Articles tagged with Electrophysiology
Researchers at Kyoto University have discovered a genetic mutation that causes lethal arrhythmia in humans. The study found that a novel variant of the CALM2 gene produces robust arrhythmogenicity in human-induced pluripotent stem cell-derived cardiomyocytes.
A new study finds that wireless pacemakers can safely regulate slow heartbeats in select pediatric patients. The leadless pacemaker, a miniature device implanted directly into the heart, has shown stable performance with no reported complications in children aged 4-21.
Researchers found that chloride ions bind to sweet taste receptors and evoke a taste sensation. The study suggests that low concentrations of Cl- can produce a 'light' sweet taste sensation via the T1r in the taste buds.
Researchers at the Francis Crick Institute have identified a new cell type, named F-Cell, that plays a crucial role in touch sensing in fruit flies. The study published in Nature Cell Biology reveals that F-Cells are recruited to tactile hairs and participate in sending signals to neighbouring epidermal cells.
Researchers collected electrophysiological recordings from prefrontal cortical regions in three human subjects with severe treatment-resistant depression. They found lower depression severity correlated with decreased low-frequency neural activity and increased high-frequency activity.
A group of researchers from Osaka University has shown that the segregated function of a messenger ion (Ca2+) can help improve our sense of smell. The study reveals that Ca2+ signaling plays a crucial role in regulating the amplification and reduction of sensory signals, and its processes are clearly segregated within a tiny structure ...
Researchers found that certain wearable devices using bioimpedance sensing technology can interfere with CRT devices, causing pacing interruptions or unnecessary shocks to the heart. The study suggests that future clinical studies are needed to evaluate patients with CIEDs and wearables.
A study of 4,078 cases found that sports-related cardiac arrests in people 65 and older are rare, occurring in only 1.9% of cases. Those who experienced exercise-related cardiac arrests tended to have fewer cardiovascular risk factors and better health outcomes.
Researchers have found evidence that high frequency brain waves in the motor cortex contain information about planned movements, providing a new understanding of how the brain controls movement. The study's findings could inform the development of brain-machine interfaces and reveal new insights into cortical function.
Researchers have developed a novel portable and low-cost macroscopic mapping system for all-optical cardiac electrophysiology using optogenetics and machine vision cameras. The system can stimulate and image engineered networks of human heart cells, providing insights into cardiac wave function and stability.
Researchers discovered that physical activity suppresses insulin-producing cells in fruit flies, allowing for efficient energy replenishment. This finding has implications for human health, as reduced insulin activity is linked to healthy ageing and longevity.
An AI-based model has been developed to assist radiologists in detecting and identifying leadless implanted electronic devices (LLIEDs) on chest X-ray images. The model achieved high detection and classification accuracy, even with suboptimal image quality, and showed promise for real-world deployment.
A new study published in Current Biology found that carrying crying infants for 5 minutes can promote sleep and reduce crying. The technique, known as the Transport Response, involves steady walking followed by sitting before laying the baby down to sleep. This method offers an immediate solution for parents of newborns struggling with...
A study found that 47% of parents meeting criteria for post-traumatic stress disorder (PTSD) symptoms, compared to 12% of children with implantable cardioverter-defibrillators. The trauma triggered by a child's heart problems can affect the entire family.
Researchers tested a new needle ablation technique called SERF to treat ventricular tachycardia in patients who had not responded to other treatments. The study found that 31 of 32 patients experienced eliminated clinical ventricular tachycardia, with device therapies reduced by 89% during follow-up.
Researchers at the University of Missouri-Columbia have developed a novel approach to reprogramming cardiac implantable devices during MRI scans remotely. This technology has shown safe and effective results, saving time and money by eliminating the need for device representatives or on-site personnel.
A new study in Heart Rhythm reveals that only 12% of clinical electrophysiologists are women, with significant disparities in representation compared to other cardiologic specialties. The study highlights the need to recruit and retain more women in electrophysiology to improve patient care.
Scientists have created a new technology using colour pigments from the food industry to stimulate nerve cells with the help of implantable mini solar cells. This innovation could lead to accelerated healing and prevention of complications in severe brain injuries, as well as potential applications in pain therapy and retinal implants.
Researchers identify a neural circuit in midbrain, thalamus, and cortex that orchestrates neuronal activity to trigger planned movement. The discovery has important clinical implications for motor disorders like Parkinson's disease.
Research suggests stress plays a bidirectional role in AFib, both increasing episodes and contributing to mental health issues. Stress reduction strategies, such as mindfulness-based stress reduction and anxiolytic therapy, may improve AFib symptoms and quality of life.
Researchers have created the first patient-specific zebrafish model for arrhythmogenic cardiomyopathy (ACM), a heart disease caused by a genetic mutation. The model recapitulates the human form of ACM, including fat accumulation in the heart and changes in calcium levels, and shows promise for relieving symptoms.
A new web-based application can predict which epilepsy patients will not benefit from stereo-electroencephalography (SEEG), a costly and invasive procedure. The '5-SENSE' score reliably identifies patients who will not have a focal seizure onset zone, allowing clinicians to avoid unnecessary procedures.
Researchers developed a predictive model that maps electric activity of mouse, rabbit, and human cardiac cells, allowing translation of findings across species. The model is expected to accelerate drug development and improve understanding of disease mechanisms.
A recent study published at Masonic Medical Research Institute found that electrocution-induced physiological stress can lead to overlapping cardiac conditions in individuals. The research used human induced pluripotent stem cells to investigate the mechanisms behind these conditions, shedding light on potential new treatments.
Researchers confirm FDA recommendation that patients keep consumer electronics, such as cell phones and smart watches, six inches away from implanted medical devices. Studies found that these devices can trigger magnet mode in pacemakers and defibrillators, posing a risk to patient safety.
The OpenEP platform enables researchers to analyze large amounts of clinical patient data, reducing the need for specialized software and increasing reproducibility. This allows clinicians to focus on their specific hypothesis or research question, accelerating progress towards innovative treatments.
A study found that sudden deaths outside the hospital in New York City followed the geographic distribution of SARS-CoV-2, suggesting an association between the two. The rate of sudden death in 2019 was also predictive of increased sudden deaths during the pandemic surge.
Researchers used a technique called Patch-seq to capture data from over 4,200 mouse neurons, classifying them into 28 different types based on their morphology, electrical properties, and gene expression profiles. This new categorization lays the groundwork for a more complete understanding of the mammalian brain.
Researchers developed a new class of medical instruments equipped with advanced soft electronics, enabling simultaneous in vivo measurements and real-time feedback control. The new system conforms better to the body's soft tissue, reducing the length of invasive ablation procedures and exposure to X-ray radiation.
Researchers from Arizona State University have made significant progress in understanding TRPV1's thermosensing mechanism. The study provides a framework for distinguishing specific activation mechanisms that can be targeted to develop new non-addictive pain therapies.
A new study shows that physically fit patients are more likely to benefit from atrial fibrillation ablation, with a lower risk of recurrent arrhythmia and improved outcomes. The study found that high cardiorespiratory fitness can act as an antiarrhythmic medication, keeping patients in rhythm after the procedure.
Physicians using a holographic display developed by WashU were more accurate in performing cardiac ablation procedures, resulting in fewer lesions outside the target area. The technology allows physicians to control the procedure with hand-free and sterile gestures.
Researchers found that mantis shrimp's hammer blows are significantly weaker in air compared to water, with forces averaging only 18 km/h. The crustaceans may be downgrading their attacks to avoid joint damage and injury.
Researchers create highly sensitive implant that detects and transmits NMR data from nanoliter volumes of brain oxygen metabolism. The breakthrough design enables unparalleled spatial and temporal resolution for probing brain physiology.
Researchers have developed ultrasensitive nanoscale optical probes to monitor the bioelectric activity of neurons and other excitable cells. The new technology could enable scientists to study neural circuits at an unprecedented scale, leading to powerful brain-machine interfaces.
Twelve emerging scientists from Argentina, Brazil, Chile, Mexico, Spain, and Uruguay have won PROLAB travel grants to collaborate with top researchers in the US, Canada, and Spain. They will work on various projects, including reproductive biology, neuronal proteostasis regulation, exercise-induced mood changes, and cancer progression.
The researchers developed a 3D organ-on-chip platform using bioelectrical sensors to measure the electrophysiology of heart cells in three dimensions. This platform enables studying cell communication in multicellular systems, potentially screening drugs on human-like tissue.
Researchers developed an algorithm that guides catheter movements to detect atrial fibrillation sources with high accuracy. The iterative catheter navigation (ICAN) algorithm achieves over 95% success rate in human Afib simulations, even in challenging scenarios like fibrosis and patchy scars.
Researchers have developed a new imaging technique that allows them to see how living monkey brains are wired, revealing precise connections between the two hemispheres. The opto-OISI method combines optical intrinsic signal imaging and optogenetics to map brain connections point-to-point.
A bioabsorbable antibiotic envelope has been shown to reduce the risk of major device-related infections in cardiac devices by 40% within one year. The study involved nearly 7,000 patients across 25 countries and demonstrated the safety and effectiveness of this innovation.
Researchers create experimental device to mimic realistic chest impacts, testing its effect on bioengineered heart tissue. Contrary to previous studies, they found that even very rapid strains had no effect on the propagation of electrical impulses.
Researchers create experimental device to subject bioengineered heart tissue to dynamic strain cycles and measure electrophysiological response. Contrary to previous studies, they found that rapid strains do not disrupt electrical impulses, suggesting alternative explanations for deadly blows to the chest.
Loyola Medicine is testing a new catheter ablation system called Durablate that can destroy troublesome heart tissue not accessible to standard techniques. This approach may improve treatment outcomes for patients with ventricular tachycardia.
A new AR device enables surgeons to interactively explore 3D cardiac data in real-time, reducing the risk of infection and improving patient care. The technology has shown exciting potential for guiding treatment and improving treatment outcomes.
Subarachnoid hemorrhage can disrupt brain signaling, leading to extreme constriction of blood vessels and energy deprivation. The 'negative ultraslow potential' is an electrophysiological correlate of infarction and tissue death due to inadequate blood supply.
Researchers have identified a shared neural mechanism for building confidence across multiple senses, including vision, audition, and touch. The study's findings support the supramodality hypothesis, suggesting that confidence estimates share a common format in the brain.
Researchers have developed a new technique to visualize the human cardiac conduction system in 3D, providing unprecedented details. This technology will aid cardiologists in placing prosthetic valves near the heart's conduction system, reducing risks and improving surgical outcomes for patients with congenital heart diseases.
Researchers from NewYork-Presbyterian and Weill Cornell Medicine call for increased adoption of fluoroless catheter ablation to reduce radiation exposure. The procedure uses high-frequency sound waves to create a precise image of the heart, guiding treatment with computerized three-dimensional mapping systems.
Researchers found that participants' brains responded positively to sentences conforming to traditional Welsh poetry rules, even when they couldn't explicitly identify the correct form. This suggests an innate appreciation for poetic structure in the human brain.
Researchers have identified a subpopulation of neurons that represent navigational goals in the bat brain. These 'tuners' vary their activity based on the angled directionality of flight paths toward specific locations, suggesting goal-directed memory is essential for navigation.
Researchers develop space-division multiplexing optical coherence tomography (SDM-OCT) to image single neurons in live tissue, enabling label-free and depth-resolved images of neural activity. This breakthrough technology could revolutionize brain mapping and provide insights into brain disorders such as Alzheimer's and schizophrenia.
Researchers from University of Wisconsin-Madison have revealed a fabrication process for revolutionary transparent sensors, which can be used for brain imaging, electrophysiology, fluorescent microscopy, optical coherence tomography, and optogenetics. The technology has the potential to expand its applications into areas such as stroke...
A new cardiac magnetic resonance (CMR) imaging technique removes the need for patients to breathe, allowing for higher quality images in less time. The lack of motion enables physicians to accurately plan radiation therapy fields, leading to improved patient outcomes.
Researchers at George Washington University have developed a new system using optogenetics to control human heart cells, enabling the fast testing of potential new drugs. The technique can test 30,000 cells in under 10 minutes, streamlining a primarily manual process and reducing timeline from hours or years to minutes.
A new study has identified potential health risks for healthcare professionals performing x-ray guided cardiovascular procedures due to radiation exposure. The research found that workers with higher radiation exposure were at increased risk of developing orthopedic problems, cataracts, and cancers.
Scientists are using new brain-machine interfaces to restore motor function, while developing tools to repair and improve cognition. New electrophysiology techniques allow for a sharper view of the brain's activity, enabling researchers to study human brains in real-time.
Researchers have identified 39 generic biomarkers for human neuronal maturation using single cell transcriptome profiling. The study found that certain genes are consistently elevated when neurons mature, highlighting the importance of calcium signaling, mitochondrial function, and ubiquitination-related processes.
Researchers at Max Planck Florida Institute for Neuroscience used electrophysiological and optical approaches to visualize and manipulate neuronal activity in individual neurons of the somatosensory cortex. They found that the formation of functional microcircuits was determined by specific settings and the number of neurons stimulated...
The new CVIA journal published its second issue with a special focus on Electrophysiology. Key findings include strategies for preventing stroke in high-risk atrial fibrillation patients, catheter ablation as a cornerstone in AF management, and the role of multimodality imaging in substrate characterization.
Researchers at Carnegie Mellon University have developed a high-throughput, machine-learning tool to analyze synaptic density in the brain. This allows them to identify synapses from an entire cortical region and gain insights into how synaptic properties change during development and learning.