Articles tagged with Malaria
A network of African scientists has secured funding to develop new drugs for malaria and TB, two major diseases affecting the continent. The Grand Challenges Africa Drug Discovery Accelerator Programme will support leading research efforts on these diseases.
DNA analysis of ancient Bahraini remains shows the presence of a malaria-protective G6PD Mediterranean mutation in three samples, suggesting many people in ancient populations enjoyed protection from malaria. The discovery provides insights into human history and disease progression in the region.
Scientists at the University of California, Riverside, have identified 898 RNA-dependent proteins in the deadliest human malaria parasite, Plasmodium falciparum. These findings could lead to novel therapeutic targets against malaria and highlight the importance of RNAs in biological pathways in the parasite.
Researchers at Virginia Tech found that blocking two enzymes in the malaria parasite prevents it from growing, offering a potential new way to fight the disease. The study, published in Proceedings of the National Academy of Sciences, used an in vitro culture dish and discovered compounds that can inhibit parasitic growth.
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
Researchers from ANU discovered a new ability of Atypical B cells (ABCs) to fight infectious diseases like malaria. ABCs play a crucial role in developing T follicular helper cells that generate powerful antibodies.
Researchers have developed a novel approach to determine the age of mosquitoes, which could help improve pesticide strategies and reduce the spread of diseases like malaria. The method uses surface-enhanced Raman spectroscopy (SERS) to analyze biomolecules in mosquito water extract.
A new study published in Nature Communications has provided structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum. The research suggests that the drug, TDI-8304, can selectively target and kill resistant parasites, offering hope for more effective treatments against ...
The MAMAH trial found that preventive treatment with DHA-PPQ significantly reduces the risk of malaria infection and disease in pregnant women living with HIV. Women in the treatment group had almost eight times lower risk of clinical malaria and half the risk of becoming infected compared to the placebo group.
A recent study in Uganda found that asymptomatic individuals with low-level malaria infections had highly variable parasite dynamics and species present. Frequent sampling every other day or daily was sufficient to detect a proportion of infections similar to daily testing, but less frequent tests may miss up to one-third of cases.
A new study published in Cell Host & Microbe concludes that even people with the protective Duffy-silent blood type can still become infected with malaria. The research suggests that the parasite may have found alternative ways to infect red blood cells, raising questions about how to combat this type of malaria.
Researchers discovered that only a small proportion of red blood cell precursor cells infected by Plasmodium vivax are likely to produce the parasite, confirming its ability to replicate outside the bloodstream. This finding raises new questions about malaria diagnosis and treatment strategies in Duffy-negative individuals.
Anopheles stephensi, a malaria-carrying mosquito, has been found to exploit construction sites and brick-making facilities in Jigjiga, Ethiopia, during the dry season. Targeted control measures, such as stocking construction pits with larvae-eating fish, may help mitigate malarial outbreaks in the city.
A team of scientists developed a technique to rapidly detect genetic changes in malaria parasites using portable MinION sequencers. They demonstrated the first end-to-end, real-time pathogen monitoring from clinical blood samples in rural, resource-limited malaria hotspots.
A team of researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg has combined artemisinin with coumarin to develop an autofluorescent compound that destroys certain malaria pathogens. The new compound is effective against drug-resistant strains and shows promise for treating malaria.
The Malaria Atlas Project has received a $16 million grant from the Bill & Melinda Gates Foundation to track and tackle malaria globally. The project will focus on boosting research in Sub-Saharan Africa, where malaria is endemic, and strengthening research capacity.
A new study published in PLOS Neglected Tropical Diseases found that adding small quantities of liquid soap to some classes of pesticides can boost their potency by more than ten-fold. This discovery is promising news as malaria-carrying mosquitoes display an increasing resistance to current insecticides.
The Asian malaria mosquito Anopheles stephensi is spreading drug and diagnostic resistant malaria in Africa, increasing the risk of malaria infections by 270%. Its unique ecology and resistance to insecticides make it challenging for conventional mosquito control tools.
Research identifies specific gut bacteria that increase risk of severe malaria in humans and mice, sparking new approaches targeting gut microbiota. The study's findings could lead to prevention strategies for severe malaria-related deaths.
Researchers discovered a malaria protein, PfAP2-P, that plays a key regulatory role in immune evasion and parasite development. This protein acts as an activator of proteins required for the parasite to exit infected red blood cells and invade new ones.
A species of Asian mosquito, Anopheles stephensi, is responsible for a sharp expansion of malaria cases in Africa, particularly in urban areas. The mosquito's ability to thrive in dry conditions and adapt to new breeding sites has made it a significant threat to public health.
A study published in Nature Communications suggests that a key mutation rendering malaria parasites resistant to atovaquone also makes them non-transmissible via mosquitoes. Researchers propose an injectable formulation of atovaquone for long-acting protection against malaria, overcoming concerns about resistance.
A new study by Duke University researchers has found endemic malaria in Turkana County, Kenya, with a significant incidence of Plasmodium vivax, a parasite historically rare in sub-Saharan Africa. The presence of invasive mosquito species Anopheles stephensi also poses challenges to the continent's malaria control efforts.
A systematic review by ISGlobal found that malaria parasite prevalence is highest in migrants from the Sub-Saharan region, particularly those from Central Africa. The study included 23 studies with a total of 4,203 participants tested for malaria parasites.
Scientists discovered a key regulator that balances X chromosome genes between male and female mosquitoes, which could help develop new ways to prevent the spread of malaria. The finding sheds light on how mosquitoes compensate for having only one X chromosome, offering potential strategies to reduce blood-sucking female mosquitoes.
In Eritrea, a new artemisinin-resistant variant has been detected, accompanied by gene deletions that render rapid diagnostic tests ineffective. This emergence poses a significant threat to malaria control efforts in the Horn of Africa and beyond.
Malaria parasites have developed resistance to artemisinins, a critical treatment for non-severe cases, with devastating consequences. The study found that effectiveness declined by 2025% between 2016 and 2019, highlighting the urgent need for new treatments.
Researchers found that next-generation interventions like triple ACTs resulted in treatment failure counts at least 81% lower than traditional therapies. The study suggests extending treatment courses and using multiple drugs simultaneously may hold treatment failure rates near 10%.
Philip Low, a Purdue University researcher, is working on validating a previously successful malaria treatment by reducing the number of days required for therapy. His goal is to prevent drug-resistant strains from proliferating and save lives in developing countries.
Scientists have detected new strains of malaria-causing parasites in Ethiopia that are resistant to current treatments and escape detection by common diagnostic tests. The prevalence of these double-resistant parasites is a concern for malaria control and elimination efforts in Africa, where the disease remains endemic.
A new study found that snakebites resulted in the loss of 3,000 productive days of work and school, with median financial setbacks of $17 per household. The study highlights the significant disease and economic burden of snakebites in rural Mozambique.
Scientists have identified specific long noncoding RNAs that regulate gene expression and life cycle progression of the deadly Plasmodium falciparum malaria parasite. The discovery could lead to new therapeutic strategies against malaria.
The Phase 3 study confirmed that combining the RTS,S vaccine with antimalarial drugs reduces clinical malaria episodes, severe malaria cases, and deaths from malaria in young children by nearly two-thirds compared to either intervention alone. The vaccine-drug combination provided greater than 90% protection against malaria episodes.
A study by Cornell University researchers found that current methods for measuring malaria parasite multiplication rates vastly overestimate the actual rates, which has significant implications for vaccine efficacy and understanding of drug resistance.
A systematic review by the University of Adelaide found combining pyrethroid insecticide with chlorfenapyr improves its effectiveness in treating malaria-preventing mosquito nets. The WHO has updated its guidelines to include these new recommendations.
A systematic review and meta-analysis found that dual active ingredient insecticide-treated nets are effective in preventing malaria. The study showed that these nets can control the spread of the disease when traditional pyrethroid-based nets become less effective due to resistance.
A new malaria vaccine candidate has shown promising results in a cohort of Tanzanian infants, with substantial anti-RH5 immune responses achieved safely through vaccination. The vaccine targets the RH5 protein used by the malaria pathogen to invade red blood cells, providing a second line of defense against disease.
A new study reveals that mosquitoes use a specific receptor in their ears to modulate their hearing, which is crucial for reproduction and mating. This discovery could lead to the development of novel insecticides or mating disruptors to control mosquito populations and reduce human disease.
Researchers tested an automated microscope combined with AI software to diagnose malaria in blood samples. The system achieved 88% accuracy, comparable to expert microscopists, and has potential benefits including reducing workload and increasing patient load.
The first locally acquired malaria cases in the US in 20 years have been reported, highlighting the need for clinicians to be vigilant about the disease's symptoms. Malaria thrives in warmer climates and can cause serious illness and death if not treated, emphasizing the importance of rapid diagnosis and treatment.
Research by the Peter Doherty Institute found that inflammation alters plasma composition, hindering parasite maturation. This work reveals a new mechanism slowing down malaria parasite development in the bloodstream.
The widespread use of insecticides for malaria control has unintended consequences, including the development of resistance in other disease-carrying arthropods. This can lead to the spread of overlooked and dangerous tropical diseases. Understanding the behavior and insecticide susceptibility status of these organisms is crucial to pr...
Researchers from Leicester and Nottingham universities have received £600,000 funding to study sexual development and gene shuffling in the malaria parasite. The study aims to uncover new targets for therapies to control disease transmission.
A breakthrough mRNA vaccine has been developed to target and stimulate protective immune cell responses against malaria. The vaccine combines an RNA-based approach with a liver-specific adjuvant, generating resident memory cells that halt malaria infection in the liver, providing a broader and more protective immune response.
The digitization of Johanna Bonne-Wepster's field notes has filled significant gaps in mosquito research and tropical medicine. The collection contains valuable information on vector-borne diseases and their spread, which can inform current public health issues and future disease modeling.
A study published in Nature Communications found that infection rates in pregnant women attending antenatal care visits closely reflect the rates in children from cross-sectional studies, especially when molecular tests are used. This correlation can help estimate disease burden and inform control measures.
Scientists have developed a new genetic technology called Ifegenia that suppresses populations of Anopheles gambiae mosquitoes, which primarily spread malaria in Africa. The system targets females, which are the primary disease carriers, and kills them, halting parasite transmission.
Scientists at Tokyo Institute of Technology identified ApSigma, a nuclear-encoded apicoplast RNA polymerase σ subunit that coordinates gene expression with the life cycle of Plasmodium falciparum and host circadian rhythm. Melatonin is shown to increase apicoplast transcription and expression of the apSig gene.
A new genomic analysis reveals a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique. The findings suggest that artemisinin remains effective for treating malaria, while piperaquine can be used in combination therapies. However, the high frequency of quintuple mutants requires close monitorin...
Researchers have identified anti-malarial properties in cancer drugs, offering a potential solution to the growing crisis of drug-resistant malaria. The study found that certain protein kinase inhibitors exhibited strong anti-malarial effects, highlighting a new approach to accelerating drug discovery.
Researchers at UNIGE have identified a new type of molecular sensor that enables the malaria parasite to infect human cells or mosquitoes at just the right moment. By understanding how this sensor works, scientists can potentially scramble its signals to disorientate the parasite and block its multiplication and transmission.
CNRS scientists have identified a molecule that prevents parasites of Plasmodium from invading blood cells, paving the way for a new class of antimalarials. The discovery is based on the key role of myosin A in malaria infection and its inhibition by KNX-002.
Researchers detected Plasmodium falciparum, the deadliest form of malaria, in mummified tissues from Medici family members. The parasite was identified through microscopic and molecular analyses, revealing characteristic ring-shaped structures and Maurer's clefts.
A study by Florida Atlantic University and Duke University reveals that the malaria parasite's biological clock is 'in sync' with its human host's circadian clock. The researchers discovered a 'coupling' mechanism between the parasite and its host, which could lead to new treatments for this deadly disease.
Researchers found that malaria parasites synchronize their gene expression with the host's internal clock, repeating every 24 hours. The study reveals a potential new target for anti-malarial drugs by 'jet-lagging' the parasites' clocks.
A study of almost 65,000 children aged up to 5 found that nearly 27% are infected with malaria, with older under-five children and those from large families or rural areas being most vulnerable. Insecticide-treated bed nets and improved housing are promising means to prevent malaria infection among children.
An observational study of 329,000 Medicare admissions found that older persons receiving hospital care from allopathic (M.D.) or osteopathic (D.O.) physicians experience similar quality and cost of care. Researchers also highlight systemic health inequities faced by persons with sickle cell disease.
Mosquitoes use human body odor to find hosts over long distances, with specific airborne components making some people more attractive than others. Researchers found that carboxylic acids and eucalyptol are key contributors to this attraction, with varying levels affecting mosquito choosiness.
A new study has identified a second key gene, AAT1, involved in malaria's resistance to the drug chloroquine. The finding, published in Nature Microbiology, has implications for the ongoing battle against malaria.
Researchers identified compounds in Labrador tea leaves that have antimalarial properties, particularly ascaridole, which has activity against drug-resistant Plasmodium falciparum parasites. The study highlights the importance of investigating and protecting plants used in traditional medicines.