Articles tagged with Malaria
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Scientists have identified a way to stop malaria parasites from multiplying by targeting the NMT enzyme, which is essential for various processes in the parasite. The discovery raises hopes for new treatments and could be effective against multiple species of malaria parasites.
A team of researchers has discovered a way to identify malaria-causing Plasmodium falciparum parasites that are resistant to artemisinin, the key drug for treating this disease. The study found that parasites with a mutant version of the K13-propeller gene were more likely to survive exposure to artemisinin.
Scientists from NTU have discovered a key process during the Malaria parasite's invasion of red blood cells and developed antibodies that can interfere with this process. This breakthrough has the potential to lead to the development of a low-cost vaccine that could save millions of lives.
The UCSF Global Health Group will conduct research on community-based strategies to identify and clear the last remaining malaria parasites in areas close to elimination. The goal is to determine risk factors associated with malaria transmission and explore effective interventions for high-risk groups.
A large pooled analysis of over 7,000 patients with malaria suggests that dihydroartemisinin-piperaquine is highly efficacious but that young children are at higher risk of treatment failure due to insufficient doses. The study highlights the need for optimal drug dosing levels in this population.
The RH5-basigin interaction is crucial for the invasion of red blood cells by Plasmodium falciparum parasites. The team found that this interaction allows P. falciparum to infect humans but not chimpanzees or gorillas, mirroring its known infection profile.
Scientists have identified a key metabolic enzyme used by Plasmodium species at each stage of infection, paving the way for more effective drugs and potentially eradicating malaria. The discovery could lead to radical cures and prevent infections, blocking transmission back to mosquitoes.
Researchers have identified phosphatidylinositol 4-kinase (PI4K) as a potential malaria drug target, essential throughout the Plasmodium life cycle. Imidazopyrazines inhibit PI4K activity, blocking parasite development in both liver and bloodstream stages.
Scientists discover genetic mechanisms allowing Plasmodium vivax parasite to invade red blood cells, potentially rendering Duffy-negative individuals susceptible to vivax malaria. The research suggests the parasite may be rapidly evolving, increasing the risk for millions of Africans who previously had natural protection.
Researchers have discovered genetic mutations in Plasmodium vivax that may be causing a rise in infections among Duffy negative individuals. The mutations include a duplication of the Duffy binding protein and two new proteins that resemble those used by related malaria parasites to enter red blood cells.
The updated 2013 Malaria Vaccine Technology Roadmap sets a new target for vaccines to reduce malaria cases by 75 percent and be licensed by 2030. The roadmap also aims for malaria elimination through the development of safe and effective vaccines that prevent disease, death, and transmission.
Researchers found that lower doses of primaquine are as effective as higher doses in reducing malaria transmission, and may play a crucial role in malaria elimination. The study suggests that low-dose primaquine is safe in G6PD-normal individuals and could be used to block malaria transmission.
Professor Alan Cowman has been recognized for his substantial contributions to understanding malaria development and drug resistance. His work has led to the development of two potential malaria vaccines, one in clinical trials and the other in preclinical development.
Scientists have developed a 3D filming technique that helps researchers understand how malaria parasites mate and spread the disease. The unique motion of malaria sperm, moving in an irregular corkscrew motion, has revealed new insights into prevention and control methods.
A 15-year study on P. vivax population genetics in South Korea found drastic genetic change occurred between 2002-2003, suggesting parasites were introduced from North Korea. This explains why South Korea was unable to eliminate vivax malaria for 20 years.
A new study has shown that egg development in malaria mosquitoes depends on a switch activated by a male hormone delivered during sex, which could be a viable strategy for controlling the disease. Blocking this switch may impair the ability of the species to reproduce.
Researchers discovered a new molecular target for controlling malaria by blocking egg development in mosquitoes. The study found that a male hormone delivered during sex activates a protein switch, which boosts egg production. This finding holds promise for developing new tools to control malaria-transmitting mosquito populations.
Researchers discovered four genera of haemosporidian parasites in West African bats, closely related to the malaria pathogen Plasmodium. The study highlights the complex relationship between bats and pathogens, with potential implications for understanding human malaria evolution and developing new vaccines.
Researchers challenge prevailing argument that farm movement led to US malaria decline in the 1930s. Instead, targeted public health interventions and infrastructure development played a crucial role. The study's findings have significant implications for eradicating malaria in parts of Africa, Asia, and Latin America.
Scientists find that malaria and toxoplasmosis parasites can survive without AMA1 protein, but still attach to host cells. This discovery challenges current therapeutic strategies and suggests alternative approaches for improving treatments.
Professor Alan Cowman's work has led to a better understanding of malaria biology, informing new treatments and vaccines. The development of potential malaria vaccines is a significant step towards eradicating the disease.
The malaria vaccine candidate RTS,S has shown significant protection against clinical malaria and severe malaria cases in young children and infants. Over 18 months of follow-up, the vaccine reduced clinical malaria cases by almost half in children aged 5-17 months and malaria hospitalizations by 42%.
Researchers uncover a wide variety of malaria parasites in West African bats, including those closely related to rodent-infecting pathogens. The study reveals two bat-infecting parasites that made evolutionary jumps from rodents into bats and then likely back again.
A CDC and Massachusetts General Hospital study finds that pretravel consultations and preventive medications can save money for both payers and most travelers. The study analyzed data from over 1,000 travelers to West Africa and found that the costs associated with contracting malaria outweighed the costs of preventive care.
A study in Malawian children found chronic inflammation in blood vessels after recurrent malaria episodes, predisposing future infections and cardiovascular disease. The findings explain high childhood mortality rates in malaria-endemic areas.
Researchers at MIT developed a new model of malaria transmission that combines global forecasts with local rainfall data, predicting minimal increase in disease incidence despite projected temperature and rainfall changes. The study aims to provide more accurate predictions for specific variables relevant to society, such as malaria in...
A study published in Vaccine suggests that genetically engineered malaria parasites can be used as a vaccine to protect against infection. The attenuated parasites, which are stunted through precise gene deletions, induce robust immune responses that provide long-lasting protection.
Researchers have developed two rapid tests to monitor resistance spread and screen new drugs for malaria. The simple tests can predict whether a patient has slow-clearing, drug-resistant parasites in just 72 hours.
A new simple and rapid test can clearly identify artemisinin-resistant malaria parasites in people with the disease. The test was developed using ring-stage survival assays (RSAs) and shows promise for use in field-based settings to monitor artemisinin resistance.
A study found that iron supplementation among children in a malaria-endemic area did not increase the incidence of malaria. However, hospital admission rates were higher in the iron group compared to the no-iron group.
Researchers found that mosquitoes have higher olfactory sensitivity and protein abundance of odorant-binding proteins (OBPs) at night, making them more effective at detecting human hosts. This discovery has significant implications for developing novel insect control methods to reduce malaria transmission.
A new University of Michigan-led study reveals that irrigation systems in arid regions can increase malaria risk for over a decade, even with intensive mosquito control efforts. The research highlights the need for long-term public health and safety programs to mitigate this impact.
Researchers found that higher dosages of the PfSPZ Vaccine generated more antibodies and T cells, providing protection against malaria infection. The study's results suggest a potential breakthrough in developing a safe and effective malaria vaccine.
A systematic review and meta-analysis found that barriers to preventing malaria in pregnant women are consistent across sub-Saharan African countries. Common issues include unclear policy, healthcare facility shortages, and confusion among providers, delaying antenatal care and impacting uptake of interventions.
Scientists at MIT have developed a system to grow liver tissue that can support the liver stage of malaria parasites, allowing for testing of new drugs and vaccines. The system was used to study a vaccine for P. falciparum and showed promising results.
Researchers at University of California, Riverside identified odor molecules that impair mosquitoes' carbon dioxide detection machinery. Olfactor Labs developed a wearable patch that delivers non-toxic compounds to repel mosquitoes, providing up to 48 hours of protection.
The study reveals high genetic diversity of Plasmodium vivax in the Americas, similar to Asia and Oceania, suggesting multiple introductions. This diversity has important implications for control and eradication efforts.
Researchers have made significant progress in developing new gene therapies to treat Sickle Cell Disease, malaria, and Mucopolysaccharidosis Type IIIA. In the Journal of Clinical Investigation, scientists successfully delivered a replacement gene to the brain in mice and dogs with MPSIIIA using intra-cerebrospinal fluid gene therapy.
Researchers have developed a malaria vaccine using blood-stage parasites that are chemically attenuated, inducing immunity to multiple species. The study demonstrates protective immunity in mice for over 100 days, suggesting a promising approach to target human malaria species.
A collaborative study led by Durham University found that children from the poorest families are at double the risk of contracting malaria compared to those from less impoverished backgrounds. The research highlights the need for development programs as an essential component of malaria control to ensure transmission continues to decline.
A systematic review and meta-analysis published in The Lancet found that the world's poorest children are twice as likely to contract malaria as their better-off counterparts. Investing in socioeconomic development, such as improved education and nutrition, is crucial to controlling and eliminating malaria.
A Kansas State University researcher has received a prestigious fellowship to study mosquitoes and their role in spreading malaria. The goal is to understand how the mosquito's immune system responds to parasites, which could lead to new methods to limit parasite development and potentially find a cure for malaria.
Researchers discovered how malaria parasites stick to blood vessels by binding to endothelial protein C receptor (EPCR). This finding may lead to new means of combating malaria, including vaccines and drugs. The discovery sheds light on the mechanisms behind severe malaria symptoms.
Researchers have characterized the Bacillus thuringiensis Cry4B toxin as highly toxic against Anopheles gambiae, a principal vector of malaria. The study demonstrates that Cry4B can kill even Permethrin-resistant mosquito larvae, providing an environmentally safe approach to controlling malaria.
The ProMPT project distributed over 12 million mosquito nets, improving malaria prevention and treatment in Ghana. The initiative also strengthened health facilities' capacity to manage malaria, particularly during pregnancy.
The GHIT Fund will screen Japanese pharmaceutical companies' and research institutes' compound libraries for new treatments of malaria, tuberculosis, and neglected diseases like leishmaniasis and sleeping sickness.
Researchers found a chemical that interferes with mosquito proteins, causing kidney failure and affecting flight capabilities. The discovery may lead to the development of new insecticides for combating malaria and dengue fever.
Adult wild chimpanzees exhibit a strong association between age and malaria parasite detection rates, with significantly lower positivity in adults. This suggests that individuals reaching adulthood mount an effective protective immunity against malaria parasites, consistent with human observations.
A new LAMP test kit can detect even the lowest levels of malaria parasites in under an hour, improving diagnosis for imported UK cases and field use in Uganda. The simple test requires minimal equipment and training, making it accessible to non-specialist health workers.
Research published in PLOS ONE reveals that malaria-infected mosquitoes are significantly more attracted to human odors than their uninfected counterparts. The study suggests that understanding the olfactory changes underlying infected mosquito behavior may help identify new compounds for developing mosquito traps.
A study published in PLOS ONE found that female mosquitoes infected with malaria parasites are significantly more attracted to human odour than uninfected mosquitoes. The team aims to identify the chemical compounds in human odour that attract infected mosquitoes, which could help develop improved mosquito traps.
Researchers discovered malaria parasites can send signals to each other in infected red blood cells, triggering transformation into sexually mature forms that can be transmitted to mosquitoes. This social behavior could provide a target for developing new antimalarial drugs or vaccines.
A study at Michigan State University demonstrates that using a strain of the bacteria Wolbachia can interrupt the transmission of malaria via mosquitoes. This approach could provide an important tool in fighting the disease, particularly in areas where poverty and lack of resources are prevalent.
Researchers have successfully infected mosquitoes with the Wolbachia bacterium, rendering them immune to malaria parasites. The scientists maintained a stable infection in Anopheles stephensi mosquitoes for 34 generations, and all infected female mosquitoes became infected within eight generations when mated with uninfected males.
Researchers developed a test to predict cerebral malaria progression in children with malaria. Testing patients' blood for HRP2 protein levels can identify those likely to develop life-threatening cerebral malaria, allowing for targeted treatment and improved outcomes.
The Bill & Melinda Gates Foundation has awarded a $2.9 million grant to Aeras, Oxford University, and Okairos to develop novel vaccines against tuberculosis, HIV, and malaria. The collaboration aims to create scalable methods for large-scale production of multiple chimpanzee adenovirus vector constructs.
Research finds an association between a rare pregnancy condition called chorangiosis and full-blown malaria in pregnant women. The study suggests that active malarial infection enhances blood vessel growth in the placenta, potentially leading to complications like low birth weight.
Researchers engineered algae to produce a fusion protein that blocks malaria transmission, suggesting its potential use in treating other mucosal lining infections. The study's findings encourage the development of algae-based vaccines as a cheaper alternative for distributing life-saving medicines to developing countries.
As malaria incidence declines, it becomes increasingly concentrated in specific locations and groups, making targeted approaches crucial. Effective identification and treatment of infected individuals, particularly migrant workers and mobile populations, are essential for successful malaria elimination.
Sanofi launches large-scale production of partially synthetic artemisinin, a breakthrough in synthetic biology. The drug, developed by Professor Jay Keasling's team, aims to provide stable supply and low cost for developing countries.