Articles tagged with Parasites
Researchers developed a modified CRISPR/Cas9 system to efficiently edit the malarial parasite Plasmodium falciparum's gene expression. By altering histone acetylation near invasion-related genes, they increased or decreased erythrocyte invasion efficiency.
Researchers at SUTD and NTU developed ferrocene-based molecules that impair malaria parasite's metabolic function, leading to parasite death. G3, a gold complexed ferrocinyl phosphine derivative, demonstrated potent antimalarial activity against standard and drug-resistant strains.
A URI researcher found that oyster aquaculture can limit the spread of disease among wild oysters. Aquaculture operations can reduce disease by filtering parasites from the water and holding oysters long enough to prevent their development. Intensive oyster aquaculture, when done correctly, can be beneficial for wild populations.
Researchers at Kanazawa University have discovered that a baculovirus can completely eliminate liver-stage malaria parasites in mice. The study suggests a new approach to developing non-haemolytic single-dose alternative drugs for P. vivax treatment, potentially reducing the risk of infection and side effects.
Researchers developed a new approach to prevent malaria by targeting the parasite at an earlier stage in its lifecycle. They tested over 500,000 chemical compounds and identified 631 promising candidates that could form the basis for new drugs.
Researchers have identified a natural flavonoid, 2'-Hydroxyflavanone (2HF), effective in treating Leishmania amazonensis infections. The compound showed no side effects and reduced parasite loads and lesion sizes in infected mice.
Researchers have pinpointed details of a signal that enables parasites to change form and be transmitted by flies, offering a new way to tackle the disease. Disrupting this process with drugs could limit drug resistance and provide a treatment option.
A new study reveals that Plasmodium falciparum parasites can directly convert from their asexual to sexual form without an additional replication cycle, increasing the parasite's survival and transmission capabilities. This finding provides important information on the malaria parasite's lifecycle and its transmission to mosquitoes.
Researchers at Clemson University have discovered a key role for glucose in the parasite's life cycle, potentially leading to new treatments for African sleeping sickness. The study sheds light on how the parasite adapts to its environment and can inform strategies to defuse outbreaks.
Researchers discovered that malaria parasites adjust their reproduction strategy based on host conditions, opting to invest more in reproduction when conditions are favorable and prioritizing survival during adverse times. This finding could inform the development of new treatments by prompting parasites to spread more easily.
A balanced pro and anti-inflammatory cytokine signature is associated with lower clinical malaria risk between ages 3-4. Early parasite exposure does not affect the risk, but may impact long-term immunity.
Karine Le Roch, a UC Riverside professor, is awarded two NIH grants totaling $6.6 million to study Plasmodium falciparum parasites and develop novel therapeutics. The research aims to target RNA-binding proteins, or RAPs, which are essential to parasite development.
A new study reports that over 100 working dogs in the US have been infected with Chagas disease, a tropical parasite known to cause heart problems. The dogs were tested for antibodies to the parasite and many showed signs of heart abnormalities associated with the disease.
A recent study led by ISGlobal identifies new antibody markers associated with the RTS,S malaria vaccine's protective effects. The research reveals that IgG1 and IgG3 antibodies provide crucial protection against disease, while IgG2 and IgG4 may increase disease risk.
Researchers found that sniffer dogs could scent malaria in samples of socks worn by infected children, with an accuracy rate of 70% for malaria-infected samples. The trained dogs could distinguish between the scent of malaria parasites and uninfected individuals, providing a non-invasive way to screen for the disease at ports of entry.
Researchers reconstructed species distribution using environmental DNA signals from stationary organisms and their parasites in rivers. Environmental DNA may be a tool for monitoring biodiversity in river networks.
A new study has successfully trained sniffer dogs to detect malaria infections in socks worn by African children, with an accuracy rate of 70% and a potential to assist in malaria elimination campaigns. The dogs were able to identify the distinctive odor emitted by malaria parasites, which was not present in uninfected individuals.
The Himalayan gold fungus, valued at $11 billion, is facing extinction due to intensive harvesting and climate change. The fungus's decline may have severe consequences for communities that rely on it for their livelihood.
Researchers at Scripps Research have discovered how antibodies work together to bind to a vulnerable spot on the malaria parasite, blocking its life cycle. This breakthrough could lead to the development of more effective vaccines that stimulate the same antibody response.
Scientists have discovered that DNA packaging proteins play a central role in the parasite's ability to alter its surface coat protein, enabling it to evade the host's immune system. This process, known as antigenic variation, allows trypanosomes to stay one step ahead of the game and establish long-term infections.
A study published in Parasites & Vectors found that host decoy traps baited with human or cattle odour can effectively collect outdoor-biting mosquitoes, including the main malaria vector species Anopheles arabiensis. The traps outperformed traditional methods such as human landing catch and caught more mosquitoes than expected.
Researchers found that the peppermint shrimp outperformed other species in a set of experiments, reducing parasite infection by 87% and targeting environmental stages. This discovery provides a viable candidate for a natural biocontrol agent to combat parasites in aquaculture industries.
University of Otago researchers have discovered a way to culture cynomolgi malaria parasites, which are almost identical to vivax malaria. This breakthrough could help eliminate the relapsing form of human malaria, a major public health concern worldwide.
Malaria parasites have evolved to replicate in sync with mosquitoes' feeding cycles, causing regular bouts of fever. Scientists discovered that these parasites are more infectious to mosquitoes during the day, and their replication patterns likely evolved to optimize transmission.
A study published in eBioMedicine found that the absence of four particular genes in the Leishmania infantum parasite makes it less susceptible to miltefosine, an oral drug used to treat visceral leishmaniasis. This discovery could lead to a new prognostic test to predict treatment outcomes and tailor medicines accordingly.
Some species are unable to recognize genetic differences between their own offspring and those of intruders, leading to acceptance. Genetic features associated with recognition may have died out due to the disadvantage of being different, making it impossible for parents to reject parasitic offspring.
Melbourne researchers have discovered a way to halt the invasion of the toxoplasmosis-causing parasite into cells, depriving it of a key factor necessary for its growth. This breakthrough could lead to a vaccine or treatment for Toxoplasmosis and shed light on general processes involved in other diseases caused by related parasites.
Scientists have discovered a way to enhance the effectiveness of artemisinin, a powerful antimalarial drug, by combining it with chemotherapy medicines that target the parasite's waste disposal system. The combination works by jamming the recycling process, leading to cell death in the parasite.
Researchers at Imperial College London have identified six compounds that can prevent malaria parasites from maturing inside mosquitoes, reducing disease transmission. These compounds, which target the parasite's sexual forms, could be used to develop new antimalarial drugs that not only cure individuals but also protect communities.
A new model developed by scientists at the University of Bristol aims to help farmers tackle multi-million losses due to liver fluke infestations. The model explicitly links liver fluke prevalence with key environmental drivers like soil moisture, enabling farmers to make informed decisions on grazing and treatment.
A mathematical model for malaria shows that competition between parasite strains within a human host reduces the odds of drug resistance developing in high-transmission settings. The model reveals how once a drug-resistant strain becomes established, it will spread faster in high-transmission areas than in low-transmission areas.
Researchers discovered fossil parasites inside their hosts, describing four extinct wasp species that were unknown until now. The study provides major information on the evolution of parasitism and its impact on ecosystems.
The NIH study found that the EXP2 protein forms a channel in the vacuole membrane of Plasmodium falciparum, enabling the parasite to obtain essential nutrients. This discovery could lead to the development of new drugs targeting this nutrient transport mechanism.
Researchers at INRS have developed a cost-effective approach to rapidly identify molecules capable of eliminating Leishmania, a parasite responsible for the deadly tropical disease. The innovation, led by Professors Albert Descoteaux and Steven LaPlante, aims to overcome obstacles in finding effective treatments.
Researchers found that a specific type of fish louse, Argulus japonicus, can accumulate high concentrations of metals, potentially serving as an early warning system for water quality. The lice's unique mechanisms for protecting themselves from toxins may hold the key to detecting metal pollution.
Researchers at James Cook University found that shrimp clean parasites from injured fish without aggravating their injuries. The interaction between cleaner shrimp and client fish also reduces stress levels, potentially increasing the fish's ability to heal.
A new study reveals that lower-risk malaria regions are breeding grounds for drug-resistant strains of the Plasmodium falciparum parasite. The research suggests that emerging resistant strains spread rapidly in areas with high transmission rates, making it crucial to tailor malaria response strategies for local conditions.
Researchers analyzed ape parasite genomes related to Plasmodium vivax, the main source of mosquito-borne malaria outside Africa. They found near-identical genomes between ape and human parasites, differing by only two percent within gene sequences that code for proteins.
A new interaction between plant and insect parasites is found when the two exist on a shared host. The parasite-leeches nutrients and moisture away from the wasp larvae developing in the tree, while also attacking unusual growths caused by the wasps. This discovery has implications for agriculture and medicine.
A study comparing ape and human P. vivax genomes reveals nearly identical DNA sequences, but with key differences in genetic diversity and binding proteins. The findings suggest an evolutionary bottleneck where the parasite passed from apes to humans in Africa, then spread globally.
Researchers from Harvard University review the tripartite system between bats, bat flies, and Laboulbeniales fungi, highlighting the need for further study on this understudied phenomenon. The team aims to advance our understanding of the biology, host associations, and phylogenetic relationships of these organisms.
Research from Purdue University found that when two strains of a parasite infect a host, the combined virulence is often worse than with only one strain. This could be bad news for people affected by schistosomiasis, a disease prevalent in Africa, the Middle East, and the tropics.
A recent study predicts the widespread presence of rat lungworm in Hawaii's islands and its expansion into higher elevations as climate warms. Researchers used molecular techniques to screen snails and slugs across the islands, finding the parasite in numerous species on five of six largest islands.
Scientists found that damage from chronic inflammation induces the death of white blood cells essential to eliminating the parasite, allowing it to sustain the infection. The findings may lead to possible treatment and shed light on a phenomenon shared by other chronic infections.
Researchers observed red-fronted lemurs in Madagascar chewing on millipedes to rid themselves of intestinal parasites. The animals then rubbed the area around their genitals, anuses, and tails with the chomped millipedes to treat conditions like itching and weight loss.
Researchers detected the Angiostrongylus cantonensis parasite in two patients in a Chinese hospital who consumed raw wild centipedes, linking it to foodborne illnesses. The parasite can cause meningitis, paralysis, and death, and has been found in snails, giant African land snails, and other regions.
Researchers analyzed mosquito screening as a tool to gauge parasite presence in lymphatic filariasis. No W. bancrofti DNA was detected in mosquitos collected from endemic and non-endemic areas of Bangladesh.
A team of malaria experts has published results supporting the need for a radical cure strategy to tackle Plasmodium vivax, a debilitating form of malaria. The study found that chloroquine is currently given in lower doses than recommended, leading to higher rates of treatment failure.
Scientists found that malaria parasites are ten times nimbler than the fastest of our immune cells and literally outrun our immune defences. This difference is due to a key issue in how actin filaments are formed and broken down, which could lead to new drugs targeting parasite actin.
Researchers have identified a critical protein produced by malaria parasites that can be targeted to elicit protection against re-infection. The vaccine, which targets the protein PMIF, has shown promise in mouse models and could potentially prevent transmission of the disease.
A study found that elevated CO2 levels reduce the protective compounds in milkweed plants, making monarch caterpillars more susceptible to parasites. This threat could have broad implications for animals and humans who rely on plant-based medicines.
Researchers at Morgridge Institute for Research identified key stem cells governing the complex life cycle of Schistosoma. A gene associated with germline development was also found, providing potential targets for prevention and treatment of schistosomiasis, a deadly neglected tropical disease affecting hundreds of millions.
Researchers have discovered a potential malaria vaccine target in the ICAM1 binding motif, which is critical to the parasite's virulence. Children with higher antibody levels to this motif had lower rates of clinical and severe malaria.
Researchers have developed a novel technique using genetically-encoded glucose biosensors to monitor Trypanosoma brucei parasite metabolism and identify molecules that disrupt glucose levels. This could lead to the development of therapeutics for African sleeping sickness, a disease causing fatal results in sub-Saharan Africa.
Researchers found that adult stem cells in the intestines are replaced by fetal growth genes after parasite injury, enabling rapid wound repair. This discovery could lead to new treatments for internal wounds and improve understanding of mammalian body repair mechanisms.
A new quantitative suspension array assay (qSAT) has been developed to measure antibodies against multiple Plasmodium falciparum proteins, simplifying sero-epidemiological studies and vaccine development. The assay is highly sensitive and specific, allowing for detailed analysis of natural and vaccine-induced antibody responses.
Toxoplasmosis is a widespread infection caused by the parasite Toxoplasma gondii, which multiplies within a host and causes irreversible tissue damage. The parasite implements an ingenious invasive strategy involving a protein complex and rotational force to gain entry to host cells.
Researchers have mapped the first contact between Plasmodium vivax malaria parasites and human red blood cells using cryo-EM technology. The discovery provides critical information for developing potential new antimalarial drugs and vaccines.
A study by ISGlobal reveals the presence of proteins from hypnozoites in circulating extracellular vesicles, providing a potential diagnostic tool for asymptomatic patients. This breakthrough could help identify and stop malaria vivax transmission, an essential requirement to achieve the WHO's target of eliminating malaria by 2030.
Researchers have developed a new approach for studying Cryptosporidium using lung and intestinal organoids, which support the complete life cycle of the parasite. This tool enables the testing of drugs and identification of vaccine candidates, providing hope for developing effective treatments.