Articles tagged with Parasites
Researchers from Singapore University of Technology & Design (SUTD) and CSIR-National Chemical Laboratories (NCL) completed phenotypic screening of the MMV Malaria Box against Plasmodium falciparum and Toxoplasma gondii, identifying 24 molecules with nanomolar potency against both parasites.
Researchers identify hundreds of genetic changes that enable malaria parasite resistance to multiple drugs. The study provides insights into the development of drug-resistant strains, highlighting potential targets for novel treatment options.
A study identified new drug targets and resistance genes in malaria parasites resistant to 37 diverse antimalarial compounds. The research, published in Science, revealed a complex chemogenetic landscape of the parasite's underlying biology.
Researchers describe two poly(A)-binding proteins that protect mRNA from translation in malaria parasites. The non-nuclear protein accumulates on the surface of sporozoites, suggesting a role in interacting with outside RNA and facilitating transmission.
Researchers developed an epidemiological model to study the effect of climate warming on host-parasite dynamics in Eurypanopeus depressus and its parasitic barnacle Loxothylacus panopaei. Infection prevalence declined at a 1°C temperature increase, with localized extinction occurring at 2°C warming in the southeastern United States.
Researchers successfully developed antibodies that disabled the Plasmodium vivax malaria parasite from infecting humans by hijacking a protein crucial for iron delivery. The discovery solved a decades-long mystery and brings the world closer to a potential effective vaccine against P.vivax malaria.
A study published in Nature Communications reveals that African trypanosomiasis, also known as sleeping sickness, is a circadian rhythm disorder caused by the acceleration of biological clocks. This understanding could lead to the development of new therapeutic alternatives to toxic treatments.
Researchers discovered dodder's sophisticated gene manipulation system, which operates like a computer virus, allowing the parasite to silence specific genes in its hosts. This finding has implications for engineering parasite-resistant plants.
Researchers discovered that a parasitic plant called Dodder can silence the expression of genes in its host plants, including those involved in defense against parasites. By targeting specific regions of the gene sequence, Dodder regulates the flow of nutrients to itself while preventing the host from producing defensive proteins.
Boris Striepen has received a $1.8-million grant from the Bill & Melinda Gates Foundation to support drug development efforts against cryptosporidiosis, a disease that sickens approximately 750,000 people annually in the US. The project aims to identify and validate therapeutic targets to guide medicinal chemistry.
Researchers have identified a common phospholipid pathway in plants and parasites, including malaria-causing Plasmodium. This discovery may lead to the development of new therapies for parasitic infections. The study also revealed that plant enzymes with similar structures can play different roles in the plant.
A team of researchers from the University of Pennsylvania has discovered a molecule that can suppress the lethal form of infection in a mouse model of Strongyloides stercoralis. By using this molecule, they were able to prevent the formation of larvae that trigger a persistent cycle of infection in the host.
A team of researchers identified a molecular mechanism leading to ART treatment failures in malaria parasites, finding that blocking a specific stress pathway prevents latent stage entry. This breakthrough could lead to the development of new approaches to combat malaria by preventing treatment failure.
A new study from Stockholm University shows that the parasite Toxoplasma gondii takes control of immune cells, turning them into 'zombies' that spread the infection. This allows the parasite to infect the brain, which may be linked to mental illnesses such as schizophrenia and depression.
Researchers discovered Plasmodium falciparum uses nanovesicles to deliver misleading messages to the immune system, allowing it to multiply unhindered. The team identified a key molecular sensor called STING that plays a crucial role in this subversive strategy.
Researchers at UT Southwestern Medical Center identified a chemical that suppresses the lethal form of a parasitic infection caused by roundworms. The study developed a mouse model susceptible to the full range of infection and found that a synthetic steroid called Δ7-dafachronic acid significantly reduced worm burden.
A research group at Osaka University has identified key molecules involved in severe malaria. The study found that RIFIN proteins expressed on infected erythrocytes suppress the host immune response by binding to an inhibitory receptor, contributing to the pathogenesis of severe malaria.
Researchers investigate pretreatment with etanercept to manage post-treatment inflammation in neurocysticercosis, a major cause of epilepsy worldwide. Etanercept suppresses inflammatory pathways involved in treatment-induced inflammation.
Scientists found that parasitic nematodes use odors from host mice as cues to position themselves where they have a higher chance of being eaten. The worms are attracted to fresh mouse feces and can migrate towards new hosts based on odorants produced by mammalian skin, feces, or urine.
Scientists demonstrate that Leishmania adaptation results from frequent and reversible chromosomal amplifications, which enables the parasite to maintain genetic diversity while selecting for new alleles. This study has important consequences for understanding human Leishmania infection and identifying parasite drug resistance mechanisms.
Researchers at the University of Edinburgh identified a previously unknown mechanism by which immune responses are regulated. The discovery found that Th2 cells express EGFR, releasing defense molecules only in response to parasites, preventing tissue damage.
A recent study has identified a fatty molecule in human blood that controls the malaria parasite's decision to switch from replicating in humans to transmitting to mosquitoes. This discovery improves understanding of a critical stage in the Plasmodium life cycle and may lead to new strategies for controlling and treating malaria.
A study on guppy fish reveals how their immune genes evolve to resist parasites while maintaining critical function over millions of years. The research sheds light on the evolutionary dynamics of the immune system and its ability to adapt to new threats.
A research team led by Charissa de Bekker found that the fungus has its own biological clock, which may be driving the timing of when it infects and manipulates the ants. The study reveals how the parasite controls the ants' behavior to spread its spores more effectively.
Portuguese researchers have identified a crucial defence mechanism used by the malaria parasite to survive inside its host's liver cells. The protein UIS3 binds to LC3, forming a protective shield against autophagy, allowing the parasite to evade the host's cellular defence mechanism.
A recent study found that populations of Plasmodium vivax in the Americas are as genetically diverse as those in Southeast Asia, contradicting previous assumptions. The research suggests that P. vivax may have originated from Africa, Europe, and Asia, and its genetic diversity was retained upon arrival in the Americas.
Researchers have identified two essential proteins, plasmepsin IX and X, which play critical roles in the life cycle of malaria parasites. Targeting these proteins could lead to the development of effective anti-malaria drugs.
Scientists have discovered five new targets that can help create an effective malaria vaccine by reducing the parasite's ability to invade red blood cells. The study suggests combining these multiple factors could lead to a more effective vaccine.
Researchers at the University of Edinburgh have made a significant discovery on how a harmful parasite harnesses energy, which could lead to new treatments. The study reveals that targeting a key enzyme linked to metabolism could be an effective way to kill the parasite without harming humans.
A new study suggests that reducing nutrient pollution in salt marshes could help prevent human disease. The research found that nutrient enrichment increased the number and biomass of parasites in a specific host species, which may have implications for human health.
Researchers have identified two microRNAs, miR-294 and miR-721, that are upregulated in macrophages infected with Leishmania parasites, potentially inhibiting the immune system's response. By analyzing the expression of these microRNAs, scientists hope to identify molecular targets for developing new treatments against leishmaniasis.
Researchers have discovered how Leishmania donovani uses physiological response to low oxygen levels to establish a chronic infection. The parasite induces the expression of HIF-1α, a master regulator of cellular response to hypoxia, in monocytes and macrophages.
Research has found that most Central American 'kissing bugs' infect people with just two strains of the Chagas disease parasite, TcI and TcIV. The study identified a high level of genetic variation within these strains, which may impact vaccine development and treatment.
Researchers at Johns Hopkins University engineered GM mosquitoes with altered microbiota that suppresses human malaria-causing parasites. The trait was successfully passed along to multiple generations of offspring, even when combined with wild mosquitoes, and maintained for 7 years.
Researchers found that metabolism directly impacts malaria development and severity. A study by Instituto de Medicina Molecular revealed that dietary shifts can lead to a 90% reduction in parasite load.
Researchers at UC are studying tick populations to develop strategies for preventing tick-borne illnesses like Lyme disease. The study focuses on the distribution of four species in southwest Ohio, their ability to withstand winters, and the diseases they carry.
Research shows fish modify behaviors to avoid parasites, with behaviorally-modified individuals displaying increased surface activities and reduced swimming. This discovery could lead to new strategies for preventing parasite infections in aquaculture.
Researchers have identified new hosts for Chagas Disease vectors, including tayras, monkeys, sloths, porcupines, and coatis, using DNA analysis. This discovery increases knowledge of Chagas disease transmission in rural environments and will support efforts to control the disease, particularly in poor, rural populations in South America.
Researchers discovered that carbohydrates on malaria parasites play a critical role in infecting human and mosquito hosts. The study suggests steps for improving the malaria vaccine, which has been only partially effective in preventing the disease.
Researchers found connections between Toxoplasma infection and neurodegenerative diseases, including altered GABAergic signaling and manipulated human olfactory receptors. The study also identified potential mechanisms by which the parasite may cause disease, providing insights for designing medicines and vaccines.
Researchers use NASA satellite data to predict malaria outbreaks in the Amazon Rainforest by tracking mosquito breeding grounds and human movement. The tool combines land surface modeling, vegetation maps, and deforestation data to identify areas at high risk of outbreaks.
Researchers seek to understand how trypanosome parasites cause long-term infections in cattle, with potential to develop novel ideas for prevention and treatment. The project aims to target the parasite's defences using drug therapy or vaccines.
A new study published in Scientific Reports found that Leishmania parasite infections are controlled by internal body clocks, leading to varying severities depending on the time of day. The research, led by Professor Nicolas Cermakian, discovered that the immune response is strongest at night, making it an ideal time for the parasite t...
A new study from Weill Cornell Medicine reveals that nerve cells in the gut play a crucial role in triggering an immune response to infection. The researchers found that these nerve cells communicate with immune system cells through a protein called neuromedin U, enabling them to rapidly respond to threats.
A new class of compounds, hexahydroquinolines (HHQs), shows promise in preventing Plasmodium falciparum parasite transmission from infected hosts to mosquitoes. HHQs also enhance the effectiveness of existing antimalarial treatments, making it harder for drug-resistant parasites to emerge.
Researchers found that neurons at mucosal tissues can detect an infection and prompt immune cells to produce a substance that acts like adrenaline, rapidly activating a protective response. This discovery highlights the important role of peripheral nervous cells in mounting immune responses and preserving health.
A global analysis suggests that climate change could lead to the extinction of up to a third of parasite species by 2070. The study used museum collections and GPS coordinates to understand conservation risks. Parasite diversity is a key indicator of ecosystem health, highlighting their critical role in maintaining balance.
Researchers from the University of Edinburgh studied two species of trypanosome parasites that can co-infect animals at once. Communication between the species may aid their survival by controlling numbers and optimizing transmission, potentially leading to more severe human infections.
Researchers confirm zoonotic transmission of Plasmodium simium in 28 human cases in the Atlantic Forest region of southern Brazil, where malaria was previously thought to be eliminated. The study highlights the need for further investigation into the natural history and biology of the parasites in their non-human primate hosts.
Researchers found that wood frogs with pesticide tolerance are more susceptible to a deadly virus and a parasitic worm, while those far from agriculture have reduced susceptibility. This study highlights the complexity of pesticide-parasite interactions and the need to consider multiple stressors in environmental conservation.
Researchers used X-ray fluorescence microscopy and soft X-ray tomography to study malaria parasites in liquid nitrogen, gaining insights into their ravaging mode of operation. The findings suggest a potential mechanism controlling the speed of hemoglobin digestion and crystallization, which could be targeted with new medication.
Schistosoma mansoni parasite is a major cause of human schistosomiasis, with $1.9-million NIH grant aimed at understanding its prevalence and exploring new control methods. Researchers plan to domesticate competitor parasites to combat the spread of the disease.
Research finds that boat noise affects cleaner fish behavior, leading to increased cheating and decreased cleaning efficiency. This study highlights the need to control man-made noise in protected habitats.
Research reveals that dodder plants transmit herbivory-induced signals among host plants, triggering defense responses and reducing insect growth. The discovery showcases the complex ecological interactions between parasitic plants and their hosts.
Researchers highlight the crucial role of outreach and education in disease elimination programs. In Thailand's successful liver fluke control model, educational efforts, including comics and songs, have led to significant reductions in human infection rates. The campaign's focus on community empowerment and addressing social factors h...
Scientists discover dodder parasite transmits insect feeding-induced signals among different hosts, triggering defense reactions in neighboring plants. The parasitic plant's vascular system connects with its hosts, enabling the transfer of warning signals.
A study found that 7% of healthy Santa Barbara residents tested positive for raccoon roundworm antibodies, highlighting a previously undetected human infection risk. The parasite can survive over a year in the environment and cause severe health effects, including blindness or brain damage.
Researchers at OIST Graduate University have decisively classified Dicyemida, a microscopic parasite in cephalopods, as part of the Spiralia clade and closest to Orthonectida. This classification sheds new light on the evolutionary history of Spiralia and the process of evolution.
Researchers found that amphibian susceptibility to parasites varies with proximity to agriculture and evolutionary responses to pesticides. Wood frogs living closer to agriculture with high baseline tolerance had lower trematode loads, while those far from agriculture with inducible pesticide tolerance had higher viral loads.
A recent study analyzing over half of the malaria parasite's genes found that two thirds are essential for survival, opening up new avenues for antimalarial drug development. The researchers developed a method to decipher gene function by switching off and counting the growth of genetically modified parasites.