Articles tagged with Parasites
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Researchers identify LMIT1, a mitochondrial iron transporter in Leishmania parasites, as crucial for parasite virulence. Inhibiting LMIT1 function can abolish parasite virulence and reduce disease severity.
A recent study found that dihydroartemisinin-piperaquine treatment has failed in certain provinces of Cambodia due to parasite resistance. The WHO has reinstated artesunate plus mefloquine as the first-line treatment in these areas. New surveillance and clinical trials are needed to track the spread of piperaquine resistance.
Scientists reveal that inflammatory molecules driving the immune response in clinical and severe malaria also prevent protective antibodies from developing against the parasite. This discovery could lead to new approaches for boosting key immune cells needed for long-lasting immunity.
A team of NUS researchers discovered over 120 protein targets of artemisinin in Plasmodium falciparum, the most pathogenic malaria parasite. The study found that haem is the main activator of artemisinin, which targets essential biological processes in the parasite.
A US$200,000 grant from the Bill & Melinda Gates Foundation will support the development of a one-shot vaccine for tapeworms, reducing deaths from neurocysticercosis in developing countries. The vaccine aims to break the lifecycle of the parasite, causing brain cysts and seizures.
Researchers discovered how a common parasite, Toxoplasma, hijacks host cells to store food for decades, altering host behavior. The findings could lead to vaccines and drugs to protect against the parasite's serious risks, including miscarriage and birth defects.
Researchers have discovered a way to manipulate the parasite that causes African sleeping sickness, making it easier for the host immune system to eliminate. By inhibiting specific proteins, they can 'trick' the parasite into a different stage of its lifecycle.
Researchers have found a way to manipulate trypanosomes in the mammalian bloodstream to acquire fly stage characteristics, making them easier for the host immune system to eliminate. Inhibiting specific proteins that interact with chromatin can 'trick' the parasite into differentiating to a different stage of its lifecycle.
The study reveals how malaria parasites infect liver cells, a critical step in their lifecycle. The discovery provides new insights into the molecular details of malaria infection and has significant implications for developing new drugs and vaccines.
A team of researchers developed a model to predict the effects of parasite refugia on disease prevalence and drug resistance. The model suggests that introducing drug-susceptible parasites into a population can reduce overall drug resistance.
A new study suggests parasitic worms can impact human reproduction rates, with roundworms increasing childbearing by up to two more children than uninfected women, while hookworms decrease it by up to three fewer children.
Research by UCSB anthropologists found that parasitic intestinal worms can impact the timing of pregnancies among Tsimane women, with hookworm infection increasing intervals between births and roundworm infection shortening them. This study suggests helminth infections may affect demographic patterns in developing populations.
Researchers identify unique expansions of gene families related to chemoreception and feeding in Rhodnius prolixus, the kissing bug that transmits Chagas disease. These findings may lead to novel approaches for controlling or eliminating the disease by targeting specific genes or processes.
Researchers from University of Nottingham uncover cyclin's crucial role in malaria parasite development within mosquitoes and mammal hosts. The study identifies three types of cyclin, shedding light on the disease's complex life cycle.
A computer simulation study suggests that treating malaria with a combination of more effective and less effective drugs can slow the spread of drug-resistant parasites. The non-artemisinin therapy, even when only 85% effective, works best in this approach.
Researchers analyze Cryptosporidium parvum protein involved in energy metabolism, identifying it as a potential target for developing therapeutics. The study found that lactate dehydrogenase inhibitors can inhibit parasite growth and ATP production.
Scientists have identified the poly(A) tail as a crucial component in LINE-1 retrotransposition, a process that can cause genetic mutations and diseases. Without the tail, the parasite's jumping ability is significantly impaired, offering new strategies for inhibiting its movement.
A new study reveals that relapsed malaria infections are a significant obstacle to malaria eradication in the Asia-Pacific region. Most childhood infections in Papua New Guinea are caused by relapsed P. vivax infections, which can hide in the liver and re-emerge after treatment.
Lesly Temesvari will research the cellular biology and life cycle of Entamoeba histolytica to develop drug therapies or a vaccine. Improving sanitation is also crucial in preventing the spread of amoebic dysentery.
Researchers at the University of Cincinnati uncovered ancient parasites on marine animals, including snails and worm-like creatures. The parasitic interactions between crinoids and these organisms reveal complex adaptations and co-evolutionary relationships over hundreds of millions of years.
Researchers explored the use of ivermectin in mass drug administration campaigns to reduce malaria infections in Africa and slow down drug resistance in Asia. Preliminary results showed a 16% reduction in childhood malaria episodes in Burkina Faso, where most population members received regular ivermectin doses.
Researchers found developing resistance to miltefosine in patients with post-kala-azar dermal leishmaniasis, leading to higher relapse rates. The study suggests a pressing need for new therapies to combat drug-resistant strains of the disease.
A recent NIH study found that artemisinin-resistant Plasmodium falciparum parasites can infect diverse mosquito species in Africa, including Anopheles coluzzii. This discovery suggests a higher risk of drug-resistant malaria infections in Africa, posing challenges to efforts to prevent and eliminate the disease.
A Griffith University PhD candidate has discovered that up to 40% of Indian Mynas in eastern Australia carry avian malaria parasites, posing a significant threat to native wildlife. The spread of these invasive birds could expose native birds such as parrots and magpies to new diseases.
Researchers have identified a five amino acid segment of Plasmodium parasite protein with protective antigenic properties, which can be used to develop antibodies and prevent malaria transmission through mosquitoes. The finding has the potential to lead to the development of a powerful malaria vaccine.
Researchers at Queen's University Belfast have developed a technology using peptide mimics to combat parasitic nematodes, which infect crop plants and reduce yields by up to 50%. The project aims to protect crops like banana and plantain, grown by smallholders in developing countries.
Researchers have discovered that short segments of genes associated with severe malaria are shared across multiple species, including humans, apes, and chimps. This finding suggests an ancient genomic structure underlying human malaria virulence factors, which could aid in developing new treatments and vaccines.
Research found that carbohydrate-binding protein Gal-1 modified infection in heart muscle cells, highlighting its importance in response to parasite infection. Galectins, like Gal-1, play a role in regulating parasite interactions and may recognize glycans on the host cell surface used for invasion.
Researchers discovered that the parasite Brugia malayi releases microRNA-containing vesicles to infect human hosts. These vesicles activate a pro-inflammatory response in human macrophages, opening up new avenues for therapeutic targets and treatment strategies.
A new study found that species extinction can lead to secondary extinctions of parasites, compromising ecosystem stability and biodiversity. Researchers identified key host species that contribute to the overall network structure of fish communities and are essential for maintaining a healthy ecosystem.
Researchers have found that parasites resistant to artemisinin-based therapies can also resist other antimalarial drugs, making combination therapies less effective. This new multi-drug resistance is a serious threat to malaria treatments in Southeast Asia.
Researchers successfully silenced genes in human cells to induce immunity against the parasitic disease caused by E. histolytica, which affects 50 million people worldwide. The study identified key genes involved in managing potassium flow into and out of human cells, paving the way for new drug targets.
Research by Vladimir Dinets and Mark Hauber found that two invasive Eurasian cuckoo species are on the verge of invading North America, posing a threat to native bird populations. The cuckoos' sophisticated parasitic behavior, including egg mimicry, may evade defenses developed by Native American birds against cowbirds.
UK researchers find tissue cysts of Toxoplasma gondii are active, contradicting long-held notion of dormancy. This discovery has significant implications for understanding chronic toxoplasmosis in the brain and its connection to neurological diseases.
A study by University of Texas at El Paso researchers found that 61% of kissing bugs in west Texas are infected with the Trypanosoma cruzi parasite, which causes Chagas disease. The disease can lead to life-threatening symptoms like heart rhythm abnormalities and difficult eating or passing stool.
Researchers discovered a way to create cell immunity to the E. histolytica parasite by silencing specific genes involved in potassium transport. This approach could lead to the development of new drugs targeting the parasite and preventing deadly diseases.
Researchers demonstrate how community ecology can provide new analytical tools for understanding diseases and their impacts on multiple hosts and vectors. The approach highlights the need for a broad contextual understanding of diseases and identifies strategies such as managing symbiotic microbial communities and preserving biodiversity.
Researchers identified a nanobody that stabilizes an enzyme essential for parasite invasion and reproduction. The discovery reveals a previously unappreciated feature of the enzyme's activation, making it a potential target for prevention and treatment of diseases like malaria.
Researchers found that injecting specific adult fat tissue cells early after Chagas Disease infection can modify the animal's response, reducing parasite presence and heart inflammation. The study aims to explore the use of these cells as a potential treatment for cardiac damage caused by the disease.
Researchers found four common bee parasites dispersed via flowers, causing diseases such as lethargy, dysentery, and colony collapse. The study suggests planting more flowers can provide bees with options, reducing parasite spread.
Researchers at the Walter and Eliza Hall Institute have developed a new class of antimalarial drugs by targeting the critical malaria 'conductor' protein plasmepsin V. The discovery could effectively kill two species of malaria parasites, including the deadliest form Plasmodium falciparum, which causes most malaria-related deaths.
Scientists have uncovered a port of entry for malaria parasites in the liver, highlighting a potential new drug target. The discovery could help prevent the spread of disease and reduce malaria-related deaths worldwide.
A study published in Ecology found that parasite prevalence and diversity increase with higher latitude, challenging the typical latitudinal diversity gradient. This exception suggests that local ecological factors play a role in shaping biodiversity, despite the general pattern of decreasing species richness towards the poles.
A new anti-basigin drug has cured mice of established malaria infection with minimal side effects, offering hope for treating the deadly disease. The drug's development path may be less complex than traditional clinical trials, as it builds on existing knowledge of the protein's role in cancer and graft-versus-host disease.
Scientists have identified a potent agent, DSM265, that thwarts drug resistance in malaria parasites. This breakthrough treatment has the potential to be used for both single-dose and once-weekly doses, offering new hope against the disease.
Researchers found that existing malaria infections in mosquitoes facilitate replication of secondary infections, leading to higher parasite loads. This could disproportionately contribute to malaria transmission, especially if control measures focus on reducing mosquito feedings.
Researchers at the University of Georgia have developed new tools to study and genetically manipulate cryptosporidium, a major cause of life-threatening diarrhea in infants and toddlers. The breakthrough techniques will help find new treatments and vaccines for the parasite.
University of Washington chemists have developed a novel drug to fight malaria, DSM265, which targets the critical protein DHODH. The compound has shown promise in laboratory tests and is suitable for clinical trials in humans.
Scientists have identified a key protein that, if targeted, can stop the disease. The discovery could lead to precise drug design with limited toxicity, making it safe for vulnerable populations.
Researchers will study the complex interaction of human and natural forces that may alter patterns of disease transmission. Small prawns are expected to kill snails effectively, providing a potential solution to schistosomiasis.
Researchers developed targeted nanoparticles that deliver existing drugs directly into parasite cells, reducing the curative dose by 100-fold and circumventing drug resistance. This high-tech approach has the potential to reverse resistance to many first-line treatments for infectious diseases.
A new study finds that calcineurin is essential for malaria parasites to invade red blood cells. The protein allows the parasite to recognize and attach to the red blood cell surface, and inhibitors of calcineurin can prevent infection.
A months-long literature search uncovered evidence that a microscopic aquatic parasite, Blastulidium paedophthorum, is a widespread and virulent multi-host parasite in southeastern Michigan lakes. The research found that the parasite significantly impacts host fecundity without reducing Daphnia lifespan.
Researchers have discovered a new and promising target site for a potential vaccine against malaria, a mosquito-borne illness that kills hundreds of thousands each year. The AnAPN1 protein is believed to be central to the transmission of the malaria parasite through mosquitoes.
Researchers uncover detailed information on AnAPN1 protein shape and antibody binding sites, enabling the design of more effective mosquito-based vaccines. This breakthrough may lead to a reduced number of infected mosquitoes and eventual disease eradication.
A University of South Florida study confirms the dilution effect hypothesis, suggesting biodiversity loss poses a public health threat by causing disease outbreaks. The research found broad evidence that species-rich communities suffer less infectious disease, implying maintaining biodiversity could reduce parasite abundance.
A two-year study on bumble bees in Alaskan agricultural areas reveals declining populations of the western bumble bee species Bombus occidentalis, which is infected with Nosema and social parasites. The research provides baseline data for understanding reported patterns of bumble bee declines in North America.
A new study published in PLOS Pathogens reveals that malaria parasites growing in different host cells can develop resistance to antimalarial drugs. Researchers found that the metabolic state of red blood cells provides a unique environment for Plasmodium parasites, allowing them to scavenge essential resources and evade drug targeting.
Researchers have identified two genetically divergent subpopulations of P. knowlesi in human cases, each associated with a different species of reservoir host. This discovery highlights the complexity of zoonotic malaria transmission and may lead to new possibilities for parasite adaptation to humans.
A new study uses 3D printed eggs to test how birds identify and reject parasitic eggs with greater precision. Researchers found that robins accepted 100% of blue-green eggs but rejected 79% of cowbird-like eggs, similar to past studies but with less variability and precise reproduction.