs and allows for rapid analysis of thousands of vertebrates.
Digital embryo gains wings
Researchers at EMBL developed a technique to capture high-quality images of fruit fly embryos and zebrafish development, revealing previously unseen details. By combining multiple images and angles, scientists can now study complex processes in real-time.
EMBL picture release: Developing zebrafish patchwork
Scientists at EMBL discovered that a molecular signal triggers cell shape change necessary for zebrafish lateral line development. This change in shape allows cells to migrate properly along the embryo's sides, forming a rosette structure.
For the first time, scientists capture very moment blood flow begins
Researchers observed that early blood flow begins all at once in zebrafish embryos, involving hundreds of cells. Red blood cells initially stick to the vessel wall before releasing themselves with a protease enzyme called ADAM8.
Following the sugar right from the start
Researchers have successfully attached imaging probes to glycans in zebrafish embryos just seven hours after fertilization, allowing for the first-ever images of glycan activity on embryonic cells. This new technique enables scientists to study physiological changes during embryogenesis without damaging the embryos.
SourceDOE/Lawrence Berkeley National Laboratory·JournalProceedings of the National Academy of Sciences·DateMay 28, 2010
Singapore scientists develop zebrafish model for studying Parkinson's disease
Researchers at the Genome Institute of Singapore have developed a zebrafish model to study Parkinson's disease, which can aid in drug development and screening. The model demonstrates that zebrafish can be used to study human diseases, including PD, and has potential for large-scale drug screening.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalPLOS Genetics·DateApr 22, 2010
Zebrafish swim into drug development
Researchers at Vanderbilt University Medical Center used zebrafish to identify novel compounds that selectively target bone-related diseases and cancer. By leveraging the zebrafish model, they discovered potent BMP inhibitors with improved selectivity, bypassing off-target effects.
Zebrafish behavior monitoring system could boost drug discovery: UBC-Harvard research
A new zebrafish behavior monitoring system has been developed to capture on video and barcode the behavioral responses of fish to chemicals, allowing for rapid identification of new compounds. The system has already identified new chemicals affecting fish behavior and holds promise for treating nervous system disorders.
Zebrafish journal publishes cancer biology special issue
Researchers utilize zebrafish to study human cancer, leveraging transplantable tumors, genetic models, and transgenic fish to understand tumor development and metastasis. The special issue presents innovative approaches for modeling human cancer in zebrafish.
A master mechanism for regeneration?
Researchers at the University of Michigan have found that genes involved in fin regeneration and heart repair are also required for rebuilding damaged light receptors in the eye. The study suggests that a common molecular mechanism guides the process, no matter what body part is damaged.
SourceUniversity of Michigan·JournalProceedings of the National Academy of Sciences·DateOct 19, 2009
Spare gene is fodder for fishes' evolution
Researchers found a duplicate copy of a gene involved in embryonic development has taken on a new role in the formation of fish scales. This discovery supports the idea that gene duplication can provide raw materials for evolutionary change, as seen in domesticated carp with reduced scales.
Drug-proof zebrafish reveal secrets of addiction
Researchers discovered a set of genes that respond inappropriately to amphetamine in 'drug-proof' zebrafish mutants, which do not experience the drug's pleasurable effects. This finding suggests a link between adult neurogenesis and addiction, with potential implications for understanding susceptibility.
Pitt team finds molecule that regulates heart size by using zebrafish screening model
Researchers at the University of Pittsburgh have identified an enzyme inhibitor that increases cardiac progenitor cells and influences heart development in zebrafish. The findings have broad implications for understanding heart development and improving treatments for damaged or diseased tissues.
SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalNature Chemical Biology·DateJul 5, 2009
Zebrafish provide a model for cancerous melanoma in humans
Scientists use zebrafish to investigate the role of RAS mutations in melanoma formation and progression. The research found that altering signaling pathways can reduce the effects of RAS mutations, providing a potential therapeutic approach.
Zebrafish offer clues to treatments for motor neurone disease
Scientists at the University of Edinburgh have discovered that zebrafish can produce motor neurones after spinal cord damage, offering a potential stem cell treatment for humans. Researchers are now screening small molecules to find drugs that could kick-start motor neurone regeneration.
Alzheimer cell death in zebrafish: Demise of neurons observed live for the first time
Scientists successfully observed extensive nerve cell death in zebrafish with a severe form of Alzheimer's disease, enabling targeted search for drugs to stop dementia. This breakthrough allows for the testing of drugs on living organisms.
SourceLudwig-Maximilians-Universität München·JournalJournal of Clinical Investigation·DateApr 14, 2009
JCI online early table of contents: April 13, 2009
A team of researchers has identified a class of drugs that may enhance the therapeutic effects of imatinib mesylate in treating chronic myeloid leukemia. They also developed a zebrafish model for screening potential therapies for Alzheimer's disease and identified a molecular mechanism underlying aggressive prostate cancer.
Mutated gene in zebrafish sheds light on blindness in humans
Researchers at Florida State University have identified a mutated gene in zebrafish that determines the development of photoreceptors, which could provide new insight into inherited retinal diseases in humans. The study, published in PNAS, reveals the genetic switch responsible for cells developing as rods or cones.
SourceFlorida State University·JournalProceedings of the National Academy of Sciences·DateMar 24, 2009
Phylonix granted broad US patent for assessing cardiac functions in zebrafish
Phylonix received a broad US patent for its zebrafish-based assays to assess cardiac functions and toxicity. The company's eZ-ScreenTM technology enables thorough assessment of cardiotoxicity during early stages of drug development, leveraging the speed and cost-effectiveness of the zebrafish model.
Why 'lazy Susan' has a weak heart
Heidelberg cardiologists have discovered a single amino acid mutation that can severely limit heart function in zebrafish, a model similar to the human genome. The researchers hope to develop new therapies for patients with cardiac insufficiency by targeting this mutation.
Transparent zebrafish a must-see model for atherosclerosis
Researchers used transparent zebrafish to study atherosclerosis development, revealing plaque buildup in blood vessels. The study showed that ezetimibe significantly improved vascular wall thickness and barrier function.
Zebrafish journal publishes skin pigmentation studies that shed light on the evolution of race
Researchers explore genetic mechanisms of skin color in zebrafish, a model organism for understanding human skin color and race. The studies shed light on the evolution of skin pigmentation and its relationship to environmental factors.
NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
Phylonix Pharmaceuticals has been awarded a Phase II SBIR grant from the NIH to develop high-throughput in vivo zebrafish assays for assessing Cytochrome P450 drug metabolism and safety. The assay will accelerate drug metabolism and safety profiling, reducing costly late-stage development failures.
Mutations common to cancer and developmental disorder examined in a novel disease model
Researchers have identified a novel zebrafish model of Costello syndrome, a developmental disorder caused by mutations in the H-RAS gene. The study reveals that activated H-RAS promotes overabundant cell growth and hallmarks of Costello Syndrome, including heart defects and physical deformities.
Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
Researchers use zebrafish to track GnRH neurons' migration, a critical step in pubertal development. The study aims to understand molecular mechanisms behind delayed puberty and its causes, such as Kallmann syndrome.
New technique allows targeted inactivation of genes in research model
Researchers at UMass Chan Medical School have developed a new technique to target individual genes for inactivation in zebrafish embryos using engineered zinc-finger nucleases. This method has the potential to answer questions that were previously out of reach and will fundamentally change how researchers make knockouts in model organi...
MicroRNAs help zebrafish regenerate fins
Biologists at Duke University Medical Center have discovered microRNAs that control the regeneration of zebrafish fins. The study found that reducing levels of one microRNA, miR-133, speeds up fin regrowth, while increasing it slows it down. This discovery could lead to new ways to stimulate human tissue regeneration.
A screening strategy using zebrafish targets genes that protect against hearing loss
Researchers developed a zebrafish-based screening strategy to identify genes and chemical compounds that protect against hearing loss caused by ototoxic medications. The study identified five mutations in genes that, when inherited, protected hair cells from damage.