Research on malaria and the fight against it. Covers red-blood-cell inflammation, malaria resurgence, drug-resistant parasites, and mosquito-based control.
The world invested more than $200 billion to improve health in lower-income countries between 2000 and 2014. Despite a significant increase in funding after the Millennium Development Goals were established, global health financing stagnated between 2010 and 2014.
A systematic review and meta-analysis of 90 studies found residents of modern homes were 47% less likely to be infected with malaria than those living in traditional houses. Modern housing features, such as closed eaves, ceilings, screened doors and windows, can block mosquitoes from entering homes and prevent transmission of the disease.
Ruth S. Nussenzweig, Victor Nussenzweig and Tu Youyou will share the unrestricted award of $500,000 for their groundbreaking discoveries in chemistry and parasitology that have resulted in treatments saving lives globally.
The March of Dimes Foundation has funded a Portuguese laboratory to study factors that act in the placenta to protect the fetus from malaria. The research focuses on trophoblast cells, which are crucial for maternal-fetal exchanges of nutrients and gases.
Researchers have identified two genetically divergent subpopulations of P. knowlesi in human cases, each associated with a different species of reservoir host. This discovery highlights the complexity of zoonotic malaria transmission and may lead to new possibilities for parasite adaptation to humans.
A study in Nigeria found that 9.3% of antimalarial drugs purchased in Enugu were of poor quality, while 1.2% were falsified and 6.8% substandard. The results highlight the need for improved drug regulation and monitoring to protect patients from receiving ineffective or harmful treatments.
Researchers found that a viral co-infection with Epstein-Barr virus can suppress the immune response to malaria in mice, leading to severe anemia. The study suggests that similar effects may occur in humans, particularly young children living in malaria-endemic areas.
Co-infection with Epstein-Barr virus (EBV) may make a survivable malaria parasite infection lethal, according to experimental results with mice. EBV infection can suppress the immune system, allowing malaria parasites to take hold.
Researchers have discovered a novel antibody insecticide that targets the African malaria mosquito, offering an alternative control strategy to halt the spread of the disease. The antibodies work by targeting a key component of the mosquito's nervous system, killing over 90% of infected insects within a day.
A new model systematically evaluates malaria treatment programs in multiple countries, finding no country shows reductions in malaria treatment associated with testing as hypothesized. Contextual factors such as access to care and stockouts largely explain the variation in program experiences.
Researchers at Harvard T.H. Chan School of Public Health have identified a critical host factor, CD55, that enables the malaria parasite to invade human red blood cells. The discovery opens up new avenues for developing therapies to treat and prevent malaria.
A research team from Griffith's Eskitis Institute led by Professor Vicky Avery receives a major boost to develop effective anti-malarial drugs against Plasmodium falciparum and Plasmodium vivax. The project aims to combat drug resistance and prevent relapse.
A study by Lisa White and colleagues found that parasite half-life is a key predictor of artemisinin-resistant malaria, but the current definition of resistance is inaccurate. The researchers suggest refining the definition to account for parasite load at the start of treatment.
Researchers developed a model of a malaria-infected red blood cell to understand the mechanism behind stiffening and stickiness. The model found that protein nodules called knobs contribute to stiffness, suggesting a promising approach to treat the disease by softening the cells.
Researchers have pinpointed a new mechanism responsible for the progression of malaria, which could lead to new therapies. The study found that nanoscale knobs on infected red blood cells cause cell stiffening and reduced blood flow.
The RTS,S/AS01 vaccine candidate demonstrates partial protection against clinical malaria in young African children, with efficacy increasing with a booster dose. The vaccine's impact on severe malaria and hospitalizations is also significant, especially in areas of high transmission.
New estimates suggest that the West African Ebola outbreak could have resulted in comparable number of malaria deaths as those due to Ebola itself. Implementing mass drug administration and ITN campaigns may largely mitigate the impact of Ebola on malaria.
Researchers discovered that combining artemisinins with a low dose of an anti-cancer drug can increase the effectiveness of anti-malarial drugs and overcome the parasite's defences. This finding has the potential to combat resistant malaria parasites, which are currently spreading globally.
Researchers at London School of Hygiene & Tropical Medicine discovered a genetic mutation in the ap2mu gene that makes Plasmodium falciparum malaria parasites less susceptible to artemisinin and quinine. This finding suggests a different route to drug resistance may be developing independently in Africa.
Researchers at Notre Dame have made a breakthrough discovery in understanding the mechanism of artemisinin resistance in malaria. They found that a specific lipid called phosphatidylinositol-3-phosphate (PI3P) is produced by an enzyme called PfPI3K, and its levels are linked to artemisinin resistance.
A new study found that 79% of southeast African birds were infected with haemosporidian parasites, including novel malaria parasite lineages. The study's findings indicate that lifestyle characteristics of birds can influence their association with different parasite genera.
A new study by University of California - Berkeley Haas School of Business researchers found that offering purchase subsidies to retailers can increase the availability and affordability of malaria drugs. This approach is particularly effective for long-shelf life products, such as ACTs, which are considered the best anti-malarial drugs.
Researchers found that certain red blood cell variants, such as HbAS, correlated with protection from malaria in early childhood. Additionally, a genetic condition known as homozygous X-linked G6PD deficiency reduced malaria risk in girls, while HbC-trait increased risk.
Research finds that malaria-infected cells produce specific terpenes attractive to mosquitoes, which can be detected in breath or sweat. This discovery may lead to new diagnostic tests and improve malaria control by understanding mosquito attraction.
A new genetic method called MCR enables biologists to rapidly generate mutations in both copies of a gene, accelerating genetic research on diverse species. This method has the potential to control insect-borne diseases such as malaria and animal/plant pests by disseminating genetic elements with high efficiency.
Researchers have discovered a naturally occurring chemical, cedrol, that attracts pregnant malaria-transmitting mosquitoes, offering a new way to control mosquitoes. The team found that the chemical increased the likelihood of female mosquitoes laying eggs in treated water by two to three times.
Researchers discovered that brain swelling is the cause of death in children with cerebral malaria, which may lead to new treatments targeting the swelling. The study's findings could help reduce mortality rates from malaria in Africa, where the disease still claims thousands of lives each year.
A groundbreaking study by MSU doctors discovered that brain swelling is the cause of death in children with cerebral malaria. This breakthrough knowledge will help develop new treatments targeting the swelling, which may save lives by using ventilators to keep children breathing until the swelling subsides.
A two-year study found malaria incidence on the rise in rural Uganda, defying global trend of decline, due to inadequate current interventions. The study suggests a need for scaling up bednet distribution and considering new prevention measures.
Researchers from Karolinska Institutet identified the key role of RIFIN protein in protecting blood type O individuals from severe malaria. The protein binds strongly to A blood cells but weakly to O, explaining why O individuals are less susceptible to the disease.
Researchers developed ultra-sensitive detection methods for malaria parasites, detecting 58% of infections in human blood samples at low concentrations. The new assays surpass current standards, identifying 16% more cases and reducing false negatives.
Researchers from the University of South Florida have discovered how malaria parasites replicate their chromosomes up to thousands of times before spinning off into daughter cells. This understanding could lead to a powerful new treatment for malaria-caused illnesses, which kill over 600,000 people annually.
A study by University of Miami researchers found dengue virus circulating in urban areas of Ghana, with 21.6% of malaria patients tested positive for long-lasting dengue IgG antibodies, indicating lifetime exposure. The findings suggest that up to one-third of all outpatient visits could be misdiagnosed as malaria.
Researchers found that male mosquitoes' reproductive traits evolved with their capacity to transmit malaria, leading to new targets for control. The study reveals key factors driving mosquito ability to spread the Plasmodium parasite.
Researchers at University of British Columbia discover that parasites in the apicomplexan family evolved to become parasites earlier than thought, with some relatives being photosynthetic algae. Advanced genomic analysis and observations of cell structure and behavior reveal a more complex evolutionary history.
A study confirmed artemisinin-resistant malaria parasites in Homalin, Sagaing Region, Myanmar, just 25km from the Indian border. This finding poses a significant threat to global control and eradication of malaria, as drug resistance spreads from Asia to Africa and potentially emerges independently.
Scientists at University of California - San Diego School of Medicine developed a malaria parasite protein produced by algae, generating antibodies in mice that nearly eliminated mosquito infection. The method uses an affordable and environmentally friendly approach to prevent malaria transmission from host to mosquito.
Researchers are using satellite data to target deadly parasites by identifying areas where disease flourishes. The project combines skills from various scientists to create maps accessible to countries with limited capacity for managing disease data.
A study by University of Veterinary Medicine -- Vienna researchers has identified avian malaria in 15% of examined wild birds in Austria, showing that native bird populations are susceptible to the disease. Three different Plasmodium species were also found, with one new species still requiring analysis and classification.
A new study by University of Pennsylvania researchers found that mosquitoes increase production of immune system proteins called leucine-rich repeat immune proteins (LRIMs) after feeding on blood, which helps fight off parasites that may be present in the blood.
Researchers at MIT have discovered a way to grow liver-like cells from induced pluripotent stem cells that can be infected with several strains of the malaria parasite. These cells offer a plentiful source for testing potential malaria drugs, which are badly needed due to emerging drug resistance.
Eve, an AI robot scientist, has demonstrated the success of its approach to speed up drug discovery and make it more economical. It discovered a compound that has anti-cancer and malaria properties, which could potentially improve the lives of millions of people worldwide.
A large study in sub-Saharan Africa found that vitamin A supplementation reduced malaria risk in children by 54% if administered during the wet season and to older children. The researchers suspect vitamin A boosts immunity and helps clear out the malaria parasite more quickly.
Researchers at Harvard T.H. Chan School of Public Health discovered a link between food intake during early infection stages and disease outcome. Reducing leptin levels or using pharmacologic inhibitors protected against cerebral malaria in mouse models.
Researchers discovered that mild malaria infections in birds accelerated telomere shortening, leading to premature death. Infected individuals produced fewer offspring despite no visible symptoms.
A University of Michigan-led research team found that combining bed nets and certain malaria vaccines can lead to increased morbidity and mortality in older age classes. The study suggests that the joint use of bed nets and some malaria vaccines may make the problem worse, contradicting previous assumptions.
Researchers estimate best times for mass drug treatment and house spraying to combat malaria, finding optimal seasons to target mass drug administration during the low season and house spraying just before the high season. The study's findings can help optimize combination of existing interventions and inform novel control measures.
A hybrid of two malaria mosquito species has been found to be highly resistant to insecticide-treated bed nets, threatening efforts to control malaria in Africa. The discovery highlights the urgent need for new and effective vector control strategies.
Researchers at UMass Amherst found a whole plant therapy more effective than purified drug artemisinin in killing malaria parasites, even those resistant to the pharmaceutical treatment. The study suggests using the whole plant may be a sustainable alternative for treating human malaria.
Researchers found that a new malaria treatment combination of artemisinin-naphthoquine was non-inferior to existing therapy for uncomplicated malaria caused by Plasmodium falciparum, but more effective against another species. The study suggests this regimen could be considered for children in settings with multiple parasite species.
A research team has sequenced the genomes of 16 Anopheles mosquitoes, revealing new insights into how they adapt to humans as primary hosts of malaria. The findings suggest an underlying genetic/genomic plasticity that enables variation in key traits determining transmission capacity within the genus.
A study revealed that malaria parasites change surface proteins every 48 hours to hide from the immune system, creating millions of new variants. This rapid evolution makes it difficult to develop an effective vaccine against the disease.
The National Institute of Allergy and Infectious Disease has awarded a new contract to develop the Eukaryotic Pathogen Genomics Database, providing free access to genomic data related to pathogens important to human health. The database encompasses disease-causing eukaryotes and includes over 3,000 genomes from more than 300 species.
NTU scientists have identified two major ways malaria parasites become resistant to Artemisinin, a key front-line drug. The breakthrough findings will help doctors design new treatment cocktails and monitor drug resistance more effectively.
Scientists at IRB Barcelona have identified two derivatives of borrelidin that completely remove the parasite load from mice and confer immunological memory to fight future infections. These compounds act on the protein production machinery of the parasite, making them efficient in all phases of infection.
Researchers at the University of Basel have developed nanomimics of host cell membranes that trick malaria parasites. These nanomimics effectively disrupt the parasite's cycle, blocking its invasion of new red blood cells while exposing it to the immune system.
Researchers at Texas Biomed are using new genomic tools to analyze individual malaria parasites, allowing for more effective treatment and vaccine design.
A new study in The Lancet has found that combining insecticide spraying with bed nets offers no additional protection against malaria. In fact, the researchers suggest that investing more resources into providing bed nets may be a more effective solution to tackle malaria, as it is a low-cost and cost-effective method.
A study published in The Lancet found that using insecticide-treated bed nets alone is sufficient to protect children from malaria in areas with low or moderate transmission. Researchers led by Durham University concluded that combining wall sprays and bed nets does not offer additional protection against the disease.
A promising anti-malarial compound, (+)-SJ733, has been identified that rapidly destroys malaria-infected red blood cells by recruiting the immune system. The compound's mechanism of action is expected to slow and suppress development of drug-resistant parasites, making it a potential addition to global malaria eradication efforts.