A study from the University of California, Davis found a clear connection between an amphibian die-off and a spike in malaria cases in Costa Rica and Panama. The research suggests that stable ecosystems are crucial for disease prevention and health, and massive ecosystem disruptions can have significant consequences for human well-being.
SourceUniversity of California - Davis·JournalEnvironmental Research Letters·TypeData/statistical analysis·DateSep 20, 2022
Researchers have developed a malaria vaccine candidate that is safe and immunogenic in adults, offering improved protection against the disease. The vaccine combines FMP013 antigen with ALFQ adjuvant, which displays promising immune-enhancing effects.
SourceThe U.S. Military HIV Research Program (MHRP)·JournalVaccine·TypeRandomized controlled/clinical trial·DateSep 14, 2022
A new study reveals that partner-drug resistance facilitates artemisinin resistance in malaria parasites. The research collaboration found a 10-fold increase in partner-drug resistant genotypes led to earlier artemisinin resistance establishment among these parasites, resulting in significant treatment failures globally.
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Researchers have found that human antibodies can incorporate foreign genetic material from the mitochondria and ends of chromosomes, leading to increased immune diversity. This discovery challenges the long-held assumption that antibody diversity results solely from gene mutations.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalProceedings of the National Academy of Sciences·DateAug 29, 2022
A study published in Lancet Regional Health – Americas found that malaria in pregnancy is still a major public health problem in the North of Brazil, with younger women being most at risk. The researchers believe that expansion of healthcare services and inclusion of artemisinin in therapeutic schemes contributed to the decline in cases.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalThe Lancet Regional Health - Americas·DateAug 16, 2022
Researchers developed a statistical mapping tool to predict genetic markers of resistance to Plasmodium falciparum, the parasite that causes malaria. The model uses data from the WorldWide Antimalarial Resistance Network and fills in gaps by making continuous predictions in space and time.
SourceUniversity of Melbourne·JournalPLOS Computational Biology·TypeComputational simulation/modeling·DateAug 12, 2022
A new drug, TB31F, has been shown to block the transmission of malaria parasites by mosquitoes, preventing further malaria cases. The antibody was tested in humans and found safe with no important side effects.
SourceRadboud University Medical Center·JournalThe Lancet Infectious Diseases·TypeRandomized controlled/clinical trial·DateAug 10, 2022
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A Phase 1 clinical trial found a monoclonal antibody to be highly protective against malaria in US adults. L9LS was administered subcutaneously and fully protected 88% of participants from infection.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateAug 4, 2022
A new study published in PLOS Biology reveals the significance of kinesins in basic cellular processes needed for malaria parasite development, multiplication and invasion. Researchers found that eight out of nine kinesins present in the parasite genome are required for cell proliferation to cell movement in mosquito hosts.
SourceUniversity of Nottingham·JournalPLOS Biology·TypeExperimental study·DateJul 28, 2022
Researchers used Plasmodium falciparum 7G8 challenge trials to test the PfNF54-based PfSPZ Vaccine, providing conservative predictions of its efficacy in Africa. The study found that VE over 24 weeks was as good as or better than VE against Pf7G8 CHMI at 24 weeks.
A new machine learning-based AI tool has been developed to aid doctors in distinguishing between tropical diseases such as dengue and malaria. The tool has shown promising results in improving diagnosis accuracy.
SourcePLOS·JournalPLOS Neglected Tropical Diseases·DateJun 30, 2022
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A new digital PCR technique helps identify mutations in malaria parasites that evade detection by rapid tests, reducing false negatives. This allows for more accurate selection of diagnostic tests tailored to specific regions.
Research in western Amazonia found that at least 150 minutes of exercise per week correlated with lower birth weight and reduced risk of childhood obesity and diabetes. The study also showed that physical activity during pregnancy may help prevent excessive weight gain, contributing to a reduced birth weight.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPLOS ONE·DateJun 13, 2022
Researchers found that increasing serotonin levels in mosquito blood reduces their flight speed and motivation to seek second blood meals, making them less efficient vectors of malaria parasites. This discovery provides a promising new avenue for insect-targeted interventions to prevent malaria transmission.
SourceFrontiers·JournalFrontiers in Physiology·TypeExperimental study·DateJun 13, 2022
Researchers have identified an anti-malarial compound, ML901, that inhibits the malaria parasite without harming mammalian cells. The compound works by hijacking a reaction to make the parasite self-destruct, showing rapid and prolonged action against resistant strains.
SourceUniversity of Melbourne·JournalScience·DateJun 2, 2022
A WHO-supported series has collected 13,700 new database records on mosquito-borne diseases, providing valuable resource for studying and containing infectious diseases. The data can be used to train machine-learning models for vector detection and classification, improving global human health.
SourceGigaScience·JournalGigabyte·TypeObservational study·DateMay 31, 2022
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Researchers have captured the first 3D images of malaria parasites and how anti-malarial compounds like PMIX and PMX work to stop their spread. The findings will enable the design of new compounds that can effectively block Plasmepsins, preventing malaria parasite replication.
SourceWalter and Eliza Hall Institute·JournalStructure·TypeExperimental study·DateMay 16, 2022
Researchers from Australian National University have discovered how malaria parasites evade treatment by transporting drugs to 'safe zones', which can lead to new and longer-lasting treatments. The discovery could also inform cancer treatment development.
SourceAustralian National University·JournalPLOS Biology·TypeRandomized controlled/clinical trial·DateMay 5, 2022
Researchers discovered that mosquito brains use a surprisingly simple mechanism to recognize human odor, involving just two nerve centers. The team identified the specific compounds decanal and undecanal as key components of human scent, which are also present in other mammal odors.
SourcePrinceton University·JournalNature·TypeExperimental study·DateMay 4, 2022
Asymptomatic malaria infections have been found to suppress the immune system, preventing it from eradicating parasites from the bloodstream. This new information provides a framework for considering new policies supporting screening and treatment of asymptomatic malaria in endemic areas.
SourceWalter and Eliza Hall Institute·JournalMolecular Systems Biology·TypeExperimental study·DateMay 4, 2022
Two fatal cases of airport malaria were reported in Belgium, highlighting the need for healthcare awareness near airports. The most likely route of transmission was through an imported infectious exotic Anopheles mosquito that was possibly brought via the international airport or military airport.
SourceEuropean Centre for Disease Prevention and Control (ECDC)·JournalEurosurveillance·DateApr 25, 2022
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new study by Georgetown University Medical Center scientists found that geoengineering the climate could shift malaria transmission regions, increasing the risk of infection in some areas. The research used climate models to simulate malaria transmission under different warming scenarios with and without geoengineering.
SourceGeorgetown University Medical Center·JournalNature Communications·TypeComputational simulation/modeling·DateApr 20, 2022
Scientists tracked Cryptosporidium in real-time, revealing a simplified lifecycle that completes in three days with only three stages: asexual cells, male cells, and female cells. This understanding paves the way for potential vaccines or therapies to combat the disease.
SourceUniversity of Pennsylvania·JournalPLOS Biology·TypeObservational study·DateApr 19, 2022
Researchers at Karolinska Institutet study how the immune system protects against malaria, finding that people who have contracted the disease before develop a tolerance that prevents severe disease. This knowledge can aid in the development of more effective vaccines.
SourceKarolinska Institutet·JournalCell Reports·DateApr 19, 2022
Researchers have discovered that P. malariae, a malaria parasite infecting humans, originated in African apes before evolving to infect people. This breakthrough reveals the evolutionary links between the two species and sheds light on how the parasite adapted to infect humans.
SourceUniversity of Edinburgh·JournalNature Communications·TypeExperimental study·DateApr 6, 2022
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Scientists at UC San Diego are working on next-generation gene drive systems based on CRISPR technology to combat malaria and reduce mosquito populations. The $1.4 million grant will support the development of new technologies, including a neutralizing system called ERACR, to mitigate risks associated with gene editing in mosquitoes.
A novel class of bed net that kills mosquitoes resistant to traditional insecticides by making them unable to move or fly significantly reduces malaria infection in children. The study found a 43% reduction in malaria prevalence and 44% reduction in clinical episodes over two years.
SourceUniversity of Ottawa·JournalThe Lancet·DateMar 28, 2022
A novel bed net treated with chlorfenapyr has been shown to significantly reduce malaria infection in children, with a 43% decrease in the first year and 37% decrease in the second year. The study found that the bed net reduced clinical episodes of malaria by 44% over two years.
SourceLondon School of Hygiene & Tropical Medicine·JournalThe Lancet·DateMar 24, 2022
Researchers found that mosquitoes' odor sensors shut down when forced to produce odor-related proteins, ignoring common insect repellents. This 'expression' process allows mosquitoes to adapt to their surroundings and avoids human scents.
SourceJohns Hopkins Medicine·JournalCell Reports·DateMar 16, 2022
A team of scientists led by Karine Le Roch has identified two proteins, RAP01 and RAP21, crucial to the malaria parasite's survival. Knocking down these proteins can interrupt protein translation in the mitochondria, leading to the parasite's death.
SourceUniversity of California - Riverside·JournalNature Communications·TypeExperimental study·DateMar 11, 2022
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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new study using pooled individual patient data from over 70,000 patients has found that artemisinin-based combination therapy can suppress the bone marrow response and contribute to anaemia. The analysis identified patients at greatest risk of severe anaemia and highlights potential advantages of alternative treatment regimens.
SourceInfectious Diseases Data Observatory·JournalBMC Medicine·TypeMeta-analysis·DateMar 8, 2022
Researchers at Weill Cornell Medicine have identified a protein called HDP1 that plays a critical role in activating genes required for the development of male and female stages of the malaria parasite. Without HDP1, parasites are unable to assemble mature gametocytes, leading to their death and inability to infect mosquitoes.
SourceWeill Cornell Medicine·JournalNature Microbiology·DateFeb 25, 2022
A recent study found a high prevalence of HIV, tuberculosis, and malaria in the Gambela region of Ethiopia, highlighting the need for targeted health services. The research suggests that addressing these diseases at a local level could be more effective than a nationwide response.
SourceCurtin University·JournalBMJ Global Health·DateFeb 25, 2022
Researchers have discovered a protein that plays a key role in the malaria parasite, leading to a potential new way to fight the disease. Deactivating this protein reduces the growth of the parasite by over 75%, making it a promising target for treatment development.
SourceUniversité Laval·JournalmBio·TypeExperimental study·DateFeb 17, 2022
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Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Female mosquitoes learn to avoid pesticides after a single exposure, allowing them to seek out safer food sources and resting sites. The study found that pre-exposed mosquitoes were more likely to avoid pesticide-treated nets and rest in pesticide-free containers.
SourceScientific Reports·JournalScientific Reports·DateFeb 17, 2022
A 22-year study in Tanzania found that children who slept under bed nets at an early age had a 40% higher survival rate compared to those who didn't. The study tracked over 6,700 children and provided unique insights into the long-term benefits of malaria control in young children.
SourceLondon School of Hygiene & Tropical Medicine·JournalNew England Journal of Medicine·TypeObservational study·DateFeb 2, 2022
A team of scientists has discovered that the enzyme DNA topoisomerase VI plays a critical role in removing chromosome tangles in plants, which may lead to new antimalarial drug targets. The study provides unprecedented insight into the mechanism of action of this enzyme and its potential applications in plant breeding.
SourceJohn Innes Centre·JournaleLife·TypeExperimental study·DateFeb 2, 2022
A study from Johns Hopkins Malaria Research Institute uses CRISPR/Cas9 gene-editing to delete a protein called CTL4 from mosquitoes, resulting in a 64% decrease in infection prevalence. The researchers believe targeting the CTL4 protein could be a new strategy for controlling malaria.
SourceJohns Hopkins Bloomberg School of Public Health·JournalPLOS Biology·DateJan 26, 2022
Researchers developed autohaem devices to automate blood smears, increasing accuracy and efficiency in malaria diagnosis. The devices can produce high-quality smears equivalent to those created by human experts, reducing errors and improving patient outcomes.
SourceAmerican Institute of Physics·JournalReview of Scientific Instruments·DateJan 18, 2022
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers found that male mosquitoes beat their wings up to 500-1,000 times a second, changing frequency to produce 'distortion tones' more audible to the male ear. This change is partly due to their circadian clock and allows males to detect females in swarms.
SourceUniversity College London·JournalScience Advances·TypeObservational study·DateJan 12, 2022
Researchers at UNICAMP discovered that total parasite biomass is a better predictor of complications in patients with P. vivax malaria than parasitemia. The study highlights the importance of parasite biomass in the bone marrow and spleen, which play a major role in vivax malaria complications.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournaleLife·DateDec 22, 2021
Researchers from Ethiopia and Germany identified a traditional African medicinal plant that alleviates malaria symptoms in infected mice. The plant extract's active compound, anemonin, shows promise in treating the disease.
SourceMartin-Luther-Universität Halle-Wittenberg·JournalMolecules·TypeExperimental study·DateDec 20, 2021
A new study reveals that gamma delta T cells play a critical role in promoting clinical protection against malaria. The unique T cell receptor on these cells enables them to recognize and tolerate Plasmodium falciparum parasite fragments, providing a vital component of an effective immune response.
SourceMonash University·JournalScience Translational Medicine·DateDec 1, 2021
Researchers found high rates of SARS-COV-2 infections in Mali but low evidence of severe disease, hospitalization, or deaths. In contrast, COVID-19 patients with high levels of previous malaria infections showed lower risks of severe outcomes in Uganda.
SourceAmerican Society of Tropical Medicine & Hygiene·DateNov 19, 2021
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers at the Ragon Institute of MGH, MIT and Harvard have developed a new anti-malarial antibody that provides significant protection against malaria, outperforming existing best-in-class antibodies. The breakthrough could lead to improved distribution of monoclonal antibodies in endemic countries.
SourceMassachusetts General Hospital·JournalImmunity·TypeExperimental study·DateNov 16, 2021
Scientists sequenced Plasmodium falciparum genomes to understand malaria parasite populations and track drug resistance biomarkers. The study identified population-specific SNPs that can be used to determine transmission routes and monitor drug resistance.
SourceOsaka City University·JournalScientific Reports·TypeMeta-analysis·DateNov 16, 2021
Researchers from the University of Copenhagen have discovered that naturally acquired immunity to malaria works differently than immunity following vaccination. The immune system uses natural killer cells to fight the parasite, which is more tailored to the disease than other typical infections.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalNature Communications·DateNov 12, 2021
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Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A new study from Karolinska Institutet shows that explicitly addressing falsehoods is more effective in busting misbeliefs than simply stating scientific facts. The study found that two communication campaigns using WhatsApp audio dramas significantly reduced participants' incorrect beliefs about typhoid and malaria.
SourceKarolinska Institutet·JournalBMJ Global Health·TypeRandomized controlled/clinical trial·DateNov 10, 2021
Researchers have detected antibodies primarily made in response to mucous membrane infections, not typically thought of as a blood and liver infection, in study participants with malaria. The discovery provides new insight into the human body's response to malaria and may help identify new ways to treat or develop vaccines.
SourceUniversity of Maryland School of Medicine·Journalnpj Vaccines·TypeExperimental study·DateNov 2, 2021
A promising new antimalarial compound has been discovered in a collaboration between McMaster University and the University of Hamburg. The compound, duocarmycin PDE-I2, shows potent malaria-killing properties without the adverse effects of previously known compounds.
SourceMcMaster University·JournalCell Chemical Biology·TypeExperimental study·DateOct 27, 2021
A Brazilian study found that children exposed to malaria from birth are more likely to develop anemia by age two. The researchers, led by Dr. Marly Augusto Cardoso, followed 1,539 children and discovered that 12.6% were anemic, with a higher prevalence in rural areas not covered by the study.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPLOS Neglected Tropical Diseases·DateOct 13, 2021
Scientists have developed a technique to sequence individual malaria parasites' genomes, allowing for the detection of new mutations. These mutations are often targeting a gene family controlling transcription in malaria, suggesting potential avenues for developing more effective treatments and vaccines.
SourceTexas Biomedical Research Institute·JournalCell Host & Microbe·DateOct 13, 2021
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A study at Stockholm University has discovered a novel, eco-friendly feeding trap that can be deployed to control mosquito populations. The trap uses a beetroot-based mix with added toxins, which attracts and kills female mosquitoes, while leaving male mosquitoes unaffected.
SourceStockholm University·JournalCommunications Biology·TypeExperimental study·DateOct 12, 2021
Chronic P. vivax infections cause significant damage to kidneys, brain, and circulatory system, affecting impoverished communities. The parasite can hide at low levels, making diagnosis difficult and treatment efforts challenging.
SourcePLOS·JournalPLOS Medicine·TypeCommentary/editorial·DateOct 7, 2021
Researchers studying blood samples from over 12,000 individuals in Ethiopia found that malaria parasites can evade detection by rapid diagnostic tests due to genetic mutations. The study highlights the need for alternative diagnostic approaches and surveillance across the Horn of Africa.
SourceUniversity of North Carolina Health Care·JournalNature Microbiology·TypeData/statistical analysis·DateSep 28, 2021
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Researchers at Kanazawa University have identified a new vaccine platform that targets liver cells to induce anti-malaria immunity. The AAV8 vaccine platform was found to be more effective in eliciting a T cell-mediated response in the liver, providing sterile protection against malaria in a murine model.
SourceKanazawa University·JournalFrontiers in Immunology·DateSep 16, 2021
Researchers have identified global hotspots where bird malaria is spreading rapidly, with significant impacts on bird populations. The study found that climate and forest conditions play a crucial role in predicting infection risks, highlighting the need for conservation efforts to protect bird species from this deadly disease.
SourceUniversity of Queensland·JournalGlobal Ecology and Biogeography·DateSep 7, 2021
A new study published in the New England Journal of Medicine found that a combination of seasonal vaccination with RTS,S/AS01 E and antimalarial drugs significantly reduces clinical episodes, hospital admissions, and deaths from malaria. The results show a 70% reduction in these outcomes compared to current interventions.
SourceLondon School of Hygiene & Tropical Medicine·TypeRandomized controlled/clinical trial·DateAug 25, 2021
A new study led by ISGlobal has identified a gene called PfAP2-HS that allows the malaria parasite to defend itself from febrile temperatures and other adverse conditions within the host. The study found that this gene activates a protective response against high temperatures, helping the parasite survive in the host's environment.
SourceBarcelona Institute for Global Health (ISGlobal)·JournalNature Microbiology·DateAug 16, 2021
A new monoclonal antibody called CIS43LS safely prevented malaria for up to nine months in a small clinical trial. The study builds on encouraging early results and will inform additional research to confirm and extend the finding.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateAug 11, 2021
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