A mathematical modeling study reveals that photosensitivity and PER2 level affect the efficacy of a clock-modulating drug, enabling precision medicine for circadian disruption. The researchers identified adaptive chronotherapeutics to identify precise dosing regimens that can restore normal circadian phase under different conditions.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalMolecular Systems Biology·DateJul 9, 2019
A study led by Michigan Medicine has revealed the presence of naturally occurring DMT in mammalian brains, sparking interest in its role within human brains. The discovery was made possible by detecting DMT in brain neurons using techniques such as in situ hybridization.
SourceMichigan Medicine - University of Michigan·JournalScientific Reports·DateJun 27, 2019
Researchers found that morning exercise increases metabolic response in skeletal muscle, while evening exercise boosts energy expenditure for an extended period. The effects of exercise timing may differ due to the body's circadian clock.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell Metabolism·DateJun 13, 2019
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that the LUX gene regulates stomata opening and closing, as well as activating defense mechanisms. The study could lead to more resistant crops and better treatment for human diseases.
SourceUniversity of Maryland Baltimore County·JournalNature Communications·DateJun 12, 2019
A recent review article by Dr. Tobias Eckle and colleagues reveals a link between circadian rhythms and cardioprotection in the face of limited oxygen availability. The study identifies period 2 (PER2) as an adenosine signaling target, which plays a crucial role in cardiac adaptation to hypoxia.
SourceBentham Science Publishers·JournalCurrent Pharmaceutical Design·DateJun 11, 2019
A new study by UCI researchers found that body parts like the liver and skin have internal clocks that respond to light changes, regardless of the brain's central clock. This discovery has significant implications for understanding circadian rhythms, aging processes, and overall well-being.
SourceUniversity of California - Irvine·JournalCell·DateMay 30, 2019
Researchers identified TIMELESS as a potential circadian clock regulator involved in minor sleep phase changes. A mutation in the TIMELESS gene causes accumulation of the protein, leading to phase advances in mice and advanced sleep phase in humans.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateMay 27, 2019
Research reveals humans are more sensitive to evening light than previously thought, with large individual differences in sensitivity. Exposure to light after dusk can disrupt the circadian rhythm, leading to potential health consequences.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateMay 27, 2019
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers at Saint Louis University found that low levels of the hormone adropin predict increased weight gain and metabolic dysregulation in male monkeys fed a high-sugar diet. Adropin regulates glucose and fat metabolism, and its expression is controlled by biological clocks.
SourceSaint Louis University·JournalJournal of Biological Chemistry·DateMay 23, 2019
Researchers found that circadian rhythms impact immune responses, with morning immune cells elevated and nighttime levels suppressed. This discovery may lead to time-tailored therapies for human patients.
SourceCell Press·JournalTrends in Immunology·DateMay 17, 2019
Researchers from Kanazawa University discovered that saturation of transcription or translation generates a dead zone in the circadian clock system, enabling it to remain insensitive to light signals during daytime. This finding highlights the fundamental properties of circadian clocks determined at the single-cell level.
SourceKanazawa University·JournalPLOS Computational Biology·DateMay 14, 2019
A new study finds that women and mice experience changes in their daily schedules and activity levels during the first third of pregnancy. The study suggests that these changes may be related to hormonal influences and could have implications for preterm birth prevention.
SourceWashington University in St. Louis·JournalJournal of Biological Rhythms·DateApr 30, 2019
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Research suggests that exercise performed in the evening may be more productive due to increased levels of ZMP, a metabolite that activates metabolic pathways related to glycolysis and fatty acid oxidation. In human studies, lower oxygen consumption and better exercise efficiency were observed in the evening compared to morning.
Rhythmic food intake drives liver gene expression independently of the molecular clock, regulating metabolic pathways and potentially leading to health issues like aging and obesity. The study's findings have implications for understanding circadian biology and the impact of timing on health.
Researchers found that low-dose BPA exposure during gestation alters circadian rhythms, leading to increased activity and disrupted daily patterns in mice. This study suggests a potential contributing factor to hyperactivity observed in BPA-exposed mice.
Researchers identified 727 genes in fat tissue that express their own circadian rhythm, many carrying out key metabolic functions. Morning-peaking transcripts regulate gene expression and nucleic acid biology, while evening-peaking transcripts are associated with redox activity and organic acid metabolism.
SourceUniversity of Surrey·JournalScientific Reports·DateFeb 25, 2019
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers have discovered a promising new drug that targets the biological clock of cancer cells, slowing their growth and halting their spread. By disrupting the circadian rhythm of cancer cells, this drug may provide an effective new treatment option for various types of cancer.
SourceUniversity of Southern California·JournalScience Advances·DateJan 23, 2019
New research reveals that shift work can impair glucose tolerance and disrupt maternal circadian rhythms in early pregnancy, leading to reduced fetal growth and longer pregnancies. This study provides valuable insights into the effects of shift work on human metabolism and pregnancy outcomes.
SourceThe Physiological Society·JournalThe Journal of Physiology·DateJan 22, 2019
A UCI-led study reveals that fasting affects circadian clocks in the liver and skeletal muscle, rewiring metabolism for improved health. Fasting-driven cellular responses prime the genome for new gene expression patterns, suggesting optimal timed fasting could benefit health.
SourceUniversity of California - Irvine·JournalCell Reports·DateJan 14, 2019
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Research by neurobiologists at the University of Würzburg reveals that high-intensity light extends sleep duration and delays evening activity in Drosophila. The study's findings suggest a molecular mechanism involving photo receptors and neuropeptides that regulate the circadian clock.
Researchers found that dairy cows' milk yield and composition follow predictable annual cycles driven by photoperiod, regardless of geographic location. The study's findings will help dairy farmers better manage their herds and interpret the effects of management strategies.
SourcePenn State·JournalJournal of Dairy Science·DateDec 20, 2018
Researchers found a novel time-keeping mechanism within liver cells that contributes to disease development when its natural rhythm is disrupted. The study suggests that the circadian clock modulates HNF4A's classical functions, providing a potential explanation for diseases such as diabetes and cancers.
SourceUniversity of Southern California·JournalProceedings of the National Academy of Sciences·DateDec 11, 2018
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A new study finds that spinal cord injuries profoundly impact the body's internal clocks, affecting body temperature, hormone fluctuations, immunity, and other bodily processes. The researchers discovered that expression of clock genes was reduced in both injured and uninjured tissue, with implications for recovery.
SourceUniversity of Colorado at Boulder·JournaleNeuro·DateDec 4, 2018
A study of male and female rats found that moderate spinal cord damage alters daily body temperature and activity patterns. Restoring normal routines through circadian therapies may promote recovery after spinal cord injury.
SourceSociety for Neuroscience·JournaleNeuro·DateDec 3, 2018
A new study reveals that cells decide when to divide based on their internal clocks, with the time of day having a stronger influence than previously thought. The circadian clock continuously influences cell division throughout the day and night, fine-tuning the process by decreasing or accelerating division at different times.
SourceImperial College London·JournalProceedings of the National Academy of Sciences·DateNov 16, 2018
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
New studies reveal that disrupted circadian rhythms can drive anxiety and exacerbate brain disorders, highlighting the importance of regulating wake-sleep cycles. Healthy sleep habits are also found to be critical in preventing various diseases, including Alzheimer's disease and anxiety disorder.
Researchers are developing sensing technologies to measure circadian rhythm in shift workers, exploring the impact on cognitive performance, productivity, and accidents. The goal is to provide personalized feedback to enhance users' well-being and cognitive ability.
Researchers discovered that midazolam, a commonly used anesthetic, alters cardiac circadian biology and increases susceptibility to myocardial ischemia. Targeting the circadian rhythm protein Period 2 (PER2) with nobiletin, a flavonoid found in citrus peels, provides significant cardioprotection against MI in a mouse model.
SourceBentham Science Publishers·JournalCurrent Pharmaceutical Design·DateOct 17, 2018
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A novel mathematical approach has uncovered 12-hour cycles of genetic activity in animal cells, independent of 24-hour circadian rhythms. Laboratory experiments confirm the existence and independence of these cycles, which have significant implications for understanding gene functions over time and their influence on health and disease.
SourceBaylor College of Medicine·JournalPLOS ONE·DateSep 20, 2018
A study of over 1,000 patients with epilepsy found that seizures are linked to natural rhythms in around 80% of cases, with most occurring in a circadian rhythm. Weekly and longer cycles were also detected, with two-thirds of people having multiple types of cycles associated with their seizures.
SourceThe Lancet·JournalThe Lancet Neurology·DateSep 12, 2018
Researchers at Northwestern University developed a simple blood test called TimeSignature that can identify the body's precise internal time clock. The test measures gene expression markers and can be taken any time of day, allowing for more accurate diagnosis and treatment of diseases such as heart disease, diabetes, and Alzheimer's.
SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·DateSep 10, 2018
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A new study published in Cell Metabolism found that limiting the times when lab mice eat can correct obesity and other metabolic problems, even when they're fed an unhealthy diet. The results suggest a previously unknown link between disruption of the clock and eating behavior.
Salk Institute researchers found that restricting food intake to a 10-hour window can protect against obesity and metabolic diseases. By controlling the animals' feeding and fasting cycles, they can override their genetically programmed sickness.
SourceSalk Institute·JournalCell Metabolism·DateAug 30, 2018
Scientists at Helmholtz Zentrum München discovered a metabolic network controlled by muscle cell circadian clocks, regulating fat storage and glucose metabolism. The study found that without this internal clock, mice became leaner and had more muscle mass.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalPLOS Biology·DateAug 21, 2018
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Marimo algae balls sink at night and float during the day due to photosynthesis and biological circadian rhythms, according to a new study published in Current Biology. The research has implications for conserving these endangered species, which have experienced a global decline.
SourceUniversity of Bristol·JournalCurrent Biology·DateAug 20, 2018
Researchers found that plant's daily oscillatory clock interacts with the aging linear clock during their lifetime, influencing leaf yellowing timing. The study identified key genes, such as PRR9, involved in this interaction.
SourceInstitute for Basic Science·JournalProceedings of the National Academy of Sciences·DateAug 9, 2018
Neurons in brain's master clock exhibit regular activity cycle that is disrupted under constant light conditions. Blocking these neurons reduces the severity of shifts in daily rhythms, suggesting a potential mechanism for modern sleep disorders.
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A study discovered that plants regulate their internal 'circadian clock' using sugars from photosynthesis to stay in tune with day and night cycles. This process enables plants to match their activities to the time of day, crucial for growth, flower opening, and energy reserve management.
SourceUniversity of Bristol·JournalCurrent Biology·DateAug 2, 2018
Researchers found that mice with obesity develop new liver circadian rhythms that impact fat accumulation and burning, suggesting a potential therapeutic strategy for treating obesity-related liver diseases. Administering drugs at specific times when PPAR-alpha is most active could enhance effectiveness and reduce toxicity.
SourceUniversity of Pennsylvania School of Medicine·JournalCell·DateJul 26, 2018
The American Academy of Sleep Medicine has published a clinical practice guideline on the use of actigraphy in evaluating adult and pediatric patients with suspected sleep disorders. Actigraphy is recommended as a useful tool for gathering objective data on sleep habits, but not used as a substitute for polysomnography.
SourceAmerican Academy of Sleep Medicine·JournalJournal of Clinical Sleep Medicine·DateJul 16, 2018
Researchers find two opposing kinases regulating circadian clock, one stabilizing key protein PER2 and the other promoting its degradation. This discovery provides new targets for treating circadian disorders.
SourceKyoto University·JournalProceedings of the National Academy of Sciences·DateJul 11, 2018
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A Finnish study found a link between a gene variation and increased risk of Alzheimer's disease in the elderly, particularly those with job-related exhaustion in shift workers. The research suggests that genetic predisposition combined with lifestyle disruptions can increase Alzheimer's risk.
SourceUniversity of Helsinki·JournalSLEEP·DateJul 6, 2018
A recent study by the American Academy of Sleep Medicine found that NFL teams perform better at night due to their circadian rhythms. The research revealed fewer turnovers and mental errors during late evening games compared to afternoon games, suggesting a significant impact of circadian timing on game-day statistics.
SourceAmerican Academy of Sleep Medicine·DateJun 4, 2018
A study has found that circadian rhythms influence atherosclerosis, a condition leading to heart attacks and strokes. The researchers identified the molecular mechanism controlling rhythmic arterial leukocyte migration and developed a targeted therapy to stop its recruitment in atherosclerotic areas.
SourceLudwig-Maximilians-Universität München·JournalCell Metabolism·DateMay 31, 2018
A team of researchers has found that light and temperature stimuli mutually regulate the circadian rhythm of fruit flies. The study identified molecular pathways in photoreceptors that affect the fly's inner clock, including a previously unknown pathway involving photopigments.
SourceUniversity of Münster·JournalCurrent Biology·DateMay 28, 2018
Researchers found that chronic sleep deprivation, even without extended wakefulness, was associated with increased reaction time performance and daytime arousal. The study highlights the complex relationship between sleep and alertness in humans.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateMay 21, 2018
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers analyzed human plasma proteins over time, identifying 30 proteins regulated by the circadian clock and affecting cancer, immune function, and metabolism. Circadian misalignment altered glucose homeostasis and energy metabolism pathways.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateMay 21, 2018
A large study of over 91,000 people found a strong association between disrupted body clock rhythms and an increased risk of depression, bipolar disorder, and poor wellbeing. Disruptions to normal daily circadian rhythms were linked to mood instability, loneliness, lower happiness, and worse cognitive function.
SourceThe Lancet·JournalThe Lancet Psychiatry·DateMay 15, 2018
Researchers at Texas A&M University have identified the Period 2 (Per2) gene as a potential contributor to breast cancer risk. Per2 suppresses a gene called BMAL or CLOCK, and its expression is lost in many mammary tumors, suggesting it may have protective effects.
SourceTexas A&M University·JournalDevelopment·DateMay 8, 2018
Research suggests that night shift work can disrupt human circadian rhythms, leading to gene expression changes and immune system dysregulation. The study's findings highlight the potential risks of long-term night shift work on human health, particularly in relation to medical disorders such as diabetes and cancer.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateMay 7, 2018
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A study published in PNAS found that genes regulating immune system and metabolic processes fail to adapt to new sleep patterns caused by night shifts. Eight healthy volunteers were subjected to a five-day schedule simulating night shift work, showing that almost 25% of rhythmic genes lost their biological rhythm.
SourceMcGill University·JournalProceedings of the National Academy of Sciences·DateMay 7, 2018
Researchers measured DNA repair in mice treated with cisplatin over a 24-hour period, finding nearly 2,000 genes repaired according to the circadian clock. This study suggests that understanding the interaction between circadian clocks and DNA repair could lead to more effective chemotherapy regimens.
SourceUniversity of North Carolina Health Care·JournalProceedings of the National Academy of Sciences·DateMay 7, 2018
A study by researchers at the University of Copenhagen has confirmed a connection between the circadian rhythm and aggression in Alzheimer's patients. The team identified a circuit linking the brain's circadian clock to an aggression centre, suggesting a potential target for pharmacological intervention. This discovery may lead to new ...
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalNature Neuroscience·DateMay 2, 2018
A new study found that intermittent bright light exposure at night can cause significant phase shifts in the body's internal clock, but not necessarily melatonin suppression. This challenges the common assumption that one can be used as a proxy measure for the other.
SourceThe Physiological Society·JournalThe Journal of Physiology·DateApr 29, 2018
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers found that regular mid-day naps improve neurocognitive function and daytime attention in adolescents. The ideal nap duration is between 30-60 minutes, and routine napping is associated with better nighttime sleep quality.
SourceUniversity of Delaware·JournalBehavioral Sleep Medicine·DateApr 25, 2018
A new study published in Chronobiology International found that night owls have a 10% higher risk of dying than morning larks. This is the first study to look at mortality risk and highlights the importance of allowing evening types greater flexibility in working hours.
SourceNorthwestern University·JournalChronobiology International·DateApr 12, 2018
Studies found that a specific brain circuit regulates daily aggression patterns, which can be controlled to minimize evening-time agitation common in dementia patients. By manipulating this circuit, researchers aim to develop new treatments for managing sundowning syndrome.
SourceBeth Israel Deaconess Medical Center·JournalNature Neuroscience·DateApr 9, 2018
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research published in The Journal of Physiology suggests that shifting brain clock through light exposure can improve sleep quality and health benefits for night shift workers. A personalized approach considering individual morning or evening types is essential.
SourceThe Physiological Society·JournalThe Journal of Physiology·DateMar 27, 2018
Researchers discovered that aging reduces sensitivity to light in the brain's circadian rhythm control center, affecting the SCN's ability to set a stable circadian rhythm. This structural change in the glutamate receptor impairs its function, contributing to age-related disruptions in sleep patterns and overall wellbeing.
SourceUniversity of Kent·JournalNeurobiology of Aging·DateMar 27, 2018
Researchers at Osaka University have created a new form of art illumination that uses synchronized fluctuations in light to mimic natural rhythms, creating a unique and cozy setting. This technology has the potential to enhance quality of life by providing a more human-friendly and nature-inspired lighting solution.