Research on malaria and the fight against it. Covers red-blood-cell inflammation, malaria resurgence, drug-resistant parasites, and mosquito-based control.
A new study by ISGlobal has identified six microRNAs that may be used as biomarkers to predict disease severity in children with severe malaria. The findings provide a potential breakthrough in understanding the mechanisms underlying severe malaria and improving treatment outcomes.
Researchers discover new mutations in malaria parasite that enhance resistance to sulfadoxine-pyrimethamine, a key preventive drug. These mutations are already widespread in Africa and Asia, threatening efforts to use the drug to prevent malaria in vulnerable groups.
A study published in PLOS Pathogens reveals that mosquitoes feeding on blood multiple times increase malaria transmission potential, shortening the incubation period and making disease control more challenging. The research suggests that younger mosquitoes with reduced reproductive ability may contribute to infection, undermining curre...
A Convoluted Neural Network was trained on a library of mosquito images to classify species, sex, and strain. The system achieved 99.96% prediction accuracy for class identification.
Researchers used neuroimaging techniques to reveal that severe oxygen deprivation is the biggest cause of malaria deaths in adults. The study found no correlation between brain swelling and death in adult patients, unlike children, who die from respiratory arrest caused by brain swelling.
A study found that amphibian declines due to the amphibian chytrid fungus exacerbated malaria outbreaks in Costa Rica and Panama during the 1990s and 2000s. Preserving biodiversity can benefit humans as well as local ecosystems.
Researchers discovered that severe infections disrupt the processes that form blood cells in mice, causing long-term damage. However, a hormone treatment and antioxidant may reduce this damage. The study found that this treatment can increase HSC function by up to tenfold.
International experts will discuss COVID-19's effects on the human body when combined with other health conditions, such as HIV/AIDS and tuberculosis. The panel aims to provide advice on coping with multimorbidity in high-income countries.
A study in Uganda reveals that school-age children with asymptomatic malaria infections can serve as stealth super spreaders responsible for the majority of malaria parasites circulating in local mosquitoes. This hidden reservoir poses a barrier to long-term efforts to eliminate malaria and an immediate threat for disease resurgence.
Researchers at University of California have made a major advance in controlling malaria parasites by developing a new CRISPR-based gene drive system. The system successfully overcomes the issue of resistance in female mosquitoes, which was a significant challenge in previous attempts.
Researchers created a test device using protein biomarkers in dermal interstitial fluid, detecting malaria in 20 minutes and requiring no medical expertise or equipment. The patches could cost around $1 each and be adapted for other diseases with biomarkers in interstitial fluid.
Research shows malaria parasites can remain dormant in human blood stream during dry season, re-emerging when mosquito populations resurge. The parasite alters gene expression and uses spleen to evade immune system detection.
Researchers found that females can clear asymptomatic malaria infections at a faster rate than males, which could inform epidemiologists and public health strategies. The study, published in eLife, suggests biological sex-based differences play a crucial role in the human response to malaria parasites.
A meta-analysis of preventive malaria treatments among school-age children found that treatment cuts malaria prevalence by 46% and subsequent cases by 50%. Preventive treatment also improves learning outcomes and reduces anaemia cases.
A new study found that malaria-preventive drugs can dramatically reduce infections in school children by half, leading to improved learning and reduced anemia. The analysis included 15,000 schoolchildren across seven African countries and showed a significant association between preventive treatment and better health outcomes.
A new study led by ISGlobal found that blood transfusions can increase the survival of children with severe malaria, even at higher haemoglobin levels than recommended thresholds. In cases with complications, such as impaired consciousness or acidosis, transfusion improved survival even at high haemoglobin levels.
Researchers have discovered the molecular mechanisms that allow malaria parasites to move and spread disease within their hosts. The glideosome complex is a critical target for future antimalarial treatments, with two novel proteins identified as key players in parasite motility.
Scientists discovered how deadly parasites from the phylum Apicomplexa, such as Plasmodium and Toxoplasma, glide into human cells using actin and myosin proteins. The study reveals the molecular structure of essential light chains that facilitate gliding movements.
Researchers at New York University have developed a new fast-acting form of deltamethrin, a widely used insecticide, that is up to 12 times more effective against mosquitoes than the existing form. The new crystal form remains stable and kills mosquitoes for at least three months.
A study developed a new crystal structure of deltamethrin that kills mosquitoes 12 times faster than the original form. This could lead to more effective malaria control even in areas with high insecticide resistance.
Researchers at NYU Abu Dhabi have discovered a new immune evasion strategy used by the Plasmodium parasite, which could help develop novel therapeutic strategies and vaccines for malaria. The study found that microRNAs play a crucial role in regulating genes involved in the immune response.
A new computational model suggests that certain protective mutations against malaria have not become widespread due to rapid immune system adaptation, making it less likely for these mutations to spread among the population. The study highlights the need for further genetic studies of populations living in regions impacted by malaria.
A Duke University-led team has discovered how malaria parasites can survive fevers by producing a special lipid molecule and binding to heat shock proteins. This could lead to new ways to fight resistant strains of the disease. The findings also suggest caution when using fever reducers with artemisinin-based compounds.
A new CRISPR-based assay detects all four major malaria-causing Plasmodium species with high sensitivity and specificity, providing a viable solution to diagnose asymptomatic carriers. The SHERLOCK system enables rapid testing in just 60 minutes, surpassing WHO requirements for low parasite density detection.
A new CRISPR-based diagnostic method has been developed to detect four species of the malarial parasite Plasmodium. The test uses a nucleic acid detection platform called SHERLOCK and is optimized for field conditions, with a cost of $0.61 per test.
Red blood cells in people with Dantu blood variant have a higher surface tension that prevents Plasmodium falciparum from invading. This natural process could be imitated to prevent or reduce malaria infection.
A study suggests that urban mosquito species Anopheles stephensi could spread to dozens of cities across Africa, putting millions at higher risk of contracting malaria. The authors used location data and spatial models to predict the spread of this Asian mosquito species in Africa, identifying 44 highly suitable locations.
Researchers predict a shift toward mosquitoes carrying dengue fever and other diseases, posing a significant threat to public health in Sub-Saharan Africa. The study highlights the need for targeted control measures, including diagnostics and community-based interventions, to combat this emerging threat.
A new study reveals that climate change could lead to a shift in malaria transmission patterns across Africa, with southern Africa experiencing increases in suitable areas and West Africa seeing decreases. River corridors are identified as year-round hot spots of malaria transmission.
Researchers discovered new types of mosquito immune cells and molecular pathways implicated in controlling the malaria parasite. A rare cell type called a Megacyte was found to have high levels of a key molecule needed for immune priming, which could limit malaria transmission.
Researchers have created a genetically engineered mosquito strain with a Cas9/guide RNA-based gene drive that targets the cardinal gene to prevent malaria transmission. The drive achieved an average efficiency of 96.7% in both sexes, ensuring every mosquito carries at least one copy within six generations.
A three-year intervention in southern Mozambique averted almost 40,000 malaria cases and reduced disease transmission by 85%. Despite this drastic reduction, the study finds that disease transmission was not interrupted, highlighting the need for new strategies to achieve elimination.
Researchers found a higher prevalence of anemia in pregnant women with malaria and HIV coinfections compared to those without infections. The study suggests that multipronged strategies to prevent and treat these infections are critical to ensure the survival of mothers and their unborn babies.
The emergence of artemisinin-resistant malaria parasites in Rwanda marks a major concern for global health. Significant proportions of parasites carrying the R561H mutation have been detected, indicating that these resistant strains can spread between locations and acquire resistance to partner drugs.
Researchers discovered new channels enabling lipid transport between the malaria parasite and red blood cells, raising possibility of nutrient-blocking treatments. The study found Niemann-Pick C1-related protein (PfNCR1) channels made of PfNCR1.
Research reveals insecticide-treated mosquito nets, crucial in global malaria fight, have lost significant protection effectiveness. Long-lasting insecticidal nets (LLINs), credited with saving millions lives since 2000, are now only killing 40% of mosquitoes they come into contact with.
A modelling study predicts that COVID-19 could lead to a significant increase in HIV, TB, and malaria deaths in low- and middle-income countries. The study suggests that prioritizing antiretroviral therapy, timely diagnosis and treatment of TB, and long-lasting insecticide-treated nets could mitigate the impact of the pandemic.
A new approach developed by Kyoto University scientists provides insight into the liver stage of the Plasmodium vivax malaria parasite. The method involves infecting human liver cells with mosquito-bred parasites, enabling researchers to study the parasite's life cycle and develop more effective treatments.
Researchers at the Francis Crick Institute have identified a protein used by the malaria parasite to protect itself from toxic compounds in red blood cells. This discovery could lead to the development of drugs that block this process, potentially providing valuable insights for treating malaria.
A recent study mapped mosquito insecticide resistance patterns across Africa, finding dramatic increases in resistance to five mainstream insecticides between 2005 and 2017. This surge in resistance poses a significant threat to malaria control efforts, particularly in Sub-Saharan Africa where over half of all cases occur.
Scientists at Seattle Children's Research Institute have developed a genetically attenuated parasite (GAP) that arrests late in the liver stage of human malaria, paving the way for a novel next-generation vaccine. The GAP technology has the potential to offer protection to those living in regions where malaria transmission is widespread.
A new tetrahydroquinolone compound, JAG21, has been discovered to eliminate both active and dormant forms of Toxoplasma gondii and P. falciparum parasites. The compound shows promise in treating toxoplasmosis and malaria, with the potential to prevent and cure all life-cycle stages of malaria.
A research team at ISGlobal has developed a system to induce massive sexual conversion of the P. falciparum malaria parasite in vitro, enabling deeper understanding and design of new tools to block malaria transmission. This technique allows for synchronization of parasites at the initial stages of sexual development.
Researchers discovered Plasmodium parasites use internal clocks to regulate gene expression and cell cycle activities in response to host signals. The finding of a genetic metronome and SR10 receptor protein could lead to novel drug targets for combating malaria.
A new study found that an indoor residual spray made from volcanic glass is effective in controlling mosquitoes carrying malaria. The spray, called Imergard WP, shows mortality rates of over 80% against both wild and susceptible strains of Anopheles gambiae mosquitoes.
A recent study found that the international trade in timber, tobacco, cocoa, coffee, and cotton significantly contributes to malaria risk in countries with deforestation hotspots. The research linked over 10% of malaria cases to demand from developed countries for these commodities.
Extracellular vesicles play a key role in the pathology of malaria vivax by promoting parasite adhesion to human spleen fibroblasts. The study found that EVs induce the expression of ICAM-1 on fibroblast surfaces, serving as an anchor for parasite-infected red blood cell adherence.
A new blood test has been developed to detect recent Plasmodium vivax infections and identify individuals with hypnozoites, which can cause relapsing malaria. The test offers high sensitivity and specificity, and mathematical models suggest it could reduce P. vivax prevalence by 59-69%.
Two malaria vaccines developed using genetically engineered malaria parasites have shown safety and preliminary protection in phase 1/2a clinical trials. The vaccines, created by Isaie Reuling and Meta Roestenberg teams, delayed infections when exposed to mosquitoes infected with Plasmodium falciparum, the primary cause of malaria in h...
A genetically modified malaria vaccine has been found to be safe and elicit a defense response against malaria infection in humans. The vaccine, developed with the American company Sanaria Inc., targets the liver stage of the disease and was administered to 67 volunteers, showing promising results.
Research reveals that malaria parasite P. vivax adheres to human spleen cells via variant proteins, allowing it to hide from the immune system and evade elimination. This finding suggests a double role for the spleen in malaria pathology and opens new avenues for vaccine targets and exposure markers.
Research found that malaria parasites have an inherent clock that drives their activity, resulting in cyclical fevers in humans. The parasite's gene expression patterns remained consistent despite changes in lighting conditions and host circadian rhythms.
Scientists have discovered that malaria's characteristic cycle of fever and chills is controlled by an intrinsic biological oscillator within the parasite. The study found that 87-92% of tracked genes were cyclical, providing strong evidence for an innate control mechanism.
Researchers discovered that malaria parasites can tick their own internal clocks, with 90% of genes showing rhythmic patterns. This internal metronome may help the parasite synchronize its escape from red blood cells and evade the human immune system.
Scientists have discovered that malaria parasites have an intrinsic clock controlling their invasion of human cells. This finding opens up new avenues for treating the disease by disrupting its biological rhythms.
Researchers found that the malaria parasite, P. falciparum, has a 48-hour developmental cycle with synchronous release of parasites from red blood cells, triggering fever cycles in humans. The study suggests that parasites have evolved mechanisms to precisely maintain periodicity.
A recent study using lidar technology reveals that mosquitoes are most active during morning and evening hours in Tanzania, with males being 87 times more active than usual. This finding suggests that light levels affect mosquito behavior, creating opportunities for developing light-based measures to prevent malaria.
Scientists at Imperial College London used gene drive technology to create an all-male population of malaria-carrying mosquitoes, leading to a total collapse in the population. The modified mosquitoes produce more male offspring, causing females to be born and eventually leading to no females being present.
Melbourne researchers have identified a microscopic protein, RPL6, that can be added to a malaria vaccine for efficient protection. The combination offered complete protection against malaria in mice, building upon the 2016 discovery of T cells resident in the liver and the 'prime and trap' vaccination strategy.
A new diagnostic approach in malaria has been adapted to track immunity to COVID-19, providing valuable details about when a person was exposed to the infection. The test can pinpoint how long ago a person was exposed, making it essential for tracking the spread of an infection and monitoring the effectiveness of control programs.