Articles tagged with Malaria
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A novel bed net treated with chlorfenapyr has been shown to significantly reduce malaria infection in children, with a 43% decrease in the first year and 37% decrease in the second year. The study found that the bed net reduced clinical episodes of malaria by 44% over two years.
Researchers found that mosquitoes' odor sensors shut down when forced to produce odor-related proteins, ignoring common insect repellents. This 'expression' process allows mosquitoes to adapt to their surroundings and avoids human scents.
A team of scientists led by Karine Le Roch has identified two proteins, RAP01 and RAP21, crucial to the malaria parasite's survival. Knocking down these proteins can interrupt protein translation in the mitochondria, leading to the parasite's death.
A new study using pooled individual patient data from over 70,000 patients has found that artemisinin-based combination therapy can suppress the bone marrow response and contribute to anaemia. The analysis identified patients at greatest risk of severe anaemia and highlights potential advantages of alternative treatment regimens.
Researchers at Weill Cornell Medicine have identified a protein called HDP1 that plays a critical role in activating genes required for the development of male and female stages of the malaria parasite. Without HDP1, parasites are unable to assemble mature gametocytes, leading to their death and inability to infect mosquitoes.
A recent study found a high prevalence of HIV, tuberculosis, and malaria in the Gambela region of Ethiopia, highlighting the need for targeted health services. The research suggests that addressing these diseases at a local level could be more effective than a nationwide response.
Researchers have discovered a protein that plays a key role in the malaria parasite, leading to a potential new way to fight the disease. Deactivating this protein reduces the growth of the parasite by over 75%, making it a promising target for treatment development.
Female mosquitoes learn to avoid pesticides after a single exposure, allowing them to seek out safer food sources and resting sites. The study found that pre-exposed mosquitoes were more likely to avoid pesticide-treated nets and rest in pesticide-free containers.
A team of scientists has discovered that the enzyme DNA topoisomerase VI plays a critical role in removing chromosome tangles in plants, which may lead to new antimalarial drug targets. The study provides unprecedented insight into the mechanism of action of this enzyme and its potential applications in plant breeding.
A 22-year study in Tanzania found that children who slept under bed nets at an early age had a 40% higher survival rate compared to those who didn't. The study tracked over 6,700 children and provided unique insights into the long-term benefits of malaria control in young children.
A study from Johns Hopkins Malaria Research Institute uses CRISPR/Cas9 gene-editing to delete a protein called CTL4 from mosquitoes, resulting in a 64% decrease in infection prevalence. The researchers believe targeting the CTL4 protein could be a new strategy for controlling malaria.
Researchers developed autohaem devices to automate blood smears, increasing accuracy and efficiency in malaria diagnosis. The devices can produce high-quality smears equivalent to those created by human experts, reducing errors and improving patient outcomes.
Researchers found that male mosquitoes beat their wings up to 500-1,000 times a second, changing frequency to produce 'distortion tones' more audible to the male ear. This change is partly due to their circadian clock and allows males to detect females in swarms.
Researchers at UNICAMP discovered that total parasite biomass is a better predictor of complications in patients with P. vivax malaria than parasitemia. The study highlights the importance of parasite biomass in the bone marrow and spleen, which play a major role in vivax malaria complications.
Researchers from Ethiopia and Germany identified a traditional African medicinal plant that alleviates malaria symptoms in infected mice. The plant extract's active compound, anemonin, shows promise in treating the disease.
A new study reveals that gamma delta T cells play a critical role in promoting clinical protection against malaria. The unique T cell receptor on these cells enables them to recognize and tolerate Plasmodium falciparum parasite fragments, providing a vital component of an effective immune response.
Researchers found high rates of SARS-COV-2 infections in Mali but low evidence of severe disease, hospitalization, or deaths. In contrast, COVID-19 patients with high levels of previous malaria infections showed lower risks of severe outcomes in Uganda.
Scientists sequenced Plasmodium falciparum genomes to understand malaria parasite populations and track drug resistance biomarkers. The study identified population-specific SNPs that can be used to determine transmission routes and monitor drug resistance.
Researchers at the Ragon Institute of MGH, MIT and Harvard have developed a new anti-malarial antibody that provides significant protection against malaria, outperforming existing best-in-class antibodies. The breakthrough could lead to improved distribution of monoclonal antibodies in endemic countries.
Researchers from the University of Copenhagen have discovered that naturally acquired immunity to malaria works differently than immunity following vaccination. The immune system uses natural killer cells to fight the parasite, which is more tailored to the disease than other typical infections.
A new study from Karolinska Institutet shows that explicitly addressing falsehoods is more effective in busting misbeliefs than simply stating scientific facts. The study found that two communication campaigns using WhatsApp audio dramas significantly reduced participants' incorrect beliefs about typhoid and malaria.
Researchers have detected antibodies primarily made in response to mucous membrane infections, not typically thought of as a blood and liver infection, in study participants with malaria. The discovery provides new insight into the human body's response to malaria and may help identify new ways to treat or develop vaccines.
A promising new antimalarial compound has been discovered in a collaboration between McMaster University and the University of Hamburg. The compound, duocarmycin PDE-I2, shows potent malaria-killing properties without the adverse effects of previously known compounds.
A Brazilian study found that children exposed to malaria from birth are more likely to develop anemia by age two. The researchers, led by Dr. Marly Augusto Cardoso, followed 1,539 children and discovered that 12.6% were anemic, with a higher prevalence in rural areas not covered by the study.
Scientists have developed a technique to sequence individual malaria parasites' genomes, allowing for the detection of new mutations. These mutations are often targeting a gene family controlling transcription in malaria, suggesting potential avenues for developing more effective treatments and vaccines.
A study at Stockholm University has discovered a novel, eco-friendly feeding trap that can be deployed to control mosquito populations. The trap uses a beetroot-based mix with added toxins, which attracts and kills female mosquitoes, while leaving male mosquitoes unaffected.
Chronic P. vivax infections cause significant damage to kidneys, brain, and circulatory system, affecting impoverished communities. The parasite can hide at low levels, making diagnosis difficult and treatment efforts challenging.
Researchers studying blood samples from over 12,000 individuals in Ethiopia found that malaria parasites can evade detection by rapid diagnostic tests due to genetic mutations. The study highlights the need for alternative diagnostic approaches and surveillance across the Horn of Africa.
Researchers at Kanazawa University have identified a new vaccine platform that targets liver cells to induce anti-malaria immunity. The AAV8 vaccine platform was found to be more effective in eliciting a T cell-mediated response in the liver, providing sterile protection against malaria in a murine model.
Researchers have identified global hotspots where bird malaria is spreading rapidly, with significant impacts on bird populations. The study found that climate and forest conditions play a crucial role in predicting infection risks, highlighting the need for conservation efforts to protect bird species from this deadly disease.
A new study published in the New England Journal of Medicine found that a combination of seasonal vaccination with RTS,S/AS01 E and antimalarial drugs significantly reduces clinical episodes, hospital admissions, and deaths from malaria. The results show a 70% reduction in these outcomes compared to current interventions.
A new study led by ISGlobal has identified a gene called PfAP2-HS that allows the malaria parasite to defend itself from febrile temperatures and other adverse conditions within the host. The study found that this gene activates a protective response against high temperatures, helping the parasite survive in the host's environment.
A new monoclonal antibody called CIS43LS safely prevented malaria for up to nine months in a small clinical trial. The study builds on encouraging early results and will inform additional research to confirm and extend the finding.
Researchers successfully tested gene drive technology to control malaria-carrying mosquitoes in large cages mimicking natural environments. The technology, which spreads a genetic modification blocking female reproduction, worked as expected and showed significant population decline within one year.
Researchers used mass cytometry and machine learning to discover 'immune signatures' that differentiate between symptomatic and asymptomatic Plasmodium vivax malaria infections. The study found a previously unrecognised role for immune CD4 T cells in preventing serious disease and controlling asymptomatic infection.
Researchers define the atomic-level architecture of a protein-receptor connection that allows the malaria parasite to evade the immune response. A drug designed to fit into this space could block the interaction, allowing the immune system to clear away the pathogen and potentially reducing severe malaria cases.
A new study predicts that climate change could increase the global population at risk of malaria and dengue by up to 4.7 billion people by 2100, particularly in lowlands and urban areas. Reducing greenhouse gas emissions could prevent millions from contracting these diseases.
Researchers developed a statistical model using platelet and white blood cell counts to distinguish between severe malaria and other illnesses. This model could help identify misdiagnosed children with alternative causes of illness, speeding up research on new treatments.
A Sanaria vaccine has demonstrated complete protection against a variant malaria parasite in six subjects, with the dosage being only 20% of its original strength. The results, published in Nature, have significant implications for the prevention of malaria in African populations and travelers to Africa.
A new malaria vaccine has shown unprecedentedly high levels of durable protection in phase 1 trials, potentially reversing the stalled decline of global malaria. The vaccine combines live parasites with antimalarial drugs and has induced sterile hepatic immunity.
Researchers explored whether ivermectin administration influences malaria transmission, finding large effects on mosquito mortality but no significant impact on malaria incidence in children. Further studies are underway to determine the efficacy of community-wide ivermectin treatment for reducing malaria transmission.
Researchers identified six antibody characteristics that protect pregnant women from placental malaria infections, which could be used to identify women at risk and develop new therapies. The study found that these antibodies help prevent malaria parasites from binding to placental cells and destroying infected blood cells.
A novel mRNA-based vaccine has shown high levels of protection against malaria in animal models, offering new hope for combatting this deadly disease. The vaccine uses a lipid nanoparticle to stimulate the immune system and trigger a protective response.
A new method for collecting pure malaria parasites from infected mosquitoes could accelerate the development of new, more potent malaria vaccines. The 'mosquito smoothie' innovation enables rapid purification with fewer contaminants, increasing scalability and efficacy.
A study in Uganda reveals that school-aged children with asymptomatic malaria are a significant source of mosquito infections, driving the spread of the disease. Targeting these children for control interventions could help sustain malaria gains and prevent resurgences.
Using lattice light sheet microscopy, researchers captured high-resolution videos of individual malaria parasites invading red blood cells, revealing key steps in the parasite life cycle. The study's findings may lead to new antimalarial therapies by targeting specific components of the parasite, potentially bypassing drug resistance.
Researchers at Martin-Luther-University Halle-Wittenberg have developed a simple method to prepare artemisone, a promising substance against malaria. The new formulation shows improved efficacy in combating harmful parasites, reducing the need for high doses and potential side effects.
Researchers discovered a molecular mechanism that alters immune response to infection in Gouin children, but not in Fulani children. The study's findings could lead to better malarial therapeutic interventions and vaccine responsiveness in populations.
Recent studies have demonstrated excellent efficacy of Sanaria's PfSPZ-CVac malaria vaccine, with 77% protection rate in malaria-naive adults. Optimizing immunization timing has increased efficacy to 75%, overcoming negative impacts of blood stage parasites.
Researchers create synthetic fly species with a genetic barrier to limit gene drive spread, offering a safe and reversible method of controlling populations. The technology has potential applications in disease elimination, crop protection, and pest management.
Researchers have developed a fine-scale malaria risk map to help public health experts target interventions in Haiti. The map uses data from satellite images, health facilities, and hand-written medical logs to identify areas at high risk of infection.
A study published in PLOS Medicine reveals that malaria parasites survive and replicate within the spleen of asymptomatic individuals infected with Plasmodium vivax. The research found a substantial biomass of intact asexual-stage malaria parasites accumulated in the spleen, targeting immature red blood cells for invasion.
A study found that malaria parasite Plasmodium vivax accumulates in the spleen to a greater extent than its relative P. falciparum after infection. Imaging techniques revealed increased glucose metabolism in the spleen of participants infected with P. vivax.
A new study estimates global economic burden of P. vivax malaria, finding that widespread access to radical cure could reduce costs substantially and achieve elimination of the disease.
A comprehensive genetic resource of rat-infecting malaria parasites has been published, providing insights into the evolution, virulence, and transmissibility of the disease. The study reveals diverse genetic and phenotypic variations between subspecies, which may aid in understanding malaria parasite gene functions.
Researchers developed a genetic editing toolkit for Culex mosquitoes, which transmit devastating diseases like West Nile virus and avian malaria. The new CRISPR tools aim to create gene drives that can disable pathogen transmission in the targeted mosquito population.
Researchers have mapped the genetic changes of malaria parasites in unprecedented detail, revealing new targets to block key stages in the parasite's development. This could lead to new ways to prevent transmission through future drugs or vaccines.
Researchers found that houses with higher floors had significantly fewer female Anopheles gambiae mosquitoes, with a 84% reduction at 3m. This could lead to comparable reductions in malaria transmission. The study suggests elevating homes may be an effective intervention in sub-Saharan Africa.
Researchers have designed a new drug compound that effectively blocks a critical step in the malaria parasite life cycle, trapping it in the cell and preventing its replication. The compound works by blocking an enzyme called SUB1, which is crucial for the parasite's exit route from red blood cells.
The R21/Matrix-M malaria vaccine has shown high efficacy of 77% in a phase IIb trial and is now being assessed in a larger phase III trial across five sites in West and East Africa. The vaccine aims to reduce malaria deaths by at least 90% by 2030, with the potential to provide over 200 million doses annually.