Articles tagged with Biological Rhythms
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Researchers from Waseda University found damped, low-amplitude circadian oscillations in cyanobacteria lacking KaiA, challenging previous studies. The findings suggest the circadian clock may have evolved gradually from these oscillations.
Scientists have discovered that malaria parasites have an intrinsic clock controlling their invasion of human cells. This finding opens up new avenues for treating the disease by disrupting its biological rhythms.
Research found that malaria parasites have an inherent clock that drives their activity, resulting in cyclical fevers in humans. The parasite's gene expression patterns remained consistent despite changes in lighting conditions and host circadian rhythms.
New research reveals that certain internal clock neurons in fruit flies, previously thought to send time-keeping cues to the brain, actually receive cues from the external environment. This finding has significant implications for understanding circadian rhythm disruptions and their associated health problems.
Researchers at Nagoya University's ITbM discovered two new compounds that target specific components of the circadian clock. KL101 and TH301 lengthen the period of the circadian clock and are expected to provide a promising foundation for treating obesity.
Researchers discovered that plant circadian clocks play a critical role in water consumption, allowing plants to use resources more efficiently. The study found that altering circadian rhythms can improve water use efficiency without compromising plant growth.
A randomized clinical trial found that cataract surgery increased melatonin secretion in patients aged 60 and above. The study suggests that changes in light perception due to cataract surgery may affect the body's natural circadian rhythm.
Researchers discovered a pigment called melanopsin sensitive to blue light affects circadian rhythms but cone photoreceptors respond strongly to long wavelength oranges and yellows at sunrise and sunset. The study identifies a cell in the retina regulating brain centers that impact sleep, mood and learning.
A study published in PLOS Biology found that global brain fluctuations decrease as the day progresses, affecting cognitive function and connectivity. The researchers analyzed fMRI data from over 900 subjects and observed a cumulative decrease in global signal fluctuation and functional connectivity with time of day.
A study published by the American Academy of Sleep Medicine found that later school start times significantly reduce vehicle accidents involving teen drivers. Teenagers who get more sleep are less likely to make poor decisions such as not wearing a seat belt or engaging in distracted driving.
Shift workers are at a higher risk of developing metabolic syndrome, heart disease and type 2 diabetes due to disrupted circadian rhythms. Employers and workers can take steps to mitigate these risks, including establishing consistent sleep schedules, controlling light exposure and promoting healthy nutrition and exercise.
Disturbances in the internal clocks of pancreatic cells are linked to type-2 diabetes. Researchers successfully restored clock function using a natural compound, improving insulin secretion and providing new hope for diabetes care. The study shows that synchronizing the internal clocks can help regulate blood sugar levels.
A study led by McGill University found that anti-inflammatory medications are most effective when taken during the active periods of our biological clocks, promoting post-operative healing and recovery. This discovery suggests a new approach to treating pain and inflammation following surgery.
A German high school's flexible scheduling system, which allows students to start school later, has been shown to improve their sleep patterns and ability to concentrate. The study found that students who started school later slept more soundly and were better equipped to handle coursework.
Researchers found that mice's visual capability changes between day and night due to their internal clock, not eye changes. They used a maze experiment to study how the circadian rhythm influences behavior and nerve signals in the retina.
Researchers at Salk Institute discover intrinsically photosensitive retinal ganglion cells (ipRGCs) in humans, which respond to blue light and help establish healthy day-night cycles. The study's findings may lead to 'smart' lights that prevent depression, foster sleep, and maintain circadian rhythms.
A pilot study found that limiting food consumption to a 10-hour window per day improved health outcomes in participants with metabolic syndrome. Participants experienced significant weight loss, reduced abdominal fat, and stable blood sugar and insulin levels.
Researchers found that time-restricted eating can lead to weight loss, reduced abdominal fat, lower blood pressure and cholesterol, and more stable blood sugar and insulin levels. The study included 19 participants with metabolic syndrome who experienced improved sleep and a 3-4% reduction in body weight.
Researchers at the University of Copenhagen have discovered that stress hormones, such as corticosterone, play a crucial role in controlling the circadian rhythm of brain cells. By using test rats and a new method involving medical micropumps, they were able to restore the rhythmic activity of clock genes in the cerebellum even after t...
Researchers studied Drosophila and Chymomyza flies, revealing two possible explanations for arrhythmic behavior in high-latitude species. The study suggests that strong behavioral rhythms may be a disadvantage in polar regions, but certain characteristics could aid survival.
Daylight Saving Time transitions can have lasting impacts on health, causing biologic clocks to become desynchronized and increasing the risk of heart attacks and ischemic strokes. Average sleep duration shrinks by 15-20 minutes during DST, potentially leading to fatal accidents.
Researchers found that skin in mice expresses its own photoreceptors using neuroposin, synchronizing circadian clocks to light-dark cycles independently of eyes or brain. This discovery has implications for understanding skin physiology and potentially enhancing medical practice.
Research by LMU Munich chronobiologists reveals that sleep-wake cycles drive cycles of protein abundance and phosphorylation in synaptic proteins. Synaptic phosphorylation plays a key role in regulating synaptic function, particularly during sleep-wake transitions.
The study reveals that the compound eyes of fruit flies play a crucial role in synchronizing their circadian clocks with light exposure. As daylight periods increase, the evening activity peak is delayed and the 'siesta' period is extended, highlighting the flexibility of the circadian clock mechanism.
Researchers found a key driver of nutrient absorption synchronization with Earth's day-night light cycle, linking it to weight gain. The commensal bacteria program the metabolic rhythms by activating protein histone deacetylase 3 (HDAC3), which enhances fat absorption.
Researchers at the University of Minnesota Medical School found that a little stress can actually improve the functioning of our internal biological clock. Stress leads to rhythmic phosphorylation of eIF2α, promoting production of ATF4 protein, which activates Per2 gene, ultimately making the clock tick faster.
Researchers from North Carolina State University have shown that the E75 protein plays a critical role in regulating biological rhythms in Daphnia magna. Suppression of E75 results in longer molt cycles and reduced numbers of offspring. The study highlights the potential impact of environmental stressors on population sustainability.
Researchers at the University of Miami discovered that fruit flies have an innate time- and color-dependent preference for light, contrary to decades-long assumption that they are attracted to blue light. The study found that fruit flies prefer green light early in the morning and late afternoon, and avoid blue light throughout the day.
Researchers at the Champalimaud Centre for the Unknown discovered that the brain's circadian clock controls the function of immune cells in the gut, which are crucial for maintaining gut health. Disrupting this clock leads to reduced immune cell numbers, severe inflammation, and increased fat accumulation.
Researchers discovered GABA neurons play a crucial role in refining circadian output rhythms in mice, ensuring noiseless communication with neurons outside the suprachiasmatic nucleus. This finding could aid the development of new clinical approaches for diseases related to the circadian clock.
Scientists at USC and UC San Diego have discovered a potential novel target for treating glioblastoma, the deadliest form of brain cancer. They found that targeting the circadian clock in tumor stem cells can disrupt the growth and development of the tumor, leading to its death.
Researchers have found that gene expression patterns in the brain are highly disrupted in people with schizophrenia, suggesting a link to the disease's molecular mechanisms. The study's findings could help researchers better understand schizophrenia and identify potential therapeutic targets.
Research finds that more than 64% of employed Russians work evenings, nights, or weekends, disrupting their biological and social rhythms. The negative effects include depression, headaches, burnout, and chronic fatigue, leading to workplace accidents and injuries.
A new Northwestern University study found that distinct areas of the brain process short pulses of light to affect sleep, challenging the widely accepted belief that all light information is relayed through one central pathway. The research suggests that acute exposure to light does not interfere with overall circadian rhythms.
A study published in Sleep Medicine Reviews found that bathing 1-2 hours before bedtime in water of 104-109 degrees Fahrenheit can significantly improve sleep quality. This is due to the cooling effect on the body, which regulates the circadian cycle and helps with rapid sleep onset.
A mathematical modeling study reveals that photosensitivity and PER2 level affect the efficacy of a clock-modulating drug, enabling precision medicine for circadian disruption. The researchers identified adaptive chronotherapeutics to identify precise dosing regimens that can restore normal circadian phase under different conditions.
A study led by Michigan Medicine has revealed the presence of naturally occurring DMT in mammalian brains, sparking interest in its role within human brains. The discovery was made possible by detecting DMT in brain neurons using techniques such as in situ hybridization.
Researchers found that morning exercise increases metabolic response in skeletal muscle, while evening exercise boosts energy expenditure for an extended period. The effects of exercise timing may differ due to the body's circadian clock.
Researchers found that the LUX gene regulates stomata opening and closing, as well as activating defense mechanisms. The study could lead to more resistant crops and better treatment for human diseases.
A recent review article by Dr. Tobias Eckle and colleagues reveals a link between circadian rhythms and cardioprotection in the face of limited oxygen availability. The study identifies period 2 (PER2) as an adenosine signaling target, which plays a crucial role in cardiac adaptation to hypoxia.
A new study by UCI researchers found that body parts like the liver and skin have internal clocks that respond to light changes, regardless of the brain's central clock. This discovery has significant implications for understanding circadian rhythms, aging processes, and overall well-being.
Researchers identified TIMELESS as a potential circadian clock regulator involved in minor sleep phase changes. A mutation in the TIMELESS gene causes accumulation of the protein, leading to phase advances in mice and advanced sleep phase in humans.
Research reveals humans are more sensitive to evening light than previously thought, with large individual differences in sensitivity. Exposure to light after dusk can disrupt the circadian rhythm, leading to potential health consequences.
Researchers at Saint Louis University found that low levels of the hormone adropin predict increased weight gain and metabolic dysregulation in male monkeys fed a high-sugar diet. Adropin regulates glucose and fat metabolism, and its expression is controlled by biological clocks.
Researchers found that circadian rhythms impact immune responses, with morning immune cells elevated and nighttime levels suppressed. This discovery may lead to time-tailored therapies for human patients.
Researchers from Kanazawa University discovered that saturation of transcription or translation generates a dead zone in the circadian clock system, enabling it to remain insensitive to light signals during daytime. This finding highlights the fundamental properties of circadian clocks determined at the single-cell level.
A new study finds that women and mice experience changes in their daily schedules and activity levels during the first third of pregnancy. The study suggests that these changes may be related to hormonal influences and could have implications for preterm birth prevention.
Research suggests that exercise performed in the evening may be more productive due to increased levels of ZMP, a metabolite that activates metabolic pathways related to glycolysis and fatty acid oxidation. In human studies, lower oxygen consumption and better exercise efficiency were observed in the evening compared to morning.
Rhythmic food intake drives liver gene expression independently of the molecular clock, regulating metabolic pathways and potentially leading to health issues like aging and obesity. The study's findings have implications for understanding circadian biology and the impact of timing on health.
Researchers found that low-dose BPA exposure during gestation alters circadian rhythms, leading to increased activity and disrupted daily patterns in mice. This study suggests a potential contributing factor to hyperactivity observed in BPA-exposed mice.
Researchers identified 727 genes in fat tissue that express their own circadian rhythm, many carrying out key metabolic functions. Morning-peaking transcripts regulate gene expression and nucleic acid biology, while evening-peaking transcripts are associated with redox activity and organic acid metabolism.
Researchers have discovered a promising new drug that targets the biological clock of cancer cells, slowing their growth and halting their spread. By disrupting the circadian rhythm of cancer cells, this drug may provide an effective new treatment option for various types of cancer.
New research reveals that shift work can impair glucose tolerance and disrupt maternal circadian rhythms in early pregnancy, leading to reduced fetal growth and longer pregnancies. This study provides valuable insights into the effects of shift work on human metabolism and pregnancy outcomes.
A UCI-led study reveals that fasting affects circadian clocks in the liver and skeletal muscle, rewiring metabolism for improved health. Fasting-driven cellular responses prime the genome for new gene expression patterns, suggesting optimal timed fasting could benefit health.
Research by neurobiologists at the University of Würzburg reveals that high-intensity light extends sleep duration and delays evening activity in Drosophila. The study's findings suggest a molecular mechanism involving photo receptors and neuropeptides that regulate the circadian clock.
Researchers found that dairy cows' milk yield and composition follow predictable annual cycles driven by photoperiod, regardless of geographic location. The study's findings will help dairy farmers better manage their herds and interpret the effects of management strategies.
Researchers found a novel time-keeping mechanism within liver cells that contributes to disease development when its natural rhythm is disrupted. The study suggests that the circadian clock modulates HNF4A's classical functions, providing a potential explanation for diseases such as diabetes and cancers.
A new study finds that spinal cord injuries profoundly impact the body's internal clocks, affecting body temperature, hormone fluctuations, immunity, and other bodily processes. The researchers discovered that expression of clock genes was reduced in both injured and uninjured tissue, with implications for recovery.
A study of male and female rats found that moderate spinal cord damage alters daily body temperature and activity patterns. Restoring normal routines through circadian therapies may promote recovery after spinal cord injury.
A new study reveals that cells decide when to divide based on their internal clocks, with the time of day having a stronger influence than previously thought. The circadian clock continuously influences cell division throughout the day and night, fine-tuning the process by decreasing or accelerating division at different times.